Acetyl-L-Carnitine Effective for Tinnitus?

Discussion in 'Treatments' started by Stink, Apr 8, 2015.

tinnitus forum
    1. Stink

      Stink Member

      Location:
      US
      Tinnitus Since:
      09/2000
      Efficacy of carnitine in treatment of tinnitus: evidence from audiological and MRI measures-a case study.

      BACKGROUND:
      Tinnitus, or ringing in the ears, is an extremely common ear disorder. However, it is a phenomenon that is very poorly understood and has limited treatment options.

      PURPOSE:
      The goals of this case study were to identify if the antioxidant acetyl-L-carnitine (ALCAR) provides relief from tinnitus, and to identify if subjective satisfaction after carnitine treatment is accompanied by changes in audiological and imaging measures.

      RESEARCH DESIGN:
      Case Study.

      PATIENT CASE:
      A 41-yr-old female with a history of hearing loss and tinnitus was interested in exploring the benefits of antioxidant therapy in reducing her tinnitus. The patient was evaluated using a standard audiological/tinnitus test battery and magnetic resonance imaging (MRI) recordings before carnitine treatment. After her physician's approval, the patient took 500 mg of ALCAR twice a day for 30 consecutive days. The audiological and MRI measures were repeated after ALCAR treatment.

      DATA COLLECTION AND ANALYSIS:
      Pure-tone audiometry, tympanometry, distortion-product otoacoustic emissions, tinnitus questionnaires (Tinnitus Handicap Inventory and Tinnitus Reaction Questionnaire), auditory brainstem response, functional MRI (fMRI), functional connectivity MRI, and cerebral blood flow evaluations were conducted before intake of ALCAR and were repeated 30 days after ALCAR treatment.

      RESULTS:
      The patient's pretreatment pure-tone audiogram indicated a mild sensorineural hearing loss at 6 kHz in the right ear and 4 kHz in the left ear. Posttreatment evaluation indicated marginal improvement in the patient's pure-tone thresholds, but was sufficient to be classified as being clinically normal in both ears. Distortion-product otoacoustic emissions results showed increased overall emissions after ALCAR treatment. Subjective report from the patient indicated that her tinnitus was less annoying and barely noticeable during the day after treatment, and the posttreatment tinnitus questionnaire scores supported her statement. Auditory brainstem response peak V amplitude growth between stimulus intensity levels of 40-80 dB nHL indicated a reduction in growth for the posttreatment condition compared with the pretreatment condition. This was attributed to a possible active gating mechanism involving the auditory brainstem after ALCAR treatment. Posttreatment fMRI recordings in response to acoustic stimuli indicated a statistically significant reduction in brain activity in several regions of the brain, including the auditory cortex. Cerebral blood flow showed increased flow in the auditory cortex after treatment. The functional connectivity MRI indicated increased connectivity between the right and left auditory cortex, but a decrease in connectivity between the auditory cortex and some regions of the "default mode network," namely the medial prefrontal cortex and posterior cingulate cortex.

      CONCLUSIONS:
      The changes observed in the objective and subjective test measures after ALCAR treatment, along with the patient's personal observations, indicate that carnitine intake may be a valuable pharmacological option in the treatment of tinnitus.


      Link to Study http://www.ncbi.nlm.nih.gov/pubmed/25751698

      ANYBODY TRY ALCAR FOR TINNITUS?

      http://www.amazon.com/Foods-Acetyl-L-Carnitine-500mg-Vcaps/dp/B000QSLINE/
       
      • Helpful Helpful x 1
    2. ruben ruiz

      ruben ruiz Member

      Location:
      Tucson, AZ
      Tinnitus Since:
      2012
      Cause of Tinnitus:
      I believe it was meds and stress
      Thanks. I was taking that and the dr. told me to stop. I don't know why I believe your thread is more viable than my dr.
       
      • Agree Agree x 1
    3. Twitch

      Twitch Member

      Location:
      Earth
      Tinnitus Since:
      2014
      Cause of Tinnitus:
      Unknown
      Came across this pubmed a short while ago via Google and was going to share it here before I came across your thread :p

      I might give this a try next month as I have surgery next week so want to avoid supplements a few weeks before and after anaesthesia. It looks promising and I wonder what if any additional benefits the subject would have had if they continued supplementation beyond 30 days. I noticed a thread earlier on on L-Carnosine and a quick search on Wikipedia reveals both carnosine and carnitine were discovered by the same Russian chemist. Not sure on supplementation of both carnosine and carnitine but it's something I might try.
       
