Ototoxic Drugs: Drugs That Cause Tinnitus

Discussion in 'Support' started by calin, Jun 18, 2012.

tinnitus forum
    1. calin
      Inspired

      calin Member Benefactor

      Tinnitus Since:
      Oct 2011
      These drugs are listed in the Physicians Daily Reference as causing tinnitus as a side effect. This information is provided as a service and you are advised to check the product literature supplied with the medications you are on.

      Abelcet Injection (Liposome)
      Accutane
      Accutane Capsules
      Aceon Tablets (2 mg, 4 mg, 8 mg)
      Aciphex Tablets
      Acromycin V
      Actifed with Codiene Cough Syrup
      Actiq (Anesta)
      Actonel Tablets
      Adalat CC
      Aggrenox Capsules
      Agrylin Capsules
      Alferon N Injection (Interferon)
      Alka-Seltzer Original Antacid and Pain Reliever Effervescent Tablets
      Alka-Seltzer Cherry Antacid and Pain Reliever Effervescent Tablets
      Alka-Seltzer Lemon Lime Antacid and Pain Reliever Effervescent Tablets
      Alka-Seltzer Extra Strength Antacid and Pain Reliever Effervescent Tablets
      Alka-Seltzer PM Effervescent Tablets
      Alferon N
      Alumadrine Tablets
      Altace
      Alumadrine Tablets
      Ambien
      Amerge Tablets
      Amicar
      Anatranil
      Anaprox and Anaprox DS
      Anestacon
      Ansaid
      Anzemet Injection
      Anzemet Tablets
      Aralen Injection
      Aralen Tablets
      Arithritis Strength BC Powder
      Aricept Tablets
      Aricept Tablets
      Arthrotec Tablets
      Asacol
      Ascriptin A/D
      Ascriptin
      Asendin
      Aspirin
      Atacand HCT Tablets
      Atretol
      Atrofen
      Atrovent Nasal Spray
      Atrohist Plus
      Avelox Tablets
      Azactam Tablets
      Azactam for Injection
      Azo Gantanol
      Azo Gantrisin
      Azulfidine EN-tabs Tablet
      BC Powder
      Bactrim DS
      Bactrim I.V.
      Bactrim
      Arthritis Strength BC Powder
      Benadryl Parenteral
      Betaxon Ophthalmic Suspension
      Biaxin Filmtab Tablets
      Biaxin for Oral Suspension
      Biaxin XL Filmtab Tablets
      Bicillin L-A Injection
      Buprenex Injectable
      Blocadren
      BuSpar
      Calan Tablets
      Calan SR Caplets
      Cama
      Capastat Sulfate
      Carbocaine Hydrochloride
      Carbatrol Capsules
      Cardene
      Cardioquin
      Cardizem
      Cardura
      Cartrol
      Cataflam
      Celebrex Capsules
      Celebrex Capsules
      Celexa Oral Suspension
      Celexa Tablets
      CellCept Capsules
      CellCept Intravenous
      CellCept Oral Suspension
      CellCept Tablets
      Cerebyx Injection
      Chibroxin Sterile Ophthalmic Solution
      Childrens Advil
      Cibalith-S
      Cinobac
      Cipro I.V.
      Cipro Tablets
      Cipro Oral Suspension
      Claritin Reditabs
      Claritin Syrup
      Claritin Tablets
      Claritin-D 12 Hour Extended Release Tablets
      Claritin-D 24 Hour Extended Release Tablets
      Clinoril
      Clomid Tablets
      Cognex Capsules
      Colazal Capsules
      Copaxone for Injection
      Coreg Tablets
      Corgard
      Corzide
      Cosopt Sterile Ophthalmic Solution
      Covera-HS Tablets
      Cozaar Tablets
      Cuprimine
      Cytotec
      Cytovene Capsules
      Cytovene-IV
      Dalgan
      Dapsone USP
      Daranide Tablets
      DaunoXome Injection
      Daypro
      Dasprin
      Deconamine
      Demadex
      Depacon Injection
      Depakene Capsules
      Depakene Syrup
      Depakote Sprinkle Capsules
      Depakote Tablets
      Depakote ER Tablets
      Depen Titratable Tablets
      Desferal Vials
      Desyrel & Desyrel Dividose
      Diamox Intravenous
      Diamox Sequels Sustained Release Capsules
      Diamox Tablets
      Diovan HCT Tablets
      Dilacor XR
      Dipentum Capsules
      Diprivan
      Disalcid Capsules
      Disalcid Tablets
      Dolobid Tablets
      Doxil Injection
      Duraclon Injection
      Duranest Injections
      Dynabac Tablets
      Dyphenhydramine [Nytol, Benydrl, etc]
      Dyclone
      Easprin
      Ecotrin
      Edecrin
      Effexor Tablets
      Effexor XR Capsules
      ELA-Max Cream
      Elavil
      Eldepryl
      Emcyt
      Emla cream
      Empirin with Codiene
      Erythromycin
      Engerix-B
      Equagesic
      Esgic-plus
      Eskalith
      Ethmozine
      EtrafonEvoxac Capsules
