Hough Ear Institute's Hair Cell Regeneration Project

Having taken an antidepressant for years I have come to the conclusion that everything in my body has been affected by it and my nervous system in particular. The side effects are many, with more to come I feel.

Taking something else that targets the brain fills me with dread a little. I can't see any drug being without side effects.

 

According to Justin De Moss, Hough Ear Institute is scheduled to speak with Tinnitus Talk Podcast on December 13.

 

PLEEEASE ask him about chronic tinnitus and if this would be useful for that and what the evidence was AND if it is something you'd need to take daily in perpetuity. Puh Leeeez!

 

God bless you and all your family Hazel! Thanks so much for all you do, no need to apologize.

 

Just read through this thread, how encouraging! I'd also be intrigued to know whether they feel this treatment would help alleviate hyperacusis as well as tinnitus - hoping this question can be addressed on the Tinnitus Talk Podcast!

 

Send some of that positive vibe my way, I'm all out and frustrated as hell.

 

I sent Hough an email earlier this morning asking their opinion on this! Will be interesting to hear the response.

 

@Justin De Moss

What do you think about this?



I am thinking that our brains are always wanting to ring, because that's what sound is, your auditory cortex is the sound generator, it is not receiving the sound signal. Silence in this case would be a full signal from the auditory nerve and sound would be the absence of the signal, like the opposite of a speaker wire. This would explain why noise damage could immediately induce tinnitus while walking into a silent room would not. It would also explain why older people that lose hair cells would not have tinnitus, because their nerve is still functioning. It would also explain how your pill could treat tinnitus, because it would allow the nerve to heal and begin sending the silencing signal again.

 

The question is why do antioxidants allow nerves to heal and is this only acutely? The Hough pill is a very powerful free radical scavenger and antioxidant, not a growth factor.

 

When you say very powerful I can't help but think loads of side effects will come along with it. I so hope I am wrong.

 

From my understanding, Anti-Oxidants prevent the nerves from dying by attacking free radicals before they can do damage. Which is why I also asked if this could be used beyond 2-3 day window from damage onset, just not sold on that yet. I hope I'm wrong.

I'm not really worried about Anti-Oxidants. Probably one of the safer approaches, of course too much of a thing is bad for us, so perhaps the amount they need to get this formula to work, is in excess of what our bodies can handle. As with everything else, only time will tell. Hopefully we'll know sooner rather than later.

 

For anyone who donated to Hough (or any other Tinnitus and Hearing research and support orgs, or really any worthwhile cause for that matter) and work for Corporations that have a Donation-matching program, please consider submitting your charitable contribution for matching.

I was delighted to see that my employer already had Hough set up as an approved donation match organization.

 

I really like how this was sitting on a shelf somewhere and could have potentially stopped me from getting chronic tinnitus.

 

They finished Phase 1 in 2015. It could have been in Phase 3 or in the market by now.

I wish they got enough funding back in 2015 so we could see it in Phase 3 or released in markets by now.

 

Maybe the PRP + Dexamethasone injections would have helped you more if you had gotten them within 24 hours of your tinnitus onset.

 

I truly believe that. Not even PRP more so than dexamethasone. Yeah, you're right. I went to my doctor within 48 hours and he gave me oral steroids.

Considering how chicken ENT's are to administers IT injections the existence of that pill probably would have been more plausible only if.

 

Is the Hough pill only for acute cases?

 

ALERT: Definitely not a repost.

 

Phew! Let's hope it works.

Ha ha, just looked up the thread to see the same post.

I noticed when looking at their site that at least half of their research team are from China. I wonder why that is? Not that it matters, just interested.

 

If the pill is just a high potency anti oxidant and free radical scavenger, shouldn't things like Astaxanthin and high dose vitamin C at least partially have the same response? There are no actual nerve growth factors in the pill.

 

That's where I am confused as well. I'm just going by what DeMoss said and taking his word for it.

 

I’m also confused by this. Add me in to the pile of people who would like some more clarification.

 

"Surprisingly, the observation that HPN-07 treatment initiated within four hours after noise exposure and continued for 2 days has long-lasting effects, some of which only become evident 21–180 days later, is not readily explained from our evaluations but could be interpreted to suggest that HPN-07 may have the capacity to initiate repair mechanisms or a regenerative response among one or more components of the cellular architecture of the cochlea."
"In summary, the physiological and histological findings presented here indicate that acute post-trauma intervention with HPN-07 as a single therapeutic agent promotes both acute and chronic recovery of hearing function."

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5568441/



Looks like they are guessing that it could treat chronic tinnitus and hearing loss and they didn't actually test it in chronic models. I could be wrong.

Update: Looks like I was wrong. See below.

 

Gather 'round little children, have you a seat there on Papaw's lap:


FIG. 1 shows that HPN-07 induced a neuritogenic response in murine spiral ganglion (SG) tissue explants in vitro. HPN-07 induced marked neurite outgrowth relative to untreated controls cultured in the same organotypic culture medium (NC, normal control). Both the number of neurites radiating out from each SG explant and the corresponding length of each of these extensions increased in the presence of HPN-07.



FIG. 29 shows NHPN-1010 treatment (HPN-07 plus NAC) restored IHC ribbon synapse numbers in established, chronic hearing loss model.



FIG. 30 shows NHPN-1010 treatment (HPN-07 plus NAC) resulted in recovery of ABR Wave I amplitudes in established chronic hearing loss model.





http://www.freepatentsonline.com/y2018/0117115.html

 

Thanks, Papaw. This surely means the currently available anti oxidants have benefit past the acute stage then, too, right? At least partial benefits since HPN-07 is stronger.

 

Please tell me again why we can't have any of this medicine, like right f----ing now?

 

Not necessarily. We can't assume that just because it is an anti-oxidant that it is only an anti-oxidant. Take curcumin for example. It's an anti-oxidant but it is also a verified potent notch1 inhibitor.