Antidepressants (SSRIs, SNRIs, MAOs, TCAs, TeCAs)

Discussion in 'Treatments' started by Pat, May 10, 2012.

    1. PeanutButter

      PeanutButter Member

      Tinnitus Since:
      03/2021
      Cause of Tinnitus:
      Pristiq (desvenlafaxine)
      That terrible drug gave me tinnitus after I took 50 mg for 24 days. I immediately stopped taking it because I hated it in the first place, and didn't like my head buzzing.

      Now 7 MONTHS OFF I still have tinnitus and it has not changed, I am worried it is permanent, and I cannot deal with it for the rest of my life. I get headaches everyday because of stress and anxiety, and I'm sure that drug killed a lot of brain cells, including the inner ear hair cells, which is probably why I HAVE TINNITUS FOR 7 MONTHS.

      God please, why did I take that drug, It ruined my life, I hate tinnitus.
       
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    2. apple core

      apple core Member

      Location:
      Milwaukee, Wisconsin, USA
      Tinnitus Since:
      12/2020
      Cause of Tinnitus:
      most likely noise
      Hi. I did a slow taper off of the Sertraline/Zoloft this past spring/summer and by mid-July was off. I replaced it with Mirtazapine.

      To spare a long story - by October of this year my anxiety was through the roof, tinnitus would spike to extreme high pitch levels, and I decided I needed to get back on the Zoloft. I'm back to 150 mg per day. I no longer have panic attacks since getting back on.
       
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    3. slc

      slc Member

      Tinnitus Since:
      04/2011
      Watch out for Trazodone. I'm pretty sure it is ototoxic and causes tinnitus, at least as one stops using it. I was prescribed it after a hip replacement, and between the Oxycodone, Ibuprofen, Trazodone and a load of other stuff, it was hell clearing out my system.

      (Note: I already take 1 mg of Klonopin, 300 mg of Gabapentin, and 30 mg of Celexa for tinnitus. There are times when this combo is helpful but right now, after having been on my Valley of the Dolls post-op drug fiesta trip, not so helpful.)

      By the way, avoid Oxycodone at all costs if possible. I built up a tolerance after 10 days and went through 2 plus weeks of nasty withdrawal -- that's off topic in terms of tinnitus but if Oxycodone is prescribed, try to find an alternative, even if it's just Tylenol.
       
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    4. Uklawyer

      Uklawyer Member

      Tinnitus Since:
      03/2020
      Cause of Tinnitus:
      Medication - antidepressants
      I wonder if anyone has taken antidepressants and has, once they have kicked in, totally turned around their view of it - i.e. they stop thinking about, or noticing it, so much, and start habituating and generally stop giving a shit about it. Like a Success Story: "Antidepressants were the answer".

      My mood gets better with them in general, but awareness of the tinnitus just drags me back down again.
       
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    5. JimmyR

      JimmyR Member

      Tinnitus Since:
      07/2010
      Cause of Tinnitus:
      sinus infection
      Amitriptyline: Two weeks ago my ENT gave me low-dose (10 mg/day) Amitriptyline (to be taken a bit before bedtime) because it has helped some of his patients. After three days my tinnitus went to near zero and has stayed there. I'm going to talk to my ENT about perhaps reducing the dose a bit, just so that I can take as little as needed. He did say that after six months of usage, if I stop taking it, I will likely have trouble sleeping.

      I'm trying not to get excited about this because my tinnitus has subsided quite a few times in the past and stayed gone for days or even weeks. But I am slightly giddy. It seems too much of a coincidence that the tinnitus would have vanished right at this time. Still, it's possible. So, I will need about two months before I say, yes, I've been cured (at least for the moment, knock wood.)

      I understand that Amitriptyline has been reported by some people to have caused tinnitus, as well as to have alleviated it, depending on the person. So, I assume that anyone trying this risks having their tinnitus get worse.

      Anyone have any recent good experience with Amitriptyline? (I see the past posts on it.)
       
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    6. JimmyR

      JimmyR Member

      Tinnitus Since:
      07/2010
      Cause of Tinnitus:
      sinus infection
      Update on my post above. I would love to hear any feedback from anyone having similar experience with anticholinergics, in particular Diphenhydramine and Amitriptyline.

      I had neglected to mention that I was using Diphenhydramine, too, along with the new addition of Amitriptyline. Elated with the performance of Amitriptyline, I dropped my Diphenhydramine. The tinnitus came back. So, now I'm back on both. This seems good. Time will tell.

