Frequency Therapeutics — Hearing Loss Regeneration

Discussion in 'Research News' started by RB2014, Dec 8, 2016.

    1. Diesel

      Diesel Member Benefactor Ambassador Hall of Fame Advocate

      Tinnitus Since:
      1-2019
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      20+ Years of Live Music, Motorcycles, and Power Tools
      Right now, they can only really send out communications on data they have clear evidence on. That data is from the Phase 1 and 1/2. IF more data is revealed from the Phase 2A that is significant, the range/variety of communications will increase.
       
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    2. Gb3

      Gb3 Member

      Tinnitus Since:
      12/19
      Cause of Tinnitus:
      Sshl
      I don't know what would make you think that honestly. If anything it probably won't help for hidden hearing loss.
       
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    3. Diesel

      Diesel Member Benefactor Ambassador Hall of Fame Advocate

      Tinnitus Since:
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      If hidden hearing loss is hearing in noisy environments, then it would appear that FX-322 may help. They just tweeted about hidden hearing loss, and this slide shows that there is a probable trend in Word-In-Noise improvement.

      Screen Shot 2021-02-19 at 11.58.23 AM.png
       
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    4. Jrblovsky

      Jrblovsky Member

      Location:
      USA
      Tinnitus Since:
      Christmas 2019
      Cause of Tinnitus:
      NOISE/Menieres Who knows
      We are all in the same spot. I haven't left my bed in two days. Wait for the Phase 2 results. It may not even work and you would be wasting your time.
       
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    5. Gb3

      Gb3 Member

      Tinnitus Since:
      12/19
      Cause of Tinnitus:
      Sshl
      Well I have high frequency hearing loss starting at 4000 Hz and really struggle to hear in background noise. I just think in regards to hidden hearing loss that it just isn't identifiable on an audiogram, especially a standard one. There is most likely hearing loss in the higher frequencies.
       
    6. Still-Hope
      Cool

      Still-Hope Member Benefactor

      Location:
      France
      Tinnitus Since:
      JULY 2020
      Cause of Tinnitus:
      Noise induced. (working music for too long in Headphones)
      Here in France, after having passed an audiogram from 40 Hz to 16 kHz with an ENT, I've done one more audiogram (more precise as you described) with an audiologist.

      He checked a lot more frequencies, especially in the areas where I had losses, and tinnitus.

      And it showed a lot more information about my hearing loss. (See the attached result).

      Also, as a music producer and sound engineer, what you say about word recognition and vowels / consonants is very relevant. We learn this in audio mixing technique, each vowel and consonant corresponds to a frequency zone.

      20201110_145939.jpg
      Definitely! Massive thanks, @Diesel! :thankyousign:
       
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    7. Diesel

      Diesel Member Benefactor Ambassador Hall of Fame Advocate

      Tinnitus Since:
      1-2019
      Cause of Tinnitus:
      20+ Years of Live Music, Motorcycles, and Power Tools
      Thank you for sharing this. I wish here in the US, we all got this much attention to detail on the audiogram. It might be more telling in helping us understand our condition. Oh yay, I see you work in sound/audio! I'd love to pick your brain about the tinnitus you experience!

      Just curious, when I look at your audiogram, I see some significant dips at 3 kHz - 4 kHz, 6 kHz-ish, and 10 kHz - 12 kHz.

      Do the tinnitus sound(s) that you experience sound like they are in the range of losses? Like do you hear a sound that somewhat sounds like a 3 kHz - 4 kHz sine wave or tone?

      If so, when you put in ear plugs in a quiet setting, is the tinnitus at those ranges amplified or more defined?

      I always ask this, because I believe that FX-322 even causing a mild improvement (like 10 dB) in those areas of deficiency, may be enough to give the brain signal to eliminate the tinnitus experienced at least in a normal setting.
       
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    8. Still-Hope
      Cool

      Still-Hope Member Benefactor

      Location:
      France
      Tinnitus Since:
      JULY 2020
      Cause of Tinnitus:
      Noise induced. (working music for too long in Headphones)
      You're welcome!
      Thank you for sharing useful knowledge, I'm happy to contribute best as I can!

      I can answer you with certainty, being a person who has listened to sine waves for years, being a producer of electronic music...

