Hough Ear Institute's Hair Cell Regeneration Project

Discussion in 'Research News' started by all to gain, Oct 2, 2019.

    1. Defiant-Decay

      Defiant-Decay Member

      Tinnitus Since:
      2019
      Cause of Tinnitus:
      Loud noise/ music in headphones
      I uh... Wasn't worried but thanks for your concern though, and that's good because no one wants to take a pill for the rest of their life because of tinnitus.
       
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    2. AUTHOR
      AUTHOR
      all to gain

      all to gain Member

      Tinnitus Since:
      June 2019
      Cause of Tinnitus:
      dirty drugs
      Would stopping it mean any benefits would be lost?
       
    3. pinklights98
      No Mood

      pinklights98 Member

      Tinnitus Since:
      08/2016
      Cause of Tinnitus:
      Loud Noise Exposure
      To be honest, if they had a pill I could take every day of my life that would nullify my tinnitus, I would not mind. True, this would be a treatment, and not a cure but there are a lot of things there are not a cure for, like high blood pressure. If only we had something similar.
       
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    4. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Vatican
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      ¯\_(ツ)_/¯

      I don't think so.
       
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    5. Piney

      Piney Member

      Tinnitus Since:
      March 2018
      Cause of Tinnitus:
      Shingles virus
      I would, but maybe mine is different than yours. I’m emailing every legislator in my state for funding this problem through VA.
       
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    6. Allan1967

      Allan1967 Member Benefactor Hall of Fame

      Tinnitus Since:
      1997
      Cause of Tinnitus:
      Ear infection
      How credible are the Hough Ear Institute?

      I'm prepared to donate.
       
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    7. Piney

      Piney Member

      Tinnitus Since:
      March 2018
      Cause of Tinnitus:
      Shingles virus
      No one truly knows. We can assume good things with its representative boldly coming to Tinnitus Talk. The ATA needs to knock on Hough Ear Institute's door and see what’s going on.
       
      • Agree Agree x 3
    8. Markku
      Inspired

      Markku Founder Staff Podcast Patron Benefactor Hall of Fame Advocate

      Tinnitus Since:
      04/2010
      Cause of Tinnitus:
      Syringing
      As an update to the above post by @Hazel:

      We have scheduled the recording date for the Tinnitus Talk Podcast episode with Hough Ear Institute. It's going to take place about a month from now.

      If all goes well, we'll have the episode released before end of year or early on in the new year.

      Like Hazel said, we'll go through this thread for input to the interview. We'll do that a couple of weeks from now so HEI has time to prepare.

      If you have questions we should ask in the podcast (and which have not yet been discussed in this thread), feel free to post below!
       
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    9. FGG

      FGG Member Podcast Patron Benefactor

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Multi-factorial
      Very I would say.
       
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    10. UKBloke

      UKBloke Member Podcast Patron Benefactor

      Tinnitus Since:
      1991
      Cause of Tinnitus:
      Loud Music / family history
      Great news!

      Q: There are people with hearing loss that don't suffer with tinnitus. Please can HEI comment.
       
    11. Chriscom

      Chriscom Member Podcast Patron Benefactor

      Location:
      Northern Virginia USA
      Tinnitus Since:
      May 2019
      Cause of Tinnitus:
      Likely infection/ear stress after walking pneumonia
      I certainly would even if I don't necessarily want to, and many of us are accustomed to taking medication or optional supplements every day anyway. I've been taking a beta-blocker every day for a quarter-century to calm heart arrhythmia and in order to have a normal life, that is not optional.

      I think for most the issue would be cost.
       
    12. HootOwl

      HootOwl Member Benefactor

      Location:
      California
      Tinnitus Since:
      2009
      Cause of Tinnitus:
      Explanation in About You
      I’m a tad bit confused and maybe Justin or someone else could clear this up.

      The reduction in tinnitus has so far only been shown in their animal models correct? During the phase 1 safety trial did any people report a reduction in their tinnitus (of course assuming any of the participants had it)?
       
      • Good Question Good Question x 1
    13. Rb86

      Rb86 Member

      Tinnitus Since:
      5/31/19
      Cause of Tinnitus:
      Noise
      I've still been in contact with Justin.

