Hough Ear Institute's Hair Cell Regeneration Project

Discussion in 'Research News' started by all to gain, Oct 2, 2019.

    1. AUTHOR
      AUTHOR
      all to gain
      No Mood

      all to gain Member Podcast Patron Benefactor

      Tinnitus Since:
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      Having taken an antidepressant for years I have come to the conclusion that everything in my body has been affected by it and my nervous system in particular. The side effects are many, with more to come I feel.

      Taking something else that targets the brain fills me with dread a little. I can't see any drug being without side effects.
       
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    2. Rb86

      Rb86 Member

      Tinnitus Since:
      5/31/19
      Cause of Tinnitus:
      Noise
      According to Justin De Moss, Hough Ear Institute is scheduled to speak with Tinnitus Talk Podcast on December 13.
       
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    3. Hazel
      Dreaming

      Hazel Director Staff Podcast Patron Benefactor Hall of Fame Advocate

      Location:
      the Netherlands
      Tinnitus Since:
      10/2017
      Cause of Tinnitus:
      one-sided hearing loss (of unknown origin)
      That is correct, we were due to interview them today. I had a preliminary call with Justin and Rick last week, and they were really nice and keen to collaborate with us. However, unfortunately, we've had to postpone the recording. This is entirely my fault. I am currently staying with my mom, for work and family reasons, which I had not originally planned. This means I don't have access to a quiet space for recording. Being a volunteer project, the Tinnitus Talk Podcast cannot afford to rent a professional recording studio, we have to record from home. But we care a lot about audio quality, which is why we felt it better to postpone. We will reschedule for January, or February at the latest. My sincere apologies for the delay, but we hope to make it worth your while! :)
       
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    4. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Vatican
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      PLEEEASE ask him about chronic tinnitus and if this would be useful for that and what the evidence was AND if it is something you'd need to take daily in perpetuity. Puh Leeeez!
       
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    5. Chriscom

      Chriscom Member Podcast Patron Benefactor

      Location:
      Northern Virginia USA
      Tinnitus Since:
      May 2019
      Cause of Tinnitus:
      Likely infection/ear stress after walking pneumonia
      God bless you and all your family Hazel! Thanks so much for all you do, no need to apologize.
       
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    6. serendipity1996
      No Mood

      serendipity1996 Member Podcast Patron

      Tinnitus Since:
      2011
      Cause of Tinnitus:
      Unknown but suspect noise-induced
      Just read through this thread, how encouraging! I'd also be intrigued to know whether they feel this treatment would help alleviate hyperacusis as well as tinnitus - hoping this question can be addressed on the Tinnitus Talk Podcast!
       
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    7. Rb86

      Rb86 Member

      Tinnitus Since:
      5/31/19
      Cause of Tinnitus:
      Noise
      Send some of that positive vibe my way, I'm all out and frustrated as hell.
       
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    8. serendipity1996
      No Mood

      serendipity1996 Member Podcast Patron

      Tinnitus Since:
      2011
      Cause of Tinnitus:
      Unknown but suspect noise-induced
      I sent Hough an email earlier this morning asking their opinion on this! Will be interesting to hear the response.
       
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    9. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Vatican
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      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      @Justin De Moss

      What do you think about this?

      20191218_102608.jpg

      I am thinking that our brains are always wanting to ring, because that's what sound is, your auditory cortex is the sound generator, it is not receiving the sound signal. Silence in this case would be a full signal from the auditory nerve and sound would be the absence of the signal, like the opposite of a speaker wire. This would explain why noise damage could immediately induce tinnitus while walking into a silent room would not. It would also explain why older people that lose hair cells would not have tinnitus, because their nerve is still functioning. It would also explain how your pill could treat tinnitus, because it would allow the nerve to heal and begin sending the silencing signal again.
       
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    10. FGG
      No Mood

      FGG Member Podcast Patron Benefactor Hall of Fame Advocate

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Multi-factorial
      The question is why do antioxidants allow nerves to heal and is this only acutely? The Hough pill is a very powerful free radical scavenger and antioxidant, not a growth factor.
       
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    11. AUTHOR
      AUTHOR
      all to gain
      No Mood

      all to gain Member Podcast Patron Benefactor

      Tinnitus Since:
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      When you say very powerful I can't help but think loads of side effects will come along with it. I so hope I am wrong.
       
    12. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Vatican
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      upload_2019-12-18_11-56-24.png
       
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    13. Auron
      Pacman

      Auron Member

      Location:
      Planet Earth
      Tinnitus Since:
      Spring
      Cause of Tinnitus:
      Acoustic Shock
      From my understanding, Anti-Oxidants prevent the nerves from dying by attacking free radicals before they can do damage. Which is why I also asked if this could be used beyond 2-3 day window from damage onset, just not sold on that yet. I hope I'm wrong.
      I'm not really worried about Anti-Oxidants. Probably one of the safer approaches, of course too much of a thing is bad for us, so perhaps the amount they need to get this formula to work, is in excess of what our bodies can handle. As with everything else, only time will tell. Hopefully we'll know sooner rather than later.
       
    14. LostOutWest
      Not amused

      LostOutWest Member Benefactor

      Tinnitus Since:
      09/2019
      Cause of Tinnitus:
      Unknown
      For anyone who donated to Hough (or any other Tinnitus and Hearing research and support orgs, or really any worthwhile cause for that matter) and work for Corporations that have a Donation-matching program, please consider submitting your charitable contribution for matching.

