Frequency Therapeutics — Hearing Loss Regeneration

Discussion in 'Research News' started by RB2014, Dec 8, 2016.

    1. ThomasRobert

      ThomasRobert Member Benefactor

      Location:
      ME
      Tinnitus Since:
      06/2019
      Cause of Tinnitus:
      Ototoxic
      You misread what I wrote:
      Damage can occur in either one of the below:

      Brain
      Nerves
      Auditory
      Inner ear
      Middle ear
      Blood flow
      Hormones
      Cholesterol
      Etc...

      Tinnitus alarm is in the brain...
       
    2. Diesel

      Diesel Member Benefactor Ambassador Hall of Fame Advocate

      Tinnitus Since:
      1-2019
      Cause of Tinnitus:
      20+ Years of Live Music, Motorcycles, and Power Tools
      Then you wrote:
      Which is... not even close to complete. You fixed it above with your list... and treating the above is the solution.
       
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    3. tommyd87

      tommyd87 Member

      Tinnitus Since:
      1999
      Cause of Tinnitus:
      tmj music
      You then also said that the tinnitus source is in the brain directly after that. This has been demonstrated multiple times to be categorically false and incorrect.
       
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    4. ThomasRobert

      ThomasRobert Member Benefactor

      Location:
      ME
      Tinnitus Since:
      06/2019
      Cause of Tinnitus:
      Ototoxic
      Man, in simple English, treating the root cause fixes tinnitus...

      If the root cause is not fixed, then we need a drug to shut it up...
       
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    5. ThomasRobert

      ThomasRobert Member Benefactor

      Location:
      ME
      Tinnitus Since:
      06/2019
      Cause of Tinnitus:
      Ototoxic
      Yes. Tinnitus is in the brain.

      FED18D85-CAB8-48CF-8CCD-09FC9425158D.png
       
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    6. Diesel

      Diesel Member Benefactor Ambassador Hall of Fame Advocate

      Tinnitus Since:
      1-2019
      Cause of Tinnitus:
      20+ Years of Live Music, Motorcycles, and Power Tools
      The Root Cause is the site of damage and I quote:
       
    7. Gb3

      Gb3 Member

      Tinnitus Since:
      12/19
      Cause of Tinnitus:
      Sshl
      Where did you even get that?
       
    8. GregCA
      Jaded

      GregCA Member Benefactor Hall of Fame

      Tinnitus Since:
      03/2016
      Cause of Tinnitus:
      Otosclerosis
      Not always (e.g., otosclerosis, when losses are purely conductive).
       
    9. Cernuto
      Spaced

      Cernuto Member

      Tinnitus Since:
      2010
      Cause of Tinnitus:
      Noise Induced
      All perception of everything is in our brain. I don't see the point.
       
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    10. ThomasRobert

      ThomasRobert Member Benefactor

      Location:
      ME
      Tinnitus Since:
      06/2019
      Cause of Tinnitus:
      Ototoxic
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    11. Aaron91
      Gloomy

      Aaron91 Member Podcast Patron Benefactor Ambassador Advocate

      Tinnitus Since:
      2007
      Cause of Tinnitus:
      Loud music/headphones/concerts - Hyperacusis from motorbike
      Man, the overall tone of this thread has taken a serious turn for the worse since the readout.

      I know I haven't contributed much over the last 100 pages or so, so I took the liberty to put something together to lighten the mood. Admittedly, I stretched the truth in 1 or 2 places for comedic effect - I hope you'll forgive the creative licensing.

      Frequency Therapeutics employee discusses...


      P.S. Volume warning, but can be enjoyed without sound for those of us with hyperacusis.
       
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    12. Stacken77
      Cowabunga

      Stacken77 Member Benefactor

      Location:
      Sweden
      Tinnitus Since:
      10/2020
      Cause of Tinnitus:
      Noise(likely headphones & cars), Acoustic trauma did me in
      I thought it was pretty much settled that tinnitus is an issue of the brain. The hyperactive neurons that is causing the sound isn't located in the ear, otherwise a section of the auditory nerve would have been demonstrated to be effective by now. But the neurons in the brain become hyperactive due to the gap in the auditory input, hence it's a central problem with a peripheral cause. As @ThomasRobert said; either we fix the root cause by regenerating hearing, filling the gap, or we may be able to stop the hyperacitivty, for example with upcoming drugs targeting voltage channels.

      That's my understanding of it.
       
