Pipeline Therapeutics

Discussion in 'Research News' started by FGG, Nov 14, 2019.

    1. Justin Mills

      Justin Mills Member

      Tinnitus Since:
      2 year
      Cause of Tinnitus:
      loud music
      Looks like we're getting the news from everything, Pipeline Therapeutics, Otonomy, and Frequency Therapeutics in mid 2022.
       
      • Like Like x 6
      • Friendly Friendly x 1
    2. Wrfortiscue
      Cowabunga

      Wrfortiscue Member Benefactor Hall of Fame

      Tinnitus Since:
      1999
      Cause of Tinnitus:
      Trauma
      2022 is a huge year lol.

      Crossing fingers not just for me but for those truly suffering.
       
      • Agree Agree x 4
      • Friendly Friendly x 4
      • Like Like x 1
    3. Street Novelist
      Depressed

      Street Novelist Member

      Location:
      Bay Area
      Tinnitus Since:
      February 2018
      Cause of Tinnitus:
      Listening to loud music through headphones
      I know this has been talked about before, but with their supposedly unique delivery system that can reach all the way to the end of the cochlea, I think this drug should fully repair hearing due to sudden noise exposure.

      A direct quote from their July 2020 press release: "The dual mechanism of action for PIPE-505, involving repair of the cochlear synapse and the regeneration of outer hair cells critical for hearing quality and sensitivity, uniquely positions this small molecule to address two of the main cochlear elements commonly lost in SNHL."
       
      • Like Like x 1
      • Optimistic Optimistic x 1
    4. Trevor_phillips

      Trevor_phillips Member

      Tinnitus Since:
      2019
      Cause of Tinnitus:
      NIHL
      Yeah but from what i've heard the regeneration of outer hair cells is not sufficient enough to completely erase hearing loss. It regenerates only a few hair cells, the main purpose of this drug remains to regrow synapses.
       
      • Like Like x 1
    5. SD7
      Angry

      SD7 Member

      Tinnitus Since:
      Mid /June 2021
      Cause of Tinnitus:
      Vaccine + Noise
      This is true!
       
      • Like Like x 1
    6. star-affinity
      Wishful

      star-affinity Member Podcast Patron Benefactor

      Tinnitus Since:
      1993, increase in 2020, then new in 2021
      Cause of Tinnitus:
      Unsure about the first. Too many beers? Music during sleep.
      Where can I read more about that it's not enough to regrow hair cells?

      In the presentation here they seem pretty certain that regrowing the hair cell that is lost will make the nerves connect back to it:

      Hearing Health Hour Webinar | The Present and Future of Inner Ear Hair Cell Regeneration

      Hearing Health Hour Webinar | The Present and...


      And so what I can say is there is a lot of evidence that in the mouse when you can create hair cells in a place where they're not supposed to be the spiral ganglion neurons will follow, and they're pretty good at sorting out and trying to find a target to innervate. And I think there is a very good chance that if you made a hair cell in the right place that it could get innervated and the neuron is already connected to the central nervous system and will be there and ready to go. So, of course it's going to depend on why the hair cells are lost and what the state of the spiral ganglion neurons is, but I think in many cases, yes – I think they could be connected in a functional way.

      When it comes to tinnitus things seems more complex according to these researchers:

      Once you have the tinnitus it's not maintained anymore by the cochlea, it's maintained probably by the cerebellum and the brainstem and that's a different ballpark.

      So despite its complexities it seems easier and more concrete to fix hearing loss than tinnitus. :(

      I'd like to fix both of course, but definitely tinnitus firsthand.

      I so wonder what I will hear in my head on my death bed – hopefully silence and crystal clear hearing since at least a decade back or two. :D
       
      • Like Like x 2
      • Agree Agree x 2
    7. SD7
      Angry

      SD7 Member

      Tinnitus Since:
      Mid /June 2021
      Cause of Tinnitus:
      Vaccine + Noise
      You can look into theories about hidden hearing loss where some articulate that the hair cell is intact however the synapses have been undone. This is what Pipeline Therapeutics is attempting to amend. There are individuals who have no distortions or issues with audiograms yet struggle with high frequency sounds or have troubling understanding words in noise.
       
