Hough Ear Institute's Hair Cell Regeneration Project

Discussion in 'Research News' started by all to gain, Oct 2, 2019.

    1. DimLeb

      DimLeb Member

      Tinnitus Since:
      03/2021
      Cause of Tinnitus:
      Idiopathic Cochleopathy or Maybe Loud Music
      @dbeats, they didn't. Whichever company has the drug is still waiting for funding or something.
       
    2. Brian Newman

      Brian Newman Member

      Tinnitus Since:
      12/2016
      Cause of Tinnitus:
      Shooting/loud noise
      I talked to somebody from Oblato. They are not starting Phase 2 for a long time. He didn’t say the exact reason. He mentioned the compassionate use and that’s it for now.
       
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    3. dbeats

      dbeats Member

      Tinnitus Since:
      2020
      Cause of Tinnitus:
      Loud noise
      That's really disappointing, but thanks for the answer.
       
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    4. Brian Newman

      Brian Newman Member

      Tinnitus Since:
      12/2016
      Cause of Tinnitus:
      Shooting/loud noise
      Yeah I know it is, but they’re still doing trials using the drug for other conditions so could get FDA approval that way. I’m just getting the drug for compassionate use because if I don’t do something soon, I will probably die. I think good things to be hopeful for are OTO-313, OTO-413, FX-322, PIPE-505, and SPI-Ebselen. Who knows what will happen with these drugs.
       
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    5. scotty03874

      scotty03874 Member

      Location:
      Boston / Miami Beach
      Tinnitus Since:
      04/2019
      Cause of Tinnitus:
      Slap to the ear / Leading to more issues
      Did you get approved for compassionate use? They told me the same thing. But the process seemed difficult to fill out yet. I'm also seriously suffering and suicidal some days.
       
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    6. ThomasF
      Creative

      ThomasF Member

      Location:
      Florida
      Tinnitus Since:
      2001
      Cause of Tinnitus:
      Probably loud music
      In a sense, compassionate use patients are the beginning of testing the efficacy of the drug. Really people here are likely good candidates in general for such a role. Be proud and hopeful in your actions. I thank you for you guys giving this medicine a chance.
       
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    7. Brian Newman

      Brian Newman Member

      Tinnitus Since:
      12/2016
      Cause of Tinnitus:
      Shooting/loud noise
      Damn Scotty, sorry to hear. Well, since most doctors don’t know about this drug I think Dr. Kesari is our best bet on getting it. He is very understanding and he said he is waiting for Oblato with the final details, then will start getting the drug. He’s figuring out if he can get the pills or IV and if he can get the IV shipped to our local doctor.

      He’s going to let me know in a month or so. I will be posting here when I hear back.

      And yeah, the process is a ton of work for the doctor and that’s why when everybody on this forum was most likely blowing him up I was getting upset because I know he doesn’t want to fill out a crap ton of compassionate use paperwork when he’s got patients with brain tumors to work on. I didn’t want to overload him and cause him to not want to deal with us altogether. Hopefully this does not happen.

      I believe to fix my catastrophic pain hyperacusis I definitely need synapse regeneration. My tinnitus is pretty shit too. If your main ENT is Dr. Foster in Miami, and if this drug starts rolling out for compassionate use, maybe he will be on board. Because if it’s an IV you have to get it at the doctor anyways. Dr. Foster did know about regenerative medicine for the ear, so if I do get the IV, I will probably have it done there or at Silverstein.
       
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    8. scotty03874

      scotty03874 Member

      Location:
      Boston / Miami Beach
      Tinnitus Since:
      04/2019
      Cause of Tinnitus:
      Slap to the ear / Leading to more issues
      Where is Dr. Kesari located?
       
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    9. Brian Newman

      Brian Newman Member

      Tinnitus Since:
      12/2016
      Cause of Tinnitus:
      Shooting/loud noise
      California. He does Zoom calls though. I’m trying to get Silverstein on board for the drug so we could probably get it there if they do IV. I think Dr. Kesari could also contact Silverstein and tell him what to do.
       