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    13. Pero1234

      Pero1234 Member

      Tinnitus Since:
      02/2018
      Cause of Tinnitus:
      home theatre system + high pressure washer
      Thanks, made my day :ROFL:

      It may be closer to the truth than we would like it to be :confused:
       
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    14. GlennS

      GlennS Member Podcast Patron Hall of Fame

      Tinnitus Since:
      1992
      Cause of Tinnitus:
      Loud music
      Love it. That was sorely needed in this thread.
       
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    15. GlennS

      GlennS Member Podcast Patron Hall of Fame

      Tinnitus Since:
      1992
      Cause of Tinnitus:
      Loud music
      Does nothing to change my take. Being satisfied with this, even when qualified as a "babystep", is your prerogative but unjustified. There is nothing to be pleased with here. It's like Edison's try everything that doesn't work until it does approach.

      Sure, every failure brings you closer to a success, but a failure is still a failure in my book, especially when it's already got a stock ticker symbol and investors are about to take a dunk. I'm not going to give FREQ a participation trophy, sorry. You want to keep feeling personally attacked and unfairly mischaracterized by this, be my guest. I'm hardly alone in my opinion of FREQ's performance based on other recent postings (like the meme video).
       
    16. Diesel

      Diesel Member Benefactor Ambassador Hall of Fame Advocate

      Tinnitus Since:
      1-2019
      Cause of Tinnitus:
      20+ Years of Live Music, Motorcycles, and Power Tools
      GREAT ANALOGY GLENN!

      FX-322 is EXACTLY like Edison's perfection of the light blub and that is a GOOD thing, and why supporting Frequency Therapeutics to keep going is still voiced here.

      Edison's first functioning bulb burned for about a day in 1879. Not impressive or practical to have a filament that lasts a day. Imagine the upkeep! What a shit product! That's when he was quoted "the 10,000 things that didn't work." Did he give up there? No, they had something that "worked," but needed development. Nonetheless, it was still a big step from candles + oil-based torch lights.

      The end of 1880, just a year later, Edison Company had worked on a number of improvements to that 1879 filament+bulb design. They had essentially developed the incandescent bulb that is still used today.

      To use your analogy, FX-322 is Edison's 1879 Bulb. It did something, but needs work. So, why stop now?
       
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    17. Zugzug

      Zugzug Member Podcast Patron Benefactor Ambassador Hall of Fame Advocate

      Tinnitus Since:
      05/2019
      Cause of Tinnitus:
      Autoimmune hyperacusis from Sjogren's Syndrome
      Throw it out. And your little dumb light bulb too.
       
    18. r34d1ng

      r34d1ng Member

      Tinnitus Since:
      Unknown
      Cause of Tinnitus:
      Unknown
      On a side note, this guy, Risitas, died a few weeks ago, unfortunately.
       
    19. Chinmoku

      Chinmoku Member Benefactor

      Tinnitus Since:
      10/2018
      Cause of Tinnitus:
      Started with a cold, possibly worsened by medication/noise
      Man, good work, although this is funny and depressing at the same time. Few get the urgency of getting something that works for those of us in the trenches of daily disabling torture.
       
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    20. d'Wooluf

      d'Wooluf Member

      Tinnitus Since:
      2010
      Cause of Tinnitus:
      unknown
      Pity we're a bit of a niche market. Otherwise that could go viral. It's kind of close to how I imagine it all went down.
       
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    21. ThomasRobert

      ThomasRobert Member Benefactor

      Location:
      ME
      Tinnitus Since:
      06/2019
      Cause of Tinnitus:
      Ototoxic
      Or it could be like Elizabeth Holmes, founder of Theranos…
       
    22. AUTHOR
      AUTHOR
      RB2014
      Confused

      RB2014 Member Benefactor

      Location:
      US
      Tinnitus Since:
      12/2014 became noticable
      Cause of Tinnitus:
      Loss of hearing and then stress and anxiety
      It is relevant to the company and their future. That is the only reason why I brought it back up. We all want the trials to keep going and this could derail that. Hopefully it turns out to be nothing.

      The results from the next trial is still a ways out. This thread would go dead if we didn't keep it alive.
       
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    23. Joeseph Stope
      Innocent

      Joeseph Stope Member

      Tinnitus Since:
      1992
      Cause of Tinnitus:
      noise? infection? negative stress? other?
      I certainly learned one heckova lot from following Tinnitus Talk through the stage of initial hope, the reassurance that selling options is normal practice for executives and that acts in lieu of salary, the drama when the German chap posts his tax returns from his winnings and then the final results. It was a wild ride and it was nothing if not gripping.

