The 'Love Hormone' (Oxytocin) May Quiet Tinnitus

Discussion in 'Research News' started by Tim Hogan, Sep 23, 2016.

    1. Uklawyer

      Uklawyer Member

      Tinnitus Since:
      03/2020
      Cause of Tinnitus:
      Medication - antidepressants
      @ploughna, sorry to hear about the setback - hopefully it will not be long-lasting and the next attempt on Oxytocin will prove fruitful.

      To be clear: you are now trying Oxytocin individually, and not as part of the trial, right? And the trial is ongoing and blinded?
       
    2. ploughna

      ploughna Member

      Tinnitus Since:
      2017
      Cause of Tinnitus:
      motor racing and power tools
      @Uklawyer, that's correct, I'm having my prescription filled this week so will start on it again shortly. And, yes, I believe the trial is still ongoing. I say this because my detailed results are not yet available to the researchers.
       
    3. Uklawyer

      Uklawyer Member

      Tinnitus Since:
      03/2020
      Cause of Tinnitus:
      Medication - antidepressants
      @ploughna, thanks. Just a quick one: if the study is ongoing, how do you know that you were given the Oxytocin? (Perhaps I am missing something, but I thought that, in blind studies, the participant did not know what they were getting — unless they reveal results to individuals as they finish?)
       
      • Like Like x 1
    4. ploughna

      ploughna Member

      Tinnitus Since:
      2017
      Cause of Tinnitus:
      motor racing and power tools
      For the first half of the study, everyone is given Oxytocin. For the second half, it's 50% placebo and 50% Oxytocin.
       
    5. Lurius
      Frustrated

      Lurius Member Benefactor

      Location:
      Oslo, Norway
      Tinnitus Since:
      September 2018
      Cause of Tinnitus:
      Valsalva maneuver
      @kuromi, tagging you because I think you may find this very interesting.

      Ok, so I spoke to Dirk De Ridder this morning. I got a lot of very interesting information, he answered all my questions and I feel enlightened.

      He recommended some stuff for me. One of the things he mentioned was Oxytocin. He referred to a study in Brazil. He would not normally recommend it, because it doesn't really work, except for in a particular circumstance. That circumstance is "people with autism", which I happen to have. It works on people with autism. I have an appointment with my doctor tomorrow, I'm testing for a genetic condition called hemochromatosis. I will ask my doctor for a prescription for Oxytocyin and then I will use it for 1 month. He said it may give me some serious relief. I feel hopeful about this.
       
      • Like Like x 2
    6. Christiaan
      Inspired

      Christiaan Member Podcast Patron Benefactor Hall of Fame

      Location:
      The Hague, the Netherlands
      Tinnitus Since:
      2016
      Cause of Tinnitus:
      2016: headphones, 2020: worsened thanks to Rammstein
      Count me in @Lurius :) I'm also a proud member of the Auti club. Thanks for taking some time to talk to Dr. De Ridder about this issue.

      Anyway, did Dr. De Ridder provide a reason why people with autism are more susceptible to Oxytocin? It seems super interesting.

      I hope your doctor knows how to fix hemochromatosis. From what I've read on Wikipedia, it sounds rather serious.
       
      • Like Like x 1
      • Agree Agree x 1
    7. Lurius
      Frustrated

      Lurius Member Benefactor

      Location:
      Oslo, Norway
      Tinnitus Since:
      September 2018
      Cause of Tinnitus:
      Valsalva maneuver
      If I had known you had autism, I would have tagged you as well. There aren't that many of us, we need to look out for each other. I seriously recommend that you try Oxytocin, it may work for you. Nothing is guaranteed in life, but I'm seriously going to try this. It's a hormone, not a drug, so the risk is very low. I think the worst thing that can happen is that you might feel clogged in the nose.
       