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    10. scotty03874

      scotty03874 Member

      Location:
      Boston / Miami Beach
      Tinnitus Since:
      04/2019
      Cause of Tinnitus:
      Slap to the ear / Leading to more issues
      Dr. Foster retired I believe. But I live in MA now anyways...
      Let's only hope so and that we see some positive results. I might even go to South Korea to visit Dr. Minbo Shim.

      Money isn't an issue, my suffering everyday really is. I also have severe hearing loss in my right ear and hyperacusis and of course tinnitus. I have to sleep with my hearing aid in, otherwise I can't sleep due to the tinnitus being so loud. FML.
       
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    11. Padraigh Griffin

      Padraigh Griffin Member Podcast Patron Benefactor

      Tinnitus Since:
      05/2020
      Cause of Tinnitus:
      Unknown/Stress
      Hough Ear Institute are wasting their time moving at a snail's pace. Unfortunately it does not seem like progress towards a meaningful clinical trial is being made.
       
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    12. lello

      lello Member

      Tinnitus Since:
      2018
      Cause of Tinnitus:
      unknown
      Hello everybody.

      I have read this long thread, but one thing is still not clear to me: will this treatment (assuming it works) also work with cases of sensorineural hearing loss? Or only with the noise-induced cases?
       
    13. Gb3

      Gb3 Member

      Tinnitus Since:
      12/19
      Cause of Tinnitus:
      Sshl
      I believe it was originally intended for acute noise induced hearing damage. But to be honest I don’t even know if Hough Ear Institute knows what the drug is capable of what it will be able to treat.

      Assuming if people with sensorineural hearing loss have damaged hair cells just like some people noise induced I don’t see why not. A lot of people on this forum suffer from noise induced tinnitus and don’t even have hearing loss.
       
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    14. John Carrozza

      John Carrozza Member

      Tinnitus Since:
      01/2020
      Cause of Tinnitus:
      Unknown
      Hi everyone. Please inform us if you succeed applying for expanded access and if you get to use the drug. All people suffering from hearing loss and/or tinnitus are dying to know if it works. Please share your experience. Thank you very much.
       
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    15. Mica Rambin

      Mica Rambin Member

      Tinnitus Since:
      09/2020
      Cause of Tinnitus:
      NIHL
      Who is the new Justin De Moss equivalent at Hough Ear Institute now? It would be nice to have them update us. I saw an image they shared on their Twitter a while back that showed cochlear hair cells that they grew from their lab.
       
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    16. John Carrozza

      John Carrozza Member

      Tinnitus Since:
      01/2020
      Cause of Tinnitus:
      Unknown
      This should be the lady:

      ASHLEY EVERETT
      Philanthropy Coordinator
      3400 NW 56th Street, Oklahoma City, OK 73112
      d 405-639-2856 | m 405-534-6100
       
      • Winner Winner x 4
    17. Brian Newman

      Brian Newman Member

      Tinnitus Since:
      12/2016
      Cause of Tinnitus:
      Shooting/loud noise
      @IntotheBlue03, you hear back from Dr. Kesari yet? And I read your tinnitus is much better now?
       
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    18. dbeats

      dbeats Member

      Tinnitus Since:
      2020
      Cause of Tinnitus:
      Loud noise
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    19. reggie green
      Balanced

      reggie green Member

      Tinnitus Since:
      03/08/2001
      That says enough right there.

      "Under the terms of the agreement, Autigen will receive an undisclosed upfront payment and research funding support. The company is also eligible to receive future success-based milestone payments of a total potential value of more than $100M if all milestones are achieved over the course of the partnership."​
       
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    20. InNeedOfHelp

      InNeedOfHelp Member

      Tinnitus Since:
      08/2021
      Cause of Tinnitus:
      MRI Scan
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    21. DimLeb

      DimLeb Member

      Tinnitus Since:
      03/2021
      Cause of Tinnitus:
      Idiopathic Cochleopathy or Maybe Loud Music
      I don't really understand how this is big news. Maybe I read it wrong, but are they just starting out to find therapies for hearing loss? I get that it's a big company and all, but it just means that we MAYBE have a treatment in about 10-20 years, right?
       
