The 'Love Hormone' (Oxytocin) May Quiet Tinnitus

It began in 2017, increased in 2018 but was stable, then accidental noise exposure in 2020 put me over the edge - much louder, highly reactive and unpredictable. Before this, I was well habituated but now find that impossible.

I do need to stop the treatment and see what happens in case I'm simply seeing some natural improvement over time, but haven't had the courage to do so yet!

 

I fully understand. Tough choice. You do have the chance to go back on the medicine in case you stop. Going from 1 out of 3 bad, barely functioning days to 1 out of 10 (10%) seems like a great improvement. Gives me hope that I can one day too can make such improvements, with or without medicine. Eager to see the study results. This is one of the least invasive medicinal treatments in the pipeline.

 

I did keep a daily severity log for approx a year which covers before/after starting with this. When I get a chance, I'll put it into a spreadsheet and see if it shows any meaningful insights. I stopped tracking recently though as it was just another reminder of the unfortunate situation I (along with everyone else on here) is. I keep telling myself the same about this website and I should try and stay away, but the Research News section is an excellent source of information.

 

So this trial closed yesterday.

With only 41 participants I expect results being published not to take years. Not sure if you need additional phases after this, I assume not. Only the formulation is different, the active ingredient remains the same.

The principal investigator is Lawrence Newman from NYU Langone. Did anyone ever reach out to him to learn what the timelines are, and if a new FDA approval is required?

I'm excited because the first two trials both showed a reduction in tinnitus of roughly 20-30%, and also the placebo controlled trial. This might be the bridge to overcome the gap towards the Auricle device.

 

@ploughna, any update on whether or not this is still an effective treatment for you?

 

Does cunnilingus give men Oxytocin? If so...

 

@InNeedOfHelp, how do you know it closed?

 

Seems to be - my tinnitus is very reactive (always increases with sound exposure, but often also for no apparent reason), so with the treatment, the level of severity on 'bad' days is somewhat less - it's enough of an effect for me to want to continue taking it given its low risk and no obvious adverse effects. I believe people in the study experienced a range of benefit - dramatic in some cases, minimal in others.

 

Based on the last modification date which changed the participation status but did not update the estimated completion, and this was one month before closure. I assume the completion date is correct.

No way to check though - neither researcher is no longer at NYU Langone (the main researcher retired), so not sure how to get any information at this stage. Since the study page was updated in April I assume that this wasn't cancelled or anything.

 

@ploughna, did you see Dr. Newman to get the prescription after the study or someone else? If it was a different doctor, would you mind sharing? Thanks!

 

How do I get this treatment? I am desperate for some relief from my highly reactive tinnitus & want to have any kind of improvement to be able to breathe and live.

 

Yes - it was Dr. Newman. I don't know of any other doctors.

 

How do I get ahold of this doctor to get the drug?

 

Honestly, I don't know - as mentioned above, Dr. Newman is now retired so I need to find a new source once my current prescription runs out.

 

@Travis Henry, you could probably reach out to your PCP (or any receptive one) and show them this study. The study only shows 16 IU 4x daily so could also show them this patent filed that discusses examples of even higher doses (like the 45 IU @ploughna is dosing with).

 

I tried Oxytocin, and unfortunately it did nothing for me

 

Someone correct me if I’m wrong but this patent indicates they altered the chemical compound somehow. So if they have a patent you can’t just get it from any doctor and it’s not the same as the other Oxytocin everyone is trying.

 

https://www.walmart.com/ip/OxyPure-Oxytocin-Spray-12IU/378166215

 

DO NOT BUY THIS. It's a scam! Oxytocin needs to be refrigerated, it degrades very quickly in room temperature. That definitely is NOT the pharmaceutical quality Oxytocin therefore.

 

Ok ty.

 

Look at my post above. This isn’t just regular Oxytocin. It has been modified.

 

No problem. Wish I could find something that lowers my tinnitus. I am in a bad zone.

 

Travis, Oxytocin is worth a try if you can get your hands on it - but could be hit or miss regarding efficacy. There are quite a few compounding pharmacies that can make it - it's more a matter of finding a doctor willing to prescribe.

I'll update on my progress when I have new news.

 

@ploughna, would you mind sharing the exact prescription? That way someone could reach out to a compounding pharmacy with exactly what they prescribed for the study. Assuming that’s what you have. Sorry if you’ve already done earlier in the thread.

 

Sorry, I don't want to post my personal prescription, but the details are on both the clinical study webpage and in even more detail on the patent application both referenced above. The exact dosage is tailored to the patient (also detailed in the patent application).

 

Patent!

 

This is a matter of giving me relief and keeping me on this planet from my spinning raging level 90 dB tinnitus. Any help wanted on getting proper prescription for this.

Any help on getting the proper prescription done by my GP would be welcomed. I am at the end of my rope with how reactive my tinnitus is and it's insanely loud. Would do anything for any improvement.

 

Try some Clonazepam.

 

Travis, call the hospital where this trial is ongoing. Ask for the one overseeing the trial at the moment.

https://clinicaltrials.med.nyu.edu/

Number is at the bottom. That would be your best chance. The one currently overseeing the trial might even take patients outside of the trial. Who knows. I don't know who is currently overseeing the trial. This is not something that needs to go through a Phase 1-2-3 study so this is worth a shot.

 

I just messaged my MD about it and she said:

"Not commercially available in that formulation."

So it's not available for market?