      • Friendly Friendly x 1
    8. Christiaan
      Inspired

      Christiaan Member Podcast Patron Benefactor Hall of Fame

      Location:
      The Hague, the Netherlands
      Tinnitus Since:
      2016
      Cause of Tinnitus:
      2016: headphones, 2020: worsened thanks to Rammstein
      It's totally alright @Lurius, it's not like as if I'm walking around with ''autism'' tattooed on my forehead (though it has crossed my mind to put something like that on my arm) ;)

      After reading your story, I've decided to go down this route as well. Tomorrow morning, I'll give my GP a call and ask her about this.

      But again, thanks for sorting this out. Hopefully, we'll figure it out asap if it works!
       
    9. Isabella 123
      Curious

      Isabella 123 Member

      Location:
      Chapel Hill NC
      Tinnitus Since:
      12/2013
      Cause of Tinnitus:
      Probably traumatic noise event
      @ploughna, are you still doing the Oxytocin Rx? Would love to hear an update from you.

      My tinnitus is like yours, very unpredictable. Mine is caused by dysfunctional Glutamate neurotransmitter re-uptake system so the volume goes up unbearably sometimes depending on what I’ve eaten... something that contains Glutamate that I wasn’t aware of. So I’m not sure this is going to help me. But my point was, that I know how horribly frustrating it is to have a couple of “good” days and wake up with a shrieking head.
       
    10. paul mclean

      paul mclean Member

      Tinnitus Since:
      2018
      Cause of Tinnitus:
      falling asleep with headphones in on loud
      I'll be doing 2 months of Oxytocin therapy soon. Will post results once I'm done with my experiences.
       
      • Like Like x 1
      • Informative Informative x 1
    11. DebInAustralia
      No Mood

      DebInAustralia Member Benefactor Hall of Fame Advocate

      Location:
      Geelong, Victoria
      Tinnitus Since:
      12/2013
      Just curious. How do you know you have a dysfunctional Glutamate neurotransmitter re-uptake system?
       
      • Good Question Good Question x 1
    12. ajc

      ajc Member

      Tinnitus Since:
      11/2002; spike 2009; worse 2017-18
      Cause of Tinnitus:
      Loud music - noise damage
      @Lurius, you said you were prescribed Oxytocin. Is it a nose spray? How were you able to convince your doctor to prescribe it?
       
    13. Suaimhneach

      Suaimhneach Member

      Location:
      Ireland
      Tinnitus Since:
      2010
      Cause of Tinnitus:
      Unknown
      How is it going so far @paul mclean ?
       
    14. JRC1

      JRC1 Member Benefactor

      Tinnitus Since:
      2016
      Cause of Tinnitus:
      medication
      @ploughna, thank you for your posts.

      Do I understand correctly that this doctor will prescribe Oxytocin treatment outside the trial?
       
    15. Gb3

      Gb3 Member

      Tinnitus Since:
      12/19
      Cause of Tinnitus:
      Sshl
      @ploughna keeps signing in but isn’t responding.
       
    16. Damocles
      No Mood

      Damocles Member Benefactor Hall of Fame

      Location:
      England
      Tinnitus Since:
      2009
      Cause of Tinnitus:
      Otitis media
      Gonna have to get @Matchbox on the case.
       
    17. ploughna

      ploughna Member

      Tinnitus Since:
      2017
      Cause of Tinnitus:
      motor racing and power tools
      Yes, I saw your message - sorry for the delay in responding.

      The doctor running the study agreed to continue seeing me and prescribed it on the basis that I thought it might be benefiting me. Whether this is offered only to prior study participants or anyone, I don't know. However, I'd imagine post study.

      I've been taking it for about a month now. As mentioned previously, my tinnitus is quite variable, and that continues to be the case, but I've had a couple of days lower than anything previously (never more than 2 days in a row though), and on the bad days, levels don't seem to go quite as high as previously (and there is meant to be a mood enhancing element to Oxytocin also, so maybe that's a factor?).

      So, I do think it's doing something, not a huge improvement (previous range of 4-7/10, now maybe 3-6/10) but enough that I'm going to continue with the treatment for a while - it seems a lower risk option than many of the other medications often prescribed.
       
