Otonomy OTO-313 — Treatment of Tinnitus

Discussion in 'Research News' started by Michael Larsen, Jan 9, 2018.

    1. Exit

      Exit Member Benefactor Hall of Fame

      Tinnitus Since:
      01/2020
      Cause of Tinnitus:
      Noise
      Microsuction is more likely to hurt you. Pain is simple!
       
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    2. bill 112
      Fine

      bill 112 Member

      Location:
      Republic Of Ireland
      Tinnitus Since:
      02/2012
      Cause of Tinnitus:
      Noise exposure
      The thing is they don’t actually HAVE to suction it out. It’s just the fastest, most effective way but not necessarily the only way. When I refused suction after that incident, all of a sudden anytime they needed to clear earwax they cleared it manually which, yes, took longer but was far better in terms of ear safety. When they put an earwax softener in my ear, once they were able to manually clean out the ear and clear up the rest with a gauze and cotton, so there are ways to clear it out without suction it’s just suction is the “quickest” and “easiest” way for them.

      What’s scary for me and after seeing it commented here just now is that I am one of those people who can feel pain even after numbing. It started last year and I first noticed it after a trip to the dentist. At first they thought it was an infection because infections block the anaesthesia apparently. Two courses of antibiotics later and I could still feel everything he was doing even after my jaw was loaded to the max with the stuff but hey, if OTO-313 worked, I’d get a needle through my eyeball if I had to.
       
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    3. Darktale

      Darktale Member

      Location:
      France
      Tinnitus Since:
      2010
      Cause of Tinnitus:
      Accoustic Trauma
      It makes me think about me and my rheumatologic problems... I have to go from time to time for intra-articular injections of corticosteroids... directly inside the joint (finger, elbow...).

      Normally they use first Xilocaine/Lidocaine as an anesthetic agent, which can be ototoxic. Even if the risk is minimal when used for local injection, I prefer to avoid it so everytime I say to the doctor, I will do the injection direct, without the anesthetic...

      I must avoid any movement or the needle could hurt for example my tendons...
      At the end the doctor always say "dude, you are a real warrior" :rockingbanana:
       
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    4. NYCGuy
      Wishful

      NYCGuy Member Benefactor

      Location:
      NY
      Tinnitus Since:
      10/2021
      Cause of Tinnitus:
      Neck, Jaw or Stress, who knows.
      Pain is not the issue. The issue is when you feel severe pain, you will move with a needle inside your ears. Just think of that.

      It doesn't matter how tolerant you are to pain, when extreme pain happens, your body reacts automatically.
       
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    5. Exit

      Exit Member Benefactor Hall of Fame

      Tinnitus Since:
      01/2020
      Cause of Tinnitus:
      Noise
      You have a good point, but whenever someone has got a needle or a knife against me I usually freeze up and do my best NOT to move :)

      Also does it hurt that much? Some Oxycontin usually relaxes you :)

      A good doctor would also be accustomed to people twitching so I think it will be okay? At least better than an acoustic trauma.

      After the hole is made in the eardrum, my understanding is they just push the goo out into the ear canal and hopes it sticks around...?
       
    6. dbeats

      dbeats Member

      Tinnitus Since:
      2020
      Cause of Tinnitus:
      Loud noise
      I'm guessing the numbing agent is on the eardrum itself? I can't imagine that any ENT would actually remove a numbing agent from the eardrum with a curette? Sounds unlikely considering the risks.

      Seems like suction might be the only way.
       
    7. bill 112
      Fine

      bill 112 Member

      Location:
      Republic Of Ireland
      Tinnitus Since:
      02/2012
      Cause of Tinnitus:
      Noise exposure
      Trust me, they can. It just takes a while. I don’t want to be graphic or anything but when they put that earwax softening stuff into my ears, my ear canals were completely blocked by what felt like an oily goo. All of it was removed by hand and the rest was removed with mild irrigation, not the horrible irrigation they normally do, just a mild gentle stream of warm water. It’s entirely possible but it just takes a lot longer hence why ENTs etc prefer to use microsuction.
       
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    8. dbeats

      dbeats Member

      Tinnitus Since:
      2020
      Cause of Tinnitus:
      Loud noise
      That's completely different. The "earwax softening stuff" normally gets washed out during syringing or a normal shower. With an intratympanic injection, you have a hole in your eardrum, and to my understanding, you need to avoid any liquid going into the middle ear until the eardrum heals.
       
