Frequency Therapeutics — Hearing Loss Regeneration

Discussion in 'Research News' started by RB2014, Dec 8, 2016.

    1. Zugzug

      Zugzug Member Podcast Patron Benefactor Ambassador Hall of Fame Advocate

      Tinnitus Since:
      05/2019
      Cause of Tinnitus:
      Autoimmune hyperacusis from Sjogren's Syndrome
      Lol, this was my actual quote. I'm curious how you will misrepresent it.
      I bolded and underlined the part that is easy to comprehend. How can something not crossing the finish line yet contradict pleasing me thus far?

      Your logic is insane. There's no intermediate steps. So when they were trying to land man on the moon, were there ever any moments of prolific aerospace engineering beforehand? Why can't intermediate steps please us? How is that a contradiction?

      My message is pretty clear: Go scientists, management has fucked up, let's save this thing.

      Also, I see that I've been promoted from unpaid Evangelist to lawyer so I'll take it for sure.
       
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    2. Chinmoku

      Chinmoku Member Benefactor

      Tinnitus Since:
      10/2018
      Cause of Tinnitus:
      Started with a cold, possibly worsened by medication/noise
      Problem with this discussion sometimes is that there is too much "nuance compression" for lack of a better term, and sometimes not even nuance but just logic. We need to keep all the bits and steps or we risk straw-manning arguments like yours.
      The skepticism and disillusionment of many posters is understandable but it's not over yet.

      I do agree with your compressed message though and that embeds my hopes that this may still lead to a beginning of hearing regeneration. Go scientists! I had better hopes because the management looks scientifically savvy, but in the end it's the scientists in the trenches that are doing the fundamental work. I really hope the management wakes up. In this sense possible use of OAE tests is a good step forward in addition to audiograms and WR. I don't think you ever claimed audiograms and WR to be meaningless, rather incomplete and prone to errors and manipulations. Better trial design and OAE should improve this.

      P.S. You are a renaissance man: mathematician, statistician, evangelist and lawyer. Leibniz is dying of envy
       
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    3. Zugzug

      Zugzug Member Podcast Patron Benefactor Ambassador Hall of Fame Advocate

      Tinnitus Since:
      05/2019
      Cause of Tinnitus:
      Autoimmune hyperacusis from Sjogren's Syndrome
      After hearing regeneration is available, let's do it. We can blast the speakers and if anyone experiences a noise injury, we can file a lawsuit against the speaker manufacturer. I will represent.
       
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    4. Zugzug

      Zugzug Member Podcast Patron Benefactor Ambassador Hall of Fame Advocate

      Tinnitus Since:
      05/2019
      Cause of Tinnitus:
      Autoimmune hyperacusis from Sjogren's Syndrome
      If Leibniz is still alive, that's the real takeaway from this post lol.
       
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    5. tommyd87

      tommyd87 Member

      Tinnitus Since:
      1999
      Cause of Tinnitus:
      tmj music
      Frequency Therapeutics won't have to actually do much to mount a defense in regards to the failed investment lawsuits. It is very difficult for anyone to prove that Frequency Therapeutics was willfully/wantedly negligent in their decisions and manner in which they conducted this trial. Therefore this might cost them some money in the short term, however their legal costs will certainly be recovered from a successful defense.
       
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    6. athan86
      Angelic

      athan86 Member

      Location:
      Greece
      Tinnitus Since:
      30-5-2020
      Cause of Tinnitus:
      Repetitive Strain Injury (probably)
      After reading as many pages of this thread as I could, I still have some questions:

      1) How long will it take before FX-322 is available in the market?
      2) My tinnitus frequency is around 8,000 Hz. Is FX-322 effective for this frequency?
      3) In which stage of trials is FX-322 now?
       
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    7. ThomasRobert

      ThomasRobert Member Benefactor

      Location:
      ME
      Tinnitus Since:
      06/2019
      Cause of Tinnitus:
      Ototoxic
      Phase 1: currently being finalized
      Phase 2: we can expect it to start in December 2021, duration 1 year
      Phase 3: duration 1 year
      FDA: Apply for Approval (a few months)

      If David and Team decides to go watch the World Cup FIFA December 2022 in Qatar, it might take a bit longer.
      Yes, so far it has shown that the drug reaches the 8,000 Hz.
      Finalizing Phase 1, about to start Phase 2.
       
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    8. wreni

      wreni Member

      Tinnitus Since:
      03/13
      Cause of Tinnitus:
      Acoustic trauma
      Do we know whether or not FX-322 has shown any improvement in lower frequencies?
       
