Otonomy OTO-413 — Treatment of Hidden Hearing Loss

Discussion in 'Research News' started by Michael Larsen, Jan 9, 2018.

    1. lello

      lello Member

      Tinnitus Since:
      2018
      Cause of Tinnitus:
      unknown
      Sorry for the ignorance, but how many decibels does a clinically-meaningful improvement correspond to? I seem to remember 20 dB but maybe I'm wrong.
       
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    2. Geatly

      Geatly Member

      Tinnitus Since:
      12/2021
      Cause of Tinnitus:
      Noise induced, by jackhammering into concrete on constructio
      That is because FX-345 is actually second generation. Well that would be amazing. I think it will, even more than just 20 dB.
       
    3. patorjk
      No Mood

      patorjk Member Benefactor

      Tinnitus Since:
      2008
      Cause of Tinnitus:
      Several reasons
      I just realized that Otonomy posted a slide deck detailing the Phase 2a top-line results. I think it's pretty enlightening. This slide in particular seems to show how real the effect is:

      sin_test_phase2a.png
       
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    4. Diesel

      Diesel Member Benefactor Ambassador Hall of Fame Advocate

      Tinnitus Since:
      1-2019
      Cause of Tinnitus:
      20+ Years of Live Music, Motorcycles, and Power Tools
      They noted at the beginning of the webcast that the patients recruited in Phase 2A had hearing that was worse on-average than those in the Phase 1/2. It seems to me considering how heterogeneous hearing loss is, that a worse group probably also has greater variations between each individuals in extent and type of damage. So that may explain the lower % of responders.

      Good news is in a few months, we’ll learn about how the higher dosages may have a greater effect to a similar group.

      They also have the option to p-hack their drug population like Frequency Therapeutics is doing with FX-322, by just recruiting baselines that show the highest likelihood of responding to drug. Which they will know before the”full” Phase 2.
       
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    5. ThomasF
      Creative

      ThomasF Member

      Location:
      Florida
      Tinnitus Since:
      2001
      Cause of Tinnitus:
      Probably loud music
      That graph looks good @patorjk. Certainly cause for optimism.
       
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    6. lello

      lello Member

      Tinnitus Since:
      2018
      Cause of Tinnitus:
      unknown
      I have looked at the presentation, and I understand that OTO-413 will only be suitable for moderate / severe hearing loss but not for profound hearing loss (over 90 dB): is that correct? So whoever has profound hearing loss will not find any benefit from either OTO-413 or FX-345?
       
    7. dbeats

      dbeats Member

      Tinnitus Since:
      2020
      Cause of Tinnitus:
      Loud noise
      One of the inclusion criteria was:
      • Subject has audiometrically-defined normal hearing or up to moderately severe hearing impairment.
      Doesn't mean a person with profound hearing loss wouldn't benefit from it, but maybe someone else knows more.
       
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    8. lello

      lello Member

      Tinnitus Since:
      2018
      Cause of Tinnitus:
      unknown
      Could it also depend on the residual hearing? Little residue = little chance for improvement?
       
    9. Travis Henry
      Confused

      Travis Henry Member

      Location:
      Dallas,TX
      Tinnitus Since:
      10/2021
      Cause of Tinnitus:
      1 Moderna Vac, Noise and stress I guess, its killing me
      I hope further news comes out soon.
       
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