      • Informative Informative x 1
    18. Lurius
      Frustrated

      Lurius Member Benefactor

      Location:
      Oslo, Norway
      Tinnitus Since:
      September 2018
      Cause of Tinnitus:
      Valsalva maneuver
      I started taking Oxytocin today, we'll see how it goes.
       
      • Like Like x 3
    19. Christiaan
      Inspired

      Christiaan Member Podcast Patron Benefactor Hall of Fame

      Location:
      The Hague, the Netherlands
      Tinnitus Since:
      2016
      Cause of Tinnitus:
      2016: headphones, 2020: worsened thanks to Rammstein
      Good luck @Lurius. Glad you can try it out for yourself. How did you manage to get a prescription, if you don't mind me asking?

      I've been trying to get a hold on it, but both my ENT and GP are adamant in providing for this treatment due to lack of clinical results for tinnitus. I also don't think I could get it by playing the autism card, as mine is considered pretty mild (only issues with hypersensitivity to senses).
       
    20. Lurius
      Frustrated

      Lurius Member Benefactor

      Location:
      Oslo, Norway
      Tinnitus Since:
      September 2018
      Cause of Tinnitus:
      Valsalva maneuver
      I'm having an insane spike right now, which is kinda difficult for me since last week was the best week I've had in over 2 months. I'm not blaming the Oxytocin... yet. It could just be a coincidence. I took a nap and that has a nasty tendency to cause spikes.

      My GP was being impossible as well, he said flat out that he refused to give me the Oxytocin for any reason. After much email correspondence and some calls to the Belgian office, I managed to get a prescription from Dirk De Ridder himself, it was a lot of back and forth because of some mistakes made by his secretary (I think). I actually thought, no way in hell they are going to accept this in the pharmacy, but they did actually.

      Yeah, so to get Oxytocin you just have to speak to Dirk De Ridder over Zoom... twice xD
       
      • Informative Informative x 2
    21. grate_biff
      In pain

      grate_biff Member Benefactor

      Location:
      Moss, Norway
      Tinnitus Since:
      09/2014
      Cause of Tinnitus:
      Acoustic trauma using headphones
      What did you get out of contacting the Ketamine clinic?
       
    22. Lurius
      Frustrated

      Lurius Member Benefactor

      Location:
      Oslo, Norway
      Tinnitus Since:
      September 2018
      Cause of Tinnitus:
      Valsalva maneuver
      Just a guy with a very strong American accent on his Norwegian, he explained some things to me about how Ketamine works and I asked about negative side effects etc.

      He said there are very few clinical studies on Ketamine for treating tinnitus but he was willing to try, however he warned me that most of the people who had their tinnitus treated with Ketamine had Ketamine shots directly into their ears, in his clinic he said they only give Ketamine intravenously.

      I said I would get in touch with him through email, which I admit I still have not done. I probably will at some point but there are other things on my list I want to try first so I have to give it some time.
       
      • Informative Informative x 2
      • Like Like x 1
    23. Christiaan
      Inspired

      Christiaan Member Podcast Patron Benefactor Hall of Fame

      Location:
      The Hague, the Netherlands
      Tinnitus Since:
      2016
      Cause of Tinnitus:
      2016: headphones, 2020: worsened thanks to Rammstein
      Wow, sorry to hear that. Let's hope Oxytocin is not the bad guy behind your spike and that it subsides as soon as possible, Lurius.

      Yeah, it's super frustrating. But on the other hand, it's a protocol to which they are bound to as medical practitioners. Otherwise, meds could easily fall in the wrong hands (black market), shortages could be a common thing, etc.

      Hmmm... ok. I wouldn't know why 2 appointments are needed for an Oxytocin prescription. One would be enough, I'd think? Maybe you can fill me in on that? Anyway, I've already made an appointment with Dr. De Ridder on the 30th of this month. Looking forward to it!
       