      Excedrin Extra-Strength Tablets, Caplets, and Geltabs
      Exelon Capsules
      Exelon Oral Solution
      Fansidar
      Feldene Capsules
      Fioricat with Codeine
      Flexeril Tablets
      Floxin
      Flumadine Syrup
      Flumadine Tablets
      Fortovase Capsules
      Foscavir
      Furosemide Tablet
      Fungijzone
      Gabitril Filmtab Tablets
      Ganite
      Gantanol
      Gantrisin
      Garamycin
      Gastrocrom Oral Concentrate
      Gengraf Capsules
      Geodon Capsule
      Glauctabs
      HIVID Tablets
      Halcion Tablets
      Hyperstat
      Hytrin Capsules
      Hytrin
      Hyzaar 50-12.5 Tablets
      Hyzaar 100-25 Tablets
      Ibuprofen
      Ilosone
      Imitrex Nasal Spray
      Imdur
      Indocin Capsules
      Indocin Oral Suspension
      Indocin Suppositories
      Intron A
      Infergen
      Invirase Capsules
      Isoptin SR Tablets
      Kerlone Tablets
      Lariam
      Lamictal Tablets
      Lamictal Chewable
      Lasix
      Legatrin
      Levaquin Injection
      Levaquin Tablets
      Lexxel Tablets
      Lncocin
      Lidoderm Patch
      Lipitor Tablets
      Lipitor Tablets
      Lioresal
      Lithane
      Lithium Carbonate
      Lithobid Slow-Release Tablets
      Lithonate
      Lodine Capsules
      Lodine Tablets
      Lodine XL Extended-Release Tablets
      Lopressor Ampuis
      Lopressor DCT
      Lopressor
      Lotensin HCT Tablets
      Lotrel Capsules
      Loreico
      Lupron Depot
      Luvox Tablets
      Ludiomil
      Magnevist
      Marinol (Dronabinol)
      Marcaine Hydrochloride
      Marcaine Spinal
      Maxalt Tablets
      Maxalt-MLT Orally Disintegrating Tablets
      Maxaquin Tablets
      Mazicon
      Meclomen
      Marcaine Hydrochloride
      Marcaine Spinal
      Meridia Capsules
      Mazicon
      Meclomen
      Methergine
      Methotrexate
      Mexitil Capsules
      Miacalcin Nasal Spray
      Micardis HCT Tablets
      Micardis Tablets
      Midamor Tablets
      Migranal Nasal Spray
      Minipress Capsules
      Minizide Capsules
      Mintezol Suspension
      Mintezol Chewable Tablets
      Mirapex Tablets
      Mobic Tablets
      Moduretic Tablets
      Momentum Backache Relief Extra Strength Caplets
      Monopril Tablets
      Motrin Suspension, Oral Drops, Chewable Tablets
      Mono-Cesac
      Mustargen for Injection
      Mykrox Tablets
      MZM
      Myobloc Injectable Solution
      Nalfon Capsules
      Nadolol Tablets
      Naprelan Tablets
      Naprosyn Suspension
      Naprosyn Tablets
      Naropin Injection
      Nebcin Vials, Hyporets & ADD-Vantage
      Neoral Soft Gelatin Capsules
      Neoral Oral Solution
      Neptazane Tablets
      Nescaine Injection
      Nesacaine-MPF Injection
      Neurontin Capsules
      Neurontin Oral Solution
      Neurontin Tablets
      Netromycin
      Nexium Delayed-Release Capsules
      Nicorette
      Nipent for Injection
      Nipride
      Nipent for Injection
      Noroxin Tablets
      Norpramin Tablets
      Norvasc Tablets
      Norvir Capsules
      Norvir Oral Solution
      Omniscan [less than 1%]
      Ornade Spansule Capsules
      Orthoclone OOKT3 Sterile Solution
      Orudis Capsules
      Oruvail Capsules
      OxyContin Tablets
      P-A-C Analgesic
      PBZ
      Pamelor
      Parnate Tablets
      Paxil Oral Suspension
      Paxil Tablets
      Pedia-Profen
      Pediazole Suspension
      Penetrex Tablets
      Pepcid Injection
      Pepcid Injection Premixed
      Pepcid for Oral Suspension
      Pepcid RPD Orally Disintegrating Tablets Pepcid Tablets
      Pepto-Bismol Maximum Strength Liquid
      Pepto-Bismol Original Liquid, Original and Cherry Tablets and Easy-To-Swallow Caplets
      Periactin Tablets
      Permax Tablets
      Phenergan Injection
      Phenergan Suppositories
      Phenergan Tablets
      Phrenilin Forte Capsules
      Phrenilin Tablets
      Piroxicam [1-3%]
      Plaquenil Tablets
      Platinol-AQ Injection
      Plendil
      Pletal Tablets
      Pletal Tablets
      Polocaine Injection, USP
      Polocaine-MPF Injection, USP
      Pontocaine Hydrochloride
      Ponstel Kapseals
      Prilosec Delayed-Release Capsules
      Primaxin I.M.
      Primaxin I.V.
      Prevacid Delayed-Release Capsules
      Prevpak
      Prinivil Tablets
      Prinzide Tablets
      Procardia Capsules
      Procardia Tablets