      To be clear: I have been using Diphenhydramine, 10 to 12 mg, at bedtime. (I use the syrup marketed as a sleep aid. A "dose" is 50 mg. I drink about 1/5 or 1/4th of a dose.) It has helped a lot, but not reliably. I've been using it most nights for about six months. It usually gives me a good day the next day, sometimes not, and sometimes an excellent day.

      My ENT suggested Amitriptyline two weeks ago. Adding that to the Diphenhydramine gave me three excellent days in a row (tinnitus near zero) so I got a bit excited. Dropped the Diphenhydramine. Had a bad day of tinnitus, not the worst, but bad.

      So, I'm trying a bedtime cocktail of both drugs at bedtime now. Both of these are at low doses, with the Amitriptyline at 10 mg. I can tell I am being sedated by the Amitriptyline. In the event this is a successful cocktail (after a couple months of test), I'd like to lower the Amitriptyline to 7.5 mg, probably by breaking the tiny pills up. Would like to lower the Diphenhydramine dosage. Goal would be very low dose of both and tinnitus near zero.

      These are anticholinergics. They are said to be associated with dementia. My ENT doesn't place a lot of weight on that for people who aren't tending toward dementia, anyway. Who knows. If I knew that I'd get dementia in my old age from these drugs, it wouldn't faze me. I would still take them if they keep working. It would be worth it. Anyway, at low dose, I'm thinking they won't do too much damage. My ENT said the goal would be to go off them after the brain gets used to not having tinnitus.

      It's possible that it was simply the increased level of anticholinergics in my blood that caused the excellent three days in a row, and that doubling my Diphenhydramine would have done the same thing. But I feel the sedative effect of the Amitriptyline is different from the "sleepy" effect of the Diphenhydramine and so there is a cocktail effect. A simple experiment would tell the tale: Go off Amitriptyline and double my dose of Diphenhydramine for a while.

      My background: no other health issues. No depression. In great physical shape. Great blood work. 56 years old. Tinnitus in left ear from bad sinus infection on the left side ten years ago. Meditation has helped a lot but it is difficult to keep to that schedule, a constant fight of 20 minutes meditation, three times a day, fighting tinnitus. When you get ahead of the tinnitus, you slack off and back off the meditation, and the tinnitus gets bad again. It's grueling. So, I'm reaching for meds. Had MRI (clean), CTA scan for pulsatile tinnitus (negative), nasal endoscopy. Only thing I haven't had is a CT scan of sinuses which ENT has offered. Haven't tried CBT.

      I'd say that my tinnitus ranges from zero to 6 on a scale of zero to 10, where 6 means "life is still worth living but not by a large margin." I totally understand what it must be like to have tinnitus at 7 to 10. If you have tinnitus at 7 to 10, my heart goes out to you. I get it.
       
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    7. Lane

      Lane Member Hall of Fame

      Tinnitus Since:
      02/2018
      Cause of Tinnitus:
      Single 25 mg dose of (anticholinergic) drug Promethazine
      Hi @JimmyR -- I've discovered that silently singing a spiritual mantra at night before sleeping usually calms down my tinnitus (to a degree) in a matter of minutes. In case you're interested, I described this in a couple of different posts.

      Post 1 -- Post 2

      Take care...
       
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    8. Hottopic29

      Hottopic29 Member Benefactor

      Location:
      Niagara falls
      Tinnitus Since:
      11/2013
      Cause of Tinnitus:
      Zithromycin acoustic trauma 2022
      Is there an SSRI that won't permanently increase my acoustic trauma induced tinnitus? I might try something.
       
    9. FlatDarkEarth

      FlatDarkEarth Member

      Location:
      Tennessee
      Tinnitus Since:
      2017
      Cause of Tinnitus:
      Concert (2017)
      I'm really curious on this, too. I would like to try an anti-depressant but it seems every one has someone saying it makes tinnitus worse.

      I took Prozac on and off throughout my life and never felt I developed anything from it pre-tinnitus, but at this point I'm a little scared to take it again.
       
    10. ZFire
      Tired

      ZFire Member Podcast Patron Benefactor Hall of Fame

      Tinnitus Since:
      2012 (mild) & 04/2021 (severe)
      Cause of Tinnitus:
      Ototoxicity (2012) Unknown-likely noise induce (2021)
      I have been on Nortriptyline 50 mg since August 2021. The first antidepressant I’ve ever taken.

