Otonomy OTO-313 — Treatment of Tinnitus

Discussion in 'Research News' started by Michael Larsen, Jan 9, 2018.

    1. Brian Newman

      Brian Newman Member

      Tinnitus Since:
      12/2016
      Cause of Tinnitus:
      Shooting/loud noise
      Very true. I’m thankful people are doing the trials. It helps research and brings us closer to something.
       
    2. Brian Newman

      Brian Newman Member

      Tinnitus Since:
      12/2016
      Cause of Tinnitus:
      Shooting/loud noise
      I strongly considered it. If I didn't have a hole in my right cochlea and severe noxacusis in my left ear, plus hell distortions in both, I would gladly do it. My shit is so bad that I most likely need a blood patch and am avoiding it because of the repercussions. I am teetering on edge of getting so bad I’m gonna end it. I don’t think I’m a good candidate. I have moderate tinnitus and hear it a lot. It does not bother me at all. Tinnitus is the least of my worries right now.

      Hoping if I did it, OTO-313 would help damaged nerves/synapses, theoretically helping my noxacusis, but it’s a long shot.
       
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    3. Ehren M
      Nerdy

      Ehren M Member

      Location:
      USA
      Tinnitus Since:
      01/24/2021
      Cause of Tinnitus:
      acoustic trauma
      I completely respect where you're at. I didn't mean to insinuate that I know what's best for ya, and I'm sorry if it came across that way.

      I really hope your situation improves.

      Cheers.
       
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    4. canteven

      canteven Member

      Tinnitus Since:
      03/01/2021
      Cause of Tinnitus:
      Noise
      I don’t know if this question was answered already... but what does it mean when they say they had positive results in Phase 1/2?

      Does it mean they have had people who have reduced their tinnitus?

      What does “positive results” mean?
       
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    5. Gb3

      Gb3 Member

      Tinnitus Since:
      12/19
      Cause of Tinnitus:
      Sshl
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    6. convolution

      convolution Member Podcast Patron Benefactor

      Location:
      Sweden - Italy
      Tinnitus Since:
      26/11/2020
      Cause of Tinnitus:
      White Noise from Headphones (likely)
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    7. PortugalTheMan
      Shocked

      PortugalTheMan Member

      Location:
      Portugal
      Tinnitus Since:
      01/2021
      Cause of Tinnitus:
      Anxiety / Maybe years listening to music on headphones
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    8. Fields
      Busy

      Fields Member

      Location:
      Netherlands
      Tinnitus Since:
      04/2020
      Cause of Tinnitus:
      Noise trauma
      For those worried about OTO-313 only being intended for unilateral tinnitus.

      Thanks for sharing @convolution, very interesting read.
       
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    9. Nobody19

      Nobody19 Member Podcast Patron Benefactor

      Tinnitus Since:
      2012
      Cause of Tinnitus:
      Clubbing
      Interesting, but I don't want to get too optimistic. Frequency Therapeutics also published their Phase 1 results which looked promising at the time.
       
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    10. Stacken77
      Wishful

      Stacken77 Member Benefactor

      Location:
      Sweden
      Tinnitus Since:
      10/2020
      Cause of Tinnitus:
      Noise (likely headphones & cars), Acoustic trauma did me in
      I really hope that is true, but I'm a bit doubtful that it would benefit long-term chronic sufferers since it doesn't aim to eliminate the problem in the brain. It would be interesting if they could try it on long-term sufferers, since the study had a cap of 6 month duration.
       
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    11. convolution

      convolution Member Podcast Patron Benefactor

      Location:
      Sweden - Italy
      Tinnitus Since:
      26/11/2020
      Cause of Tinnitus:
      White Noise from Headphones (likely)
      David Baguley is among the authors. He tweeted a few hours ago: "[...] The benefits for #tinnitus were modest, but clinically significant and sustained. Further trials needed: drug not yet clinically available."
       
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    12. Exit

      Exit Member Benefactor

      Tinnitus Since:
      01/2020
      Cause of Tinnitus:
      Noise
      I agree @Stacken77
      Perhaps you know this, but they did patients up to a year in the extended trial going on now.

      They’re going to release results for 0-6 months and 6-12 months, probably in about a year.
       
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    13. Gb3

      Gb3 Member

      Tinnitus Since:
      12/19
      Cause of Tinnitus:
      Sshl
      They stated this in the Tinnitus Talk Podcast.
       
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    14. Gb3

      Gb3 Member

      Tinnitus Since:
      12/19
      Cause of Tinnitus:
      Sshl
      They won’t do this if they want to get it to market. It will be definitely something you can try if it gets approved.
       
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    15. Pharz

      Pharz Member Benefactor

      Location:
      Netherlands
      Tinnitus Since:
      2019
      Cause of Tinnitus:
      Exposure to loud noise
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    16. Wrfortiscue
      Provocative

      Wrfortiscue Member

      Tinnitus Since:
      1999
      Cause of Tinnitus:
      Trauma
      So what is the drug actually doing?
       
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    17. star-affinity
      Wishful

      star-affinity Member Podcast Patron Benefactor

      Tinnitus Since:
      1993, increase in 2020, then new in 2021
      Cause of Tinnitus:
      Maybe during a soundcheck – sudden sound from speaker
      My understanding is that it contains gacyclidine which reduces the action of NMDA receptors that reside in neurons (i.e. nerve cells). I think the idea is that the NMDA receptors can ”overreact” with (some forms of?) tinnitus and therefore ”calming them down” could also calm down the tinnitus.

