Johnson & Johnson's Hearing Loss Drug Discovery — Targeting α9α10 Nicotinic Acetylcholine Receptor

Discussion in 'Research News' started by ThomasRobert, May 22, 2021.

    1. ThomasRobert

      ThomasRobert Member Benefactor

      Location:
      ME
      Tinnitus Since:
      06/2019
      Cause of Tinnitus:
      Ototoxic
      Janssen Pharmaceuticals (Johnson & Johnson) has entered the game, folks. The hearing loss drug discovery game, that is.

      a9α10 receptor modulators emerge as a novel therapeutic strategy for hearing loss.

      Introducing α9α10:

      Researchers recently identified a target that could be used to treat hearing loss and a handful of related auditory disorders -- including tinnitus -- and soon we may have another promising hearing restoration 'horse in the race'.

      What's happening -- May 22, 2021 update:

      This week, David S. Bredt -- molecular neuroscientist and Global Head Discovery Neuroscience at Johnson & Johnson -- will be presenting the recent findings at The Inner Ear Disorders Therapeutics Summit, an upcoming digital conference taking place a few days from now (May 25 - 27).

      His presentation is titled:
      Targeting the α9α10 Nicotinic Acetylcholine Receptor for Hearing Loss

      Link:
      Targeting the α9α10 Nicotinic Acetylcholine Receptor for Hearing Loss

      Article:
      Promising targets for deafness drug discovery

      ...the race to find a cure seems to be getting more interesting by the day -- with new and unexpected participants joining the action, sometimes out of nowhere.
       
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    2. Tezcatlipoca
      Question it

      Tezcatlipoca Member

      Location:
      Mexico
      Tinnitus Since:
      June 2020
      Cause of Tinnitus:
      NIHL
      Holy shit! J&J is on the game folks. It's official, we are in the big leagues now.
       
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    3. Matchbox
      Wishful

      Matchbox Member

      Location:
      BC Canada
      Tinnitus Since:
      August 2020
      Cause of Tinnitus:
      Noise Induced, Prednisone (drones), Barotrauma (distortions)
      What the heck is the mechanism behind this? Is it basically mimicking Scopolamine which helps some people with tinnitus.
       
    4. serendipity1996
      No Mood

      serendipity1996 Member Podcast Patron Hall of Fame

      Tinnitus Since:
      2011
      Cause of Tinnitus:
      Unknown but suspect noise-induced
      Just to add, The Inner Ear Disorders Therapeutics Summit, will be featuring presentations from all the major players - including David Lucchino from Frequency Therapeutics, Otonomy, Akouos, Decibel Therapeutics, and more. Rinri Therapeutics will also be presenting on their stem cell approach to hair cell regeneration (so I assume they are not going down the transdifferentiation route like many others are, then).

      This conference has a $1,700 pricetag to attend though lol.
       
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    5. Lukee

      Lukee Member Podcast Patron Benefactor Ambassador

      Location:
      Toronto, Canada
      Tinnitus Since:
      01/2021
      Cause of Tinnitus:
      Wim Hof Breathing Exercises
      Here is the gist of what I heard from a researcher: we are in the middle of a paradigm shift in medical research. While doctors might still be archaic and not listen to their patients, researchers are starting to realize that the best data points come from the patients and sufferers, not from theories or textbooks. This sentiment and fundamental shift also brings to light that we have something today that we didn’t have 20 years ago: information. Forums like this allow for an accumulation of data points that have already been parsed and organized giving researchers information and insight into illness and their respective treatments.

      Basically what this means is, even companies like J&J scour these forums to understand a) the value of a treatment and b) the efficacy of previously administered treatments. Every post that contains a reaction, a status update, a chain of events, clinical diagnoses, etc. is a valuable piece of information for future research. My friend also told me that there will be an influx of funding for chronic illnesses that were previously considered incurable due to COVID-19 and medical advancements over the last couple years, especially mRNA.

      Keep up the good work and continue to produce those data points!
       
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    6. GBB

      GBB Member Hall of Fame

      Location:
      NYC
      Tinnitus Since:
      2016-2019 (Mild, Cured) 8/2020 (Severe)
      Cause of Tinnitus:
      Virus / Microsuction / Acoustic Trauma
      This evidence led Bredt to suggest that the α9α10 receptor could help prevent sound-induced hearing loss and potentially aid in the repair and rescue of damaged hair cells before they die. “Upregulating its protective effects could therefore have a variety of applications in both industrial and military settings,” he said.

      Sound preventive or for acute hearing loss though.
       
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    7. Pete88

      Pete88 Member

      Tinnitus Since:
      02/2018
      Cause of Tinnitus:
      Likely noise
      Yeah, without going down the rabbit hole of wishful thinking theories, that's what it sounds like.

      However, the fact that now this massive company is pursuing hearing loss is awesome. As @Lukee mentioned, this is a sign of a whole new attitude towards hearing loss. The door has been cracked open and it's getting opened.

      A few years ago, the idea of repairing hearing was so absurd that medical professionals today still don't believe that regenerative medicine is anything but science fiction, due to their own ignorance.

      No disrespect to the amazing biotechs working on fixes but the fact that such a big player has entered the arena is great as it lends credibility to the fight for the Average Joe. Kind of like when alternative news outlets are reporting events that go ignored by big media and the Average Joe is oblivious to it because they didn't see it on CNN or whatever.

      It also shows that big companies are getting interested in this and more likely to partner with small biotechs to help their products get to market.

      Also, coming at a time when hearing loss and tinnitus are getting more attention thanks to the pandemic, companies are all seeing the incentive to pursue what is no longer an impossible feat; to fix hearing issues.
       
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    8. Óscar PP

      Óscar PP Member

      Tinnitus Since:
      Nov 2020
      Cause of Tinnitus:
      Coronavirus
      What % of efficacy does Scopolamine have?
       
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