Post Your Current Medication / Supplement Stack

Discussion in 'Support' started by GBB, Jan 10, 2021.

    1. Drachen
      Tired

      Drachen Member

      Location:
      United States
      Tinnitus Since:
      December 2020
      Cause of Tinnitus:
      Currently unknown; awaiting evaluation
      Are you saying the Valerian and Passionflower had an effect on the tinnitus? I've seen those two cited as valid sleep aids and have been considering getting some.
       
    2. FGG
      No Mood

      FGG Member Podcast Patron Benefactor Ambassador Hall of Fame Advocate

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Multi-factorial
      Valerian has GABA effects so this wouldn't be surprising.
       
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    3. AUTHOR
      AUTHOR
      GBB

      GBB Member Hall of Fame

      Location:
      NYC
      Tinnitus Since:
      2016-2019 (Mild, Cured) 8/2020 (Severe)
      Cause of Tinnitus:
      Virus / Microsuction / Acoustic Trauma
      My shroom dude just came through so am going to be trying .1g Psilocybin, .5g Lion's Mane, and .5g Niacin today.
       
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    4. Ela Stefan

      Ela Stefan Member

      Tinnitus Since:
      11/2018
      Cause of Tinnitus:
      Ear Infection
      How did you hold on to a sleep pattern when being off benzos? This is the most complicated problem for me, if I get off of them, how will I sleep...
       
    5. Drachen
      Tired

      Drachen Member

      Location:
      United States
      Tinnitus Since:
      December 2020
      Cause of Tinnitus:
      Currently unknown; awaiting evaluation
      I know there's no conclusive way to tell for sure, but could this mean it would be a bad idea to take long-term? I've become skeptical of trying anything that's GABAergic in fear of causing effects similar to what occurs with benzos.
       
    6. FGG
      No Mood

      FGG Member Podcast Patron Benefactor Ambassador Hall of Fame Advocate

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Multi-factorial
      Who knows. It seems susceptibility to negative effects is highly individual. I wish there was a large genetic study on GABA receptor pleomorphism and tinnitus but I haven't seen anything like that.
       
    7. AUTHOR
      AUTHOR
      GBB

      GBB Member Hall of Fame

      Location:
      NYC
      Tinnitus Since:
      2016-2019 (Mild, Cured) 8/2020 (Severe)
      Cause of Tinnitus:
      Virus / Microsuction / Acoustic Trauma
      Maybe but it's the one central mechanism of controlling the volume, at least for me. I've tried many things, probably 70 by my count, and only GABAergic substances have helped.
       
    8. Greg Sacramento

      Greg Sacramento Member Benefactor Ambassador Hall of Fame Advocate

      Tinnitus Since:
      April 2011
      Cause of Tinnitus:
      syringing and now somatic T dental work
      • Informative Informative x 3
    9. AUTHOR
      AUTHOR
      GBB

      GBB Member Hall of Fame

      Location:
      NYC
      Tinnitus Since:
      2016-2019 (Mild, Cured) 8/2020 (Severe)
      Cause of Tinnitus:
      Virus / Microsuction / Acoustic Trauma
      Anxiety scores or a measure of tinnitus?
       
    10. simb999

      simb999 Member Benefactor

      Tinnitus Since:
      nov 2018
      Cause of Tinnitus:
      noise exposure
      I'm still on the Sertraline. I have been for 2 years but I don't take anything specifically for the tinnitus anymore.

      It took me about 12 months to realise the only thing that seemed to send my tinnitus crazy was noise so I live as quiet a life as possible.
       
    11. lis

      lis Member

      Tinnitus Since:
      severe 2020
      Cause of Tinnitus:
      acoustic trauma
      @FGG @Greg Sacramento @GBB

      Do these theories help us know how to disable the panic response? How to interpret on a practical level of what to do? I think at this point my panic has a life of its own and is hardwired into my brain after extremely long uncoping stress. Help! Looking for substance or something to intervene crippling anxiety.

      Psychosomatic model: panic disorder triggered by misinterpreted internal stimuli (e.g., stimuli from vestibulocochlear dysfunction), that are interpreted as signifying imminent physical danger. Heightened sensitivity to auditory sensations leads to increased anxiety and, through conditioning, drives the development of panic disorder.

      Network alarm theory: panic which involves noradrenergic, serotonergic, and other connected neuronal systems. According to this theory, panic can be triggered by stimuli that set off a false alarm via afferents to the locus coeruleus, which then triggers the neuronal network. This network is thought to mediate anxiety and includes limbic, midbrain and prefrontal areas. Vestibulocochlear dysfunction in the setting of increased locus coeruleus sensitivity may be a potential trigger.
       