      When at the very beginning I had only one tinnitus sound, it was precisely located at 3200 Hz, I rechecked myself several times. And this was the biggest dip I had in my ear on the first audiogram I did. This confirms in a factual way that the tinnitus was exactly at the biggest dip on my audiogram.

      Unfortunately then it started modulating (between 3000 Hz and 4000 Hz). The scientific reasons I do not know... but my own interpretation is that my hearing loss has continued to progress a bit... Who knows... Stress may have played a factor too?! This remains my own interpretation.

      Unfortunately for me, a few weeks later... Because of stress, focusing on it, progressive hearing loss, or a neurological process that I have no knowledge of at all, I started hearing several other tinnitus sounds.

      It is therefore now difficult to identify them precisely in what exact frequencies they sit... because they modulate, mix with each others and change gradually during the day...

      But I can almost say for sure that yes, they are all in the frequency areas where I have the biggest hearing loss...

      So my intuition (in view of my own experience) is definitely yes, tinnitus sits in frequencies that the brain no longer receives. It's 100% sure that is one factor.

      For the rest I don't know... apparently there are probably many other neurological mechanisms involved...

      About the earplugs, I don't use them anymore, because sometimes I have the feeling that I'm hearing all these tinnitus sounds moving in my whole head... Lol. So I never do this :barefoot:
       
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    9. Diesel

      Diesel Member Benefactor Ambassador Hall of Fame Advocate

      Tinnitus Since:
      1-2019
      Cause of Tinnitus:
      20+ Years of Live Music, Motorcycles, and Power Tools
      This was incredibly informative; thank you for sharing your experience.
       
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    10. Pharz

      Pharz Member Benefactor

      Location:
      Netherlands
      Tinnitus Since:
      2019
      Cause of Tinnitus:
      Played the digital piano on loudest setting using headphone.
      Is 30% improvement over 30 days not significant? I think for people who are dealing with this this problem even 10% is good news.
       
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    11. Lucifer

      Lucifer Member Podcast Patron Benefactor Hall of Fame

      Location:
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      Remember, this was with one dose of FX-322 only. In the current Phase 2a clinical trial, some participants will be able to get 4 doses of FX-322 which should make the results look even better if additional doses of FX-322 allow it to reach deeper in the round window.
       
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    12. ThomasRobert

      ThomasRobert Member Benefactor

      Location:
      ME
      Tinnitus Since:
      06/2019
      Cause of Tinnitus:
      Ototoxic
      During Phase 2a, there will be candidates who will receive 4 doses of FX-322.

      90-day results are scheduled to be published in March and 120-day results are expected in June.

      Question:

      Would the candidates have received the 4 doses before the 90 days? Or would it be 2 doses during the first 90 days and the other 2 doses after the 90 days?
       
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    13. Jrblovsky

      Jrblovsky Member

      Location:
      USA
      Tinnitus Since:
      Christmas 2019
      Cause of Tinnitus:
      NOISE/Menieres Who knows
      Praying for large gains. Some of us have massive losses. 10 dB isn't going to do much in my case.
       
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    14. Diesel

      Diesel Member Benefactor Ambassador Hall of Fame Advocate

      Tinnitus Since:
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      Everyone in the Phase 2A FIRST received 4 doses in the first 30 days of the trial, or, 1 per week. So it would have looked like this:

      1x Dose of FX-322:

      Week 1: FX-322 - Week 2: Placebo - Week 3: Placebo - Week 4: Placebo

      2x Dose of FX-322

      Week 1: FX-322 - Week 2: FX-322 - Week 3: Placebo - Week 4: Placebo

      4x Dose of FX-322

      Week 1: FX-322 - Week 2: FX-322 - Week 3: FX-322 - Week 4: FX-322

      0x Dose of FX-322 (Placebo)

      Week 1: Placebo - Week 2: Placebo - Week 3: Placebo - Week 4: Placebo


      After the "Week 4" dose, the clock starts on the follow-up visits.

      15 Days, 30 Days, 90 Days, 120 Days, 150 Days, 180 Days, 210 Days


      For the 90-Day Results, they will show what those "Dose Groups" did on average at the 90-Day follow-up on most of the endpoints:

      Speech intelligibility as measured by WR and WIN testing
      Pure Tone Audiometry measures at frequencies from 0.25 kHz to 16 kHz
      Partial data on measures of FX-322 on tinnitus, impact on QoL
      Safety profile

      So, we'll see exactly what the Placebo, 1x, 2x, 4x groups did on average 90 days from their last dose.
       
