Rimegepant for Treatment of Migraine and Phonophobia (Hyperacusis?)

Discussion in 'Research News' started by InNeedOfHelp, Jun 9, 2022.

    1. InNeedOfHelp

      InNeedOfHelp Member

      Tinnitus Since:
      Cause of Tinnitus:
      MRI Scan
      Safety and Tolerability Study of Daily Dosing Rimegepant in Episodic Migraine Prevention

      I came across this study. This medication has been proven efficient for migraines and for sound sensitivity which is part of migraine attacks. The medicine is already EMA/FDA approved. The Phase IV study specifically marks hyperacusis as tag for the study, and targets phonophobia together with migraines. Phonophobia here is not described as anxiety for sound as we might define it but as higher sensitivity to sensory stimuli, such as uncomfort of utensils clanking together etc. Hence the hyperacusis tag. They seem to go hand in hand.

      Are the mechanisms of migraine induced 'hyperacusis/phonophobia' different from "auditory gain" hyperacusis? Is there a chance this can help general phonophobia/hearing sensitivity too? Here is a study clearly showing decrease in audio sensitivity/phonophobia against placebo:

      Rimegepant, an Oral Calcitonin Gene–Related Peptide Receptor Antagonist, for Migraine
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    2. DaveFromChicago

      DaveFromChicago Member Podcast Patron Benefactor

      Tinnitus Since:
      Cause of Tinnitus:
      To InNeedOf Help:

      Thanks ever so much for posting what is (to me) a singularly important finding.

      It's the damnedest thing: When I get a migraine my tinnitus virtually disappears, and my White Noise Masker on its regular volume level is nonetheless less loud.

      It's gotten to the point where I welcome migraines as "the perfect vacation" from this, since I can alleviate the migraine pain with Maxalt.

      When this happens, I will pull my car into my garage, close the door, turn off the engine, and roll up the windows (which is my do-it-yourself makeshift, personal sound deprivation chamber). This temporary state of the sort of total silence that as a matter of course I experienced before tinnitus is present, and luxurating in this (which I call an orgasm in reverse) will produce veritable tears of gratefulness.

      But all vacations must end, and at Midnight the Coach must turn into the Pumpkin, so after the migraine is gone there will be a tinnitus spike that will have me raving to the point where I am afraid of shocking people if I go out in Public.

      I have explained this to a few doctors, and I was so disappointed that from just the purely objective standpoint of medical curiosity they were nonetheless totally uninterested.

      Could Rimegepant be the answer I have been looking for for 8.5 years?
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    3. Joeseph Stope

      Joeseph Stope Member

      Tinnitus Since:
      Cause of Tinnitus:
      noise? infection? negative stress? other?
      It strikes me that we tinnitus crowd are quite a diverse bunch.

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    4. addot

      addot Member

      Tinnitus Since:
      Jan 2013
      Cause of Tinnitus:
      Noise exposure
      Rimegepant is a CGRP receptor antagonist. Interestingly, the Hyperacusis Research 2022 grant was awarded to a study that aims to investigate the connection between CGRP and hyperacusis. Quoting from the link above:

      "A subset of patients with hyperacusis experience pain in the presence of typically tolerated sound. Little is known about the origin of this pain. One hypothesis is that the type II auditory nerve fibers (type II neurons) of the inner ear may act as pain receptors after exposure to damaging levels of noise (acoustic damage). Our lab has shown that type II neurons share key characteristics with pain neurons: They respond to tissue damage; they are hyperactive after acoustic damage; and they express genes similar to pain neurons, such as the gene for CGRP-alpha. However, type II neurons are not the only cell type that responds to acoustic damage. The immune system responds quickly after damaging noise exposure. In other systems of the body such as the skin, CGRP-alpha can affect immune cell function. This project looks at the expression of CGRP-alpha in type II neurons after noise exposure. CGRP-alpha will be blocked during noise exposure to see if this affects the immune response to tissue damage.

      The long-term goal is to understand the role of CGRP-alpha in the neurons and immune response of the inner ear, which may illustrate a role for type II neurons in pain and inflammation following tissue damage. CGRP-alpha has been a target for therapeutics for painful conditions such as migraine, making it an attractive therapeutic target for pathologies of the inner ear."

      The researcher responsible for this study is Megan Beers Wood. You might recall her from a 2020 Hyperacusis Research Webinar on type II afferents. She is affiliated with Paul Fuchs, who is one of the main figures behind the theory that type II afferents act as pain receptors in the inner ear.
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    5. Sugar_Boy

      Sugar_Boy Member

      Tinnitus Since:
      Cause of Tinnitus:

      I have tinnitus, dizziness, headaches, isolation, anxiety, palpitations. I hope it's helpful. Is there anyone out there like me?

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