Brivaracetam — KV3.1 Modulator

Discussion in 'Research News' started by Danny Boy, Apr 2, 2015.

    1. AUTHOR
      AUTHOR
      Danny Boy
      Cheerful

      Danny Boy Member Benefactor Hall of Fame

      Location:
      England
      Tinnitus Since:
      7/2014
      Cause of Tinnitus:
      Ear infection
      Well, it works in the same way keppra does but is 10x more potent. It functions the same.
       
    2. Zechariah

      Zechariah Member Benefactor

      Location:
      Finland
      Tinnitus Since:
      05/2014
      Cause of Tinnitus:
      Acoustic Trauma
      Np then, if you are sure that it is kv3.1 modulator. Im not qualified to conclude anything to a way or to another.
       
    3. AUTHOR
      AUTHOR
      Danny Boy
      Cheerful

      Danny Boy Member Benefactor Hall of Fame

      Location:
      England
      Tinnitus Since:
      7/2014
      Cause of Tinnitus:
      Ear infection
      Well, we will know when it comes out...Which is hopefully soon. We need a KV3.1 drug as soon as possible.
       
      • Agree Agree x 2
    4. Silvio Sabo
      Pooptoast

      Silvio Sabo Member Benefactor

      Location:
      Gothenburg, Sweden
      Tinnitus Since:
      05/2006
      Cause of Tinnitus:
      Noise - I think
      Even if Brivarectam doesn't work on Kv3.1 channels there is always Autifony and I'm pretty sure that more Kv3.1 modulators are comming. If not for tinnitus then for epilepsy. It's just a matter of time now...
       
      • Optimistic Optimistic x 1
    5. AUTHOR
      AUTHOR
      Danny Boy
      Cheerful

      Danny Boy Member Benefactor Hall of Fame

      Location:
      England
      Tinnitus Since:
      7/2014
      Cause of Tinnitus:
      Ear infection
      Well, keppra works on the KV3.1 channels so I would guess this is too. I mean, they basically work in the same way, just that this is more potent.
       
    6. Silvio Sabo
      Pooptoast

      Silvio Sabo Member Benefactor

      Location:
      Gothenburg, Sweden
      Tinnitus Since:
      05/2006
      Cause of Tinnitus:
      Noise - I think
      I hope so. But when listing something as "more potent" doesn't necessarly mean it works the same way. The result in terms of siezures in epilepsy patients might be that you need less Brivarectam then Keppra but they don't have to have the same mechanism of action.
       
    7. AUTHOR
      AUTHOR
      Danny Boy
      Cheerful

      Danny Boy Member Benefactor Hall of Fame

      Location:
      England
      Tinnitus Since:
      7/2014
      Cause of Tinnitus:
      Ear infection
      I looked it up online and it said the mechanism is basically the same. So, I'd say it does. Anyway, it's worth a try...Here I come Spain.
       
      • Like Like x 1
    8. Bazz

      Bazz Member

      Tinnitus Since:
      06/2015
      Hey dannyboy

      I was just reading about this new drug online and that it's gone for approval since January so could be out soon everything going well.

      I couldn't find anything online about them testing it for tinnitus just for epilepsy. Is it being marketed as an epilepsy drug with potential to treat tinnitus or whats their plans do you know?

      Thanks
       
    9. nills
      Barefooter

      nills Member Benefactor

      Location:
      Belgium
      Tinnitus Since:
      11/2009
      Cause of Tinnitus:
      acoustic trauma
      no plans in regards to Tinnitus ... the tinnitus aspect is just something that emerged here on the forums.
       
    10. preslys

      preslys Member

      Location:
      Switzerland
      Tinnitus Since:
      05/2014
      Cause of Tinnitus:
      unknown
      hi @nills
      have you finished your sessions of rtms ? any improvement ?
       