      Prograf
      ProSom
      Protonix Tablets
      Proventil HFA Inhalation Aerosol
      Proventil Repetabs Tablets
      Proventil Tablets
      Prozac Pulvules & Liquid, Oral Solution
      Prozac Pulvules, Liquid, and Weekly Capsules
      Questran
      Quinaglute Dura-Tabs Tablets
      Quinamm
      Quinidex Extentabs
      Quinidine Gluconate Injection, USP
      Q-vel Muscle Relaxant Pain Reliever
      Rapamune Oral Solution and Tablets
      Recombivax HB
      Relafen Tablets
      Rheumatrex Methotrexate
      Requip Tablets
      Rescriptor Tablet
      ReVia Tablets
      Rifater
      Risperdal Oral Solution
      Risperdal Tablets
      Romazicon Injection
      Ru-Tuss
      Rynatan Tablets
      Rythmol Tablets
      Salflex
      Salagen Tablets
      Sandimmune I.V. Ampuls for Infusion
      Sandimmune Oral Solution
      Sandimmune Soft Gelatin Capsules
      Sandostatin LAR Depot
      Sarafem Pulvules
      Sedapap Tablets
      Sensorcaine Injection
      Sensorcaine with Epinephrine Injection
      Sensorcaine-MPF Injection
      Sensorcaine-MPF with Epinephrine Injection
      Septra I.V. Infusion
      Septra Suspension
      Septra Grape Suspension
      Septra Tablets
      Septra DS Tablets
      Seroquel Tablets
      Serzone Tablets
      Sinequan Capsules
      Sinequan Oral
      Soma Compound Tablets
      Soma Compound w/Codeine Tablets
      Sonata Capsules
      Soriatane Capsules
      Sporanox Capsules
      Sporanox Oral Solution
      Sporanox Oral Solution
      Stadol NS Nasal Spray
      Streptomycin Sulfate
      Sular Tablets
      Sulfadiazine
      Surmontil Capsules
      Sustiva Capsules
      Talacen Caplets
      Talwin Compound Caplets
      Talwin Nx Tablet
      Tambocor Tablets
      Tarka Tablets
      Tasmar Tablets
      Tavist and Tavist-D
      Tegretol Chewable Tablets
      Tegretol Suspension
      Tegretol Tablets
      Tegretol-XR Tablets
      Tenex Tablets
      Temaril
      Tenex
      Teveten Tablets
      Tequin Injection
      Tequin Tablets
      Thalomid Capsules
      Thera-Besic
      Thiosulfil Forte
      Tiazac Capsules
      Ticlid Tablets
      Timolide Tablets
      Timoptic in Ocudose
      Timoptic Sterile Ophthalmic Solution
      Timoptic-XE Sterile Ophthalmic Gel Forming Solution
      TOBI Solution for Inhalation
      Tobramycin
      Tofranil
      Tolectin 200 Tablets
      Tolectin 600 Tablets
      Tolectin DS Capsules
      Tonocard Tablets
      Topamax Sprinkle Capsules
      Topamax Tablets
      Toprol XL Tablets
      Toradol IM Injection, IV Injection
      Toradol Tablets
      Torecan
      Trexan
      Triaminic
      Tricor Capsules, Micronized
      Triavil
      Trileptal Tablets
      Trilisate Liquid
      Trilisate Tablets
      Trinalin Repetabs
      Trisenox Injection
      Trovan I.V.
      Trovan Tablets
      Tussend Syrup
      Tussend Tablets
      Tympagesic Ear Drops
      Ursinus
      Ultram Tablets
      Uniretic Tablets
      Univasc Tablets
      Vancocin HCI
      Vancenase AQ Double Strength Nasal Spray 0.084%
      Vancocin HCl Capsules & Pulvules
      Vancocin HCl Oral Solution
      Vancocin HCl, Vials & ADD-Vantage
      Vantin Tablets and Oral Suspension
      Vascor Tablets
      Vaseretic Tablets
      Vasotec I.V. Injection
      Vasotec Tablets
      Verelan Capsules
      Verelan PM Capsules
      Viagra Tablets
      Vicoprofen Tablets
      Vioxx Oral Suspension
      Vioxx Tablets
      Vistide Injection
      Vivactil Tablets
      Voltaren Tablets
      Voltaren-XR Tablets
      Wellbutrin Tablets
      Wellbutrin SR Sustained-Release Tablet
      Xanax Tablets
      Xylocaine Injection
      Xylocaine with Epinephrine Injection
      Zagam Tablets
      Zanaflex Tablets
      Zebeta Tablets
      Zestoretic Tablet
      Zestril Tablets
      Zestoretic [0.3-1%]
      Ziac Tablets
      Zithromax Capsules, 250 mg
      Zithromax for IV Infusion
      Zithromax for Oral Suspension, 300 mg, 600 mg, 900 mg, 1200 mg
      Zithromax Tablets, 250 mg
      Zoloft Oral Concentrate
      Zoloft Tablets
      Zomig Tablets
      Zomig-ZMT Tablets
      Zonegran Capsules
      Zoleft
      Zosyn
      Zyloprim
      Zyban Sustained-Release Tablets
      Zyprexa Tablets
      Zyprexa ZYDIS Orally Disintegrating Tablets
      Zyrtec Syrup
      Zyrtec Tablet
       