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    12. Greg Sacramento

      Greg Sacramento Member Benefactor Ambassador Hall of Fame Advocate

      Tinnitus Since:
      April 2011
      Cause of Tinnitus:
      syringing and now somatic T dental work
      Anxiety, depression, panic disorder, suicide tendency and SAD.
      Calculated by means HAMD -17 - differential.
      Published in nine leading science medical journals, but company isn't promoting success until FDA approval.
      Tinnitus will need an added FDA proposal.
       
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    13. linearb
      Psychedelic

      linearb Member Benefactor Hall of Fame

      Location:
      beliefs are makyo and reality ignores them
      Tinnitus Since:
      1999
      Cause of Tinnitus:
      karma
      I found that my sleep patterns post-benzos were pretty identical to while I was on benzos, which makes sense; it's pretty well established that people build at least a degree of tolerance to the hypnotic effects of benzos.

      During my first taper, I used a lot of melatonin and cannabis, and I remember my sleep as "weird" but generally I slept a fair amount. During my second taper I used no cannabis or any other drugs/supplements, and certainly got whacked with pretty severe insomnia for several months at the end of and following the taper, but again I felt like within 8-12 months my sleep patterns returned to their usual. Mind you, "usual" hasn't been "great" for me ever, or at least not since I was a little kid.
      I think sleep and tinnitus patterns both tend to reward consistency; I'd try to stick with a single stack taken the same way at the same time of day for ~4-6 weeks before coming to any conclusions. It does get expensive to play supplement whack-a-mole, too.
       
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    14. FGG
      No Mood

      FGG Member Podcast Patron Benefactor Ambassador Hall of Fame Advocate

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Multi-factorial
      When I had frequent long-lasting full spinning vertigo attacks for a period of 8 months, I had very frequent panic attacks (first ever in my life) even when I wasn't having attacks. My PT explained the "panic center" in the brain is located near balance neurons, which is an adaptation to prevent falls but when it misfires really messes with you.

      I did not go the pharmacological route with this. Two things helped me: PT with a vestibular specialist for about a year and I read a great book on panic attacks and practiced until I no longer had them and it reduced my overall anxiety significantly as well:

      https://www.amazon.com/Dare-Anxiety-Stop-Panic-Attacks/dp/0956596258/

      On another thread, I referenced Dr. Lechin's work and he had (I don't believe he is still alive) pharmacological methods that involved multiple different drugs in small amounts titrated for the individual (after being measured in a hospital setting with neurotransmitters being measured at rest, orthostasis and exercise). You can absolutely do it without that though (I asked him personally) it just takes a lot longer and a lot of mindfulness for lack of a better term.

      He was very against benzos though (even among people who tolerate them long term) because it reduced slow wave sleep which he said contributes to neuroimmune dysregulation. What's interesting is I didn't specifically ask about that, he just offered that he had patients given benzos by other doctors and he saw the class as problematic. I have no idea if other GABA drugs (e.g., Kava) would have this issue.
       
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    15. AUTHOR
      AUTHOR
      GBB

      GBB Member Hall of Fame

      Location:
      NYC
      Tinnitus Since:
      2016-2019 (Mild, Cured) 8/2020 (Severe)
      Cause of Tinnitus:
      Virus / Microsuction / Acoustic Trauma
      This won’t be real to me until it’s coursing through my veins. : )
       
    16. lis

      lis Member

      Tinnitus Since:
      severe 2020
      Cause of Tinnitus:
      acoustic trauma
      Thank you so much for the prompt response. I'm plagued more by the "cochlear" rather than the vestibular part.

      Would your feedback change about how to intervene if the tinnitus and distortions are the most panic inducing for me, as the vestibular issues have tampered down a lot?
       
    17. FGG
      No Mood

      FGG Member Podcast Patron Benefactor Ambassador Hall of Fame Advocate

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Multi-factorial
      My tinnitus was in the severe category for a period of a few months. During that time, my then husband (now ex) couldn't deal with my stress and anxiety. Because of that, I forced myself to try to stay as calm as possible to try to save my marriage (it didn't work, he didn't want to be hindered by my health problems). But somehow acting like I was doing much better than I was inside seemed to help. It was like a "fake it until you make it" situation. But truthfully I basically swapped anxiety for deep depression (which is actually not quite as bad for your neurotransmitters).

      My tinnitus did reduce to moderate where it stayed permanently but I'm not sure how that would have gone if I had severe tinnitus for years, though. Being acute, I did recognize that it's easier to stay calmer when you know it may fade (and often does) during that time.