    24. Lurius
      Frustrated

      Lurius Member Benefactor

      Location:
      Oslo, Norway
      Tinnitus Since:
      September 2018
      Cause of Tinnitus:
      Valsalva maneuver
      Haha, ok, yes so autism confirmed. That was a joke, Christiaan. Hence the little xD I made. I have some problems with irony written by complete strangers as well, though, so you're not the only one.

      Speaking to him once should be sufficient.

      My tinnitus is insanely much better today so the Oxytocin is not to blame. I already took it twice today and there has been no spike.
       
      • Like Like x 1
      • Funny Funny x 1
    25. Christiaan
      Inspired

      Christiaan Member Podcast Patron Benefactor Hall of Fame

      Location:
      The Hague, the Netherlands
      Tinnitus Since:
      2016
      Cause of Tinnitus:
      2016: headphones, 2020: worsened thanks to Rammstein
      Oops! Well, you've finally discovered my kryptonite ;) Honestly, I completely overlooked that smiley thingy, lol. Even though I wear glasses, I really need to get my eyes checked again :cool:

      Good to hear about your current tinnitus btw!

      Edit: I've found something that might be helpful for you. It's the dosage specification of previous successful cases studies at the NYU (mentioned in a patent). Maybe you can try different formulations and see if that does the job.

      Capture d’écran 2021-08-02 à 16.27.58.png
       
      • Like Like x 3
    26. Suaimhneach

      Suaimhneach Member

      Location:
      Ireland
      Tinnitus Since:
      2010
      Cause of Tinnitus:
      Unknown
      This looks very promising. Thanks for sharing. I have a question, is Oxytocin spray something that pharmacies have to hand? Or do they have to order it in / mix it up? I am in Ireland, but presume the protocol is the same in most European countries.
       
    27. Christiaan
      Inspired

      Christiaan Member Podcast Patron Benefactor Hall of Fame

      Location:
      The Hague, the Netherlands
      Tinnitus Since:
      2016
      Cause of Tinnitus:
      2016: headphones, 2020: worsened thanks to Rammstein
      Good question! I'll get back to you on that. A good friend of mine is a pharmacist and I'll forward your question to him and hopefully we'll know soon enough how that protocol generally works.
       
      • Like Like x 2
    28. Suaimhneach

      Suaimhneach Member

      Location:
      Ireland
      Tinnitus Since:
      2010
      Cause of Tinnitus:
      Unknown
      Thanks for that. Maybe some of the others here that have got their hands on it might be able to shed some light. I can't even imagine how hard it would be to get an Irish GP to prescribe a spray that they know nothing about :D but worth a shot!
       
    29. Christiaan
      Inspired

      Christiaan Member Podcast Patron Benefactor Hall of Fame

      Location:
      The Hague, the Netherlands
      Tinnitus Since:
      2016
      Cause of Tinnitus:
      2016: headphones, 2020: worsened thanks to Rammstein
      Ah, well in that case: chances are you won't get it via the regular GP route unless you're pregnant ;) So good luck with that!

      The thing is that practically most doctors normally prescribe medication if it has been absolutely clinically proven to work. So far, it has only been extensively tested on pregnant women + women with postpartum depression and for that reason specifically prescribed for that target group.

      You can copy Lurius' smart move to circumvent this all together by asking Dr. De Ridder to prescribe intranasal Oxytocin. It's weird how the prescription protocol in Europe works, but there are apparently loopholes that you can use to your own advantage. You can hook him up via an online consultation. Only thing you need to keep in mind is that you have to pay a fee of 80 euros.

      Et voilà, here's the link in case you're interested:

      https://www.brai3n.com/en/practical/
       
      • Like Like x 2
    30. Hamsti

      Hamsti Member Benefactor

      Location:
      Rhineland Palatinate, Germany
      Tinnitus Since:
      01/2021
      Cause of Tinnitus:
      Everything, I suppose. Stress, high cholesterol, TMJ...
      Hm, I can play the postpartum depression card. Thanks @Christiaan.
       

Share This Page