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    2. erik
      Breezy

      erik Manager Staff Benefactor

      Location:
      Washington State, USA
      Tinnitus Since:
      04/15/2012
      Cause of Tinnitus:
      Most likely hearing loss
      Good list although it is missing drugs such as the Benzos: Valium, Ativan, etc and some of the Antihistamines like Citrizine in which all the H1 Blocker over the counter 3rd Gen drugs are Ototoxic. Even things like Vicks vapor rub with camphor is ototoxic and most cortisone creams.
       
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    3. calin
      Inspired

      calin Member Benefactor

      Tinnitus Since:
      Oct 2011
      Yea... my beta blockers which I don't take any more are under Lopressor - not metaprolol...

      Thanks erik!
       
    4. dawne'ne

      dawne'ne Member

      Location:
      Lake Stevens, Washington
      Tinnitus Since:
      1/5/12
      calin, i've been reading all your blogs and find all your info. really helpful. i just started my journey with this illness all i'm taking is ring stop and it's helping. i 'm making an appt. with an ear throat doc . this next week!
       
    5. calin
      Inspired

      calin Member Benefactor

      Tinnitus Since:
      Oct 2011
      Hi dawne'ne! Nice to meet you!

      What is in ring stop? Can you give a bit more on how it has helped you? Lower T sound?

      And, do you have pulsing tinnitus or regular (haha - whatever that means!)
       
    6. calin
      Inspired

      calin Member Benefactor

      Tinnitus Since:
      Oct 2011
      There are about a thousand drugs/products that are Oto-Toxic (oto means hearing). Any or a combination could have caused your tinnitus.

      Here is a short list...


      Ototoxic Drugs

      The following list contains drugs that can have a temporary or permanent effect on hearing such as hearing loss or tinnitus.
      They were identified through the reading of Dr. Susan Kunkel from the Poison Center at the University of New Mexico College of Pharmacy where she is a Toxicology Fellow.

