NMDA Receptor Antagonists?

Anyone know of any supplements that antagonize or cause permanent damage/down regulation of NMDA receptors? They appear to play a role in the development of tinnitus given their excitotoxic nature. They also help regulate brain plasticity, thus they could possibly be responsible for the solely negative changes that occurs in tinnitus sufferers.

What kinds of drugs or supplement antagonize these receptors to a high degree? I don't have access to ketamine. DXM works but it's often paired with acetaminophen which is hepatotoxic at high doses. I've heard Magnesium is antagonistic to these receptors but I take that everyday as part of my Adderall dosing and feel no noticeable effect on the ringing.

What else is there? Since they play a crucial role in memory and learning I can't kill them, but my goal is to down regulate them so much the brain is forced to allow lost functions to remain lost and uncorrected.

 

Here you can find a list of drugs you can try: https://en.wikipedia.org/wiki/NMDA_receptor_antagonist#Examples

 

I took Memantine for a while. I wrote about it in the thread. Its side effects were tolerable, but really makes you feel distant and slightly spaced out!

I don’t believe it helped with my tinnitus. I had better success with anticonvulsants.

 

This is an NMDA antagonist that passed Phase 3 today:

Axsome Therapeutics Announces AXS-05 Achieves Primary Endpoint in the ACCORD Phase 3 Trial in Alzheimer’s Disease Agitation

 

Which anticonvulsants worked? I'm intrigued by all of the positive anecdotes of Lamictal.

 

There are loads:

• Gabapentin
• Carbamazepine
• Sodium Valproate
• Lamictal
• Benzodiazepines
• Pregabalin