Frequency Therapeutics — Hearing Loss Regeneration

The biggest problem, the way I see it, is they kept tweeting half ass positive shit for about a month while sitting on the bad results!

And the stock price dived from $60 to $45 in that period without any specific news!

Hard to prove anything but very clearly some people selling down knew stuff...

 

This is awesome but I was referring to the 250 Hz to 1 kHz area of the spectrum.

Apologies if I was unclear.

 

From now, it's going to take 5 to 10 years as long as everything works.

 

Right now it looks like it only reaches up to 8 kHz... They will need to figure out something for a delivery method to get further into the cochlea in order to reach those frequencies.

 

The thing that Frequency Therapeutics' team of lawyers could do however is simply stay silent and not do anything to respond to the lawsuits etc from those that try to sue them. There's totally no reason for them to even bother to entertain them until there ends up being some form of action taken in a court. Currently there are heaps of examples of firms not taking any action against parties threatening to take legal action until they do decide to. Then it will be up to those trying to take action against them to prove their claims and also actually risk incurring costs should their actions be unfounded too.

Or the price naturally dropped due to the lack of action relating to Frequency Therapeutics in the same way this stuff happens routinely with stocks.

 

Or... You could check what markets naturally did that month... Even biotechs.

 

You just said it. Team of lawyers that costs money even to hold them and for them to get familiar with what is going on. Agreed, until something is filed, there is no reason to do much, but given the number of firms I saw on the list I think it is coming. My only concern is that this starts to eat into the money Frequency Therapeutics have available to run their business and complete the trials. I doubt they are going to get any more money from investors based on the results we have seen and this possible litigation will shy them even further away.

 

It doesn't work that way. Their cash-on-hand won't be drained in a non-existent legal chicken match.

 

How does it work then? If they get sued and have to pay defense lawyers to defend the suit, where does the money come from?

 

Most companies have a Legal department, with in-house lawyers and a general counsel.

Legal matters come up constantly in the day to day running of a company.

 

They aren’t getting sued, though. It’s all posturing. The only expense they’ve had is for their council to say, “let’s not say anything unless it shows up in court, or the SEC investigates.”

 

Didn't they hire an in house counsel at some point anyhow? As a result the costs would already be incurred as a part of their daily running of the organisation. Failed litigation literally is a positive for these organisations, as it simply demonstrates that the things a firm is doing are OK and all above board, meaning that the company no longer needs to worry about any legal threat associated with that type of claim any longer.

Literally within the last month in Australia, our consumer regulation body has failed in legal action taken against a few large companies in relation to their business practices supposedly being illegal. While initially it resulted in the share price dropping due to the impending action, the instant the claims of the regulator got dismissed, the share price went back up really significantly. Shareholders simply got shown that the company was acting properly and they could be confident that the company would proceed with the activity that they were doing.

Sometimes some investors are willing to put cash into new firms fairly willingly, however they also desire having a clear understanding that the activities that the business is conducting are all above board and free of outside risks which would negatively impact upon them. Then there are other investors who are looking for outs after they have lost in failed investments or seem not willing to understand the fact that the thing with investing in shares is that there are short term and long term risk involved.

It is incredibly likely that if Frequency Therapeutics hasn't fallen afoul of the law they will be able to continue trialling the drug in the manner in which they have been doing without risks too.

 

Why are you people talking about lawyers and stuff? Look up the definition of ambulance chaser firms, nothing ever materializes out of this stuff. Just forget about it. This is a research thread, not a legal speculation one.

 

Yes, of course, but not without Apollo 1. It happens.

 

Perhaps it might be practical if some of the tinnitus sufferers who live close by to one of the research universities were to make a will granting their organs towards otological medical research. So for example, if one person has no hearing loss but suffers from tinnitus but not hyperacusis, once they depart this life, the scientists would be able to examine their cochlear make-up and be able to figure out whether the synapses were intact or whether the inner or the outer hair cells were intact etc., so as to deduce where the problem lay. Of course it would be too late for the departed soul in question, but it might provide more clarity on the direction that research should take.

Similarly one departed patient's cochlea might indicate what was the cause of their deafness, or the noxacusis and so on.

In short, we might benefit from a data-base of the patients' disabilities and the respective make-up of their damaged cochleas. I can see this being useful until such time as they invent a scanning device for the inner ear.

 

Everyone agrees it doesn’t matter until suit is filed. Issue is whether suit will be filed. At that point they have to pay to defend the case, no?

 

They already know and examined ex vivo extensively...

Tinnitus is activated as soon as any damage occurs in the brain/nerves/auditory/inner ear/middle ear/cells/etc...

They already know which area in the brain the tinnitus source is...

The question is, which substance can instruct the tinnitus part of the brain to stop.

Tinnitus is an alarm in the brain, the bigger the damage the louder the tinnitus.

For example, if a building is burning, the fire alarm is activated, if you go to the fire panel and click mute alarm, it won't mute, because the fire still burning... once the fire is extinguished, you can mute the alarm.

So with tinnitus, you either need:

1) Cure the root issue in the brain so the alarm (tinnitus) stops

or

2) Find a substance that can enter the tinnitus area in the brain and instruct it to IGNORE the root issue, so at least the brain stops the alarm

 

Tinnitus is not a direct brain issue and it is not simply stuck in the brain or directly caused by the brain either.

 

These are two of many, many, options as have been discussed on this forum. Tinnitus isn't limited to the brain.

 

You misread what I wrote:

Damage can occur in either one of the below:

Brain
Nerves
Auditory
Inner ear
Middle ear
Blood flow
Hormones
Cholesterol
Etc...

Tinnitus alarm is in the brain...

 

Then you wrote:

Which is... not even close to complete. You fixed it above with your list... and treating the above is the solution.

 

You then also said that the tinnitus source is in the brain directly after that. This has been demonstrated multiple times to be categorically false and incorrect.

 

Man, in simple English, treating the root cause fixes tinnitus...

If the root cause is not fixed, then we need a drug to shut it up...

 

Yes. Tinnitus is in the brain.

 

The Root Cause is the site of damage and I quote:

 

Where did you even get that?

 

Not always (e.g., otosclerosis, when losses are purely conductive).

 

All perception of everything is in our brain. I don't see the point.

 

I hope this sentence satisfies you:

If the root cause is not fixed at the site of damage, then we need a drug to shut the tinnitus up which is located and perceived in the brain...

https://www.researchgate.net/figure...d-to-be-involved-in-the-gating_fig3_262816281