Frequency Therapeutics — Hearing Loss Regeneration

Discussion in 'Research News' started by RB2014, Dec 8, 2016.

    1. Jack V

      Jack V Member Benefactor

      Tinnitus Since:
      1/2020
      No - the troubles with the outcomes appear on face value to stem from the fact that the drug didn't work.

      Everything else is conjecture.
       
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    2. tommyd87

      tommyd87 Member

      Tinnitus Since:
      1999
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      tmj music
      Is that why Frequency Therapeutics had successful outcomes/measures from both in vivo and their single dose trials then?

      That doesn't flat out demonstrate that the drug did not work.
       
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    3. Jurger

      Jurger Member

      Tinnitus Since:
      2004
      Cause of Tinnitus:
      Hearing loss
      The stock could tank even further and people here will tell you it’s all part of Lucchino’s Grand Plan. The truth is, of course, that they haven’t got it (yet?).
       
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    4. Diesel

      Diesel Member Benefactor Ambassador Hall of Fame Advocate

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      Again with the sensationalism?
       
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    5. Philip83
      Jaded

      Philip83 Member Podcast Patron Benefactor

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      Moped (2001) Noise blast (2014) Club (2017) Snowboard (2018)
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    6. Jurger

      Jurger Member

      Tinnitus Since:
      2004
      Cause of Tinnitus:
      Hearing loss
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    7. Gb3

      Gb3 Member

      Tinnitus Since:
      12/19
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      Sshl
    8. Diesel

      Diesel Member Benefactor Ambassador Hall of Fame Advocate

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      I don't know about a lot of people here, but I'd much rather be able to communicate with other people better (speech recog) than be able to hear 7 - 10 computer generated beeps in pure silence; even if that meant paying my local ENT an annual visit to get re-up on my hearing regen drug.
       
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    9. rei

      rei Member Benefactor

      Tinnitus Since:
      2006 but not a problem till 10/19
      Cause of Tinnitus:
      loud music spiked with lyme disease
      I agree, with the exception of a situation where a large truck is about to back into you and you don't hear the beeps.
       
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    10. Pharz

      Pharz Member Benefactor

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      Assuming that this would be a solution, I wonder how many times an eardrum can be punctured with a needle.
       
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    11. Diesel

      Diesel Member Benefactor Ambassador Hall of Fame Advocate

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      But you will hear someone screaming at you to get out of the way.
       
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    12. Koz
      Dreaming

      Koz Member

      Location:
      North East England
      Tinnitus Since:
      2009
      Cause of Tinnitus:
      Unilateral sensorineural hearing loss
      Nah, there's far more to hearing than just human speech. Pure Tone Average might not mean much to you but that is most definitely not the case for those of us with deeper and wider losses on the audiogram. Certainly more than just a few "generated beeps"

      It's fair to say this drug continues to drop down its expectation levels and that is reflected by its stock price and basic end points so far. Shame really because it keeps people making stand up arguments for it like "oh it's okay, at least we hear speech slightly clearer. Deffo gonna go spend X amount of money and get a needle put through my eardrum for that"

      This is breadcrumbs, we're already settling for breadcrumbs with what we currently have available - maybe this is subjective but I personally would not invest in any medicine that isn't clinically proven to do far more than just breadcrumbs.
       
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    13. Damocles
      Festive

      Damocles Member Benefactor Hall of Fame

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    14. Diesel

      Diesel Member Benefactor Ambassador Hall of Fame Advocate

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      If this is breadcrumbs to you, then I'm afraid you're going to have your expectations continually unmet. New drugs are rarely a single-go, cure all for any disease/disorder/etc that they are intended to treat. It takes several revisions of a drug generating cashflow for the developer to get it perfected. Furthermore, regeneration is a relatively new frontier in medicine; so the industry itself may need more time to mature in terms of investment, expertise, and research.

      I don't know why so many here continually hold these unrealistically high, "cure level" standards for hearing disorders. It just isn't going to happen that way. These first drugs will follow the same development path as those drugs for non-hearing conditions before them: all will serve a limited scope of patients with specific underlying issues, and overtime development iterations will focus on a wider range of patient populations.

      It will be those that get treatment from those "breadcrumbs" to treat their conditions that will be contributing to paving the way to making the drugs more available to a wider population.
       
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    15. Jurger

      Jurger Member

      Tinnitus Since:
      2004
      Cause of Tinnitus:
      Hearing loss
      Besides: better PTA on human speech frequencies = better speech recognition. It’s not like they don’t overlap.
       
