Otonomy Q1 2019 Financial Results & Business Update

Discussion in 'Research News' started by attheedgeofscience, May 6, 2019.

    1. JohnAdams
      Starving

      JohnAdams Member Benefactor Hall of Fame

      Location:
      here
      Tinnitus Since:
      it started.
      Cause of Tinnitus:
      hearing loss
      So OTO-313 has to be administered over and over again?
       
    2. FGG

      FGG Member

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Meniere's
      • Good Question Good Question x 1
    3. Daniel Lion
      Ape-like

      Daniel Lion Member Benefactor

      Location:
      se asia
      Tinnitus Since:
      2017
      Cause of Tinnitus:
      Noise trauma, hearing loss
      Super quick read... and I consider you the genius. I will read again. After a super quick scan, because I need to get my kids from school, sounds like BDNF is crucial in the embriotic stage and early development. NT-3 sounds like the shit we need. Again, 5 minute scan from a certified lunatic, but that was my impression.

      What do you think FGG, you're easily one of the brightest scientific minds on this forum.

      What are your thoughts?

      Daniel
       
      • Good Question Good Question x 1
    4. FGG

      FGG Member

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Meniere's
      My impression is exactly yours. The paper seems to imply that BDNF helps hair cells early in development but NT-3 is used (the crucial, limiting substance) to regenerate them in the adult. I wasn't aware that there was even limited regeneration ability in the adult that reduces with age but seems implied if I'm understanding the paper correctly.

      My hope is that the researchers at Otonomy knew this about BDNF but maybe a high enough concentration of it can induce synaptic proliferation regardless of age. I was trying to figure out when this information about BDNF in development was obtained because if it was *after* Otonomy started their pre-clinical trials, I would be worried they bet on the wrong horse.

      I might be reading too much into this, though, because my anxiety is through the roof lately.
       
      • Helpful Helpful x 1
    5. FGG

      FGG Member

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Meniere's
      Okay, found the reference to a study from 2014 about BDNF and NT-3. Looks like Liberman was one of the authors.

      I had written to him (Liberman) months ago and explained I had widespread synapathy and inner hair cell damage (and outer hair damage at higher frequencies) with resultant tinnitus and marked hearing distortion.

      I asked him (Liberman) if he could give me any kind of hopeful statement since I was devastated about losing my career, marriage and music. He told me that he can't obviously guarentee anything but that Frequency, Otonomy and Decibel all had good ideas about hearing loss, hidden hearing loss and tinnitus and he felt optimistic at least one of them would have a positive trial within 5 years.

      FWIW, I wrote to about 10 researchers and he was the only one who responded. He didn't say much (as expected, he must be extraordinarily busy) but he seemed genuine and empathetic by his tone.

      I now see an otologist the Hough Ear Institute since my vestibular case is so complex and asked him if he shares Dr. Liberman's optimism for hearing regeneration and he said that he did.

      I miss music so much. My favorite band was Magnolia Electric Company and they had a song called "Hope Dies Last". That's where i am right now but I am holding on to these studies.
       
      • Like Like x 4
      • Informative Informative x 2
    6. Ken219
      Frustrated

      Ken219 Member

      Location:
      New York Area
      Tinnitus Since:
      Summer of 1990
      Cause of Tinnitus:
      Noise exposure?
      So sorry for your losses but you still have hope! I've been hanging on through many spikes. You have a family on Tinnitus Talk and your contributions are enormous. Research is light years beyond 10 years ago. I hope for a cure for hearing loss but I'd forgo getting my hearing back just to lower or stop the tinnitus.

      @FGG you are a shining star with me :huganimation:
       
      • Like Like x 3
    7. JohnAdams
      Starving

      JohnAdams Member Benefactor Hall of Fame

      Location:
      here
      Tinnitus Since:
      it started.
      Cause of Tinnitus:
      hearing loss
      We should all regard that timeframe as unacceptable.
       
      • Agree Agree x 8
    8. Daniel Lion
      Ape-like

      Daniel Lion Member Benefactor

      Location:
      se asia
      Tinnitus Since:
      2017
      Cause of Tinnitus:
      Noise trauma, hearing loss
      Thanks for your feedback, very enlightening. And hats off to Liberman for getting back to you, Steven Heller at Stanford took some time out to write to me as well. These guys are scientists, tend to be pretty cool, and caring people. 5 years is awesome for my own optimistic projections.