      Please note that this is not an all-inclusive list of every ototoxic drug nor an exhaustive list of all drugs in each category.

      The few that are especially important are displayed in bold.

      Some drugs have more than one use and/or may fit into more than one category.
      Certain non-drug substances (e.g., various metals, chemicals and asphyxiant gases) as well as noise have been associated with hearing loss.

      In some cases, the medications listed can cause hearing changes even at regular doses.
      Nonetheless higher-than-recommended doses are never a good idea and this practice would certainly increase risk of changes in hearing.
      Users of these (or any other drugs) are advised to not exceed recommended dosages and to ask your doctor or pharmacist specifically if there are any potential ototoxic effects associated with any new drug or over-the-counter medication you are told to take.

      tp.gif NOTE: Anyone reviewing this list of ototoxic drugs is strongly advised NOT to discontinue taking any prescribed medication without first contacting the prescribing physician.

      Ototoxic Drugs by Category, with Examples

      Anti-infectives

      Aminoglycosides (amikacin, gentamicin, tobramycin…)
      Amphotericin B
      Ampicillin
      tp.gif Antihelminthics (Praziquantel, thiabendazole)
      tp.gif Chloramphenicol
      tp.gif Chlorhexidine (for topical use)
      Chloroquine
      tp.gif Colistin
      Griseofulvin (antifungal)
      Macrolides (azithromycin, erythromycin)
      Metronidazole
      Nalidixic acid
      Sulfonamides
      Tetracyclines (Minocycline, tetracycline)
      Thiabenzazole (antihelmintic)
      Vancomycin


      Anti-inflammatory agents (NSAIDs, salicylates)

      Aspirin (salicylic acid)
      Ibuprofen
      Naproxen
      Fenoprofen
      Indomethacin
      Ketoprofen
      Piroxicam
      Sulindac


      Antineoplastic agents

      Bleomycin
      Cisplatin
      Cytarabine
      Mechlorethamine
      Methotrexate (also for RA)
      Nitrogen mustard
      Vinblastine
      Vincristine


      Cardiovascular agents

      Enalapril
      Captopril
      Digitalis
      Guanethidine
      Guanfacine
      Metroprolol
      Minoxidil (also for alopecia)
      Quinidine
      Tocainide


      Diuretics

      Acetazolamide
      Bumetanide
      Ethacrynic acid
      Furosemide
      Mannitol


      Tricyclic antidepressants

      Amitriptyline
      Amoxapine
      Desipramine
      Doxepin
      Imipramine
      Nortriptyline


      Substances with abuse potential

      Alcohol
      Caffeine
      Cocaine
      Nicotine
      Phencyclidine (PCP)


      tp.gif
      Miscellaneous agents

      Albuterol
      Antihistamines
      Atropine
      Bromates
      Carbamazepine (anticonvulsant)
      Haloperidol
      Hydroquinone (antipigmentation agent)
      Lithium
      Local anesthetics (Bupivacaine, lidocaine, mepivacaine)
      Metal chelators (Deferoxamine, penicillamine)
      Methylphenidate
      Oral contraceptives
      Pentobarbital
      Quinine
      Theophylline



      _________________________________________________________________________________
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    7. mock turtle

      mock turtle Member

      Location:
      puget sound
      Tinnitus Since:
      07/26/1992...habituated after 2 years; 11/04/11 new outbreak
      calin, thanks for the list

      yep its very important that people be aware and check to see if drugs...medications ...pose a significant risk of tinnitus

      i would almost be willing to venture a guess that more drugs are ototoxic, than not !

      (sure feels that way)

      best wishes
      mt
       
    8. Karen
      Talkative

      Karen Manager Staff Benefactor Hall of Fame Ambassador

      Location:
      U.S.
      Tinnitus Since:
      05/2010
      Cause of Tinnitus:
      First time: Noise 2nd Time: Ototoxic drug
      Thanks, Calin. I feel sure that blood pressure drugs caused my severe tinnitus, although they are not on the list. I agree with Mock Turtle; before you take any new drug, please do check to see if it is ototoxic, and see there might be a substitute you can take that does not harm your ears.
       
    9. Fish
      Balanced

      Fish Member Benefactor

      Location:
      Poland
      Tinnitus Since:
      July 2012
      This is only a partial list. I cannot find it anymore but there was an article on American Tinnitus Association website about ototoxic drugs and there have been really many of them!