      • Informative Informative x 1
    11. GrosBalou
      Nerdy

      GrosBalou Member Benefactor

      Location:
      France
      Tinnitus Since:
      10/2015
      Cause of Tinnitus:
      Inner ear barotrauma (diving)
      It seems that this Bivaracetam will be sold under a product named "Briviact".
      I guess what's left is the Marketing Authorization itself (for UE availability).
      Not so much happened since January though :(

      "On 19 November 2015, the Committee for Medicinal Products for Human Use (CHMP) adopted a positive opinion, recommending the granting of a marketing authorisation for the medicinal product Briviact, intended for the treatment of partial-onset seizures. The applicant for this medicinal product is UCB Pharma SA."

      http://www.ema.europa.eu/ema/index..../human_smop_000901.jsp&mid=WC0b01ac058001d127

      http://www.ucb.com/investors/UCB-tomorrow/brivaracetam
       
      • Informative Informative x 1
    12. nills
      Barefooter

      nills Member Benefactor

      Location:
      Belgium
      Tinnitus Since:
      11/2009
      Cause of Tinnitus:
      acoustic trauma
      Great news ! :) .. this will be out in a few months i guess now it has been approved ... good news
       
      • Like Like x 1
    13. AUTHOR
      AUTHOR
      Danny Boy
      Cheerful

      Danny Boy Member Benefactor Hall of Fame

      Location:
      England
      Tinnitus Since:
      7/2014
      Cause of Tinnitus:
      Ear infection
      Spain it is.
       
    14. Karl28
      No Mood

      Karl28 Member

      Location:
      Melbourne
      Tinnitus Since:
      2001 bad since 2015
      Cause of Tinnitus:
      Loud music via headphones
      So is it worth trying Trobalt first or waiting for this?
       
      • Good Question Good Question x 1
    15. nills
      Barefooter

      nills Member Benefactor

      Location:
      Belgium
      Tinnitus Since:
      11/2009
      Cause of Tinnitus:
      acoustic trauma
      anyone have an idea if Portugal is also a place to buy these meds without prescription. i`ll be in portugal in a few weeks ...
       
    16. Kane Moffat
      Badass

      Kane Moffat Member

      Location:
      Glasgow, Scotland
      Tinnitus Since:
      06/2015
      Interesting thread. I don't know much about the different drugs that are available for tinnitus. Is this a significant development? @Danny Boy
       
    17. GrosBalou
      Nerdy

      GrosBalou Member Benefactor

      Location:
      France
      Tinnitus Since:
      10/2015
      Cause of Tinnitus:
      Inner ear barotrauma (diving)
      This is not a drug intended for tinnitus. This one is close to Keppra which didn't helped Tinnitus sufferers but helped hyperacusis.

      The interesting point is that it is more potent than Keppra and has way less secondary effects than trobalt.

      So I would say it's worth a shot.
       
      • Agree Agree x 1
    18. linearb
      Psychedelic

      linearb Member Benefactor Hall of Fame

      Location:
      temporarily banished from this plane of existence.
      Tinnitus Since:
      1999
      Cause of Tinnitus:
      karma
      I love that we have an 8 page thread in the "treatments" forum about a drug which doesn't even exist yet, which has a mechanism of action which has literally zero evidence to suggest that it is useful or safe for any kind of hearing disorder....

      We need to stop saying that keppra "helps" people with hyperacusis. There is no reason to believe this is true, any more than that colloidal silver, reiki crystals or any other bullshit anecdote is true.
       
      • Agree Agree x 4
      • Like Like x 1
    19. GrosBalou
      Nerdy

      GrosBalou Member Benefactor

      Location:
      France
      Tinnitus Since:
      10/2015
      Cause of Tinnitus:
      Inner ear barotrauma (diving)
    20. linearb
      Psychedelic

      linearb Member Benefactor Hall of Fame

      Location:
      temporarily banished from this plane of existence.
      Tinnitus Since:
      1999
      Cause of Tinnitus:
      karma
      We have no way of knowing, because uncontrolled anecdotal stories from the internet are not usable data.

      Name any given drug, and I can go and find you an account of someone saying it helped their tinnitus, and someone claiming that it caused it. Humans are very, very bad at understanding causality as it relates to their personal, subjective experience... If not, we wouldn't need controlled studies at all.
       
