N-Acetylcysteine (NAC)

Discussion in 'Treatments' started by tweak, May 16, 2012.

    1. Matchbox
      Wishful

      Matchbox Member

      Location:
      BC Canada
      Tinnitus Since:
      August 2020
      Cause of Tinnitus:
      Noise Induced, Prednisone (drones), Barotrauma (distortions)
      The real problem is a lack of real regulation of supplements treated as drugs. Hence sweeping generalizations are made.

      The same thing happened with Kava Kava in nanny state Canada.
       
    2. Tezcatlipoca
      Question it

      Tezcatlipoca Member

      Location:
      Mexico
      Tinnitus Since:
      June 2020
      Cause of Tinnitus:
      NIHL
      We need Ebselen as soon as possible so we can stop gambling with supplements and have some real spike relief and real protection.
       
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    3. nocticolor
      No Mood

      nocticolor Member

      Location:
      Germany
      Tinnitus Since:
      03/2020
      Cause of Tinnitus:
      Unknown
      In the EU as well. Very annoying.
       
    4. Óscar PP

      Óscar PP Member

      Tinnitus Since:
      Nov 2020
      Cause of Tinnitus:
      Coronavirus
      Is there any issues from taking NAC 1800 mg a day spaced in thee doses? I've been doing this for a while and it helps with some long COVID-19 issues I have.
       
    5. MRItechssuck
      Disappointed

      MRItechssuck Member

      Location:
      USA
      Tinnitus Since:
      Severe 10/17/2019
      Cause of Tinnitus:
      Loud noise, MRI
      THIS is why they are focused on NAC. Don’t think it is a coincidence. NAC has been used to treated lung mucous in the past... Ya gotta keep doctors in control, don't ya know!

      No personal responsibility, no self-medicating, because we are too stoopid (as I think of the ENTs out there... smh).
       
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    6. Yoshi
      Wishful

      Yoshi Member

      Location:
      Canada
      Tinnitus Since:
      June 2015
      Cause of Tinnitus:
      Earphones, Bus Braking, Burping (air enters ear canal)
      After taking it for some years, I'm going to say I personally haven't found that NAC prevents tinnitus spikes, temporary or permanent. I can't say for certain it doesn't prevent hearing damage, or if my tinnitus spikes would've been worse without it, but it doesn't outright prevent your tinnitus from getting worse.
       

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    7. kingsfan
      Mellow

      kingsfan Member Benefactor

      Location:
      Southern California
      Tinnitus Since:
      9-17-20 / 10-20-20 / 3-31-21 / 5-23-21
      Cause of Tinnitus:
      turning everything up to 11
      I've only been taking NAC for about 6 months, but I agree.
       
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    8. Stacken77
      Cowabunga

      Stacken77 Member Benefactor

      Location:
      Sweden
      Tinnitus Since:
      10/2020
      Cause of Tinnitus:
      Noise(likely headphones & cars), Acoustic trauma did me in
      I have tried taking like 1200 mg NAC before situations that are not considered loud, but which I know may cause a spike and it has never prevented spikes from occurring for me. I still take NAC occasionally, just in case though.

      This is just my speculation, but I believe there are different types of spikes; those that are caused by louder sounds, actually causing structural stress/damage in the cochlea, may be prevented by NAC. But I have reactive tinnitus where almost any sound causes spikes, and I believe this is instead due to hyperacusis, not structural stress/damage to the cochlea, therefore NAC never works for me.

      I may be wrong on this assertion, just my thoughts.
       
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    9. racedy

      racedy Member

      Tinnitus Since:
      01/2020
      Cause of Tinnitus:
      Ear infection and possibly noise over time
      I would not worry about overdoing it with garlic unless you have GERD. Consuming garlic does not automatically lead to reflux. However, if you have GERD, it can trigger or exacerbate it. My sister has GERD and still eats garlicky food and doesn't take Omeprazole any more. She prefers to eat garlic sauteed with other foods, because raw garlic is too strong for her. Also the long-term health concern with acid reflux is esophageal cancer, not bowel / colorectal cancer. Garlic consumption has been linked to a reduction in colorectal cancer in peer-reviewed literature, so if you don't have GERD, I say go for it. You will know when you've reached your limit when you get gassy and make life very unpleasant for your partner/family/roommates.
       