      Among the ototoxic drugs I used are:

      possibly ototoxic:

      - ibuprofen
      - H2 blocker
      - pantoprazole ("proton pump inhibiotor" type of drugs)

      highly ototoxic and neurotoxic:

      - ciprofloxacin ("fluoroquinolone" type antibiotic)

      This has taught me a lesson to be very careful and never take any drugs unless my life would depend on it!
       
    10. erik
      Breezy

      erik Manager Staff Benefactor

      Location:
      Washington State, USA
      Tinnitus Since:
      04/15/2012
      Cause of Tinnitus:
      Most likely hearing loss
      Pretty much everything can be ototoxic, even things like Vicks Vapor Rub which has camphor in it which is also on the ototoxic list. 84 of the top 100 prescribed medications are thought be ototoxic in some capacity. But we have to keep in mind that most of the ototoxic effects are dose related. Ototoxicity with NSaids for example are almost dose related and almost always reversible once stopped. If you need Tylenol or Ibuproferin, just don't max out on dosage for a long period of time.
       
    11. Thomas

      Thomas Member

      Tinnitus Since:
      10/2012
      i was recently prescribed a medication called Periactin (Cyproheptadine). According to Wikipedia, it is a first-generation anti-histamine with additional anticholinergic, antiserotonergic and local anesthetic properties.

      Do you think that this is ototoxic? Thanks, Thomas.
       
    12. Thomas

      Thomas Member

      Tinnitus Since:
      10/2012
      it's part of the Tricyclic family and i know that Tricyclic antidepressants are a problem, it's also in the same family as claritin
       
    13. Markku
      Inspired

      Markku Director Staff Benefactor Hall of Fame Team Trobalt Team Tech Team Awareness Team Research

      Tinnitus Since:
      04/2010
      Cause of Tinnitus:
      Syringing
      I merged your new thread over from the Research News to this one here.

      Welcome to the forums!
       
    14. Thomas

      Thomas Member

      Tinnitus Since:
      10/2012
      thanks!
       
    15. Karen
      Talkative

      Karen Manager Staff Benefactor Hall of Fame Ambassador

      Location:
      U.S.
      Tinnitus Since:
      05/2010
      Cause of Tinnitus:
      First time: Noise 2nd Time: Ototoxic drug
    16. Karl

      Karl Member Benefactor

      Location:
      Chicago
      Tinnitus Since:
      10/2011
      How about water?

      I think there should be a new classification of drugs that excite the auditory nerves as opposed to killing the cochlear hair cells. For too long, people have been mixing up drugs that make their tinnitus seem louder and drugs that actually cause serious damage.

      Coffee can excite the nervous system, making tinnitus louder. Some people say Zoloft can be make it louder, but that's temporary. Asprin can cause tinnitus, but that's temporary. The nervous system can get excited, making tinnitus seem louder.

      Certain antibiotics truly do damage to the cochlear hair cells - that's ototocity.
       
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    17. Thomas

      Thomas Member

      Tinnitus Since:
      10/2012
      thank you so much....that is the most logical explanation i have heard....things like antibiotics and chemotherapy drugs are designed with the intent to kill and therefore, it seems logical that they would destroy cochlear hair cells, but you're right it wouldn't make sense that they would cause hearing loss...but how do you feel about the stories regarding hearing loss after taking Amitriptyline? i also find it funny that people say that aspirin is ototoxic...aspirin is broken down in the body into salicylic acid which is nature's anti-inflammatory...if you drink enough orange juice you can achieve the same effect
       
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    18. Sybs
      Inspired

      Sybs Member

      Tinnitus Since:
      03/2013
      I have been on Zoloft for over 3 years but only just started getting Tinnitus a few weeks ago. My doctor seems to think that the side effect could have just appeared after all this time (I am not convinced), so she has asked me to come off them. I was on 50mg and for the last week have been on 25mg. And now she wants me to go to 25mg ever other day before coming off them completely. Do you think she could be right?
       
    19. Louise

      Louise Member Benefactor

      Location:
      Yorkshire, UK
      Tinnitus Since:
      29/06/2012
      Hi Sybs,

      It's a tough one to answer. Although, no offence to doctors, I don't think they know anything about tinnitus and virtually nothing about tapering the drugs they freely prescribe.

      Zoloft has been implicated with tinnitus, the same as Prozac has, and a myriad of other drugs. But, 3 years with no problems seems to suggest it's not the culprit? Is there anything else that could be the cause?

