The 'Love Hormone' (Oxytocin) May Quiet Tinnitus

Discussion in 'Research News' started by Tim Hogan, Sep 23, 2016.

    1. Gb3

      Gb3 Member

      Tinnitus Since:
      12/19
      Cause of Tinnitus:
      Sshl
      So they have applied for the patent. What does that mean going forward?
       
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    2. Watasha
      No Mood

      Watasha Member Podcast Patron Benefactor Ambassador Advocate

      Tinnitus Since:
      03/2018
      Cause of Tinnitus:
      Unknown
      I wouldn't put too much stock in the patent.

      They obviously liked what they saw in the potential for Oxytocin and sought a way to enhance the delivery. It makes sense that they'd want to patent that while running the clinical trials to prove its efficacy and hopefully bring it to market.

      My ASSUMPTION (based on various information that I've gleaned), is that there is a wealthy donor helping to fund this proof of concept who also holds the patent (which probably costs hundreds of thousands, if not maybe in the millions). It makes sense he would want to reap some sort of benefit from the idea, even if his ultimate goal is to come up with a viable treatment. That's human nature and I'd do the same.

      This is a big year. We should get results from Cognosetta (update hopefully), Shore, Oxytocin, OTO-313, Dirk De Ridder, and Hamid Djalilian. Also, an objective measure of tinnitus is likely just around the corner which should lead to an explosion in additional research.
       
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    3. ploughna

      ploughna Member

      Tinnitus Since:
      2017
      Cause of Tinnitus:
      motor racing and power tools
      I'm taking 45 IU four times a day.
       
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    4. Gb3

      Gb3 Member

      Tinnitus Since:
      12/19
      Cause of Tinnitus:
      Sshl
      I’m confused. Aren’t you a part of the clinical trial? How do you know if you are taking the real thing or placebo?
       
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    5. Athens

      Athens Member

      Tinnitus Since:
      09/27/2020
      Cause of Tinnitus:
      Unknown
      Wasn’t there already a recent story on a breakthrough on measuring tinnitus objectively (may have been from Australia)?
       
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    6. Watasha
      No Mood

      Watasha Member Podcast Patron Benefactor Ambassador Advocate

      Tinnitus Since:
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      Unknown
      I believe that you're referring to this article which → Tinnitus Talk did a podcast on.

      Technology lets clinicians objectively detect tinnitus for first time

      At the time of the podcast, the reliability was not sufficiently high enough. The same could be said of Dirk De Ridder's model of an objective measure. The number's I am familiar had his reliability a little bit higher than the Bionics institute's. So my understanding is that no sufficiently reliable objective measure is in place (I think 95% is the goal) but given how close these two are, we should have one of them reach the target in the near future.
       
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    7. ploughna

      ploughna Member

      Tinnitus Since:
      2017
      Cause of Tinnitus:
      motor racing and power tools
      Not anymore. I finished up the trial, then went back later for ongoing treatment.
       
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    8. Gb3

      Gb3 Member

      Tinnitus Since:
      12/19
      Cause of Tinnitus:
      Sshl
      Do you have to keep the spray cold all day? Do you take it at work?
       
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    9. Watasha
      No Mood

      Watasha Member Podcast Patron Benefactor Ambassador Advocate

      Tinnitus Since:
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      Which clinical trial were you a part of?
       
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    10. ploughna

      ploughna Member

      Tinnitus Since:
      2017
      Cause of Tinnitus:
      motor racing and power tools
      Yes, it needs to be kept refrigerated. I use a small cooler pack when travelling, etc.
       
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    11. ploughna

      ploughna Member

      Tinnitus Since:
      2017
      Cause of Tinnitus:
      motor racing and power tools
      At NYU Langone - full details are on ClinicalTrials.gov (and I think discussed earlier in this thread also). Last time I checked they were still recruiting.
       
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    12. Gb3

      Gb3 Member

      Tinnitus Since:
      12/19
      Cause of Tinnitus:
      Sshl
      Yeah, NYU Langone are the ones who filed for the patent on 2/8/2022. I wonder, since this is already a medication that has been approved, if you can asked to get treated with it.
       
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    13. Watasha
      No Mood

      Watasha Member Podcast Patron Benefactor Ambassador Advocate

      Tinnitus Since:
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      Unknown
      Got it, yeah I was confirming it was that trial. How do you know you weren’t being treated with placebo?
       
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    14. Athens

      Athens Member

      Tinnitus Since:
      09/27/2020
      Cause of Tinnitus:
      Unknown
      Why would this result in an “explosion of research”?

      I read an article from approximately 1998 indicating that they had found the area of the auditory system and/or brain where tinnitus originates and that this would result in effective treatment. We are still waiting all of these years later.
       