    9. scotty03874

      scotty03874 Member

      Location:
      Boston / Miami Beach
      Tinnitus Since:
      04/2019
      Cause of Tinnitus:
      Slap to the ear / Leading to more issues
      That's correct. I've had 5 different injections through my eardrum. 2 blood patches (for what the doctors thought was a PLF from a trauma to my ear), 2 stem cell injections & 1 steroid injection. It heals in about two weeks. I have first hand knowledge of this...
      Mine were totally painless. When they numb you up, you don't feel a thing but fluid in your ear.
       
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    10. dbeats

      dbeats Member

      Tinnitus Since:
      2020
      Cause of Tinnitus:
      Loud noise
      Did they remove the numbing agent afterward? With suction?
       
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    11. bill 112
      Fine

      bill 112 Member

      Location:
      Republic Of Ireland
      Tinnitus Since:
      02/2012
      Cause of Tinnitus:
      Noise exposure
      It is and it isn’t completely different. I’m not an expert. I’m going off of my brother’s experience who got grommets in years ago and my mate who ruptured his eardrum.

      They said they got an injection behind the ear, then stuff was poured in to make it numb, then taken out, so if that’s true, what’s the risk? They haven’t put a hole in the eardrum yet, that comes after the numbing, if I’m not mistaken? The guy with the ruptured eardrum just got the injection, then gauze put in to help the eardrum heal. They didn’t pour anything into his ear naturally enough.

      I’m kinda going off my and their experience. Maybe @scotty03874 might have more insight into the numbing process pre suction.
       
    12. Gb3

      Gb3 Member

      Tinnitus Since:
      12/19
      Cause of Tinnitus:
      Sshl
      I've had 4 injections in my ear. Never once did they suction the numbing agent.
       
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    13. DocTors_94
      In pain

      DocTors_94 Member Benefactor

      Location:
      Spain
      Tinnitus Since:
      11/2021
      Cause of Tinnitus:
      Loud noise/ Covid? / Benzos / Ototoxicity
      I have also wondered why would they need to do it... It's pointless in my opinion. I don't think you will have systemic Lidocaine absorption through your ear canal skin, at least nothing harmful/toxic levels. It might even help reduce the tinnitus even more for a while, if it truly gets absorbed, who knows.
       
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    14. Brian Newman

      Brian Newman Member

      Tinnitus Since:
      12/2016
      Cause of Tinnitus:
      Shooting/loud noise
      Yeah same, I ended up going to Dr. Foster in Miami for a blood patch. It’s nothing. I did the microsuction foolishly to get the numbing stuff out but I was fine. That ear was not my catastrophic ear though. Mine took like a month to fully heal but it’s fine now.
       
    15. dbeats

      dbeats Member

      Tinnitus Since:
      2020
      Cause of Tinnitus:
      Loud noise
      Was the removal of the numbing stuff optional? Could it be different depending on what they are using as a numbing agent?
       
    16. Brian Newman

      Brian Newman Member

      Tinnitus Since:
      12/2016
      Cause of Tinnitus:
      Shooting/loud noise
      I think you can get it out another way, maybe light irrigation? Or like a little gauze pad and soak it up. It’s not much. I mentioned no microsuction to him and he thought I meant something else. I had my eyes closed because there was going to be a needle going into my ear and I was trying to relax. You could ask the ENT when you do it. Depends on the doctor. They would probably have another alternative. And these people saying not to get the numbing cream, they have no idea what they are talking about. If you don’t get it, you will jump out of the chair from pain. I jumped when the numbing stuff got on my eardrum.

      It wasn’t horrible but it was actually a little painful. When he put the needle in I had bad vertigo for a few seconds. That was a weird feeling. Then I was ok. I actually had mild pain hyperacusis for a month because my eardrum was healing and sounds would give me a little stab here and there. I wasn’t worried because it felt like my eardrum. If it was deeper I would have been worried. The microsuction was not horrible, not as bad as the numbing cream. The suction is very quick and fast. I still won’t do it again just in case. If I was ok, I think most people should be fine, but everybody is different. I think it’s safer not to do microsuction for sure.
       
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    17. scotty03874

      scotty03874 Member

      Location:
      Boston / Miami Beach
      Tinnitus Since:
      04/2019
      Cause of Tinnitus:
      Slap to the ear / Leading to more issues
      No.
       
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    18. Gb3

      Gb3 Member

      Tinnitus Since:
      12/19
      Cause of Tinnitus:
      Sshl
      @Brian Newman, you jumped when the numbing cream got on your eardrum? You ok bro?
       