      - No noticeable effects on tinnitus
      - Reduced my intense migraines to almost zero
      - Helps with anxiety, sleep,
      - My loudness hyperacusis has slowly gotten better over time, although I can’t attribute that to Nortriptyline as I’m sure time played a bigger role along with gradual sound exposure.

      There’s also a possibility that it may have provided marginal relief for burning pain in the ear that I was experiencing during onset. I swear the weeks prior to Nortriptyline, I was dealing with burning sensations after moderate to loud noise exposure. The burning went away after a week of Nortriptyline usage. I can’t say for sure if it was the Nortriptyline because I had so much stuff happening, I couldn’t keep track of all my symptoms at the time. The immediate ear discomfort from sounds was still prevalent though.

      My psych thinks the Nortriptyline may be alleviating the hyperacusis to a degree because of its properties to treat neuropathic pain. I do recall reading how some neurologists believe there’s a possible link between hyperacusis and migraines. My reasons for taking it were largely for the migraines, depression, and anxiety but on the off chance it could also help with the ear stuff, it would be an added bonus.
       
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    11. JimmyR

      JimmyR Member

      Tinnitus Since:
      07/2010
      Cause of Tinnitus:
      sinus infection
      I'm ending my trial (described above) of this cocktail: Amitriptyline (10 mg) + Diphenhydramine (12 mg) nightly. It kept my tinnitus a little lower than just the Diphenhydramine alone did. But I didn't like the feeling of being slightly drugged. I discovered that the Amitriptyline alone doesn't work for me but along with Diphenhyrdramine, the cocktail is better than the Diphenhydramine alone. However, it's not worth it. The increased efficacy, though considerable, was too slight to be worth the slightly "drugged" feeling.

      (I am keeping on with 12 mg Diphenhydramine nightly because it works. But I want to get off of it eventually.)
       
    12. Rockman

      Rockman Member Benefactor

      Location:
      MN
      Tinnitus Since:
      1/2021
      Cause of Tinnitus:
      Noise, allergy
      I've been on 30 mg of Mirtazapine for a year now and my ear discomfort and hyperacusis haven't gotten much better. I'm going to start Nortriptyline tonight and see how it goes.
       
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    13. Uklawyer

      Uklawyer Member

      Tinnitus Since:
      03/2020
      Cause of Tinnitus:
      Medication - antidepressants
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    14. spedgas
      Gloomy

      spedgas Member Benefactor

      Tinnitus Since:
      09/2018
      Cause of Tinnitus:
      Unknown
      I’d be curious to hear about how the Nortriptyline goes for you. I’ve had it prescribed to me several times and haven’t had the bravery to try it out.
       
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    15. Rockman

      Rockman Member Benefactor

      Location:
      MN
      Tinnitus Since:
      1/2021
      Cause of Tinnitus:
      Noise, allergy
      Well after the first night of Nortriptyline. Within 20 minutes of taking it I was ready for bed. But I had a hard time falling asleep and staying asleep. Felt really out of it today. It's probably from switching from one AD to another and I need to adjust.
       
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    16. Wrfortiscue
      Cowabunga

      Wrfortiscue Member Benefactor Hall of Fame

      Tinnitus Since:
      1999
      Cause of Tinnitus:
      Trauma
      It most likely is.
       
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    17. Gb3

      Gb3 Member

      Tinnitus Since:
      12/19
      Cause of Tinnitus:
      Sshl
      Ya definitely. I remember when I first started Lexapro. Couldn’t sleep, anxious off the charts. I would say that is normal.
       
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    18. JimmyR

      JimmyR Member

      Tinnitus Since:
      07/2010
      Cause of Tinnitus:
      sinus infection
      Just a follow up on my post above of a couple months ago.

      I believe Amitriptyline helped. Now, long after the month or so that I was on it (10 mg with 12 mg Diphenhydramine nightly), my tinnitus is consistently lower in volume on average than before, and it doesn't spike to the high volumes that it did before the Amitriptyline. I still use Diphenhydramine, about 10 mg/night. I might even try another month of Amitriptyline, as I still have a bottle of it. I still want to go off Diphenhydramine. Will get around to it.
       
