Otonomy OTO-413 — Treatment of Hidden Hearing Loss

Discussion in 'Research News' started by Michael Larsen, Jan 9, 2018.

    1. patorjk
      No Mood

      patorjk Member Benefactor

      Tinnitus Since:
      2008
      Cause of Tinnitus:
      Several reasons
      I went down a bit of a rabbit hole and am now warmer on that idea, though I still think it's best to keep tinnitus out of the trial. If they wanted to check for that it would make more sense to do a separate Phase 1/2 study that focused just on that. If the trials aren't focused there will be problems like what was seen in the FX-322 Phase 2a trial.
       
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    2. addot

      addot Member

      Location:
      US
      Tinnitus Since:
      Jan 2013
      Cause of Tinnitus:
      Noise exposure
      Sorry, I forgot to quote that part of your last post, but I meant to say I absolutely agree with you on that! At the end of the day we all want the trial to succeed, and I share your sentiment that keeping tinnitus out of it gives them the best shot.

      (I'm still puzzled over them excluding musicians from the trial though...)
       
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    3. ThomasF
      Creative

      ThomasF Member

      Location:
      Florida
      Tinnitus Since:
      2001
      Cause of Tinnitus:
      Probably loud music
      IIRC, musicians, even those who use hearing protection, tend to have tinnitus simply due to their regular exposure to loud music. So it's probable they just wrote them off as a whole to avoid any problems.
       
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    4. addot

      addot Member

      Location:
      US
      Tinnitus Since:
      Jan 2013
      Cause of Tinnitus:
      Noise exposure
      Yeah, reading over the inclusion/exclusion criteria again, I think you're right. Maybe this is another layer of protection against people lying about their tinnitus to enter the trial. Now that I think about it, musicians are uniquely positioned as a profession that 1) is constantly exposed to loud sounds and 2) almost never wears hearing protection. In other professions, hearing protection is taken much more seriously, especially in an industrial setting. Obviously not every musician has tinnitus, but it's probably easier and less risky to not let any musicians in altogether.
       
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    5. DimLeb

      DimLeb Member

      Tinnitus Since:
      03/2021
      Cause of Tinnitus:
      Idiopathic Cochleopathy or Maybe Loud Music
      Well, they should have excluded more professions if they wanted to be really precise to who they enroll, as there are industries way more noisy (construction, waiters in clubs etc etc) and we kinda know that earmuffs, earplugs etc don't give the protection they advertise.

      The reality is that a huge chunk of musicians nowadays do their stuff from their home studio or so (music producers selling music, content creation, YouTube/TikTok, selling merch etc), minimising their noise exposure to maybe less than other jobs.

      Having said that, they could maybe have noise exposure as performers, but at least professional ones use in ear monitors which serve as hearing protection too. The other employees in live music places rarely wear any protection, let alone the audience...

      Just adding my note as a musician that feels a bit offended by that exclusion criteria lol.
       
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    6. d'Wooluf

      d'Wooluf Member

      Tinnitus Since:
      2010
      Cause of Tinnitus:
      unknown
      One of the things that is sometimes recommended to maximise your speech understanding is to learn a musical instrument. Otonomy might feel that including musicians might skew the results in some way- bearing in mind that speech understanding is the primary measure. Perhaps musicians might benefit less because they are already using their hearing closer to its full potential.
       
      • Informative Informative x 1
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