      • Agree Agree x 2
    8. hopes

      hopes Member

      Tinnitus Since:
      02/2020
      Cause of Tinnitus:
      Unknown
      Any news about the Phase 1/2 results?

      I checked ClinicalTrials.gov and they don't talk about results. In the meanwhile, it's listed as "completed" since few months now.
       
    9. Nobody19

      Nobody19 Member Benefactor

      Tinnitus Since:
      2012
      Cause of Tinnitus:
      Clubbing
      Everything is in this thread, read the posts ;)
       
    10. fletchermunson

      fletchermunson Member Benefactor

      Location:
      USA
      Tinnitus Since:
      8/2018
      Cause of Tinnitus:
      acoustic trauma, cochlear hydrops (possibly)
      • Informative Informative x 2
      • Agree Agree x 1
    11. dbeats

      dbeats Member

      Tinnitus Since:
      2020
      Cause of Tinnitus:
      Loud noise
      Pipeline Therapeutics to Present at Upcoming March Investor Conferences

      They're having a presentation very soon.
      • 32nd Annual Oppenheimer Healthcare Conference
        • Tuesday, March 15th, 2022 at 1:20 pm ET
      Hopefully, there is some info about PIPE-505 there. I have my suspicions that the results from the Phase 1/2a trial were not too great considering all the delays.
       
      • Informative Informative x 2
      • Like Like x 1
      • Agree Agree x 1
    12. dbeats

      dbeats Member

      Tinnitus Since:
      2020
      Cause of Tinnitus:
      Loud noise
      Pipeline Therapeutics have changed their "About"-paragraph in their articles from the News-section from:

      Pipeline’s lead clinical program, PIPE-505, is in an on-going Phase 1/2a study to treat sensorineural hearing loss (SNHL) associated with speech-in-noise disability. The Company also has an ongoing Phase 1 healthy volunteer study for its second clinical program, PIPE-307, targeting multiple sclerosis.

      To:

      Pipeline Therapeutics is a clinical-stage biopharmaceutical company pioneering the development and commercialization of first-in-class therapies for precision neuroregeneration including myelin restoration, synaptogenesis and axonal repair. The Company has a broad pipeline of programs to address CNS and neuro-otology conditions, and its flagship program, PIPE-307, has completed a Phase 1 clinical trial in healthy volunteers to support future studies in MS patients.

      Sounds like they're shifting into prioritizing PIPE-307 over PIPE-505, but it could be semantics.
       
      • Informative Informative x 2
    13. Padraigh Griffin

      Padraigh Griffin Member Benefactor

      Tinnitus Since:
      05/2020
      Cause of Tinnitus:
      Unknown/Stress
      Looks like nothing in the Pipeline here for us tinnitus sufferers unfortunately.
       
      • Agree Agree x 1
      • Funny Funny x 1
      • Winner Winner x 1
    14. dbeats

      dbeats Member

      Tinnitus Since:
      2020
      Cause of Tinnitus:
      Loud noise
      • Like Like x 6
      • Informative Informative x 4
    15. Street Novelist
      Depressed

      Street Novelist Member

      Location:
      Bay Area
      Tinnitus Since:
      February 2018
      Cause of Tinnitus:
      Listening to loud music through headphones
      Just 2 more months.
       
    16. Nobody19

      Nobody19 Member Benefactor

      Tinnitus Since:
      2012
      Cause of Tinnitus:
      Clubbing
      I hope that means the results are good. But you never know lol.

      Lots of companies attending!
       
    17. dbeats

      dbeats Member

      Tinnitus Since:
      2020
      Cause of Tinnitus:
      Loud noise
      This year has so far brought some interesting developments, and within the next 4 months or so, we are seeing results from at least 3 different trials.
       