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    15. ploughna

      ploughna Member

      Tinnitus Since:
      2017
      Cause of Tinnitus:
      motor racing and power tools
      For the first half of the trial period, everyone gets Oxytocin, then for the second half there's a 50/50 chance you'll either get the placebo or continue on the Oxytocin.
       
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    16. Watasha
      No Mood

      Watasha Member Podcast Patron Benefactor Ambassador Advocate

      Tinnitus Since:
      03/2018
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      Was that considered an “objective measure” that could indicate the presence and levels of intensity of tinnitus? I highly doubt, given the imaging technology available at the time, it would have been classified as a reliable objective measure.
       
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    17. Watasha
      No Mood

      Watasha Member Podcast Patron Benefactor Ambassador Advocate

      Tinnitus Since:
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      Got it. Hate to hear that they’re still recruiting. I was really hoping that they would wrap things up this June and we’d get some results by end of 2022.

      If 2022 isn’t a good year, I don’t see a big pipeline of things to look forward to in 2023/2024 yet.
       
    18. Gb3

      Gb3 Member

      Tinnitus Since:
      12/19
      Cause of Tinnitus:
      Sshl
      I disagree. It doesn’t need to go through FDA approval.

      @ploughna was allowed to continue the real deal.
       
    19. Watasha
      No Mood

      Watasha Member Podcast Patron Benefactor Ambassador Advocate

      Tinnitus Since:
      03/2018
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      Unknown
      What do you disagree with?
       
    20. Gb3

      Gb3 Member

      Tinnitus Since:
      12/19
      Cause of Tinnitus:
      Sshl
      I’m sorry, I thought you meant that this drug won’t be available.
       
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    21. Athens

      Athens Member

      Tinnitus Since:
      09/27/2020
      Cause of Tinnitus:
      Unknown
      I was not comparing an objective measurement of tinnitus with the 1998 article. I was just referencing that they thought that they had made such a major breakthrough in 1998 but it did not result in any effective treatment. Why would an objective measurement of tinnitus more quickly lead to effective treatment? I am not being argumentative. I am just curious.
       
    22. SB1981

      SB1981 Member Benefactor

      Tinnitus Since:
      06/2019
      Cause of Tinnitus:
      Multifactorial
      Because they could objectively measure improvement from drug trials with a medical test vs. subjective self-report THI scale ratings.
       
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    23. Watasha
      No Mood

      Watasha Member Podcast Patron Benefactor Ambassador Advocate

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      @Athens, pretty much this above. And depending on what the measure is, it can help better to understand the biological mechanisms of tinnitus. Current objective measure prospects are looking for relationships in brain activity. This knowledge, once the full tinnitus pathway is uncovered, can lead to effective treatments because they will know where to target. This is my understanding anyways.
       
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    24. Athens

      Athens Member

      Tinnitus Since:
      09/27/2020
      Cause of Tinnitus:
      Unknown
      O.K. Thank you.
       
    25. InNeedOfHelp

      InNeedOfHelp Member

      Tinnitus Since:
      08/2021
      Cause of Tinnitus:
      MRI Scan
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    26. Gb3

      Gb3 Member

      Tinnitus Since:
      12/19
      Cause of Tinnitus:
      Sshl
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    27. ploughna

      ploughna Member

      Tinnitus Since:
      2017
      Cause of Tinnitus:
      motor racing and power tools
      Yes, still taking it per the dosage/etc I mentioned further back in the thread.
       
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    28. Gb3

      Gb3 Member

      Tinnitus Since:
      12/19
      Cause of Tinnitus:
      Sshl
      How’s it going? Any benefit?
       
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    29. ploughna

      ploughna Member

      Tinnitus Since:
      2017
      Cause of Tinnitus:
      motor racing and power tools
      It's no silver bullet but I have had far less truly horrendous days since I started with it, which is why I'm continuing with it. Over the course of a week, I used to be a ratio of (roughly):

      30% barely able to function
      60% bad but can make it through the day
      10% manageable

      Now, it's more like: 10%, 50%, 40% respectively.

      My big issue is the variability and not knowing what the next day will bring. On top of that is sound reactivity - my own voice, when I drive (with earplugs!), talk for too long, etc will exacerbate the tinnitus. Impossible to habituate to, so if anyone has any ideas how to calm the reactivity, I'd love to know. The treatment has not made any difference to these aspects.
       
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    30. InNeedOfHelp

      InNeedOfHelp Member

      Tinnitus Since:
      08/2021
      Cause of Tinnitus:
      MRI Scan
      Sounds like a great result. Maybe you have shared before but how long have you had tinnitus?
       

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