N-Acetylcysteine (NAC)

Discussion in 'Treatments' started by tweak, May 16, 2012.

    1. Rockman

      Rockman Member Benefactor

      Location:
      MN
      Tinnitus Since:
      1/2021
      Cause of Tinnitus:
      Noise, allergy
      NAC usually gives me a runny nose.
       
      • Informative Informative x 2
    2. Uklawyer

      Uklawyer Member

      Tinnitus Since:
      03/2020
      Cause of Tinnitus:
      Medication - antidepressants
      Clear or with mucus?
       
    3. Rockman

      Rockman Member Benefactor

      Location:
      MN
      Tinnitus Since:
      1/2021
      Cause of Tinnitus:
      Noise, allergy
      Clear, darn near like water.
       
      • Informative Informative x 1
    4. juliob
      Confused

      juliob Member

      Location:
      Brazil
      Tinnitus Since:
      03/2018
      Cause of Tinnitus:
      Antidepressants / Loud Sound Exposure
      Are the cases of tinnitus induced by NAC always temporary? I mean, is there any report concerning a persistent or even permanent onset or worsening of tinnitus due to it? The listing of side effects scared me.
       
    5. TomBradyGOAT

      TomBradyGOAT Member

      Tinnitus Since:
      2016
      Cause of Tinnitus:
      Who knows
      Honestly it is used sometimes for things like Tylenol overdose at hospitals. It is safer than many people make it out to be. Are you thinking trying it for your OCD? Have you tried Inositol yet? Can be hard on the gut. Stomach cramps mostly, but some people with OCD swear by NAC and Inositol. I honestly never gave them a fair shake. Going to have to after my Nardil (Phenelzine) disaster. I think OCD is Serotonin for some people, Glutamate or mTor issues for more and honestly the majority in my guesstimate is actually an autoimmune response. Supporting information is things such as PANDAS, findings of Imood, and just a lot of people getting long term anxiety after sinus infections. OCPD is learned or a gene variant issue.
       
    6. juliob
      Confused

      juliob Member

      Location:
      Brazil
      Tinnitus Since:
      03/2018
      Cause of Tinnitus:
      Antidepressants / Loud Sound Exposure
      Agree with you on everything. The thing is unfortunately I am still polydrugged: on Fluvoxamine, Diazepam and Pregabalin. I wonder if NAC has any boosting effect on Serotonin because in my case I would be augmenting Fluvoxamine and too much Serotonin is one possible cause of tinnitus.

      I had a terrible spike with fish oil because I didn't know its effects on Serotonin: things were OK with one pill (of a strong one) but when I took 2 for some days I had vivid dreams and my tinnitus spiked. Probably because I am still on Fluvoxamine.

      I am also considering Agmatine as one of my most annoying symptoms I have to deal is sensory overload. But then again not sure if it boosts Serotonin.
       
    7. Lane

      Lane Member Hall of Fame

      Tinnitus Since:
      02/2018
      Cause of Tinnitus:
      Single 25 mg dose of (anticholinergic) drug Promethazine
      I don't have OCD myself, but after reading the below linked article, I gave it a try, and found that it helps me a lot. It can have a remarkably calming influence on the brain, and is often prescribed by non-conventional health care practitioners for OCD (Obsessive Compulsive Disorder). Here's a link to a pretty amazing article on how it originally became clear it could successfully treat OCD. -- LISTENING TO INOSITOL: CLINICAL NOTES
       
      • Like Like x 2
    8. Uklawyer

      Uklawyer Member

      Tinnitus Since:
      03/2020
      Cause of Tinnitus:
      Medication - antidepressants
      @TomBradyGOAT - what was the disaster with Nardil? I have read that it's a miracle drug for anxiety with few side effects.
       
    9. TomBradyGOAT

      TomBradyGOAT Member

      Tinnitus Since:
      2016
      Cause of Tinnitus:
      Who knows
      Pretty sure NAC works on Glutamate and Glutathione.

      Hey, fellow OCD person here. I understand going down the polydrug world. I am finding you can't polydrug to fix OCD. I'm off ADs right now. Going through withdrawals. Still on Valium 10 mg and 2000 mg of Gabapentin.

      Fish oil is used to help with brain zaps and other withdrawal symptoms of ADs. I know it helps with Serotonin synthesis.

      Serotonin is so little of the issue with OCD and same with GABA. To me it is another, let's repurpose an AD for OCD.

      Inositol I think works on Serotonin but people with OCD were found to be low on Inositol when a spinal tap was done on people with OCD. So I really think that might be why it helps with OCD.