      Not sure if that makes sense and I could be wrong. :)

      Anyway, I'm wondering if there will be any downside to taking OTO-313 if one has some hearing loss? Thinking if it could affect any future treatments to generate hair cells and/or synapses which would hopefully also help the tinnitus.

      Hopefully no downside to get OTO-313. :)

      Edit:
      Seems I wasn't too far off:

      OTO-313 is a sustained-exposure formulation of the potent and selective N-Methyl-D-Aspartate (NMDA) receptor antagonist gacyclidine. We believe that gacyclidine can reduce the severity of tinnitus symptoms following cochlear injury by decreasing the over-activation of damaged auditory nerve fibers in the cochlea and their connections.

      Otonomy Announces Publication of Phase 1/2 Trial Results Showing Tinnitus Improvement in Patients Receiving OTO-313
       
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    18. Nobody19

      Nobody19 Member Podcast Patron Benefactor

      Tinnitus Since:
      2012
      Cause of Tinnitus:
      Clubbing
      From their press release:

      OTO-313 is a sustained-exposure formulation of the potent and selective N-Methyl-D-Aspartate (NMDA) receptor antagonist gacyclidine. We believe that gacyclidine can reduce the severity of tinnitus symptoms following cochlear injury by decreasing the over-activation of damaged auditory nerve fibers in the cochlea and their connections. OTO-313 utilizes a novel, patent-protected formulation technology to provide several weeks of gacyclidine drug exposure in the inner ear following a single intratympanic injection.
       
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    19. Wrfortiscue
      Provocative

      Wrfortiscue Member

      Tinnitus Since:
      1999
      Cause of Tinnitus:
      Trauma
      Thank you. Do you know if there has been any negative side effects? This is good news for some, including myself.
       
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    20. Wrfortiscue
      Provocative

      Wrfortiscue Member

      Tinnitus Since:
      1999
      Cause of Tinnitus:
      Trauma
      Thank you. Yeah I’m wondering about side effects. Otherwise I’m all in. 6 months in for new trauma.
       
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    21. Nobody19

      Nobody19 Member Podcast Patron Benefactor

      Tinnitus Since:
      2012
      Cause of Tinnitus:
      Clubbing
      The study that someone linked to in this page talks of no serious side effects.
       
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    22. aorelia

      aorelia Member

      Tinnitus Since:
      2021
      Cause of Tinnitus:
      Headphones
      I was interested in going in and asked some questions. I was told "one subject did experience some worsening of tinnitus which was categorized as mild, and another experienced some mild hearing loss, which then resolved 5 days after onset."
       
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    23. EkkoMusic

      EkkoMusic Member

      Tinnitus Since:
      01/2021
      Cause of Tinnitus:
      Unknown
      Were these subjects from the OTO-313 group or the placebo group?
       
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    24. Gb3

      Gb3 Member

      Tinnitus Since:
      12/19
      Cause of Tinnitus:
      Sshl
      The other side effects occurred with the placebo according to the podcast interview.
       
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    25. Diesel

      Diesel Member Benefactor Ambassador Hall of Fame Advocate

      Tinnitus Since:
      1-2019
      Cause of Tinnitus:
      20+ Years of Live Music, Motorcycles, and Power Tools
      This means nothing. They could have got placebo or OTO-313.
       
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    26. Bambam0
      Cool

      Bambam0 Member Podcast Patron Benefactor

      Tinnitus Since:
      2/2018
      Cause of Tinnitus:
      Drums/Guns/Motorcycles
      I know I should scroll through the thread, but what's the best possible release date for this?
       
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    27. Exit

      Exit Member Benefactor

      Tinnitus Since:
      01/2020
      Cause of Tinnitus:
      Noise
      2025...?

      OTIC is up from $1.1 to $2 without any news :D
       
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    28. Sentinel
      No Mood

      Sentinel Member

      Tinnitus Since:
      Late November/Early December 2020
      Cause of Tinnitus:
      Really epic hobbies
      Fluctuating a bit more, but always returning to the new low level during the day. Sometimes I wake up and it's worse and then I get up and move around and it dissipates, sometimes before going to bed it's louder and quiet in the morning. Frankly, because it's at a lower level most of the time when it is louder I perceive it as being worse than it is because I have to do my journal entries for the study every night. I feel like if I wasn't monitoring it all the time I'd notice it less overall but that's part of the deal. When it's really low and I'm in a quiet room I have to almost search for it to be able to hear it, which was NOT the case before.

      My participation in the study ends at the end of this month, and I was injected in early July and am clearly still experiencing positive effects which I think is pretty awesome. It may have had a permanent effect on my tinnitus which is relieving. I feel like I have more control over it in a strange way. I'm ready to stop logging my tinnitus every night and just enjoy this new normal for as long as it lasts. It's given me the opportunity to feel like I can move past it.

      Still far preferable to the way it was before even with fluctuations.

      I'm happy.
       
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    29. Mica Rambin

      Mica Rambin Member

      Tinnitus Since:
      09/2020
      Cause of Tinnitus:
      NIHL
      This is great news.
       
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    30. ColinUK

      ColinUK Member

      Tinnitus Since:
      2013 initial, worsened 2020
      Cause of Tinnitus:
      Initial Music Gig, Worsened Cinema or possible covid
      Is 43% considered a good result?

      Not that I'm pessimistic or anything :confused:

      But if only 43% got an improvement and this is their ideal patient in the acute phase, does it really offer much hope to any long term sufferer which we all will be by the time this is released which they are less hopeful about it working for anyway?

      I mean if Dr. Shore's trial reports back only 40% saw improvement, I would consider that pretty poor or is it different for drugs?
       
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