      • Agree Agree x 4
      • Like Like x 1
    21. swc5150

      swc5150 Member

      Tinnitus Since:
      06/2012
      I had H for well over a year, and after two rounds of Keppra, it's gone (increased dosage in rnd 2). Coincidence? Perhaps? However, I noticed the difference pretty quickly after starting it, and it hasn't returned since getting off it, so I'm satisfied it worked. Call it anecdotal, but I no longer have H, and it's awesome.

      I will add that I don't know if Keppra is the answer for all. For example, aspirin and ibuprofen don't help me if I have a headache (only Excedrin works), but for millions of people they do.
       
      • Agree Agree x 1
    22. Christian78
      Alone

      Christian78 Member

      Location:
      Gothenburg
      Tinnitus Since:
      (Sep 2013)
      Cause of Tinnitus:
      progressive tinnitus, time of expiring in next 3-6 months
      How long have you been taking keppra to notice that H is gone? and on what minimal dosage?

      please tell me
       
    23. Christian78
      Alone

      Christian78 Member

      Location:
      Gothenburg
      Tinnitus Since:
      (Sep 2013)
      Cause of Tinnitus:
      progressive tinnitus, time of expiring in next 3-6 months

      What does it mean that they got positive opinion NOV 2015?

      http://prntscr.com/998e6w
       
    24. GrosBalou
      Nerdy

      GrosBalou Member Benefactor

      Location:
      France
      Tinnitus Since:
      10/2015
      Cause of Tinnitus:
      Inner ear barotrauma (diving)
      This is supposed to be the last step before they receive the actual marketing authorisation.
      This comission gave a positive opinion uppon drug commercialization. So basically nothing should prevent this drug from reaching the market.
       
    25. Kane Moffat
      Badass

      Kane Moffat Member

      Location:
      Glasgow, Scotland
      Tinnitus Since:
      06/2015
      Okay so Market Authorisation should be within the next month at least? My question, if money were no object what is the earliest one could get access to this drug?
       
    26. Kane Moffat
      Badass

      Kane Moffat Member

      Location:
      Glasgow, Scotland
      Tinnitus Since:
      06/2015
      Any one have a clue how long it would take to access the drug in spain?
       
    27. linearb
      Psychedelic

      linearb Member Benefactor Hall of Fame

      Location:
      temporarily banished from this plane of existence.
      Tinnitus Since:
      1999
      Cause of Tinnitus:
      karma
      Years, probably.

      Again. There's no reason to think this drug will help tinnitus. This is an analog of other drugs which already exist and are not known to help tinnitus.
       
      • Agree Agree x 1
    28. Kane Moffat
      Badass

      Kane Moffat Member

      Location:
      Glasgow, Scotland
      Tinnitus Since:
      06/2015
      @linearb do you have a bias against a pharmaceutical solution to tinnitus?

      It seems like you are strongly against any of the drugs being put forward.
       
    29. linearb
      Psychedelic

      linearb Member Benefactor Hall of Fame

      Location:
      temporarily banished from this plane of existence.
      Tinnitus Since:
      1999
      Cause of Tinnitus:
      karma
      I have a bias against snake oil and fake science. The second someone comes up with a real drug treatment, I'll try it and probably buy stock in the company.


      That said, all of these drugs can be very dangerous, and thinking that a keppra analog had action against tinnitus because one person kinda sorta maybe thought that keppra might have helped their hyperacusis is pretty far out there. By all means, eat all the offlabel seizure drugs you want to...

      It's ridiculous to me that this thread is in the "treatments" forum, when there is a complete lack of any research in that direction...
       
      • Agree Agree x 3
    30. OnceUponaTime
      Fine

      OnceUponaTime Member Benefactor Hall of Fame

      Location:
      New York
      Tinnitus Since:
      11/11
      Cause of Tinnitus:
      Allergies or Acoustic Trauma, Stress
      • Good Question Good Question x 1

Share This Page

Loading...