AM-102: Auris Medical and KCL Collaborate in Drug Discovery for 2nd Generation Tinnitus Treatment

Done, thanks !

 

How do you apply to be included in trials?

 

It is still in the pre-clinical phase. See this link: http://aurismedical.com/product-candidates/pipeline

 

I commented on this (indirectly) via another thread (and for another reason) - see this:

 

I agree!

This will be for newcomers, while us old will be left to kill ourselves and die off.

 

Wow....chill out

 

@Christian78 That's not at all what I was saying. If you look at their website they are still testing both for chronic T. I've had it 10 years longer than you and I don't have a lack of hope, equally I don't hang my hopes on it working. If it does, awesome, if it doesn't then I'm not going to let T rule my life in the interim. No matter what you have wrong with you, if you give in to despair the battle is all but lost.

When it's chronic it may take more effort or a different focus to get it to go away.

 

You should contact members from team trobalt.
Personally I'm not a specialist.

 

I think I will do this. What is team trobalt? Individuals who happen to know about the drug? or Researchers who are looking into it?

 

A group of people who do the right thing.

 

Team Trobalt is a group of people from this forum such as @attheedgeofscience who research or who try to help and encourage the research into this drug. They do not take the drug - other people on this forum take the drug but they and not part of team trobalt. Hope that helps to explain.

 

But they always recruit only those with fresh tinnitus? And I am sorry if misunderstood but Auris was all about 3 months... I of course wish they come out as soon as possible for everyone... And mr very nice smile I apologize to you and I am not bitter... Maybe disappointed in Autifony that one can say

Thank you for correcting me

 

Hi Christian, no problem, I would also love to experience silence again so I'm on board with the frustration at how long these things take to develop. It's generally the way that they seem to start out with trials, take the easier to treat group first and then progress. You're more likely to get results and they seem to respond better to intervention. We chronic lot are the last in line.

 

Well, any progress is still progress. I would be happy if they could cure tinnitus at the acute stage completely. You have to think of something more than just your self. What about your kids? I know you don't have any children Christian78, but there are those who do. And just not having to worry that they will face the same suffering as we all have is good enough for many people.

 

Does anyone know what this "new target" for AM-102 is? Does that mean it's for chronic T?

I'm tired of this whole waiting thing. I'd like a treatment/cure now, please.

 

If they find 100% effective drug for acute t. (inside of 3 months window) it will lowers chance that chornic t. will be cured ever! It means every year millions of suffers LESS! Less in big pharma means - not interesting, or at least less interesting.

 

I don't think they'll abandoned chronic, even if acute is cured. I live in a fairly noisy environment, and had no idea my T was as loud as it was until traveling out in the quiet woods one year to cut down a Christmas tree. I was chronic without recalling the acute phase. Unless there's a single traumatic experience, chronic T can sneak up on you...it did me anyway.

 

Claiming this is just like saying that they have abandoned research and development for people who have lost a limb just because they are able to reattach a limb if it's done within a few hours. They are of course continuing to research new ways of making prostetic and robotic arms and legs that can be connected to the nervous system and be controlled. Or growing limbs by taking cells from a patient and then be able to grow a new arm in a lab and attatch it.

Just calm down! Curing acute tinnitus is a huge step. Our time will come some day regardless!

 

That is one of the biggeeest problem in our perception, to compare lost limbs, like arms, fingers etc and tinitus.

T is marginalized condition (that is a fact) in world of medicine, so any kind of compare with research for cancer, aids, lost limbs is useless and incomparable. (unfortunately)

So, u have your right to wish perfect results for acute t.drugs. My wish is opposite, and there is reason for that, I wish firstly all people with severe t. to get rid of it, after years of suffering.
And in economic way, "perfect" cure for acute stage (up to 3 months, not few hours as u stated for lost limbs) will make big pharma less interested in chronic t research.

Actually today 27.10.2015. there is no single drug even in phase 1 for chronic t. (one more fact about interest of big pharma about chronic t.)

 

If the number of sufferers was the sole factor for interest by companies to develop drugs then chronic sufferers would be on the top of the list. There are plenty more chronic ones then there are acute ones and many of the acute ones will eventually become chronic ones. Simple logic. But that's not how things work.

There are relatively few acute sufferers compared to chronic ones because the acute ones are just those that have got tinnitus in the last couple of months whereas chronic sufferers are all of the people that have tinnitus in the whole world ranging from those that have had it for a couple of months to those that have had it for the last 60-70 years! That's a buttload of people!

So your reasoning that the number of chronics will somehow diminish and that pharmaceutical companies will loose interest in them because of that is just not adding up. All prognosis are actually pointing towards an increase in both the total number of people affected by tinnitus as well as the percentage of the population because of the modern way of life. And there will also be an increase in population as well which means more people suffering from tinnitus. Once again, simple logic.

The reason why they will most probably cure acute tinnitus first is simply because it's easier. "You have to walk before you can run" is an old saying. So curing acute tinnitus is just one step on the way.

And as to the number of trials, there have been far more trials done on chronic tinnitus than on acute tinnitus. The only problem is that all of them have failed, so far.

Also, there will always be work done in research even when we find that cure. There is still research being done in pain medicine even though we have pretty good pain killers and a lot of different types of them as well. So the logic that the world will somehow just stop researching chronic tinnitus once there is a cure for the acute stage is just silly. One example of this is AM-102. Why would Auris Medical push yet another drug through their pipeline if they already have a "cure" in AM-101? Answer: Because they won't stop perfecting their drugs, making them better and better. And others will not stop researching just because someone else has done something in the same field. They will just try to make an even better drug.

This is how the world works. Just because someone has invented something and is the first one doesn't have to mean that no one else is going to want a piece of that pie. If a drug company made a cure for tinnitus tomorrow, do you really think that every other company that has been researching a treatment for tinnitus is just going to roll over and die?! Just close down their business because someone else is first? NO! They will try to get a piece of the pie. There is virtually no market anywhere in the world in anything where a single one company has 100% of the market share. They can have it for a very short period of time, if they are first, before other companies come along and try to steal a piece of the pie. Why would the market for tinnitus treatments be any different?

 

Here it says AM-102 is "different from the drug target for AM-101"

https://globenewswire.com/news-rele...for-Second-Generation-Tinnitus-Treatment.html

This might mean that it could be for chronic sufferers too.

Does anyone else think this is possible or, dare I say, likely?

 

If you look at the homepage of the company and go to "Pipeline" it says that next key milestone is Q4 2016. It also states "Tinnitus" as indication. AM-101 states "Acute inner ear tinnitus".

It is an important question but I don't think anyone can give any information about it at this moment. The only thing we can do for now are wild speculations. We just have to wait and see.

The link to Auris Medical pipeline:
http://www.aurismedical.com/product-candidates/pipeline

 

...5 years later and still on drug discovery. Come on, bring the 2nd generation tinnitus treatment into clinical trials.