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    15. AfroSnowman
      Balanced

      AfroSnowman Member Podcast Patron Benefactor

      Tinnitus Since:
      April 16 2019
      Cause of Tinnitus:
      Nonnatural energy source
      I don't know your case, but my understanding is that dB scale is logarithmic, so a 10 dB improvement would mean a doubling of your hearing at the frequencies that it reaches from your current baseline.
       
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    16. Diesel

      Diesel Member Benefactor Ambassador Hall of Fame Advocate

      Tinnitus Since:
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      20+ Years of Live Music, Motorcycles, and Power Tools
      It’s actually 3x - 4x the sensitivity for the human ear for every 10 dB increment of improvement. There are some varied views on how this is measured.

      So, if you had a baseline of 50 dB loss at 8 kHz, and improved to 40 dB, your ear is now 3 - 4x more sensitive to 8 kHz. A move from the same 50 dB baseline to 30 dB would mean your ear is now 9x - 16x more sensitive to 8 kHz.
       
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    17. ThomasRobert

      ThomasRobert Member Benefactor

      Location:
      ME
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      06/2019
      Cause of Tinnitus:
      Ototoxic
      So basically next month’s results will be either a Pass or Failure for Frequency Therapeutics.

      Wow.
       
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    18. Jrblovsky

      Jrblovsky Member

      Location:
      USA
      Tinnitus Since:
      Christmas 2019
      Cause of Tinnitus:
      NOISE/Menieres Who knows
      I can agree with that. When I had a 25 dB loss at 8 kHz everything sounded very near normal. Now at a 75 dB loss at 8 kHz everything seems dull.
       
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    19. AfroSnowman
      Balanced

      AfroSnowman Member Podcast Patron Benefactor

      Tinnitus Since:
      April 16 2019
      Cause of Tinnitus:
      Nonnatural energy source
      Reading this gets me excited. I had some weird ultimately unknowable stuff go down that led to the noise in my head, but regardless of the cause it is in the high frequency range 12-16 kHz that I have most of my hearing loss 40-55 dB and all of the tinnitus. I can imagine that if I had a 10 dB gain, much less a 20 dB in those frequencies it really could easily make enough of a difference that I would fall into that lucky category of non-intrusive tinnitus non-sufferers.
       
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    20. Diesel

      Diesel Member Benefactor Ambassador Hall of Fame Advocate

      Tinnitus Since:
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      Cause of Tinnitus:
      20+ Years of Live Music, Motorcycles, and Power Tools
      Yeah, I am not a scientist, but I suspect that tinnitus experienced by those with NIHL / SNHL is a matter of a certain level of missing signal by enough damaged/missing hair cells in a particular area of the cochlea. Every time someone shares on here an audiogram, I ask about their tinnitus. Many have shared that the dips are what their tinnitus sounds like. This is the case for me as well. Typically the dips on the audiogram drop to anywhere from 30 dB to 70 dB where people are able to distinguish the tinnitus tone/noise/whatever.

      I suspect then, that if potentially all or at least enough hair cells are replaced in those areas where the dip exists (and therefore the tinnitus is most prominent), then the sensation should begin to be resolved.

      I also suspect that the performance of the hearing in those "tinnitus zones" may not necessarily need to go back to the "World-War 2 Era Audiogram" definition of normal hearing above 20 dB. I think its easy to get hung up on the measurements while forgetting about the biological changes taking place.

      So, for @Still-Hope's audiogram shared a few comments, back, at 6 kHz, it may only take enough hair cells to give a 10-15 dB gain; still not "normal" on the classic audiogram, but that's enough signal for the brain to no longer produce tinnitus.
       
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    21. scotty03874

      scotty03874 Member

      Location:
      Boston / Miami Beach
      Tinnitus Since:
      4/7/19
      Cause of Tinnitus:
      Slap to the ear / Leading to more issues
      I agree. When I was -40 dB it did not even affect my hearing in my opinion but once I had the surgery on my middle ear and now I'm -65 dB it is completely different and entirely dull sounding. If I could go from -65 dB back up to -40 dB I would be thrilled.
       