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    16. Damocles
      Festive

      Damocles Member Benefactor Hall of Fame

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      Mate, with respect, this is not "breadcrumbs". It's progress.

      This is what cellular phones first looked like:

      nokia.jpg

      This is what they now look like:

      samsung.png

      Need I say more?
       
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    17. tommyd87

      tommyd87 Member

      Tinnitus Since:
      1999
      Cause of Tinnitus:
      tmj music
      Not necessarily. There are people who have got a moderate hearing loss who perform very poorly on the speech recognition components of the tests, while there are people with a severe to profound loss who perform very well with the correct volume being given to them.

      There might be an overlap, however it is not as cut and dry as you are claiming it to be.
       
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    18. ThomasRobert

      ThomasRobert Member Benefactor

      Location:
      ME
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      As soon as they publish the failed results of the severe hearing loss trial in November I'm buying the dip, it will be great to start again at a position of $4 or $5 per share! My fingers are ready...
       
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    19. Frankie Toledo

      Frankie Toledo Member

      Tinnitus Since:
      10/18/20
      Cause of Tinnitus:
      Hearing damage or anything else.
      5rbhoi.jpg
       
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    20. Lucifer

      Lucifer Member Podcast Patron Benefactor Hall of Fame

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      Does anyone have the ClinicalTrials.gov link for the Phase 2b trial?

      Are they testing audiograms in Phase 2b?
       
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    21. Philip83
      Jaded

      Philip83 Member Podcast Patron Benefactor

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      Link and info is in the press release above.
       
    22. Gb3

      Gb3 Member

      Tinnitus Since:
      12/19
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      Sshl
      They are contacting people themselves.
       
    23. Nobody19

      Nobody19 Member Podcast Patron Benefactor

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    24. patorjk

      patorjk Member Benefactor

      Tinnitus Since:
      2008
      Cause of Tinnitus:
      Several reasons
      I think Frequency Therapeutics thinks that study will fail too. I found this quote from the press release interesting:
      My guess is they're going to pair the failure news with the details that support their new design. They'll need to present something that's pretty convincing too - right now they only have 1 drug. I could see them going under $3. Unless you felt really confident about Phase 2b, I would think twice about putting money in. I don't see this company having any kind of run-up when Phase 2b nears its completion. I can only see them going up if Phase 2b is a success.
       
    25. Diesel

      Diesel Member Benefactor Ambassador Hall of Fame Advocate

      Tinnitus Since:
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      I think the severe trial is already priced in. The price didn’t move after the ARHL trial. Based on their balance sheet, it’s priced about right. Any reactionary dip would rebound back to the current price in a short timeframe.

      Also, if they really thought it was a failure, why bother including, “The Company will maintain flexibility in the overall FX-322-208 design in order to be able to include additional etiologies and severities based on pending results from its ongoing FX-322 study in severe subjects (FX-322-113).”
       
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    26. Street Novelist
      Depressed

      Street Novelist Member

      Location:
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      February 2018
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      Listening to loud music through headphones
      Nebraska, Texas and Virginia... God Almighty! How do they choose the sites? Why do they not put them in more states with a large population? No California, Florida or New York. I just do not understand their strategy.
       
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    27. Lucifer

      Lucifer Member Podcast Patron Benefactor Hall of Fame

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      https://clinicaltrials.gov/ct2/show/NCT05086276

      Here’s the link to the ClinicalTrials.gov for FX-322 Phase 2b trial.

      From the information gathered there will be 124 participants with the trial starting this month with the expected study completion date of November 2022. They will be measuring speech recognition, audiograms and tinnitus level.
       
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    28. OptimusPrimed
      Spaced

      OptimusPrimed Member Benefactor

      Tinnitus Since:
      10/2007
      Cause of Tinnitus:
      Acoustic trauma
      Those places have high rates of gun use = hearing loss.
       
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    29. d'Wooluf

      d'Wooluf Member

      Tinnitus Since:
      2010
      Cause of Tinnitus:
      unknown
      Let's see. There's everything Frequency Therapeutics ever said until about a year ago.
       
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    30. Street Novelist
      Depressed

      Street Novelist Member

      Location:
      Bay Area
      Tinnitus Since:
      February 2018
      Cause of Tinnitus:
      Listening to loud music through headphones
      I just read the press release. It says it will have 25 centers to administer the drug. So, maybe these 3 are just the first and more will come.
       
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