      I was delighted to see that my employer already had Hough set up as an approved donation match organization.
       
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    15. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Vatican
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      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      I really like how this was sitting on a shelf somewhere and could have potentially stopped me from getting chronic tinnitus.
       
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    16. Lucifer

      Lucifer Member Podcast Patron Benefactor

      Tinnitus Since:
      2017
      Cause of Tinnitus:
      Ear Infection
      They finished Phase 1 in 2015. It could have been in Phase 3 or in the market by now.

      I wish they got enough funding back in 2015 so we could see it in Phase 3 or released in markets by now.
       
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    17. ajc

      ajc Member

      Tinnitus Since:
      11/2002; spike 2009; worse 2017-18
      Cause of Tinnitus:
      Loud music - noise damage
      Maybe the PRP + Dexamethasone injections would have helped you more if you had gotten them within 24 hours of your tinnitus onset.
       
    18. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Vatican
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      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      I truly believe that. Not even PRP more so than dexamethasone. Yeah, you're right. I went to my doctor within 48 hours and he gave me oral steroids.

      Considering how chicken ENT's are to administers IT injections the existence of that pill probably would have been more plausible only if.
       
    19. Hazel
      Dreaming

      Hazel Director Staff Podcast Patron Benefactor Hall of Fame Advocate

      Location:
      the Netherlands
      Tinnitus Since:
      10/2017
      Cause of Tinnitus:
      one-sided hearing loss (of unknown origin)
      Hey there, just a kind request to hold off on sending your questions directly to Hough at this point, please just post them here and wait for the podcast episode. That's more efficient for Hough, and the answers will reach a much wider audience than just the people reading this thread. Thanks!
       
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    20. AUTHOR
      AUTHOR
      all to gain
      No Mood

      all to gain Member Podcast Patron Benefactor

      Tinnitus Since:
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      Is the Hough pill only for acute cases?
       
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    21. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Vatican
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      upload_2019-12-18_11-56-24-png.png

      ALERT: Definitely not a repost.
       
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    22. AUTHOR
      AUTHOR
      all to gain
      No Mood

      all to gain Member Podcast Patron Benefactor

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      Phew! Let's hope it works.

      Ha ha, just looked up the thread to see the same post.

      I noticed when looking at their site that at least half of their research team are from China. I wonder why that is? Not that it matters, just interested.
       
    23. FGG
      No Mood

      FGG Member Podcast Patron Benefactor Hall of Fame Advocate

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Multi-factorial
      If the pill is just a high potency anti oxidant and free radical scavenger, shouldn't things like Astaxanthin and high dose vitamin C at least partially have the same response? There are no actual nerve growth factors in the pill.
       
    24. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Vatican
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      That's where I am confused as well. I'm just going by what DeMoss said and taking his word for it.
       
    25. HootOwl

      HootOwl Member Podcast Patron Benefactor Advocate

      Location:
      California
      Tinnitus Since:
      2009
      Cause of Tinnitus:
      Explanation in About You
      I’m also confused by this. Add me in to the pile of people who would like some more clarification.
       
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    26. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Vatican
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      "Surprisingly, the observation that HPN-07 treatment initiated within four hours after noise exposure and continued for 2 days has long-lasting effects, some of which only become evident 21–180 days later, is not readily explained from our evaluations but could be interpreted to suggest that HPN-07 may have the capacity to initiate repair mechanisms or a regenerative response among one or more components of the cellular architecture of the cochlea."
      "In summary, the physiological and histological findings presented here indicate that acute post-trauma intervention with HPN-07 as a single therapeutic agent promotes both acute and chronic recovery of hearing function."

      https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5568441/

      :confused:

      Looks like they are guessing that it could treat chronic tinnitus and hearing loss and they didn't actually test it in chronic models. I could be wrong.

      Update: Looks like I was wrong. See below.
       
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    27. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Vatican
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      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      Gather 'round little children, have you a seat there on Papaw's lap:


      FIG. 1 shows that HPN-07 induced a neuritogenic response in murine spiral ganglion (SG) tissue explants in vitro. HPN-07 induced marked neurite outgrowth relative to untreated controls cultured in the same organotypic culture medium (NC, normal control). Both the number of neurites radiating out from each SG explant and the corresponding length of each of these extensions increased in the presence of HPN-07.
      upload_2019-12-26_15-37-42.png


      FIG. 29 shows NHPN-1010 treatment (HPN-07 plus NAC) restored IHC ribbon synapse numbers in established, chronic hearing loss model.

      upload_2019-12-26_15-33-20.png

      FIG. 30 shows NHPN-1010 treatment (HPN-07 plus NAC) resulted in recovery of ABR Wave I amplitudes in established chronic hearing loss model.

      upload_2019-12-26_15-34-29.png



      http://www.freepatentsonline.com/y2018/0117115.html
       
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    28. FGG
      No Mood

      FGG Member Podcast Patron Benefactor Hall of Fame Advocate

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Multi-factorial
      Thanks, Papaw. This surely means the currently available anti oxidants have benefit past the acute stage then, too, right? At least partial benefits since HPN-07 is stronger.
       
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    29. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Vatican
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      Please tell me again why we can't have any of this medicine, like right f----ing now? :woot:
       
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    30. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Vatican
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      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      Not necessarily. We can't assume that just because it is an anti-oxidant that it is only an anti-oxidant. Take curcumin for example. It's an anti-oxidant but it is also a verified potent notch1 inhibitor.
       

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