    19. Padraigh Griffin

      Padraigh Griffin Member Podcast Patron Benefactor

      Tinnitus Since:
      05/2020
      Cause of Tinnitus:
      Unknown/Stress
      Otonomy - Corporate Presentation, March 22, 2022

      Exciting times ahead for Otonomy with Phase 2 results and the highly anticipated results from the higher dosing cohort of 12 patients safety study.

      Phase 3 in early 2023 with dosing to be decided based on the above results and subsequent meeting with the FDA.

      The higher dose is 0.64 mg, which is double that of the original trial which was 0.32 mg.

      The four case studies on the presentation are interesting. 63, 47, 37,46 points reduction in TFI.

      That is quite impressive. I would certainly take that.
       
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    20. Geatly

      Geatly Member

      Tinnitus Since:
      12/2021
      Cause of Tinnitus:
      Noise induced, by jackhammering into concrete on constructio
      I hope they bring Phase 3 clinical studies also to EU.
       
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    21. AfroSnowman
      Balanced

      AfroSnowman Member Podcast Patron Benefactor Hall of Fame

      Tinnitus Since:
      04/2019
      Cause of Tinnitus:
      Nonnatural energy source
      Fingers crossed that is works for chronic tinnitus too.
       
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    22. ploughna

      ploughna Member

      Tinnitus Since:
      2017
      Cause of Tinnitus:
      motor racing and power tools
      Of course the big question for many of us here is efficacy for long term tinnitus, but otherwise I agree - exciting time ahead and good to see them moving aggressively and with rigor.
       
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    23. Bruce NH USA

      Bruce NH USA Member Benefactor

      Location:
      New Hampshire, United States
      Tinnitus Since:
      1981; intolerable since 11/2021
      Cause of Tinnitus:
      Loud music, then ototoxic drug (Paxil)
      Impressive results, indeed.

      I wonder, however, if the fact that all of these tinnitus patients in the study had had tinnitus less than one year might have impacted their TFI results? For those who have had it for quite some time, there has been some habituation, typically, so might that impact the scores of a chronic tinnitus sufferer?

      Either way, with good results, and a cooperative FDA, this treatment potentially could be available within 2 years or so. I certainly would be happy to give it a try!
       
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    24. Toby1972
      Sleepy

      Toby1972 Member Benefactor

      Tinnitus Since:
      2021
      Cause of Tinnitus:
      Noise drama and stress
      Phase 2 was alsy in Germany. But they rejected me (they required unilateral tinnitus, onset less than a year ago), even though I promised them all my BioNTech stock profits, to take me in :)
       
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    25. Diesel

      Diesel Member Benefactor Ambassador Hall of Fame Advocate

      Tinnitus Since:
      1-2019
      Cause of Tinnitus:
      20+ Years of Live Music, Motorcycles, and Power Tools
      So far it looks like the window for treatment is 1 year. Even then, the drug group beat placebo, so it looks promising. I’m not sure what chronic sufferers should expect. At a minimum maybe a good treatment for mitigating further damage from a noise-induced spike. At best, maybe temporary relief or reduction for some subtypes of noise-induced chronic tinnitus.
       
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    26. AfroSnowman
      Balanced

      AfroSnowman Member Podcast Patron Benefactor Hall of Fame

      Tinnitus Since:
      04/2019
      Cause of Tinnitus:
      Nonnatural energy source
      Is there any pharmaceutical that looks promising for chronic tinnitus, meaning long term?
       
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    27. Padraigh Griffin

      Padraigh Griffin Member Podcast Patron Benefactor

      Tinnitus Since:
      05/2020
      Cause of Tinnitus:
      Unknown/Stress
      Ebselen.
       
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    28. Diesel

      Diesel Member Benefactor Ambassador Hall of Fame Advocate

      Tinnitus Since:
      1-2019
      Cause of Tinnitus:
      20+ Years of Live Music, Motorcycles, and Power Tools
      Depends on the underlying condition. If it's noise and high frequency, then OTO-413 and either of the FX drugs may have an effect. If it's not noise... well...
       
    29. blamingeverything

      blamingeverything Member Benefactor

      Tinnitus Since:
      12/2021
      Cause of Tinnitus:
      high frequency hearing loss
      Interesting, hadn't heard of it. Is any company actively pursuing it?
       
    30. UKBloke
      Caffeine

      UKBloke Member Benefactor

      Tinnitus Since:
      1991
      Cause of Tinnitus:
      Loud Music / family history
      Off label use of XEN1101.
       
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