    10. GeorgeLG
      Busy

      GeorgeLG Member

      Tinnitus Since:
      05/2021
      Cause of Tinnitus:
      Leaf blower incident after years of rock guitar playing
      There are a few good posts here describing the mechanism, but I want to add some additional info. I’ll be brief in summarizing what has already been said:

      NAC is used for a lot of different toxicity conditions as well as mucus management for COPD. We find it here because of Glutathione which is a major antioxidant that has particular relevance to our ears. One of the presumed benefits of adequate Glutathione levels is the protective effect after loud exposures because it prevents the subsequent free radical damage to the inner ear from in the days following. Some military studies use it before and after noise exposure and have seen benefits. Additionally, as we age Glutathione status drops and this may be part of the cause of age related hearing decline.

      It appears that studies confirm protective effect but can it help existing tinnitus or hyperacusis? The anecdotal report of the woman taking NAC for other reasons states that her tinnitus improved so that gets our interest but is not a placebo controlled study so... Also, correlation is not always causation. Maybe it was the NAC but it corrected a different condition that then helped with tinnitus and any one of us may not have that issue. It may also be a coincidence.

      Getting Glutathione safely into the healthy range can have many health benefits because it’s a general antioxidant. It is synthesized by three amino acids: Cysteine, Glutamate and Glycine, plus other co-factors (necessary for the complete multi step conversion process) such as B2, Selenium, Magnesium...

      In a study comparing a young group to an elderly cohort, Glutathione status was much lower in the elderly population but so was glycine. Glutamate was not an issue. We also know that any given individual can be deficient in Selenium and B12. This is part of why we are all bio-individual. If you are chronically deficient in Magnesium, as many are, then you may see dramatic results from supplementation. I did. A person with adequate tissue levels of Magnesium, not so much, just loose stools. In other studies there is such a thing as Glutamate being too high and causing problems. Fixing Glutathione synthesis might help that because we are using up the Glutamate in the process.

      So, how do we get Glutathione at healthy and protective levels? Direct oral supplementation is not very effective because absorption is poor. That is where NAC comes in. It turns out direct supplementation with cysteine can be dangerous but NAC is a precursor to cysteine which is easily absorbed and is safer. So we get our cysteine from NAC and are we done? I don’t know, we are all different, we are all bio-individual. I am 66, so statistically I may also be deficient in amino acid number 2, Glycine. I may also be deficient in some of the co-factors to make sure that the complete process takes place. Candidates are Selenium, Magnesium, B2, vitamin C, Lipoid Acid, and vitamin E. It’s hard to confirm without testing, but a safe and mainstream daily supplement helps take care of many of these.

      I read on ingredients will help you find one that has say elevated Selenium for instance if you're working on this. Everything together is always better because there is so much interdependency. Also, mega dose anything with great care as some things are dangerous in high quantities like Zinc for instance. The mechanism for harm through excess dosing can be direct toxicity or say the depletion of the antagonist. That study of the elderly versus young population dosed NAC plus Glycine and the elderly population got their Glutathione status slightly higher than the young group.

      As mentioned here, NAC may be off the market in the US shortly, Amazon has already pulled everything, so now what? I will refrain from a rant about big pharma, lobbyists and so forth. In another study they compared oral Glutathione to NAC and a new patented (read expensive) sublingual reduced Glutathione and the results confirm that oral Glutathione is ineffective but the other two had similar results in raising Glutathione status. I believe that the latest incarnation of the effective sublingual reduced Glutathione is called Terry Naturally Clinical Glutathione. I’m not affiliated and have not tried it.

      Now for the big question, can this help tinnitus and hyperacusis after years of suffering? I don’t know. Can it make it worse, I don’t know? The data that I have reference certainly suggests a protective effect and damage control with the first week after the exposure but beyond that? Logic dictates that it might protect from further damage but I don’t know.

      I’m only a month in myself with tinnitus and hyperacusis, and I’m in the research phase so I don’t even know what might work for me. I’m starting with getting all of the safe and effective stuff up to par and considering this as well as a number of other things mentioned often here, as well as reading research papers. This process has helped me solve decades old problems without drugs so I’m giving it a go again. Will I have similar success, I don’t know. One thing I do know is that science based knowledge is power and ignorance brings chaos (Lucy, although I can’t watch movies right now). In my experience you can either do extensive expensive testing or select trials based on science and your symptoms. Keep what works and get rid of what doesn’t. Listen to your body. I am getting my B12 baseline next week and if low as I suspect, I will be fixing that because correcting a B12 deficiency has lowered tinnitus loudness scores but no help for people with adequate B12.

