Otonomy OTO-6XX — Hair Cell Regeneration

Discussion in 'Research News' started by patorjk, Oct 2, 2020.

    1. paul mclean

      paul mclean Member

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      For sure that's relieving to hear.

      If they do a trial in Australia I will sign up for it 100% and I'll do a review of it and post it up here if I get accepted. Obviously after the confidentiality agreement is over.

      Otherwise I'll be looking to travel to wherever it's available first haha.
       
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    2. tommyd87

      tommyd87 Member

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      I don't think right now that there will be any trials for any of these treatments in Australia as the firms are based in North America and also most of the pharma companies which they have partnered with seem to be in Asia and/or Europe. Essentially they are able to trial the medicine there as there would probably be a sufficient number of people to actually work with.

      I am actually also in the same boat as you and would happily partake in trials if they were run in Australia, although I have a feeling that we will be buying this lol.

      Look at it this way however, we are thankfully very likely to get the medicines here ASAP after release due to the government allowing us to get medicines as soon as they meet the American requirements. Also at this stage if these treatments turn out to be successful then I can see them being offered and/or administered through the specialist hospitals like the Eye and Ear in Melbourne because based off of the government's views on supporting the provision of medicine I can absolutely see them assisting everyone to make these treatments available.
       
    3. kiki

      kiki Member Benefactor

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      What is the mechanism of action of OTO-6XX to regenerate hair cells? Is it something that activates progenitor cells like FX-322 and causes cell division? Or is it the type of γ-secretase inhibitor that transforms supporting cells into hair cells? Is it a different mechanism of action that is different from Audion and FX-322, that does not interfere with patents? I don't know even if I look it up on the internet. Does anyone know?
       
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    4. FGG
      No Mood

      FGG Member Podcast Patron Benefactor Hall of Fame Advocate

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      They haven't released the mechanism of action yet as far as I know. Very, very little is known about it. As it moves to clinical (a timeline isn't known for that either), we would know more.
       
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    5. tommyd87

      tommyd87 Member

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      I hope that this moves to clinical trials soon since there is now an agreement with Kyorin on the medicine. It will be interesting to see how OTO-6XX and all the other similar medicines compare to FX-322.
       
    6. tommyd87

      tommyd87 Member

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      I definitely didn't see this though this is really interesting to know. I reckon that this then explains why Otonomy is partnering with them.

      Apparently Kyorin has made the compound for this medicine and has agreed to partner with Otonomy in order to utilise their drug dosing/drug delivery technique to treat people with the medicine.

      This tells me that Otonomy may have a somewhat more advanced method of dosing people than what Kyorin maybe could offer themselves and hence why this agreement has been made with each other. This seems like a significantly positive move.
       

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    7. kiki

      kiki Member Benefactor

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      Is Otonomy's gel so good? Is it true that a single injection can reach the depths of the cochlea? Is it really better than the Frequency Therapeutics gel? Is Frequency Therapeutics impossible to improve in-house without patent permission from Otonomy?
       
    8. FGG
      No Mood

      FGG Member Podcast Patron Benefactor Hall of Fame Advocate

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      Their gel is extended release, which has definite and unique benefits.

      All we know so far is that it seems more effective when used in OTO-104 vs regular Dexamethasone and this is for two reasons: it maintains elevated levels of drug longer and the gel seems to solve some of the polarity issues with IT steroids.

      How this translates to other drugs should be known soon though because the results of OTO-413 will be out by end of year.
       
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    9. tommyd87

      tommyd87 Member

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      It seems very effective in Otividex trials too, especially with how deep it goes. Got a feeling that this is why there is a lot of promise with the treatment.
      The question isn't necessarily at this stage which gel is better but basically which dosing method is better. We know that the dosing method of Otonomy's treatments is initially looking like it is superior to Frequency Therapeutics. What we won't know though is whether Frequency Therapeutics or Otonomy's medicine is more effective. Essentially it might come down simply to drug dosing although we don't know yet till the trial results are published.

      Right now if it is a case of Otonomy's method of dosing being patented, then I cannot see how Frequency Therapeutics could be allowed to utilise it, especially with the agreement Otonomy has entered into with Kyorin. This tends to be why I think that there will be some attempt made by Frequency Therapeutics to look at redosing in the future using either a technique that is widely available or by entering into a deal with a dosing company.
       
    10. WillBeNimble
      Buzzed

      WillBeNimble Member Podcast Patron Benefactor

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      Promising research. We'll see how it pans out. The regrowth of the IHC, which were essentially non-existent is very promising indeed. Though the chaotic nature is a concern. Still, impressive.
       
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    11. GBB

      GBB Member

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      Sorry what are you referring to when you say chaotic nature? Just want to clarify for my own understanding.
       
    12. xyz
      Alienated

      xyz Member

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    13. FGG
      No Mood

      FGG Member Podcast Patron Benefactor Hall of Fame Advocate

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      As far as Audion, they have released comparatively little info that's publically available (perhaps more is available in research circles).

      Frequency Therapeutics released this but it's in culture:

      Clonal Expansion of Lgr5-Positive Cells from Mammalian Cochlea and High-Purity Generation of Sensory Hair Cells

      And they already confirmed in the podcast that they don't have supernummery cells in vivo though they have proliferation in culture so the appearance would be different.

      OTO-6xx is still pre clinical and i'm not sure what the conditions were for those histologic photos.
       
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    14. tommyd87

      tommyd87 Member

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      OTO-6XX I think will probably move out of pre-clinical very soon since they have now signed that agreement.
       
    15. frpp

      frpp Member

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      Honestly if they work properly, I'm down for extra hair cells. Having more functioning hair cells could be an answer to people with conductive hearing loss.
       
    16. FGG
      No Mood

      FGG Member Podcast Patron Benefactor Hall of Fame Advocate

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      Why would that help people with conductive loss?
       
    17. frpp

      frpp Member

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      I figured more hair cells would equal more amplification. I'm probably wrong.
       

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