      What I do now is try to stay insanely busy. I had to quit my career and I now resell online full time and it honestly takes 10-12 hours a day of work to support myself this way. I work with a partner, too, so I have company in that sense as well. But I would say not giving yourself any down time is probably the best way to help. All that to say, ((hug)).
       
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    18. lis

      lis Member

      Tinnitus Since:
      severe 2020
      Cause of Tinnitus:
      acoustic trauma
      @FGG, also, wondering if your distortions or hearing loss contributed to your panic attacks? My many distortions and hearing loss are horrifying to my nervous system.
       
    19. FGG
      No Mood

      FGG Member Podcast Patron Benefactor Ambassador Hall of Fame Advocate

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Multi-factorial
      I had vestibular disease many months before any hearing loss. The panic attacks were from having incapacitating full rotational vertigo attacks (the longest latest 48 hours and I had to be hospitalised for a few).

      Ironically, they gave me high dose antibiotics to try to treat the vertigo assuming it was infectious because I was also febrile initially (turned out it was viral) and that's when I lost my hearing. I had already read the Dare book that I recommended earlier in this thread at that point though (and managed to learn to manage my anxiety better as a result) so by the time I did lose hearing I was more practiced (as well as incentivized by trying to save my marriage).

      I would say my tinnitus and distortions give me some anxiety but more of a deep chronic, very frequently teary eyed depression (which sucks but as an anxiety sufferer, you know anxiety is worse). I had one severe brief tinnitus spike a few months ago but I just made my friend hug me a lot and cried a bunch and I fought the anxiety spiral with stuff I had practiced from the dare book. It doesn't get rid of anxiety (because bad tinnitus would give anyone anxiety) but stops it from reaching the peaks it otherwise would if that makes sense. I still definitely have some anxiety (and I'm sure it would be worse if my tinnitus was still severe instead of 6/10 like it is now) but it's nowhere as bad as it would be without trying to stay busy and trying to self calm.

      My distortions really suck, music especially (any music) sounds like a toy with almost dead batteries. Talking to people on the phone is mentally exhausting and I need captions for TV (which is hard to get invested in anyway because the background music ruins everything). It's not like I have "habituated" or I'm cool with this hell. I think the most useful thing I do is stay busy (both working and researching things). I also have pretty bad visual snow. It just sucks all around but I am determined to put my neuroimmune profile in as favorable of a state as I can.
       
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    20. Lilah
      Blah

      Lilah Member Benefactor

      Location:
      USA
      Tinnitus Since:
      12/2018
      Cause of Tinnitus:
      Unknown
      For the past year, I have taken these daily (some of these items, much longer) and will continue to do so for the foreseeable future.

      Pure Encapsulations ONE multivitamin
      Ferrous Sulfate - 28 mg
      Vitamin D3 - 2000 mg
      (The above three are musts as I get borderline anemic and Vitamin D deficient without them).

      Vitamin C - 500mg
      Biotin - 1000 mcg
      AREDS 2 - one pill instead two, since I take a multivitamin
      HCQ - 200-400mcg (depending on how I feel, usually on the lower end, for lupus)
      Lo Loestrin Fe (for hormonal issues)

      I take AREDS 2 (which has a lot of zinc) at night an hour before bed since it could help with sleep. I also usually take Vitamins C and D at night.

      I have B12 gummies on hand for energy. I also use flavored "Key Nutrients" electrolyte powder (sugar free) in my water everyday for one or two glasses, and that has a lot of various vitamins.

      I don't believe any of the above affect my tinnitus. I have used prescription/OTC sleep aid in the past but no longer use them, as the effects wore off. I still have OTC sleep aid on hand.
       
    21. MindOverMatter

      MindOverMatter Member

      Location:
      Norway
      Tinnitus Since:
      2004
      Cause of Tinnitus:
      Unknown (possibly stress related, and later sound induced)
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    22. Born To Slay
      Depressed

      Born To Slay Member

      Tinnitus Since:
      10/2019
      Cause of Tinnitus:
      Loud concert
      @GBB, can you tell me what hyperacusis symptoms Keppra and Nortriptyline helped relieve?
       