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    19. Rockman

      Rockman Member Benefactor

      Location:
      MN
      Tinnitus Since:
      1/2021
      Cause of Tinnitus:
      Noise, allergy
      Just an update after the first week of Nortriptyline. Tinnitus is the same, first couple of nights were tough, I got sweaty and was extremely tired but couldn't sleep. Now it's leveled out. I'm on 25 mg and supposed to up it to 50 mg after the first week.
       
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    20. TheDanishGirl
      Sad

      TheDanishGirl Member Benefactor Hall of Fame

      Location:
      Denmark
      Tinnitus Since:
      05/2017 (H since 06/2017)
      Cause of Tinnitus:
      long term noise exposure (headphones), maybe some stress.
      You just stopped Mirtazapine cold turkey?
       
    21. Rockman

      Rockman Member Benefactor

      Location:
      MN
      Tinnitus Since:
      1/2021
      Cause of Tinnitus:
      Noise, allergy
      Yes I did. Since what I switched to is similar, my psychologist said it should be safe.
       
    22. kingsfan
      Haunting

      kingsfan Member Benefactor Hall of Fame

      Location:
      Coolifornia
      Tinnitus Since:
      9-17-20 / 10-20-20 / 3-31-21 / 5-23-21
      Cause of Tinnitus:
      turning everything up to 11
      What did you start on? When I was taking it, my doctor had me start on 10 mg and increase 10 mg every 2 weeks until I hit 50 mg.
       
    23. Rockman

      Rockman Member Benefactor

      Location:
      MN
      Tinnitus Since:
      1/2021
      Cause of Tinnitus:
      Noise, allergy
      I started at 25 mg. Then after a week I'm on 50 mg now.
       
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    24. TheDanishGirl
      Sad

      TheDanishGirl Member Benefactor Hall of Fame

      Location:
      Denmark
      Tinnitus Since:
      05/2017 (H since 06/2017)
      Cause of Tinnitus:
      long term noise exposure (headphones), maybe some stress.
      I see. I really wish I could get off Mirtazapine myself. It's destroying me. Maybe I can switch to another AD. I am so wary of psych meds, but I believe that's the only slight chance I have of getting off Mirtazapine.

      Did you have many side effects on Mirtazapine? My personal belief is that the more side effects, the worse the withdrawal from it, and I have so many side effects on Mirtazapine.
       
    25. Rockman

      Rockman Member Benefactor

      Location:
      MN
      Tinnitus Since:
      1/2021
      Cause of Tinnitus:
      Noise, allergy
      The first week I was really drowsy and probably gained 20 lbs.
       
    26. TheDanishGirl
      Sad

      TheDanishGirl Member Benefactor Hall of Fame

      Location:
      Denmark
      Tinnitus Since:
      05/2017 (H since 06/2017)
      Cause of Tinnitus:
      long term noise exposure (headphones), maybe some stress.
      I have so many side effects, but oddly weight gain was never one of them (and I could use the weight). I think I am bound to have more withdrawal than you, even if I switch to another AD.
       
    27. Rockman

      Rockman Member Benefactor

      Location:
      MN
      Tinnitus Since:
      1/2021
      Cause of Tinnitus:
      Noise, allergy
      How long have you been on Mirtazapine? Maybe it is time to try something else.
       
    28. TheDanishGirl
      Sad

      TheDanishGirl Member Benefactor Hall of Fame

      Location:
      Denmark
      Tinnitus Since:
      05/2017 (H since 06/2017)
      Cause of Tinnitus:
      long term noise exposure (headphones), maybe some stress.
      Almost 5 years. I tried to taper just 3% recently, but it still gave me bad unacceptable withdrawal symptoms, worst of all some bodily tremors that haven't gotten better 4 weeks after I gave up on my taper and went back to my normal dose. These tremors are awful.
       
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    29. Rockman

      Rockman Member Benefactor

      Location:
      MN
      Tinnitus Since:
      1/2021
      Cause of Tinnitus:
      Noise, allergy
      @TheDanishGirl, I really wish something would help you out. The Nortriptyline was a little bit of a battle for a couple of nights but has leveled out.
       
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    30. ZFire
      Tired

      ZFire Member Podcast Patron Benefactor Hall of Fame

      Tinnitus Since:
      2012 (mild) & 04/2021 (severe)
      Cause of Tinnitus:
      Ototoxicity (2012) Unknown-likely noise induce (2021)
      I started at 25 mg too and made it up to 50 mg the following week. Have stayed at 50 mg since.
       
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