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    9. AUTHOR
      AUTHOR
      RB2014
      Confused

      RB2014 Member Benefactor

      Location:
      US
      Tinnitus Since:
      12/2014 became noticable
      Cause of Tinnitus:
      Loss of hearing and then stress and anxiety
      Agreed that it won't be much, but they will still have to do it at a certain point. It just eats into the money the company has for trials, employees, etc. Frivolous lawsuits happen all the time. They won't be able to recover those costs though unless they can prove the lawyers had no case. Usually both sides agree to just let it go. The court cases could still go far even without a good case and once it gets to that point it will cost money on both sides. One user did mention that there were some big stock sales before the information went public so they could be looking into that as well.
       
    10. ThomasRobert

      ThomasRobert Member Benefactor

      Location:
      ME
      Tinnitus Since:
      06/2019
      Cause of Tinnitus:
      Ototoxic
      I recall seeing a possibility for the drug reaching 6,000 Hz.
       
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    11. Exit

      Exit Member Benefactor

      Tinnitus Since:
      01/2020
      Cause of Tinnitus:
      Noise
      The biggest problem, the way I see it, is they kept tweeting half ass positive shit for about a month while sitting on the bad results!

      And the stock price dived from $60 to $45 in that period without any specific news!

      Hard to prove anything but very clearly some people selling down knew stuff...
       
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    12. wreni

      wreni Member

      Tinnitus Since:
      03/13
      Cause of Tinnitus:
      Acoustic trauma
      This is awesome but I was referring to the 250 Hz to 1 kHz area of the spectrum.

      Apologies if I was unclear.
       
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    13. ThomasC
      Lonely

      ThomasC Member Benefactor

      Location:
      France
      Tinnitus Since:
      2012
      Cause of Tinnitus:
      hearing loss
      From now, it's going to take 5 to 10 years as long as everything works.
       
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    14. AUTHOR
      AUTHOR
      RB2014
      Confused

      RB2014 Member Benefactor

      Location:
      US
      Tinnitus Since:
      12/2014 became noticable
      Cause of Tinnitus:
      Loss of hearing and then stress and anxiety
      Right now it looks like it only reaches up to 8 kHz... They will need to figure out something for a delivery method to get further into the cochlea in order to reach those frequencies.
       
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    15. tommyd87

      tommyd87 Member

      Tinnitus Since:
      1999
      Cause of Tinnitus:
      tmj music
      The thing that Frequency Therapeutics' team of lawyers could do however is simply stay silent and not do anything to respond to the lawsuits etc from those that try to sue them. There's totally no reason for them to even bother to entertain them until there ends up being some form of action taken in a court. Currently there are heaps of examples of firms not taking any action against parties threatening to take legal action until they do decide to. Then it will be up to those trying to take action against them to prove their claims and also actually risk incurring costs should their actions be unfounded too.
      Or the price naturally dropped due to the lack of action relating to Frequency Therapeutics in the same way this stuff happens routinely with stocks.
       
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    16. Exit

      Exit Member Benefactor

      Tinnitus Since:
      01/2020
      Cause of Tinnitus:
      Noise
      Or... You could check what markets naturally did that month... Even biotechs.
       
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    17. AUTHOR
      AUTHOR
      RB2014
      Confused

      RB2014 Member Benefactor

      Location:
      US
      Tinnitus Since:
      12/2014 became noticable
      Cause of Tinnitus:
      Loss of hearing and then stress and anxiety
      You just said it. Team of lawyers that costs money even to hold them and for them to get familiar with what is going on. Agreed, until something is filed, there is no reason to do much, but given the number of firms I saw on the list I think it is coming. My only concern is that this starts to eat into the money Frequency Therapeutics have available to run their business and complete the trials. I doubt they are going to get any more money from investors based on the results we have seen and this possible litigation will shy them even further away.
       
    18. Diesel

      Diesel Member Benefactor Ambassador Hall of Fame Advocate

      Tinnitus Since:
      1-2019
      Cause of Tinnitus:
      20+ Years of Live Music, Motorcycles, and Power Tools
      It doesn't work that way. Their cash-on-hand won't be drained in a non-existent legal chicken match.
       
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    19. chinup

      chinup Member

      Tinnitus Since:
      2010
      Cause of Tinnitus:
      Loud music
      How does it work then? If they get sued and have to pay defense lawyers to defend the suit, where does the money come from?
       
    20. Tanni
      Provocative

      Tanni Member Benefactor

      Tinnitus Since:
      October 2017
      Cause of Tinnitus:
      ???
      Most companies have a Legal department, with in-house lawyers and a general counsel.

      Legal matters come up constantly in the day to day running of a company.
       
    21. Diesel

      Diesel Member Benefactor Ambassador Hall of Fame Advocate

      Tinnitus Since:
      1-2019
      Cause of Tinnitus:
      20+ Years of Live Music, Motorcycles, and Power Tools
      They aren’t getting sued, though. It’s all posturing. The only expense they’ve had is for their council to say, “let’s not say anything unless it shows up in court, or the SEC investigates.”
       
