New University of Michigan Tinnitus Discovery — Signal Timing

You can’t say that and then not give more info! lol

If you can we would love to see the correspondence.

 

I don't want to be the killjoy guys but don't count on this treatment being more effective than Lenire. It's basically the same... But sure I hope I'm wrong!

 

In principle yes, but it could be a more effective design.

I don’t know though.

The design seems so simple and tinnitus is such a complex animal. Could it really work that well? If it did, surely she would have been able to get massive funding support to speed everything up, right?

Then again the published results showed 12dB improvement. I don’t think she faked that number. I trust her a lot more than Neuromod’s responder statements.

 

Not exactly. Based on my understanding, the audio stimuli is calibrated with your tinnitus pitch/frequency while Lenire sweeps the 0-8 kHz frequency range, and the pitch doesn't matter (which I don't understand why).

Lenire sends electrical stimulation to the trigeminal nerve through your tongue. The Michigan device can send electrical stimulation through different parts of the head/neck depending on the movements that make you tinnitus change.
The Michigan device seems to be better since it is more tailored to your tinnitus.

However you must have enough hearing left at your tinnitus frequency.

 

The two devices also seem to have totally different timings of the sound and shock stimulations. I think that will be the biggest reason the Shore device is more successful than Lenire.

 

@linearb how would you characterize the sounds the Shore device emitted? Were they similar to your tinnitus frequencies?

 

Given a lot of people have a drop-off in hearing at their tinnitus frequency, are they better candidates for the Lenire device or can the Shore device work if it's somewhat close? *My tinnitus is around 10 kHz, I have some hearing up to around 8-9 kHz or so.

 

This is my issue as well. The only time I can hear any frequency around my tinnitus is listening to my tinnitus tone because I am very hearing impaired at those frequencies. I can hear the tones 2000 Hz lower, though. Does that mean I would or would not be a bimodal candidate?

 

Guys. Can you help me out? Isn't this the clinical trial page? https://clinicaltrials.gov/ct2/show/NCT03621735

It says it will be finished in January 2023? But we are talking about the summer of 2020. I must be making a mistake.

 

Usually those are deadlines or dates in the latest range. Someone emailed Dr. Shore and she confirmed this.

 

@threefirefour . Oke good to hear that! Thanks a lot .

 

I haven't really seen this thread in a while. Yesterday I emailed Dr. Shore and received a couple of hours later which I've pasted below:

Thank you for the interest in our work. We are still in clinical trial. We hope to have an update on this at the end of the summer.

I am adding your name to our mailing list for updates at that time.

best wishes,

Dr. Shore

 

I want to be added to the mailing list as well. Have had the same reaction. Lets hope we know more this summer.

 

I think you can also subscribe without mailing to Dr. Shore.

 

Lol. I already felt embarresed to email her directly xD. Don't want to waste her time.

 

I thought I'd mention this. I just had an appointment with the head of the dept. that deals with tinnitus at one of the best hospitals in the world (would rather not mention where). Anyway I asked about what treatments might be helpful in the future, and he brought up the work that Michigan is doing. I mentioned Susan Shore and his eyes lit up, he knew all about the research. So ... I know theres no question that the work is legit and everyone reading this already knows that, but still, its one thing to read something in a forum, and its another to hear about it and have it confirmed by a top doctor. So I found it hopeful.

 

@mark998 were you in Michigan at the time? Just curious how far and wide Dr. Shore’s work has been heard of.

Thanks.

 

Actually it was not in the US.

 

I wish we knew some type of date when the Shore device would be available commercially. I think her device is going to be a very effective treatment.

 

Is it me or have they updated their site about commercialization?

https://innovation.medicine.umich.edu/portfolio_post/shore/

I think it's coming out next year.

 

I don’t notice any changes... why do you come to this conclusion?

 

I don’t know that anything has been updated. The linked pdf showing the pathway to commercialization has a 08/2018 date stamp on it.

 

I contacted her directly at the start of this month.

"We are currently 2/3 of the way through our clinical trial.
Pending positive outcome we will move forward with approvals etc.
I can't really say exactly how long that will take but I have added your name to our mailing list for updates later this year."

 

That's about as promising as one can expect on this front I guess.

 

Would be so awesome if their device came out sometime next year.

 

I was contacted by the University of Michigan back in November about participating in their latest trial. However since I do not live near University of Michigan and the trial would require weekly visits I was understandably turned down. They did add me to their mailing list, however I have not seen any update since then. I assume perhaps I will see something when their current trial is over.

 

Can I get some of your luck?

 

Hah it's not much luck when you get told you don't qualify. All I did was sign up for any clinical trials through the UoM website. Since I am in the NYC area I've actually scheduled a few appointments with closer universities. Hoping if anything maybe they will have the connections to offer things like the UoM device sooner? Who knows, seemed like a good idea. Appointments are out by 1-2 months.

However I wish I had lied and said I lived right next door! But they were expecting weekly visits so that would've been one long extended vacation for me haha. Was definitely a punch to the gut when they said "Oh you have to live within x miles of the facility"

If I gotta wait for the final product then so be it. The sooner the better but hey, plenty of people been suffering and waiting way longer than me.

 

Ooooh, okay yeah. That’s totally infeasible. I was under the impression you got admitted to both OTO-413 and UofMich. Shore had planned for commercialization by late 2020 but I don’t see that happening. Probably mid 2021 would be a fair guess.

 

Not to bad of a wait in the grand scheme of things. I am happy we are getting so many options in the next 5-10 years tops. Hopefully a combination of these treatments on the horizon can help many of us.

But yeah no, I was turned away with only one phone call from UofMich. OTO-413 I could've pursued further but yeah pulled the plug on that myself. I've been a long time lurker and just wanted to share my interactions with these various trials and such as I wouldn't even know about any of it without Tinnitus Talk.