      Double-blind, controlled, crossover trial of inositol versus fluvoxamine for the treatment of panic disorder

      Where I live, we just had a Fungi festival to learn about shrooms. Honestly these 0.1 g and up I am seeing for shrooms might even be too high for some microdosing. Some people are starting at 0.005g. To me it isn't the Serotonin helping as much as neurogenesis. With ADs you need to go so high sometimes to gain that effect if you do it all.

      EDIT:

      I forgot to answer your first question. Spikes are temporary in NAC. Don't let the OCD, GAD worst fear get to you. I have done Ketamine so much. Which is of course much more powerful on Glutamate and any spikes always level off.
       
    10. TomBradyGOAT

      TomBradyGOAT Member

      Tinnitus Since:
      2016
      Cause of Tinnitus:
      Who knows
      So Nardil went through a change and was sold in 2003 to Pfizer. They changed the inactive ingredients. It went from 13 ingredients to 9. Some people came out and said it was not as effective. Two companies at least decided to make their own version as close to the original as possible and were more successful. One was a company named Lupin. Lupin has shut down manufacturing to change plants. So all you can get is the Pfizer/Greenstone brand. It is really crap. Literally many people have said they felt awful on Greenstone (Pfizer). I didn't research enough.

      Basically what ensued was such a deep down depression, when OCD and low level depression were my issue. Even at 30 mg I had disabling fatigue during the day while working, but insomnia at night. Couldn't pee. Constipated. Sex life gone. What people have to realize is that people who stick with MAOIs have to add at least 1-3 meds to offset the side effects of MAOIs. It is fine for MDD because it gives you a life. For most people you end up on so many drugs.

      No help for anxiety. With Pfizer I got none of the help from GABA-T. None. All it was is issues with PEA which affects Dopamine which if you have anxiety and all you are getting is issues with PEA, you are screwed. Especially without the help from GABA-T.

      Withdrawals from 6 years of Anafranil, a walk in the park. Withdrawals from a month of Nardil is just an up and down rollercoaster.
       
    11. Uklawyer

      Uklawyer Member

      Tinnitus Since:
      03/2020
      Cause of Tinnitus:
      Medication - antidepressants
      And the other company?
      Sounds great. I thought side effects weren't generally supposed to be bad on that stuff.
       
    12. TomBradyGOAT

      TomBradyGOAT Member

      Tinnitus Since:
      2016
      Cause of Tinnitus:
      Who knows
      The other company is out of the UK. I don't know much about them. Their version you have to refrigerate.

      I thought the worst side effects were hypotension, possible with interaction with other meds and the overrated diet, that honestly doesn't need to be followed closely.

      Boy was I wrong.

      Hypotension, sometimes severe. Reading of people blanking out while standing and landing on things on the way down. It actually increased my blood pressure which is already high.

      Fatigue that crushes you so bad (to the point where some people go on Modafinil), that when you are ready for normal sleep time, you get insomnia. So add another med for sleep.

      Want sex? Let's add Wellbutrin and hope that works.

      Just the worst mood changes if PEA is a problem.

      Definitely increased my tinnitus. Every med you would have to take on for side effects has tinnitus as a side effect.

      Constipation to the point where you have to take Magnesium citrate. One person had to go to the hospital to get unplugged.

      You want to pee? Good luck with that.

      Bad weight gain issues. Some people would try meta something to counteract it.

      Supposedly a lot of this goes away after 6 months to a year.

      Nardil can also make you hypomanic, even if you aren't predisposed to bipolar.

      They actually take longer to kick in too. Sometimes up to three months. Hypotension is an indicator of it working.

      So yeah maybe you are in the UK and can get the good version.

      This website will mention the UK version:

      https://mentalhealthdaily.com/2014/...omparison-was-the-old-version-more-effective/
       
    13. TomBradyGOAT

      TomBradyGOAT Member

      Tinnitus Since:
      2016
      Cause of Tinnitus:
      Who knows
      I honestly don't know about Agmatine. I believe it has to do with nitric oxide which has more to do with Glutamate action.

      You are polydrugging to a point. My niece died with 5 meds, that caused depressed breathing. I have met a person who stared straight ahead, and say "I am on 4 meds, I don't think about dying anymore, but I am worried about the numb feeling". They were spaced out. Just gone.

      You are still in a place of great hope. I would love to be down to one med that cures all. I don't know if one exists. I the sooner, we realize meds can't solve everything, and we do ERP, and CBT and don't fight the anxiety and depression, the sooner peace will come.

      I don't like feeling "bad" emotions. I only want the good. We have to feel all emotions. Accepting that as I withdraw from meds, has been hard.
       
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