    22. tommyd87

      tommyd87 Member

      Tinnitus Since:
      1999
      Cause of Tinnitus:
      tmj music
      Didn't they hire an in house counsel at some point anyhow? As a result the costs would already be incurred as a part of their daily running of the organisation. Failed litigation literally is a positive for these organisations, as it simply demonstrates that the things a firm is doing are OK and all above board, meaning that the company no longer needs to worry about any legal threat associated with that type of claim any longer.

      Literally within the last month in Australia, our consumer regulation body has failed in legal action taken against a few large companies in relation to their business practices supposedly being illegal. While initially it resulted in the share price dropping due to the impending action, the instant the claims of the regulator got dismissed, the share price went back up really significantly. Shareholders simply got shown that the company was acting properly and they could be confident that the company would proceed with the activity that they were doing.

      Sometimes some investors are willing to put cash into new firms fairly willingly, however they also desire having a clear understanding that the activities that the business is conducting are all above board and free of outside risks which would negatively impact upon them. Then there are other investors who are looking for outs after they have lost in failed investments or seem not willing to understand the fact that the thing with investing in shares is that there are short term and long term risk involved.

      It is incredibly likely that if Frequency Therapeutics hasn't fallen afoul of the law they will be able to continue trialling the drug in the manner in which they have been doing without risks too.
       
    23. Tezcatlipoca
      Question it

      Tezcatlipoca Member

      Location:
      Mexico
      Tinnitus Since:
      June 2020
      Cause of Tinnitus:
      NIHL
      Why are you people talking about lawyers and stuff? Look up the definition of ambulance chaser firms, nothing ever materializes out of this stuff. Just forget about it. This is a research thread, not a legal speculation one.
       
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    24. Billy_Shears

      Billy_Shears Member Benefactor

      Location:
      Knoxville, Tennessee
      Tinnitus Since:
      2010
      Cause of Tinnitus:
      Pink Floyd
      Yes, of course, but not without Apollo 1. It happens.
       
    25. ThomasRobert

      ThomasRobert Member Benefactor

      Location:
      ME
      Tinnitus Since:
      06/2019
      Cause of Tinnitus:
      Ototoxic
      giphy.gif
       
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    26. Joeseph Stope
      Innocent

      Joeseph Stope Member

      Tinnitus Since:
      1992
      Cause of Tinnitus:
      noise? infection? negative stress? other?
      Perhaps it might be practical if some of the tinnitus sufferers who live close by to one of the research universities were to make a will granting their organs towards otological medical research. So for example, if one person has no hearing loss but suffers from tinnitus but not hyperacusis, once they depart this life, the scientists would be able to examine their cochlear make-up and be able to figure out whether the synapses were intact or whether the inner or the outer hair cells were intact etc., so as to deduce where the problem lay. Of course it would be too late for the departed soul in question, but it might provide more clarity on the direction that research should take.

      Similarly one departed patient's cochlea might indicate what was the cause of their deafness, or the noxacusis and so on.

      In short, we might benefit from a data-base of the patients' disabilities and the respective make-up of their damaged cochleas. I can see this being useful until such time as they invent a scanning device for the inner ear.
       
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    27. chinup

      chinup Member

      Tinnitus Since:
      2010
      Cause of Tinnitus:
      Loud music
      Everyone agrees it doesn’t matter until suit is filed. Issue is whether suit will be filed. At that point they have to pay to defend the case, no?
       
    28. ThomasRobert

      ThomasRobert Member Benefactor

      Location:
      ME
      Tinnitus Since:
      06/2019
      Cause of Tinnitus:
      Ototoxic
      They already know and examined ex vivo extensively...

      Tinnitus is activated as soon as any damage occurs in the brain/nerves/auditory/inner ear/middle ear/cells/etc...

      They already know which area in the brain the tinnitus source is...

      The question is, which substance can instruct the tinnitus part of the brain to stop.

      Tinnitus is an alarm in the brain, the bigger the damage the louder the tinnitus.

      For example, if a building is burning, the fire alarm is activated, if you go to the fire panel and click mute alarm, it won't mute, because the fire still burning... once the fire is extinguished, you can mute the alarm.

      So with tinnitus, you either need:

      1) Cure the root issue in the brain so the alarm (tinnitus) stops

      or

      2) Find a substance that can enter the tinnitus area in the brain and instruct it to IGNORE the root issue, so at least the brain stops the alarm
       
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    29. tommyd87

      tommyd87 Member

      Tinnitus Since:
      1999
      Cause of Tinnitus:
      tmj music
      Tinnitus is not a direct brain issue and it is not simply stuck in the brain or directly caused by the brain either.
       
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    30. Diesel

      Diesel Member Benefactor Ambassador Hall of Fame Advocate

      Tinnitus Since:
      1-2019
      Cause of Tinnitus:
      20+ Years of Live Music, Motorcycles, and Power Tools
      These are two of many, many, options as have been discussed on this forum. Tinnitus isn't limited to the brain.
       
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