      • Like Like x 3
      • Optimistic Optimistic x 2
    18. Street Novelist
      Depressed

      Street Novelist Member

      Location:
      Bay Area
      Tinnitus Since:
      February 2018
      Cause of Tinnitus:
      Listening to loud music through headphones
      Just 1 more month!
       
      • Optimistic Optimistic x 3
      • Like Like x 1
    19. JRC1

      JRC1 Member Benefactor

      Tinnitus Since:
      2016
      Cause of Tinnitus:
      medication
      I don’t see Pipeline Therapeutics listed as a presenter at the June 21/22 conference.

      Am I missing something here?
       
      • Good Question Good Question x 1
    20. dbeats

      dbeats Member

      Tinnitus Since:
      2020
      Cause of Tinnitus:
      Loud noise
      • Useful Useful x 1
    21. Nobody19

      Nobody19 Member Benefactor

      Tinnitus Since:
      2012
      Cause of Tinnitus:
      Clubbing
      At first sight, their speakers seems to have been replaced by Carl LeBel from Frequency Therapeutics. Weird...
       
    22. Jurger

      Jurger Member

      Tinnitus Since:
      2004
      Cause of Tinnitus:
      Hearing loss
      Looks to me as if PIPE-505 did not achieve the results they had hoped for.
       
    23. Nobody19

      Nobody19 Member Benefactor

      Tinnitus Since:
      2012
      Cause of Tinnitus:
      Clubbing
      The study ended almot a year ago, I think they've known the results for a while now. But who knows.
       
    24. xyz
      Alienated

      xyz Member

      Location:
      Germany
      Tinnitus Since:
      2006 mild T 2019 T worsening H onset
      Cause of Tinnitus:
      unknown / probably noise induced
      These Gamma-secretase inhibitors were already used by Audion with not really fantastic results. So unless they have a complete different approach, results here will not be groundbreaking.
       
    25. Street Novelist
      Depressed

      Street Novelist Member

      Location:
      Bay Area
      Tinnitus Since:
      February 2018
      Cause of Tinnitus:
      Listening to loud music through headphones
      I talked to the receptionist at Pipeline Therapeutics today and they said they are releasing the results at the end of June on ClinicalTrials.gov.
       
      • Winner Winner x 6
      • Like Like x 3
      • Informative Informative x 2
      • Agree Agree x 1
    26. KoolKat

      KoolKat Member

      Location:
      USA
      Tinnitus Since:
      2013
      Cause of Tinnitus:
      HeadPhones/ Noise induced
      God bless you for taking the initiative and doing that, boy did we need to hear this.

      Let's hope Christmas comes early for us :thankyousign:
       
      • Like Like x 9
    27. fletchermunson

      fletchermunson Member Benefactor

      Location:
      USA
      Tinnitus Since:
      8/2018
      Cause of Tinnitus:
      acoustic trauma, cochlear hydrops (possibly)
      Not sure why, but on PIPE-505’s ClinicalTrials.gov page, the company has filed for an extension to release the results of last year’s trial.
       
      • Informative Informative x 1
    28. InNeedOfHelp

      InNeedOfHelp Member

      Tinnitus Since:
      08/2021
      Cause of Tinnitus:
      MRI Scan
      Where do you see that? According to ClinicalTrials.gov, they need to publish results within a year, tomorrow the latest.
       
    29. fletchermunson

      fletchermunson Member Benefactor

      Location:
      USA
      Tinnitus Since:
      8/2018
      Cause of Tinnitus:
      acoustic trauma, cochlear hydrops (possibly)
      When I clicked on the info button, it says this is done to delay submission... unless I’m missing something.

      6CB5D0EB-EC9D-48AD-B1C7-1A1EABAB9076.jpeg
       
      • Informative Informative x 3
    30. lolkas

      lolkas Member

      Tinnitus Since:
      06/2016
      Cause of Tinnitus:
      Don`t know
      Do we know why? I mean, based on the description this may allow them delay submission for up to TWO years! This is probably going nowhere :(
       
Loading...

Share This Page