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    22. Guywithapug
      Dreaming

      Guywithapug Member

      Location:
      USA
      Tinnitus Since:
      October 2020
      Cause of Tinnitus:
      SSHL
      Same. I was at -40 dB at 4 kHz and everything sounded clear and normal to me. Now at -65 dB, I have fullness and sounds are slightly dull as well. Word recognition remains at 100%. Tinnitus tone matches the affected frequency.

      I'll also add that when my tinnitus is really quiet, I can readily notice the hearing deficit in my bad ear around sounds. However, when it is roaring, I don't notice the deficit really. I think that really supports the tinnitus tone/frequency dip theory being discussed, as the brain is filling in the missing signal.

      Does anyone else experience this?
       
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    23. Keith Handy
      Worried

      Keith Handy Member

      Tinnitus Since:
      11/2020
      Cause of Tinnitus:
      Stress + sleep deprivation + noise
      Just so you know, I've been checking every so often for this thread.
       
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    24. Keith Handy
      Worried

      Keith Handy Member

      Tinnitus Since:
      11/2020
      Cause of Tinnitus:
      Stress + sleep deprivation + noise
      Their last few quarterly press releases were mid-month. Their previous Q4 release was in March, not February.
       
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    25. AfroSnowman
      Balanced

      AfroSnowman Member Podcast Patron Benefactor

      Tinnitus Since:
      April 16 2019
      Cause of Tinnitus:
      Nonnatural energy source
      I have the opposite experience. I have a really different hearing profile than you do, no loss at lower frequencies, mild loss >4 kHz, moderate >12 kHz, and the tinnitus is all at the ultra high frequencies, but when I am having the rare mild tinnitus day it is almost like I don't have hearing loss at all, but when the tinnitus is really raging hearing becomes more challenging.
       
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    26. Ilias T
      Tired

      Ilias T Member

      Location:
      Germany
      Tinnitus Since:
      05/2017
      Cause of Tinnitus:
      Probably hearing loss or TMJ
      I have been following this research for a long time. I am very confident that FX-322 will work and succeed in all clinical trials. Hearing loss and ringing are not rare. Their stock also went up by a lot which shows that investors are also confident.

      I hope that the price of FX-322 will be affordable if they release it. I believe it will be affordable.

      Frequency Therapeutics Stock.png
       
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    27. Aaron91
      Jaded

      Aaron91 Member Podcast Patron Benefactor Ambassador Advocate

      Tinnitus Since:
      2007
      Cause of Tinnitus:
      Loud music/headphones/concerts - Hyperacusis from motorbike
      Sorry, @Keith Handy! I've been quite busy this week and it's a post I really want to make my time with in terms of accumulating all my sources and building my thesis, so I'd rather not rush it. Hopefully should have it to you guys within the week!
       
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    28. Bill Arsenault

      Bill Arsenault Member

      Location:
      Boston.
      Tinnitus Since:
      Permanent and intrusive since 2017.
      Cause of Tinnitus:
      Medication / Noise Over Exposure
      I cannot even begin to truly imagine the fear and horror severe tinnitus sufferers experienced back in the day.

      Alone with no help or hope in sight and no threads to read when unable to fall asleep.

      So grateful for everyone here.
       
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    29. Jrblovsky

      Jrblovsky Member

      Location:
      USA
      Tinnitus Since:
      Christmas 2019
      Cause of Tinnitus:
      NOISE/Menieres Who knows
      This thread is inspiring and depressing at the same time. If FX-322 doesn't work, it's going to be 10 years minimum before another treatment is available.
       
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    30. Diesel

      Diesel Member Benefactor Ambassador Hall of Fame Advocate

      Tinnitus Since:
      1-2019
      Cause of Tinnitus:
      20+ Years of Live Music, Motorcycles, and Power Tools
      The only concern right now is how well multiple doses improve hearing function. If multiple doses don't go any deeper/improve performance, they'll need to change the gel or delivery method.

      As long as FX-322 still maintains a favorable safety profile, it's coming to the market in a single-dose form. There's no alternative treatment, and even the single dose outcome from the Phase 1/2 would be beneficial to millions worldwide.
       
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