    4. jimH
      No Mood

      jimH Member Benefactor

      Tinnitus Since:
      30 years+
      Cause of Tinnitus:
      Acoustic trauma
      I've been taking 500mg of Acetyl L-Carnitine twice a day for about a month. So far, there's been no change in my T condition.
       
      • Helpful Helpful x 1
    5. Twitch

      Twitch Member

      Location:
      Earth
      Tinnitus Since:
      2014
      Cause of Tinnitus:
      Unknown
      Have you ever tried L-Carnosine or considered it? There's some more info on it in the other thread
       
    6. erik
      Breezy

      erik Manager Staff Benefactor

      Location:
      Washington State, USA
      Tinnitus Since:
      04/15/2012
      Cause of Tinnitus:
      Most likely hearing loss
      I also took this for months (I tried over 50 supplements over a couple year period), I never got any results from this or most of them.
       
      • Helpful Helpful x 2
      • Like Like x 1
      • Agree Agree x 1
    7. carlover
      English

      carlover Member Benefactor

      Location:
      London
      Tinnitus Since:
      1986
      No supplement works ,end of.
       
      • Agree Agree x 3
    8. ruben ruiz

      ruben ruiz Member

      Location:
      Tucson, AZ
      Tinnitus Since:
      2012
      Cause of Tinnitus:
      I believe it was meds and stress
      Look up Angelica it offers some relief for Anxiety, depression, Insomnia etc. etc.
       
    9. jimH
      No Mood

      jimH Member Benefactor

      Tinnitus Since:
      30 years+
      Cause of Tinnitus:
      Acoustic trauma
      No, I haven't. Thanks for the heads-up about the other thread.
       
    10. DebInAustralia

      DebInAustralia Member Benefactor Team Research

      Location:
      Geelong, Victoria
      Tinnitus Since:
      30/12/13
      Interesting to note that L Carnitine is a precursor to Acetylcholine (an important nerve signalling neurotransmitter)
       
    11. linearb
      Psychedelic

      linearb Member Hall of Fame

      Location:
      East Coast USA
      Tinnitus Since:
      1998
      I think a better statement is "no supplement works consistently for most people".

      Many people... including myself... do note significant changes/improvements from specific supplements.
       
      • Agree Agree x 1
    12. FredMas

      FredMas Member

      Is riboflavin effective for treating timnitis?
       
    13. FredMas

      FredMas Member

       
    14. carlover
      English

      carlover Member Benefactor

      Location:
      London
      Tinnitus Since:
      1986
      Glad to hear it,lets have it then linearb ,it was a strong statement from me i know ,ive tried most plus never seen on any forum anyone saying a supplement has worked for them unless it was a spammer( not you friend)
       
      • Optimistic Optimistic x 1
    15. 1MW
      No Mood

      1MW Member

      Cause of Tinnitus:
      ssnhl
      Seems that people with hearing loss do not respond in various treatments.
      When T exists with notable hearing loss is very hard to treat.
      I had T with and without hearing loss when i had hearing loss T was more more loud
      and pure tone every db regained in my hearing T was more silent when i regained
      all my hearing T stopped.
       
    16. skoupidis

      skoupidis Member

      Tinnitus Since:
      09/2014
      Cause of Tinnitus:
      Acoustic trauma or mvc
      How did you regain your hearing?
       
    17. Danny Boy
      Cheerful

      Danny Boy Member Benefactor Hall of Fame

      Location:
      England
      Tinnitus Since:
      7/2014
      Cause of Tinnitus:
      Ear infection
      Tried it, didn't work, sadly.
       
      • Winner Winner x 1
      • Informative Informative x 1
    18. 1MW
      No Mood

      1MW Member

      Cause of Tinnitus:
      ssnhl
      With corticosteroids 60db in 2khz to 8khz and 20db to other frequencies.
      Corticosteroids started 10-12 hours from the event at big doses iv
       
    19. 1MW
      No Mood

      1MW Member

      Cause of Tinnitus:
      ssnhl
      I got acetyl-L-carnitine and i will post results soon.
      For now i can say anything because i have got only one dose and i had no T the time got the ALCAR
      I will see if it works when i have T.
      The good is that has no side effects.
       