      But some lessons can be learned. We take a hit, we it down and ask: "What was that all about"!

      If we were to compare the Audion model -- I believe it' s a collection of tenured scientists funded by some European governments. Well they didn't seem to have the passion... and at the end of the day they said that there was no Eureka moment. I just hope that the tacit knowledge and the know how and experience doesn't get lost while they are awaiting renewed funding for their next thrust in tinnitus matters (might be years away).

      The boys in Massachusetts seemed to have passionate scientists and innovators. But maybe the C-suite were intoxicated by optimism, if I could put it mildly.

      Which is the best model? Government funding as in Audion or the Free Market as in the US?
       
    24. ploughna

      ploughna Member

      Tinnitus Since:
      2017
      Cause of Tinnitus:
      motor racing and power tools
      Free market wins every time imho - witness the COVID-19 vaccine development.

      Having said that, government funding to further grease the wheels can often help (depending on what political strings attached).

      In FREQ, I see a highly motivated and super-smart team with a combination of personal, professional and financial ambition driving them toward a solution. They've a lot at stake and want as much as any of us to make this work.

      I'd love to know what the scientists are actually working on on a day-day basis right now - do future Phase 2 trials need to be exact repeats of what's been done in Phase 1, or is there any leeway at all to allow for improvements in delivery methods, formulations, etc?
       
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    25. rei

      rei Member Benefactor

      Tinnitus Since:
      2006 but not a problem till 10/19
      Cause of Tinnitus:
      loud music spiked with lyme disease
      And ten years later a light bub was invented that lasted too long and planned obsolence was born. I really don't understand Glenn's argument. According to my researcher friend, small molecules are found all the time that can switch on progenitor cells but the problem is always delivery and safety is usually the main issue. At least FX-322 has been shown to be safe.

      Does anyone here think that the Phase 2a failure is more than a delivery problem?
       
    26. Coleoptere
      Alone

      Coleoptere Member

      Location:
      The Hague
      Tinnitus Since:
      2002
      Cause of Tinnitus:
      Bell's Palsy, hearing loss
      You mean the FDA? What kind of grease do they use?
       
    27. GlennS

      GlennS Member Podcast Patron Hall of Fame

      Tinnitus Since:
      1992
      Cause of Tinnitus:
      Loud music
      Edison wasn't really a very bright person, just persistent. He BRUTE FORCED his inventions rather than using his brain. While that can work, it's like playing the lottery or mindlessly sifting through Wonka bars for a golden ticket. (He also ripped off some other people's inventions and just got lucky in court but that's a whole other matter.)

      Trial and error is a part of science, yes, but Edison's ignorance meant he worked hard, not smart.

      I'd like to think we should set the bar higher for medical R&D in the 21st century.

      What you decide to try should not be purely random but based on sound principles. Yes, a glorified hunch, but better than just throwing darts against the wall. I'm not accusing Frequency Therapeutics of randomly throwing darts, just expanding on my critique of Zugzug wanting to pin a medal on failure.

      That being said, the reason why the meme video stings is that hindsight is 20/20. If indeed the lawnmower effect has occurred (and I'm not even sure that's the case--the positive case for FX-322 even working at all is weak) then it's something they should have anticipated. Likewise history is full of many preventable disasters, like the O-rings on the Challenger or that space probe that got lost because of confusion over Metric vs. Imperial systems. So I think it's really not a great thing to glorify failure. There are honest failures and then there are dumb ones. Many many failures are a matter of not using common sense and being careless. That's BAD SCIENCE.

      It is odd, though, that this thread is so split to the point where optimists/evangelists are struggling to even understand why we're not jumping for joy over where things stand. Mystifying. I don't know how many more times I or other realists can try to expound on things before it becomes a futile waste of effort.
       
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    28. Justin Mills

      Justin Mills Member

      Tinnitus Since:
      2 year
      Cause of Tinnitus:
      loud music
      If I recall, during testing on mice, they were able to quite effectively regenerate the mice' cochlear hair cells with FX-322. So we know at least the drug regenerates cochlear hair cells. Perhaps yes it is a delivery problem. FREQ has a lot of trials going on right now. We should get more information soon.
       
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    29. Gb3

      Gb3 Member

      Tinnitus Since:
      12/19
      Cause of Tinnitus:
      Sshl
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    30. Lucifer

      Lucifer Member Podcast Patron Benefactor Hall of Fame

      Location:
      Clown World
      Tinnitus Since:
      -
      Cause of Tinnitus:
      -
      @Gb3, anything important or interesting? I can’t listen to the podcast.
       
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