      We have to accept we won’t be cured, but our pain and quality of life may improve. Thanks for getting back FGG, you're awesome. Stay strong, eat well, do saunas and relaxation stuff and know you're a star.

      See you around the block, take good care,

      Daniel
       
      • Agree Agree x 1
    9. FGG

      FGG Member

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Meniere's
      Are you saying you don't think our tinnitus would be cured only reduced? Or that our hearing loss would only reverse so much or both?

      My tinnitus is only moderate (most of the time) so I would settle for enough hearing improvement to hear music again even if I was saddled with ringing my whole life. Music is so tied to how I experience life and remember things that I can't imagine spending the next 40 years on this blue dot without it.

      I just wish there was any kind of concrete answer we could get even if it was with a nebulous timeline.
       
      • Agree Agree x 4
      • Hug Hug x 1
    10. Candy

      Candy Member Benefactor Advocate

      Tinnitus Since:
      06/2016
      Cause of Tinnitus:
      Unidentified
      Thanks @FGG. I’m concerned about the OTO-313, the thi reduction of 10 points. I’m going through a horrible phase and that drug is my only hope to be fully functional again. What are your views?
       
    11. FGG

      FGG Member

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Meniere's
      The big question for me on Oto-313 is if it is useful for chronic tinnitus. I think Oto-413 will probably be more useful. All speculation though.
       
      • Agree Agree x 1
    12. Candy

      Candy Member Benefactor Advocate

      Tinnitus Since:
      06/2016
      Cause of Tinnitus:
      Unidentified
      Let’s hope... Seriously all we need is one measly treatment to give a slight improvement.
       
    13. JohnAdams
      Starving

      JohnAdams Member Benefactor Hall of Fame

      Location:
      here
      Tinnitus Since:
      it started.
      Cause of Tinnitus:
      hearing loss
      If it works, well then yeah. It looks to me like you'd have to go get a new shot of this stuff every few weeks.
       
    14. ChrisBoyMonkey

      ChrisBoyMonkey Member Podcast Patron

      Location:
      Los Angeles, CA
      Tinnitus Since:
      04/2019
      Cause of Tinnitus:
      U.S. Army/Field Artillery Veteran
      Otonomy has increased their clinical trial locations and are still recruiting. A good sign for efficacy? Check out the newly added centers, there might be one in your area if you are interested.


      Contacts
      Contact: Clinical Study Manager otonomyclinicaltrials@otonomy.com

      United States, Colorado
      Colorado ENT and Allergy Recruiting
      Colorado Springs, Colorado, United States, 80909
      Contact: Deborah Bothwell 719-867-7810 dbothwell@coloradoent.com

      United States, Illinois

      ChicagoENT Recruiting
      Chicago, Illinois, United States, 60657
      Contact: Ninos J Joseph 773-289-1823 njoseph@chicagoent.com

      United States, Kentucky
      Advanced ENT and Allergy Recruiting
      Louisville, Kentucky, United States, 40207
      Contact: Ellie Fridell 502-213-3858 ext 1185 Efridell@advancedentandallergy.com

      United States, Louisiana
      Tandem Clinical Research, LLC Recruiting
      Marrero, Louisiana, United States, 70072
      Contact: Tammy Johnson 504-934-8424 tjohnson@tandemclinicalresearch.com

      United States, New York
      Northwell Health at ENT and Allergy Associates Recruiting
      White Plains, New York, United States, 10605

      United States, North Carolina
      Charlotte Eye Ear Nose & Throat Associates Recruiting
      Charlotte, North Carolina, United States, 28210
      Contact: Sherry Fredenberg 704-295-3389 sfredenberg@ceenta.com
      Piedmont Ear, Nose, and Throat Associates Recruiting
      Winston-Salem, North Carolina, United States, 27103

      United States, Texas
      Worldwide Clinical Trials Recruiting
      San Antonio, Texas, United States, 78217
      Contact: Andrea Velasquez andrea.velasquez@worldwide.com

      Sponsors and Collaborators
      Otonomy, Inc.

      https://clinicaltrials.gov/ct2/show/NCT03918109?type=Intr&cond=Tinnitus&phase=012345&lupd_s=07/06/2019&lupd_d=14

       
      • Informative Informative x 1

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