      When drugs are reported as ototoxic the question is; is it temporary tinnitus, (and so it will go away if you come of the drug), or has the drug damaged the hearing system. Have you had a hearing test?

      About the tapering - I'd do your own on-line research if I were you. With some drugs, although I'm thinking Benzos here, if you taper too quickly it can actually cause tinnitus.

      All the best,
      Louise.
       
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    20. mick

      mick Member Benefactor

      Location:
      USA
      Tinnitus Since:
      11/2012
      A few comments based on my reading on the subject over the years:

      1. Aspirin (acetylsalicylic acid) does indeed cause tinnitus at high doses and all evidence indicates that it is reversible and not cumulative. In days of old, arthritis pain was treated by increasing the patient's aspirin dose until their ears began to ring, then the dose was cut back slowly until the ringing stopped. That dose was then the treatment dose for arthritis pain. Whether other NSAIDs like ibuproferen cause reversible or permanant T is debatable. One thing that sets aspirin apart from other NSAIDs is that its effect on platelets is not reversible whereas other NASIDs (with perhaps the exception of naproxen) is reversible. That is why aspirin is safer to take if you are subject to blood clots - platelets exposed to aspirin lose their blood clotting ability for the remainder of their lives while other NSAIDs only temporatily reduce the platelet's ability blood clotting ability. With other NSAIDs there is a rebound effect after the drug's impact on platelet's wears off making the subject more vulnerable to blood clots. Good advice for anyone who has antherosclerosis or who is otherwise predisposed to blood clots is to take aspirin for mild pain relief rather than other NSAIDs. Just pointing out that there is something different about what aspirin does in the body vs other NSAIDs. That something different might explain why aspirin induced T is reversible while that of other NSAIDs may not be.

      2. Based on the theory about excitotoxicity causing T, there is likely a cumulative component to ototoxicity. Excitotoxicity is cumulative and not reversible, thus it is entirely possible that Zoloft could cause T after 3 years of usage. I'm not saying this is what caused Sybs T, only that it is indeed a possibility that should not be shrugged off in any thorough analysis of possible T triggering vectors.

      3. Withdrawal from any drug that impacts brain chemistry seems likely to me to be able to cause T - again because of the possibility of causing excitotoxicity.
       
    21. Louise

      Louise Member Benefactor

      Location:
      Yorkshire, UK
      Tinnitus Since:
      29/06/2012
      Thanks Mick.

      Point 2. is not good news at all. It seems to me that once excitotoxicity gets started there's no stopping it. I mean - when does it stop once its rolling?

      Point 3. Yep that's why a gradual taper is safest. But again, even if you dropped it suddenly and got rebound disinhibition and hence excitotoxicity would this then stop? And, if it stops, is it the cell death from the excitotoxicity that actually causes the damage and the T?

      Ps. I took Zoloft for about 4 months years ago after a bereavement and suddenly stopped it - no T.
      PPs. I took Prozac for 3 years after a relationship break-up and tapered it very fast - no T.
      PPPs. I stuck my stupid ear in front of a speaker blaring out rock music for 1.5 hours - T.
       
      • Like Like x 1
    22. hulagirl
      Creative

      hulagirl Member

      Location:
      Las Vegas
      Tinnitus Since:
      2007
      What about antihistamines? I'm wondering about Allegra as opposed to Zyrtec or Claritin? If this is already posted somewhere else and I missed it, I apologise. My T has worsened since a dental cleaning and it was the first time I stupidly allowed the girl to use the high pressure water instead of just scraping the old fashioned way. My regular hygienist was gone and this girl didn't want to be bothered doing things the old way. Why was I so stupid!! Makes me never want to get my teeth cleaned again!
       
    23. mick

      mick Member Benefactor

      Location:
      USA
      Tinnitus Since:
      11/2012
      I don't think your decision to have the high pressure water cleaning was stupid. It was a reasonable decision, and I would venture to guess there are many other decisions you could have made during that time period that could have worsened your T, or that you made earlier in your life that made you more vulnerable to worsened T at that time. Clearly, we can't be expected to make the right choice when we really don't know for sure all the things that can cause T. Don't be quite so hard on yourself or on the hygienist for that matter. Even if the cleaning did worsen you T, I don't think its reasonable, unless you've seen a lot of evidence to the contrary, to expect yourself or the hygienist to know that it would cause you any problems. It's not as if you decided to take up smoking in the face of all the evidence that smoking causes cancer. That kind of choice does warrant the "Why was I so stupid!" treatment.
       