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    22. AfroSnowman
      Balanced

      AfroSnowman Member Podcast Patron Benefactor Hall of Fame

      Tinnitus Since:
      04/2019
      Cause of Tinnitus:
      Nonnatural energy source
      Research into Hough Ear Institute's hearing loss pill has been basically stopped due to a lack of funding. I know for a long time they were pitching the tinnitus community for donations so that clinical trials could go forward. So getting real funding gets this drug back onto the path of clinical trials and we will be able to see how effective it is.
       
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    23. dbeats

      dbeats Member

      Tinnitus Since:
      2020
      Cause of Tinnitus:
      Loud noise
      Hough Ear Institute has been working on this for many years. The publications "Regeneration of mammalian cochlear and vestibular hair cells through Hes1/Hes5 modulation with siRNA" and "Regeneration of cochlear hair cells and hearing recovery through Hes1 modulation with siRNA nanoparticles" was published back in 2013 and 2018.
       
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    24. dbeats

      dbeats Member

      Tinnitus Since:
      2020
      Cause of Tinnitus:
      Loud noise
      From Boehringer OKs $100M biobucks deal for hearing loss R&D project:

      Progress has taken longer than originally planned. Otologic talked about getting into the clinic in 2017 when it licensed the technology from Hough and targeted a 2020 start of human studies when it landed the grant funding. With Boehringer on board, Otologic, through its Autigen subsidiary, now has support for its push to get into the clinic.

      Sounds to me like human trials could come relatively soon.
       
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    25. Nobody19

      Nobody19 Member Podcast Patron Benefactor

      Tinnitus Since:
      2012
      Cause of Tinnitus:
      Clubbing
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    26. dbeats

      dbeats Member

      Tinnitus Since:
      2020
      Cause of Tinnitus:
      Loud noise
      After a joint research collaboration phase, Boehringer Ingelheim will be responsible for further preclinical and clinical development, and commercialization.
       
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    27. scotty03874

      scotty03874 Member

      Location:
      Boston / Miami Beach
      Tinnitus Since:
      04/2019
      Cause of Tinnitus:
      Slap to the ear / Leading to more issues
      This is positive news whichever way you read or interpret it. Hoping someone on this forum gets approved for compassionate use. I'll be next in line.
       
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    28. scotty03874

      scotty03874 Member

      Location:
      Boston / Miami Beach
      Tinnitus Since:
      04/2019
      Cause of Tinnitus:
      Slap to the ear / Leading to more issues
      Brian,

      Has there been any progress on finding out if Dr. Kesari will be able to handle the compassionate use?

      Secondly, why did you get a recent blood patch from Dr. Foster? For what reason? I may go down to South Beach this month and seek out a couple more blood patches from him. I spoke to him on the phone last week. I had a recent trauma on my left ear and I suspect I have a PLF. I flew recently and felt fluid in my right ear.
       
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    29. Brian Newman

      Brian Newman Member

      Tinnitus Since:
      12/2016
      Cause of Tinnitus:
      Shooting/loud noise
      My appointment was in early March. I emailed him last month and he said they were still working on it. Gonna probably contact them again in a few weeks. I’m guessing it’s Oblato’s fault. They take forever. Hopefully I hear back soon.

      And I thought I had a perilymph fistula, I just didn’t have hearing loss and vertigo. I am dizzy and have all the other symptoms in that ear, got it from a heavy deadlift. I felt a little better from the patch but it went away after a week or so. I wanted to try it because it beats getting surgery or doing any of the vestibular testing.

      Idk, I think I might have a CSF leak, probably won’t figure it out for a while. Trying to get my noxacusis under control so I can start seeing doctors again. I probably should have kept seeing Dr. Foster for more blood patches but the drive is too far.
       
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