      I have zero qualifications in nutritional counseling, tinnitus and hyperacusis treatment or the medical field. I’m just a technical guy doing research and trying to solve problems. Please seek the advice of qualified practitioners and always check for unsafe levels and interactions. Best to you all, at extreme levels this is quite a challenge, but I have faced many before. Now I will give this one a go.

      George
       
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    11. AbeS

      AbeS Member

      Location:
      Sweden
      Tinnitus Since:
      08/2019
      Cause of Tinnitus:
      Noise/headphones
      I noticed NAC is cheaper to buy in powder form compared to capsules.

      Would you recommend buying that and just mix it with water?
       
    12. Lane

      Lane Member Hall of Fame

      Tinnitus Since:
      February, 2018
      Cause of Tinnitus:
      Single 25 mg. Dose of (Anticholinergic) Drug Promethazine
      It has a really bitter taste! You do get a better deal when you buy the powder, but you then have to figure out how to get it inside you without having to taste it.
       
    13. aot
      Depressed

      aot Member Podcast Patron Benefactor Hall of Fame

      Location:
      USA
      Tinnitus Since:
      2016. Worsened 11/2019.
      Cause of Tinnitus:
      Probably sound induced, worsened due to noise expouse + flu.
      Snort it. ;)

      Don't actually snort it.
       
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    14. Rainer

      Rainer Member Benefactor

      Location:
      Germany
      Tinnitus Since:
      12/2020
      Cause of Tinnitus:
      Unknown
      I wouldn't do that. When pharmaceutical companies individually seal their NAC tablets into aluminum foil, it's probably not because they love unnecessary cost and effort. The more likely reason is that NAC is not a stable substance, it can and will oxidize when exposed to air.

      As if to illustrate the point, there are lots of customer reviews for NAC powder on Bezos' evil empire, with complaints about the substance reeking like rotten eggs, and/or inducing nausea and vomiting.
       
    15. kingsfan
      Mellow

      kingsfan Member Benefactor

      Location:
      Southern California
      Tinnitus Since:
      9-17-20 / 10-20-20 / 3-31-21 / 5-23-21
      Cause of Tinnitus:
      turning everything up to 11
      Even the capsules smell quite bad. I can't imaging tasting the actual powder.
       
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    16. Lasse S

      Lasse S Member Benefactor

      Tinnitus Since:
      12/2017
      Cause of Tinnitus:
      Acoustic trauma
      I have taken a lot of NAC in powder form. It doesn't taste good, but it's not a problem at all to get it down. Just rinse your mouth with some water afterwards to get the bad taste away.
       
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    17. Ehren M
      Nerdy

      Ehren M Member

      Location:
      USA
      Tinnitus Since:
      01/24/2021
      Cause of Tinnitus:
      acoustic trauma
      Hi All,

      I am sharing an observation regarding how NAC can negatively impact my sleep if I take it late in the day.

      I've experimented with taking NAC at different times of the day and have noticed that taking NAC within a few hours before bedtime gives me restless leg syndrome. For those who are unaware of it, restless leg syndrome is a horrid sleep disturbance.

      I now take NAC only in the morning, and it does not appear to affect my sleep.

      Cheers,

      E
       
    18. AbeS

      AbeS Member

      Location:
      Sweden
      Tinnitus Since:
      08/2019
      Cause of Tinnitus:
      Noise/headphones
      Ok, thanks for the information.

      The ones I have are just loose capsules in a can, will those get bad quickly as well?
       
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    19. Rainer

      Rainer Member Benefactor

      Location:
      Germany
      Tinnitus Since:
      12/2020
      Cause of Tinnitus:
      Unknown
      I'm afraid I don't have any sourced information about this.

      Nonetheless: I attached a picture of NAC, which is sold as cough medicine where I live. These sachets are made from coated aluminium foil. Compared to loose capsules in a can, this is a quite elaborate and expensive packaging method, and I don't believe that the manufacturer would do that if it weren't absolutely necessary.

      NAC-600-akut.jpg
       
      • Helpful Helpful x 1
    20. GeorgeLG
      Busy

      GeorgeLG Member

      Tinnitus Since:
      05/2021
      Cause of Tinnitus:
      Leaf blower incident after years of rock guitar playing
      I have only taken the NAC pills and I have no problem with the smell or taste.

      George
       
    21. El BUZZ
      Buzzed

      El BUZZ Member

      Tinnitus Since:
      2015
      Cause of Tinnitus:
      Loud music consumption plus acoustic trauma.
      Sorry, but that's deeply senseless.

      Once your floaters show up, they'll remain there for a long while. Mostly forever. So saying it worsens your floaters temporally makes me think you focus on them more during that while.
       
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