SciFluor Receives US Patent for KCNQ2/3 Activator to Treat Epilepsy and Neurological Disorders

I was referring to the big pharma corporations. The western world is run by capitalism, it means money. With such a huge base of potential "clients", it looks like that there is only a handful of companies trying to develop drugs or devices.

I am pretty sure that everyone who has read the trobalt thread is aware of the possible side effects and that is, for most people, at least a temporary relief. Luckily, my T is mild enough to not to consider taking retigabine, but for people in the edge, it might be something to consider if things get tough. It's not bad to have, at least, a relief, and AFAIK this is the first time that a orally administered drug shows a consistent and sort of reliable relief to this nasty sound. Some people can be luckier than others but at least there is the option if you are brave enough to try it.

 

Well i know when i spoke with danny we were investigating BUT we need to put money in it so they replicate a pill (reverse and replicate)

 

Well, why we don't do something about this? @grate_biff @Christian78

 

Now there is no more pills

i got used to it after 3 months and then it did not had any effect

 

And how wrong I was...

 

If this pill is fast-tracked, isn't it possible it could get to market in half the time? Like five years?

 

Count on habituation, trust me it will be easier.

 

Not sure if this has been posted but it does bring a little hope

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4461688/

 

Don't get your hopes up. Notice that the article title only mentions prevention of tinnitus development.

 

I did notice that but I would hope the preventive compound would also have properties that would help people with Chronic T...Why would you think other wise?

 

Because to stop the brain plasticity that leads to tinnitus would require different modes of action than trying to undo the deeply rooted tinnitus neural network.

 

@Nucleo is this your opinion or factual

 

it's based on the same stuff I've read; chronic T, once established, involves a much wider set of brain structures than acute tinnitus. The counterargument to this is that some people appear to have had some success with Trobalt -- but of course, Trobalt is a shotgun drug that hits a bunch of different receptors (widespread Kv channel action, also significant GABA activity at the doses people are frequently using here). It shouldn't be shocking that something which increases GABA-mediated inhibition can temporarily suppress T, this is the same reason benzos work so well for a lot of us. In fact, the observation that benzos don't work for all of us, is one good reason to suspect that there are multiple different tinnitus pathologies -- which would probably require different treatment approaches. This opinion is shared by the audiologist I am working with as part of my tinnitus research experiment at University of Michigan.... if their technology materializes into a treatment for 10% of chronic T cases I think they will see it as a significant success.

 

Educated opinion based on this paper : http://elifesciences.org/content/4/e07242

 

@linearb thanks for the explanation man you always make great sense. I read somewhere that the University of Michigan was doing allot of research on T I wish you the very best man ...Keep us posted on how it goes.
Good luck

Carlos

 

@Nucleo Thanks for the update

 

I have read the full article. They only did experiments related to the prevention, that is true. But they also says this:

"We propose that SF0034, which shows an improved efficacy and safety profile, has the potential to be an efective clinical option for patients with mild or severe (incapacitating) tinnitus"

"...we propose that SF0034 is a potential clinical candidate for the tratement of tinnitus"

Of course, the efficacy of SF0034 in preventing tinnitus it is very clear, but I think it can be used for the treatment of tinnitus with 7+days but more research is needed.

 

Even if it does make it to market (that's a big if, and still a long ways away) and only provides a small reduction while preventing us from getting noise induced spikes I'd be happy.

 

Do you have a guess how long it will take for this to get market assuming the trials are successful? 5 or 10 years? I hope pharmas realize we are happy with 20 percent reduction... Nobody's expecting 100 percent reduction.

 

They have just finished the Preclinical fase I guess (in mice). So it will take around 10 years until the release if all goes OK. I expect the 100 percent reduction. Not tomorrow but science is powerful.

 

Anyone knows anything about any drug which reduce the HCN activity? (DCN fusiform cells involved in T after acoustic trauma).

 

http://www.fda.gov/ForPatients/Approvals/Drugs/ucm405622.htm
This is the website I looked at before. My understanding is it shouldn't take too long to come to market if it is successful, it's the clinical trial part that takes the most time. I'd say it's around 10 years give or take a few away.

 

Working with mice, Prof. Tzounopoulos limits his interpretations to the acute phase. In short, the usefulness of Kv-channel openers may extend beyond prevention of tinnitus.

 

I mailed SciFlour about the progress of SF00034 and got this reply:

"We appreciate your interest in this compound. We have not begun human testing for the compound yet. We are not able to provide any forecast about when or if we will test this for tinnitus sufferers. We have a corporate policy that precludes us from sharing such information on an individual basis. I apologize but I cannot share more than that at this time. We wish you the best in your pursuits."

 

Then should I take this drug out of my "hope list" now?

 

Nah, i mean some people have had sucess with potiga, if this is way more powerful and targets only a few channel openers, it should help way more than the last compound did (with less scary side effects)

 

As I'm having a really bad spike right now, this sounds like a dream! I hope this will come true some day! Soon, I prefer.

 

Yes! its a dream....
i know some people here have different opinions than me, but i have live my dream a few times.
so i dont see why it wont happen "sooner than later"

 

Yep. I also recognized it.. So depressing.

 

Has there been any news on SF0034 ???..i think i read there was to be a clinical trial and if so has anyone heard how that went?..thanks.