New University of Michigan Tinnitus Discovery — Signal Timing

[Kam75]

I humbly admit that I tend to be a rather negative person in life, because my motto is, "Expect the worst so you are prepared for anything."

However, when it comes to Auricle, I genuinely want to believe that it will work, even if only to reduce tinnitus and finally allow me to sleep again.

I would like to remind everyone, since the latest messages in this thread have been somewhat pessimistic, that during the first phase of testing, two people were completely free of tinnitus.

I do not know how long this lasted for them, but in my opinion, it is still a remarkable achievement.

 

[AfroSnowman]

Well, I'm still excited about the upcoming Q&A. If the news were truly bad, I think we'd get a written statement. Why would they put themselves through a Q&A full of desperate, disappointed people? I figure the range of outcomes is, on the low end, a statement about where they are in the process, and possibly even the announcement of a follow-up study like Lenire had to do. On the optimistic side, it could be a "light at the end of the tunnel" update, with hopes for a 2026 release.

If nothing else, tinnitus has taught me patience in the face of things beyond my control. I'm glad they're reaching out to the community, because in the end, this is still the only potentially impactful treatment that might become available to the public in the short term.

 

[Bhaveen]

Well, I'm still excited about the upcoming Q&A. If the news were truly bad, I think we'd get a written statement. Why would they put themselves through a Q&A full of desperate, disappointed people? I figure the range of outcomes is, on the low end, a statement about where they are in the process, and possibly even the announcement of a follow-up study like Lenire had to do. On the optimistic side, it could be a "light at the end of the tunnel" update, with hopes for a 2026 release.

If nothing else, tinnitus has taught me patience in the face of things beyond my control. I'm glad they're reaching out to the community, because in the end, this is still the only potentially impactful treatment that might become available to the public in the short term.

Hmmm… if they need another trial, I would think they would already know that. For me, if they believe announcing a Q&A in August and then waiting until October to tell us they need another trial is "good engagement," then they lack understanding. Still…

 

[2noist]

Hmmm… if they need another trial, I would think they would already know that. For me, if they believe announcing a Q&A in August and then waiting until October to tell us they need another trial is "good engagement," then they lack understanding. Still…

It would be better than keeping us in the dark for years to come.

If there's another trial, at least it means the product isn't shelved.

 

[Joeseph Stope]

It would be better than keeping us in the dark for years to come.

If there's another trial, at least it means the product isn't shelved.

I hope that Professor Shore is strong, healthy, and enjoying her retirement.

Duh… what was that story about Fermat's Last Theorem?

 

[IYIiKe]

Well, I'm still excited about the upcoming Q&A. If the news were truly bad, I think we'd get a written statement. Why would they put themselves through a Q&A full of desperate, disappointed people? I figure the range of outcomes is, on the low end, a statement about where they are in the process, and possibly even the announcement of a follow-up study like Lenire had to do. On the optimistic side, it could be a "light at the end of the tunnel" update, with hopes for a 2026 release.

If nothing else, tinnitus has taught me patience in the face of things beyond my control. I'm glad they're reaching out to the community, because in the end, this is still the only potentially impactful treatment that might become available to the public in the short term.

I think you need to look at the practical side. Tinnitus Quest had just recently had William Shatner endorse it. Companies like Auricle, like it or not, do not target the moderate/severe sufferers. They're simply too small of a market. They get a marketing bump and probably by now have at least net positive news to share.

 

[Bhaveen]

It would be better than keeping us in the dark for years to come.

If there's another trial, at least it means the product isn't shelved

I think this talk of more trials and the product being shelved is probably the result of years, even decades, of promising treatments turning out to be disappointing. Or perhaps I'm too optimistic. I'm expecting real progress to be announced in October, not "stationary" news. Surely even they realize that an event like October is meant for positive updates. Why build anticipation only to share bad news, unless you're completely unhinged?

 

[2noist]

I think this talk of more trials and the product being shelved is probably the result of years, even decades, of promising treatments turning out to be disappointing. Or perhaps I'm too optimistic. I'm expecting real progress to be announced in October, not "stationary" news. Surely even they realize that an event like October is meant for positive updates. Why build anticipation only to share bad news, unless you're completely unhinged?

A new trial would be a positive update compared to them deciding to shelve the project. It's all about perspective.

If the FDA wasn't satisfied with the latest trial, they might require another one. I guess we'll find out in October.

 

[Bhaveen]

A new trial would be a positive update compared to them deciding to shelve the project. It's all about perspective.

If the FDA wasn't satisfied with the latest trial, they might require another one. I guess we'll find out in October.

My understanding is that they have been consulting with and engaging with the FDA throughout the trial process, unless my memory is wrong. Personally, it would be disappointing…

 

[Jonno02]

You can also do a pre-submission with the FDA, where you go over your proposed trials and they let you know if they're satisfied with the setup.

Who knows what was actually done.

 

[withintention]

Are there any theories about why a large minority of subjects in the trial did not experience relief?

 

[Applejuice]

Are there any theories about why a large minority of subjects in the trial did not experience relief?

Well, not really. We do know they used a personal frequency for the trial, but the timing, electrode placement, session length, and overall trial duration were standardized.

So it could be any of those factors. Still, this is all speculation for now, and it will probably become clearer once the device is cleared by the FDA. At that point, they will be free to adjust the device for each individual and see if changes in the parameters produce different results for non-responders.

 

[dd314]

Are there any theories about why a large minority of subjects in the trial did not experience relief?

A decrease of 13 TFI points was used as the threshold for success. If they had lowered that to 11 or 9, there would probably have been many more responders than the reported 60 percent.