    24. James
      No Mood

      James Member Benefactor

      Location:
      California
      Tinnitus Since:
      Pulsing 03/2013
      Have or are you taking any?


      To answer your question,
      Yes, in the past and yes, now.
      Even my medicine is on the list, - Amitriptyline

      I'm been having electric-pulsing-ears all day.
      Quinine? I use to drink gin and tonix.
      Having my wine now, ooohhh

      Anyway, thanks for the lists-
      of things to avoid.
       
    25. mick

      mick Member Benefactor

      Location:
      USA
      Tinnitus Since:
      11/2012
      I should add to my comment above: I'm not a doctor, and you would be wise to investigate things to your own satisfaction before relying on my advice. That may mean consulting your doctor depending on how much you trust him/her.

      Like all medications, even aspirin has dangerous side effect, some which may be result from cumulative effects. Increased risk of macular degeneration is one recently identified hazard of taking aspirin. I don't think taking an aspirin every now and then is going to significantly increase your risk of AMD, but ... In the end, knowing what is the right thing to do when making decisions about medications (and even how to have your teeth cleaned) is rarely cut and dried. Unfortunately, there's always a lot of ifs and unknowns. Medicine is a complicated world.
       
    26. Lulubug69
      Artistic

      Lulubug69 Member

      Tinnitus Since:
      9/2013
      I had a recent discussion with a healthcare professional regarding ototoxic drugs.. She explained to me that there are many as we have seen the list at ATA.org, some well known to cause T, some in large doses. She said that any drug that has had even 1 person that got T while using that drug would have to be mentioned as ototoxic. So how does one determine the toxicity of any one drug? And how do we determine the level of danger for using such a drug and at what dose and length of use and how many users actually got T for sure (no other possible factors) from that drug? Do the studies go that in depth?
       
    27. Riikka

      Riikka Member

      Location:
      Finland
      Tinnitus Since:
      09/2007
      At least they do to that extent that in the side effects of a drug is mentioned, if a side effect is common, rare, very rare. A common side effect for example is experienced by between 1 out of 10 and 1 out of 100. I guess the side effects are list according to the experience from clinical trials. Some side effects might be added later.

      So it makes a difference, if tinnitus is a common or a very rare side effect for a drug. If it is very rare, you might think it is more probable that the tinnitus might not be related to taking the drug. Maybe that 1 person out of 100000 that got tinnitus from the drug also listened to loud music? They probably aren't able to exclude all factors that are also influencing the occurrence of a negative health symptom.

      The information included in a drug package doesn't though mention anything about how the dosage effects the occurrence of a side effect. I would guess a larger dosage has always more risks than a smaller one. Some side effects may though only be temporary and pass after for example a couple of weeks. Can anyone explain this?
       
      • Agree Agree x 1
    28. J M

      J M Member

      Location:
      USA
      Tinnitus Since:
      2012
      Dr. Oz had a report on Tylenol (acetaminophen) ototoxicity last year. He said that over time, Tylenol can strip away the protection from your ears and damage them in the long run.

      The last time I took a Tylenol, my right ear shorted out briefly (like a bad speaker connection). No more Tylenol for me, course, your experience may differ.
       
    29. Dr. Ancill

      Dr. Ancill Member Clinician

      Tinnitus Since:
      09/2013
      There is a lot of nonsense on the Internet about drugs and tinnitus. Most so-called side-effects get on the FDA list simply because they are reported. In most cases, there is no direct evidence that the drug caused tinnitus. In my case, the tinnitus suddenly came on one day and I suppose every medication I was taking could be 'the cause' alth0ugh none of them were. There are clearly drugs that a can cause tinnitus but most of the time the tinnitus will go away as the drug level dissapates. Other drugs, especially some antibiotics and anticancer agents, are truly ototoxic and will cause irreversible damage - fortunately, those drugs are uncommon.
       
      • Like Like x 2
      • Dislike Dislike x 1
      • Informative Informative x 1
    30. J M

      J M Member

      Location:
      USA
      Tinnitus Since:
      2012
      Believe it or not, Glipizide (diabetes drug) caused my initial tinnitus. I only took five pills, but I remember a distinct high-pitched ring, and some dizziness, while on the drug. A short time later, I developed a bi-lateral inner ear infection that resulted in tinnitus.
       

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