    23. BrOKeN_1

      BrOKeN_1 Member

      Tinnitus Since:
      10/2020
      Cause of Tinnitus:
      High Frequency Hearing Loss
      Heavy Hitters
      =Lorazepam 1mg (bedtime)
      =Fluoxetine 20mg (morning)

      Daily Preferred Supplements
      =Ashwagandha/Magnesium (CALM&RELAX) Walgreens
      =Fish Oil 1200mg
      =One A Day Multivitamin

      Discontinued or Rare Use
      =CoQ10 100mg
      =B12 5000 mcg
      =Zinc 50mg
      =Melatonin 5mg
      =Vitamin D3 125mcg 5000IU
      =Ginkgo Biloba 120mg

      Supplements on Hand - Untried
      =Turmeric Curcumin Blend
      =Evening Primrose

      Interested In
      =NAC
      =Suggestions of proven Supplements

      And of course... Embarassed by
      =SynapseXT (we all make mistakes)
       
    24. Aaron91
      Gloomy

      Aaron91 Member Podcast Patron Benefactor Ambassador Advocate

      Tinnitus Since:
      2007
      Cause of Tinnitus:
      Loud music/headphones/concerts - Hyperacusis from motorbike
      Holy shit. I've been considering this stack for a while after reading about person on here curing their hyperacusis with it then disappearing. Please report back how it goes!
       
    25. __nico__
      No Mood

      __nico__ Member Benefactor

      Tinnitus Since:
      2003
      Cause of Tinnitus:
      chemo/barotrauma/noise/autoimmune disorder
      I will try this.
       
    26. Chinmoku

      Chinmoku Member Benefactor

      Tinnitus Since:
      10/2018
      Cause of Tinnitus:
      Started with a cold, possibly worsened by medication/noise
      Thank you Greg, I'll take a look. These days I don't connect much to the forum as the suffering is too debilitating.
       
      • Hug Hug x 3
    27. Ben Winders
      Pensive

      Ben Winders Member

      Tinnitus Since:
      2020
      Cause of Tinnitus:
      acoustic
      Did some more research on Bacopa Monnieri with Synapsa:

      Conclusion: Bacopa appears to upregulate GABA and acetylcholine which both seem to be a possible pathway to make the tinnitus back off a little bit.

      Googled 3 references:

      I) General
      ---

      Bacopa Monnieri is an adaptogen herb and a precursor to the GABA-boosting neurotransmitter serotonin, and it appears to upregulate GABA binding sites with consistent, long-term use.

      Bacopa supports dopamine and serotonin production, which is good for GABA. But more importantly for tinnitus control, it can upgrade neural communication.

      Aside from auditory symptoms, tinnitus can intensify anxiety, stress, and depression. Bacopa may increase the effects of key mood-boosting neurotransmitters including serotonin, acetylcholine (*) , noradrenaline, and dopamine, helping you achieve a sense of calm and maintain mood balance.

      (source)


      II) Acetylcholine (*)
      ---

      1) Kilgard and his colleagues electrically stimulated the vagus nerve in rats, which runs from the brain's medulla to the abdomen. This releases chemicals such as acetylcholine and norepinephrine, which can encourage changes in the brain. By pairing the stimulation with a high-pitched tone, the scientists were apparently able to halt the rats' tinnitus for more than three months.

      (source)

      2) Available evidence suggests that acetylcholine serves as a neurotransmitter for several centrifugal pathways of the auditory system, particularly olivocochlear and olivo-CN connections. Its effects are mostly excitatory in the CN as well as other locations, and it may function as a neuromodulator as well as a neurotransmitter.

      (source)


      @FGG @GBB sorry to tag you, you both seem knowledgeable.
       
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    28. FGG
      No Mood

      FGG Member Podcast Patron Benefactor Ambassador Hall of Fame Advocate

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Multi-factorial
      If acetylcholine is excitatory along those pathways, I fail to see how that would be a benefit to tinnitus.

      The GABA effects could somewhat counteract that I suppose. Just curious, what made you decide to take that specific drug? Did your ear dilation/vision problems subside when you backed off?
       
    29. Ben Winders
      Pensive

      Ben Winders Member

      Tinnitus Since:
      2020
      Cause of Tinnitus:
      acoustic
      I started taking it after watching a YouTube video on Nootropics for mood, unrelated to tinnitus.

      The first link is specifically talking about tinnitus though, so there seems to be some speculation for it to be beneficial (in rats :D)

      The dilation/vision problems subsided when I backed off.
       
    30. AUTHOR
      AUTHOR
      GBB

      GBB Member Hall of Fame

      Location:
      NYC
      Tinnitus Since:
      2016-2019 (Mild, Cured) 8/2020 (Severe)
      Cause of Tinnitus:
      Virus / Microsuction / Acoustic Trauma
      I’m not a medical professional, @FGG has that foundation. I defer to her.

      The only way to know if it will help is to try imo.
       
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