      • Helpful Helpful x 2
    20. physics13
      In pain

      physics13 Member

      Tinnitus Since:
      2005
      Cause of Tinnitus:
      antibiotics
      does it help hearing loss? there was one study on ACLAR on pubmed at least
       
    21. Robert44

      Robert44 Member Benefactor

      Location:
      New York
      Tinnitus Since:
      April 2015
      Cause of Tinnitus:
      loud concert
      Hi all,
      I was driving in the car and listening to Jerry Hickey WABC radio. He started talking about Tinnitus. He said that taking ALCAR with ALA would help with Tinnitus. He didn't say it would cure it but that it would reduce the level and make it more bearable .. He also said that it would help to repair the little hairs that were damaged from noise exposure. I thought they couldn't be repaired. Anyone know anything about this?
       
    22. grate_biff
      No Mood

      grate_biff Member

      Location:
      Oslo, Norway
      Tinnitus Since:
      09/2014
      Cause of Tinnitus:
      aucustic trauma, benzo withdrawl or both
      What is ALCAR and ALA, please??
       
    23. markoana

      markoana Member

      Tinnitus Since:
      2.2013
      @grate_biff it is Acetyl-L-Carnitine, an acetylated version of supplement (L-Carnitine)

      @Robert44 It may be useful just after acoustic trauma, but after months or years of t. I doubt that it could be beneficial... My opinion
       
      • Friendly Friendly x 1
    24. SoulStation
      No Mood

      SoulStation Member Ambassador Team Tech

      Location:
      New York
      Tinnitus Since:
      2012
      Cause of Tinnitus:
      Noise / Possible Medication
      Ala is Alpha lipoic acid
       
      • Friendly Friendly x 1
    25. DebInAustralia

      DebInAustralia Member Benefactor Team Research

      Location:
      Geelong, Victoria
      Tinnitus Since:
      30/12/13
      Why has everyone forgotten about the work of James Kaltenbach in the states, looking at ways to manipulate the cholinergic system? (he found cabachol eradicated the tinnitus signal but the side effects were too detrimental to justify its use in tinnitus) He is particulary interested in the effects of upregulating the muscarinic cholinergic receptors. I spoke to him last week, and mentioned my little experiment with L acetyl Carnitine 1gm/day (helping), and is very interested in this and wants me to continue to give him updates. Can we not conduct another informal trial on this supplement in the event this could help some subsets of tinnitus?
       
      • Like Like x 1
    26. attheedgeofscience
      Uninvolved

      attheedgeofscience Member Hall of Fame

      Location:
      Denmark
      Tinnitus Since:
      Childhood
      Cause of Tinnitus:
      Head Injury
      As it happens, a colleague of Prof. Moore (Prof. Gopal) has published a case study on that (Carnitine):

      www.ncbi.nlm.nih.gov/pubmed/25751698
       
    27. DebInAustralia

      DebInAustralia Member Benefactor Team Research

      Location:
      Geelong, Victoria
      Tinnitus Since:
      30/12/13
      Thanks...kaltenbach sent me link x
       
    28. Bobby B
      Fine

      Bobby B Member Benefactor

      Tinnitus Since:
      11/2015
      Cause of Tinnitus:
      long term NIHL and recent acoustic trauma
      I did try L- Carnitine yesterday and indeed it does something . within one hour the sounds are more clear and my T has considerably dropped . I was having breakfeast alone In my quiet room this morning and could not hear much t , just a faint hiss and the sounds of the birds and noise outside was far clearer than before.
      The research shows an effect for a person who had t and hearing loss for such a long time ,I only had both issues for one month so I guess the effect is even more striking.
      Will keep on using it at various dosage and report back

      Worth a try - of all the stuff I took this is what gave me the best immediate result beside the immediate minor improvement from prednisone on the first day.
      I also use an anti oxidant (hydrogen) and minoxidil as ion channel opener and adenosine channel opener in combo.
       
      • Like Like x 1
    29. valeri

      valeri Member Benefactor Team Awareness

      Location:
      Australia
      Tinnitus Since:
      09/2011
      I've been on it for a month and no change in T:(
       
      • Agree Agree x 1
    30. Bobby B
      Fine

      Bobby B Member Benefactor

      Tinnitus Since:
      11/2015
      Cause of Tinnitus:
      long term NIHL and recent acoustic trauma
      One study says it works better as a combo with an anti oxidant like Nac

      How much are you taking per day ?
       

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