Akouos — A New Company Focused on Genetic Hearing Loss

Discussion in 'Research News' started by Aaron123, Nov 30, 2017.

    1. Aaron123

      Aaron123 Member

      Tinnitus Since:
      00/0000
      Cause of Tinnitus:
      Irrelevant
      • Informative Informative x 7
      • Like Like x 3
      • Winner Winner x 2
    2. Samir
      Obedient

      Samir Manager Staff Benefactor Ambassador Advocate

      Location:
      Sweden
      Tinnitus Since:
      12/2016
      Cause of Tinnitus:
      Accoustic trauma
      Good find Aaron! :) You are on fire lately! :eek: Keep them coming! (y)
       
      • Agree Agree x 2
    3. Makrohn
      Supportive

      Makrohn Member Benefactor Advocate

      Location:
      Norway
      Tinnitus Since:
      1996
      Cause of Tinnitus:
      Hearing loss - Explosion - Stress
      • Like Like x 1
    4. AUTHOR
      AUTHOR
      Aaron123

      Aaron123 Member

      Tinnitus Since:
      00/0000
      Cause of Tinnitus:
      Irrelevant
      Here's a bit more information on Akouos. They received SBIR (small business innovation research) funding this year and are developing a minimally invasive delivery system presumably to deliver gene therapy to the inner ear: https://www.sbir.gov/sbirsearch/detail/1305311
       
      • Like Like x 3
    5. Paulmanlike

      Paulmanlike Member Podcast Patron Benefactor Hall of Fame

      Tinnitus Since:
      2008
      Cause of Tinnitus:
      Noise
      They just keep coming man, could treating hearing loss pharmaceutically (is that a word?) be the new laser eye surgery that's a multi million or billion dollar market?

      Nice find Aaron, although which will come first? Treating noise induced deafness or genetic defect deafness?
       
      • Good Question Good Question x 1
      • Optimistic Optimistic x 1
    6. Benoves

      Benoves Member Benefactor

      Tinnitus Since:
      26-9-2017
      Cause of Tinnitus:
      Unknow possibly noise trauma
      This one looks serious. Thanks for tagging me. Looks like not many companies are targeting this? Is this different from wat audion/frequency are doing?

      Hope they wil find a cure in our lifetime, for hearing loss and tinnitus. Better be soon. Untill then i hope to habituate.
       
      • Like Like x 3
      • Agree Agree x 3
    7. Enclave

      Enclave Member

      Tinnitus Since:
      Meh
      Cause of Tinnitus:
      Meh
      • Like Like x 5
      • Informative Informative x 1
    8. IvanRus

      IvanRus Member

      Tinnitus Since:
      04/2017
      Cause of Tinnitus:
      ototoxicity
      https://cen.acs.org/business/start-ups/Akouos-raises-50-million-develop/96/web/2018/08

      Yes, this is another startup that managed to attract 50 million dollars of investment.
      With their focus on genetic hearing loss, I have some misunderstandings, I will contact them.
      Probably, they focus on a new method of regeneration - viral regeneration of hearing. They hope to launch a genetically modified virus that will restore hearing.

      Reference:
      Today there are 4 main directions for the possibility of regeneration of the inner ear, this is:
      1) Treatment with stem cells;
      2) Gene therapy;
      3) Cell therapy;
      4) Viral therapy.
       
      • Informative Informative x 2
      • Like Like x 1
    9. Samir
      Obedient

      Samir Manager Staff Benefactor Ambassador Advocate

      Location:
      Sweden
      Tinnitus Since:
      12/2016
      Cause of Tinnitus:
      Accoustic trauma
      • Like Like x 5
      • Informative Informative x 1
    10. Samir
      Obedient

      Samir Manager Staff Benefactor Ambassador Advocate

      Location:
      Sweden
      Tinnitus Since:
      12/2016
      Cause of Tinnitus:
      Accoustic trauma
      • Informative Informative x 2
      • Like Like x 1
    11. FGG
      No Mood

      FGG Member Podcast Patron Benefactor Hall of Fame Advocate

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Multi-factorial
      This company is about to offer an IPO with the ticker: AKUS, if anyone is still following them.