      The pill was shown to cure tinnitus in animal models. It was shown as safe for humans in phase 1. No info regarding its efficacy is released on that, as the study is only designed to check safety. No bias can be made for future trials. They all do it this way.

      And, tinnitus has been "cured" in animals by several companies in the game. It does not mean it translates to humans. New info will be coming out in about a month or so I believe. Things are on track. That's all I know, and all they're willing to divulge at this point.
       
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    14. Defiant-Decay

      Defiant-Decay Member

      Tinnitus Since:
      2019
      Cause of Tinnitus:
      Loud noise/ music in headphones
      I trust Tinnitus Talk way more than the ATA. Has the ATA been beneficial in any way ever?
       
    15. AUTHOR
      AUTHOR
      all to gain

      all to gain Member

      Tinnitus Since:
      June 2019
      Cause of Tinnitus:
      dirty drugs
      This is great!

      I think the main questions to cover:

      - funding, i.e. where is it going to come from
      - possibility of doing trials in Europe and teaming up with European company
      - exact timeline of getting onto the market
      - effectiveness of pill/drugs, i.e. percent chance of effectiveness and based on what
      - does the pill/drug need to be taken regularly to work
      - how it is better than its competitors
      - reasons they are so enthusiastic and sure their pill/drugs will work
      - which tinnitus sufferers it will help and which it won't (noise, ototoxic reaction, disease etc)
      - possible side effects and interactions with other medication
      - method of delivery
      - availability of drug/pill if approved, i.e. I can see the military getting first dibs on it
      - how much will the pill/drug cost for the patient
      - can all Tinnitus Talk members get in on the trials or have a first go on the pill/drug
       
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    16. Jurger

      Jurger Member

      Tinnitus Since:
      2004
      Cause of Tinnitus:
      Hearing loss
      With regards to delivery method, I would be interested in answers to the following questions:

      1. Do have intratympanic injections have drawbacks in terms of getting the right concentration, duration and localization of the drug in the inner ear?

      2. Do they agree that low frequency hearing loss and tinnitus will be particularly hard to treat, since intratympanic injections are known for not/hardly being able to get the drug to the apex of the cochlea?

      3. What are their thoughts on new delivery methods to overcome the above menioned problems with intratympanic injections, like intracochlear injections or nanoparticle delivery (Otomagnetics, Bionics Institute)?

      I’d also like their thoughts on the lack of diagnostic tools for the inner ear. A lot of attention goes to therapeutics, and that’s understandable. But aren’t better diagnostic tools, like new imaging technologies and extraction of inner ear fluid, also needed to better help patients? What new developments are they seeing in that regard, if any?
       
      • Good Question Good Question x 3
    17. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Vatican
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      I wonder if they would use something like ethyl alcohol to increase the permeability of the RWM. I am also struggling to understand how they could possibly improve imaging technologies. To simply see hair cells you need an electron microscope. MRIs don't have resolutions to see that kind of detail and they are dangerously loud. Any imaging technology to peer into the in situ cochlea would have applications far beyond just hearing. It would revolutionize medicine.
       
    18. Jackjohnson183

      Jackjohnson183 Member Benefactor

      Tinnitus Since:
      2017
      Cause of Tinnitus:
      Ear wax removal
      Do you know what new info it might be?
       
    19. FGG

      FGG Member Podcast Patron Benefactor

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Multi-factorial
      Ethyl alcohol has been shown to be ototoxic in Guinea Pigs.
       
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    20. FGG

      FGG Member Podcast Patron Benefactor

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Multi-factorial
      Some excellent questions in this thread. I only have these two to add:

      1) A lot of regeneration trials exclude a history of ototoxicity. Is this because ototoxins are heterogeneous and they want to remove a diverse variable or because damage occurs in a more irreversible way?

      2) Dr. Kopke co-authored a paper showing how antioxidant treatment in chinchillas rescues synapses in the DCN soon after noise trauma as well as the cochlea. Is it suspected this will also help more chronic cases?
       