      Their AAV platform is promising for genetic hearing loss but they appear to be looking into inner ear cell (hair and possibly support cell via their website) regeneration, too.
       
      • Like Like x 4
      • Informative Informative x 2
    12. FGG
      No Mood

      FGG Member Podcast Patron Benefactor Hall of Fame Advocate

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Multi-factorial
      • Informative Informative x 1
    13. FGG
      No Mood

      FGG Member Podcast Patron Benefactor Hall of Fame Advocate

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Multi-factorial
      Anyone else listen to their webcast?

      In the foreseeable future, it looks like they are focused on genetic hearing loss. Of note, the company has apparently invented their own new surgical approach to get their drug into the cochlea uniformly (has to be done surgically with AAV drugs). Though the specifics were confusing because it sounded like he said it was an Oval window approach, then said Round Window but I believe he misspoke the second time and he meant Oval Window because he described moving the stapes footplate in the approach.

      It was an interesting talk and I think the company will do well even if it's not directly applicable to most of us in the immediate future. It's obviously good to have more of this research in general, both for the millions who suffer genetic hearing loss, and because the tech may have broader applications. E.g.. The flat epithelia problem of profound long term hearing loss might be improved with something like AAV transduction (which Akouous sounds like they are leaders on) of remaining cell populations (fibroblasts). That's pretty long term though.
       
      • Informative Informative x 1
    14. Thuan

      Thuan Member

      Location:
      California
      Tinnitus Since:
      05/2018
      Cause of Tinnitus:
      Ear infection
      I haven't watched the webcast. Forgot about it. But, can you explain why this is a novel approach? Why can't we just use a needle to inject the drug to the round window (without structural compromise of and around the stapes in the oval window) and allow the drug to diffuse naturally in the cochlear medium?

      I have always thought that if the drug is effective but the mechanism of delivery is the bottle neck, then there is always a surgical option, albeit quite invasive, to directly inject into the cochlea.
       
    15. tommyd87

      tommyd87 Member

      Tinnitus Since:
      1999
      Cause of Tinnitus:
      tmj music
      There
      There is a newsletter you can sign up to on their website too which they release each quarter.

      6C526BAA-2A01-461C-AEE1-B9864EE12178.png

      The above image is a screenshot of their various planned treatments and their current position.

      While obviously they are currently focused on genetic conditions, it is clear that they have made some progress in all aspects that they are looking to treat.

      I would be interested in learning whether some of their treatments might overlap and actually treat multiple conditions. Eg whether you could use the autosomal dominant disorder treatment as a substitute for the hair cell treatment or similar.
       
    16. FGG
      No Mood

      FGG Member Podcast Patron Benefactor Hall of Fame Advocate

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Multi-factorial
      Briefly, the difference is AAV is a viral vectored therapy and it needs to be directly injected into to its target rather than diffusing in.
       
    17. wwtsai

      wwtsai Member Podcast Patron Benefactor

      Tinnitus Since:
      2016
      Cause of Tinnitus:
      SNHL
      Akouos provided their 3Q 2020 financial results and some updates. Probably the most notable update is:

      "Continued progress towards IND filing in 2021 to enable a Phase 1/2 clinical trial for AK-OTOF, a gene therapy intended for the treatment of hearing loss due to mutations in the OTOF gene – Through a targeted delivery of a proprietary ancestral AAV, known as AAVAnc80, containing the OTOF gene, Akouos aims to restore otoferlin expression, potentially restoring physiologic hearing and providing long-lasting benefits to individuals with OTOF-mediated hearing loss. Akouos plans to submit an IND application to the FDA in 2021 to conduct a Phase 1/2 clinical trial. The planned Phase 1/2 clinical trial consists of two parts. The first part is a dose escalation phase designed to assess the safety, tolerability and bioactivity of AK-OTOF, administered to trial participants through a single unilateral intracochlear injection. The second part is a cohort expansion phase designed to assess safety and efficacy."
      Source: https://investors.akouos.com/news-r...d-quarter-2020-financial-results-and-provides
       
      • Like Like x 4
      • Informative Informative x 1

Share This Page

Loading...