      • Good Question Good Question x 3
    21. AUTHOR
      AUTHOR
      all to gain

      all to gain Member

      Tinnitus Since:
      June 2019
      Cause of Tinnitus:
      dirty drugs
      Knowing my luck it will be the latter.
       
    22. Caveman

      Caveman Member

      Tinnitus Since:
      2015
      Cause of Tinnitus:
      Unknown
      What ototoxic drug did you have to take?
       
    23. Rb86

      Rb86 Member

      Tinnitus Since:
      5/31/19
      Cause of Tinnitus:
      Noise
      I do not. I was told to hang tight, and that it's good news. We'll see.
       
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    24. mrbrightside614

      mrbrightside614 Member

      Tinnitus Since:
      July 2019
      Cause of Tinnitus:
      unknown; acoustic trauma/hyperacusis/sshl
      Gene expression of ATOH138 has been shown to influence cell differentiation bird cochlea, and has been shown to be effective to regenerate hair cells in mice. Does the Hough method have anything to do with the retinoic acid pathway or ATOH138?
       
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    25. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Vatican
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      I think that in humans the gene is just ATOH1.....
       
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    26. HootOwl

      HootOwl Member Benefactor

      Location:
      California
      Tinnitus Since:
      2009
      Cause of Tinnitus:
      Explanation in About You
      @Justin De Moss

      Hi Justin,

      I have a question regarding your nerve fiber regeneration (or it could be a question for the podcast - either way). Do you know if the regeneration occurred along both the peripheral axons and peripheral terminals? Did one regenerate more fully than the other or was there virtually no difference and you saw substantial recovery in both areas.
       

      Attached Files:

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    27. MRItechssuck

      MRItechssuck Member

      Location:
      USA
      Tinnitus Since:
      2002-2015, 10/17/2019-?
      Cause of Tinnitus:
      Loud noise, MRI
      I have difficulty believing that a “pill” will have the efficacy for the ear, which has little blood flow as it is.

      Also, what else would the pill affect... kidneys, liver, etc.

      An injection seems more reasonable in my opinion.

      And yes, I would take a pill every day forever if it ended this... I’m already taking NAC, B complex, Magnesium... etc etc etc every darn day.
       
    28. john paul
      English

      john paul Member

      Tinnitus Since:
      11/11/17
      Cause of Tinnitus:
      acoustic trauma
      Would it not be the brain that is targeted with this pill though? As long as there are no side effects taking a pill everyday for me would be the same as a cure.
       
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    29. MRItechssuck

      MRItechssuck Member

      Location:
      USA
      Tinnitus Since:
      2002-2015, 10/17/2019-?
      Cause of Tinnitus:
      Loud noise, MRI
      You could be right, I’m not that familiar with what this drug specifically... I was speaking in generalities. Having any compound diffuse in the body to target a specific part requires the rest of the body to deal with the drug as well.

      If there are no side effects, that would be good. I was just thinking if someone takes an antibiotic, for example... for some people it treats the bacterial infection while also killing the good bacteria in the gut.
       
    30. HootOwl

      HootOwl Member Benefactor

      Location:
      California
      Tinnitus Since:
      2009
      Cause of Tinnitus:
      Explanation in About You
      Well, the pill isnt targeting the brain “per se”. It’s targeting cochlear synaptopathy. The key point being when the synapse is regenerated (from the pill) the spiral ganglion neurons send out new nerve fibers to reattach to the synapse and establish meaningful connections.

      The brain is only targeted in so far as that if the nerve fibers are now generating non-dysfunctional signals the hope is that as the signal travels through the cochlear nerve to the DCN, then ICN, etc all the way to the auditory cortext that these brain structures will adjust their output accordingly to the now functional signal, thereby eliminating or reducing tinnitus.

      Right now we can’t speak to it’s efficacy in humans. Efficacy has only been demonstrated in their animal models so far.

      Phase 1 has shown it to be safe so far. But as to whether or not we’d have to take the pill long term remains to be seen. My gut says no, because once you regenerate the nerves there’s not much else that needs to be done, at least from what I think. Could be wrong tho.
       
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