Frequency Therapeutics — Hearing Loss Regeneration

Discussion in 'Research News' started by RB2014, Dec 8, 2016.

    1. JohnAdams
      In love

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Nasty Swamp
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      The fact that you even tried is very admirable.
       
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    2. Flamingo1

      Flamingo1 Member Benefactor

      Location:
      Orlando, FL
      Tinnitus Since:
      4-15-2017
      Cause of Tinnitus:
      Acoustic trauma
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    3. Badger19

      Badger19 Member

      Tinnitus Since:
      2012
      Cause of Tinnitus:
      NIHL
      Let's hope all goes well despite the bad timing.
       
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    4. Jurger

      Jurger Member

      Tinnitus Since:
      2004
      Cause of Tinnitus:
      Hearing loss
      Their website now says (on the page ‘Hearing program’) that the Phase 1/2 trial also showed improved clarity of sound, aside from improved word recognition. This is new information right?
       
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    5. Badger19

      Badger19 Member

      Tinnitus Since:
      2012
      Cause of Tinnitus:
      NIHL
    6. John Queen

      John Queen Member

      Tinnitus Since:
      2001
      Cause of Tinnitus:
      Unknown
      Nope, they will start Phase 2a this year and report the results in 2H2020 (at least that's what they anticipate). After this, if everything goes as planned, they will probably Fast Track it or will receive some other FDA drug status to speed up the process. Anyway, at the end of 2020 we should know what the drug is able to do.

      Also, there's the possibility that Astellas would also start clinical trials in other countries, and that might bring the drug to the market faster, although there's no official announcement regarding this.
       
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    7. Jomo

      Jomo Member

      Tinnitus Since:
      9/4/16
      Cause of Tinnitus:
      going for a rim shot on the snare drum.
      I have been out of the loop on this for a while and was reading through past posts to see what's going on... so thrilled they are public company now... we may be able to make some money off of our misery now lol, with that being said...

      Could someone correct me if I am wrong, but from what I have read the clinical trials have had decent success with improving word recognition, nothing else, but they are going to continue with a new trial this quarter?
       
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    8. john paul
      English

      john paul Member

      Tinnitus Since:
      11/11/17
      Cause of Tinnitus:
      acoustic trauma
      $13.64 right now, a nice start. Can't find the market cap though?
       
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    9. ChrisBoyMonkey

      ChrisBoyMonkey Member Podcast Patron

      Location:
      CA
      Tinnitus Since:
      04/2019
      Cause of Tinnitus:
      U.S. Army/Field Artillery Veteran
      That's what they have said. The amount they used for the phase I was tiny, it was supposed to be only for proving safety. What was awesome is that they saw it was already improving the recipient's hearing, even with just that small dose.
       
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    10. d'Wooluf

      d'Wooluf Member

      Tinnitus Since:
      2010
      Cause of Tinnitus:
      unknown
      Interesting choice of words. I thought at first that it was a meaningless word they'd chosen for marketing effect (which may still be true), but Harris's Principles of Internal Medicine has this:

      "Damage to the brain can lead to a central deafness. The peripheral ear and the auditory nerve may function well but the central connections are damaged by tumour, trauma or other disease and the patient is unable to hear. Primary diseases of the central nervous system can present with hearing impairment. Characteristically, a reduction in clarity of hearing and speech comprehension is much greater than the loss of the ability to hear pure tone. Auditory testing shows normal otoacoustic emissions (OAE) and an abnormal auditory brainstem response (ABR)."
       
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    11. Flamingo1

      Flamingo1 Member Benefactor

      Location:
      Orlando, FL
      Tinnitus Since:
      4-15-2017
      Cause of Tinnitus:
      Acoustic trauma
      I bought 500 shares. Will buy more tomorrow depending on the price.
       
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    12. ChrisBoyMonkey

      ChrisBoyMonkey Member Podcast Patron

      Location:
      CA
      Tinnitus Since:
      04/2019
      Cause of Tinnitus:
      U.S. Army/Field Artillery Veteran
      Dang Flamingo Moneybags over here!
       
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    13. Flamingo1

      Flamingo1 Member Benefactor

      Location:
      Orlando, FL
      Tinnitus Since:
      4-15-2017
      Cause of Tinnitus:
      Acoustic trauma
      I just as well may lose it bro' if Frequency doesn't come through!
       
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    14. Jurger

      Jurger Member

      Tinnitus Since:
      2004
      Cause of Tinnitus:
      Hearing loss
      Bob Langer originally said that ideally “one or two injections” would do the trick. We’re now talking about doubling or quadrupling that for phase IIa. I’m curious as well, but this is still a downgrade from what they thought of originally.

      We have to be cautious about being too optimistic here. There’s still almost no evidence that this drug restores hearing in the 0-8000 Hz frequencies. All we have is 4 out of 16 patients that got the drug that improved 10 dB at 8000 Hz. Promising, yes, but they have plenty of work ahead of them, possibly having to switch to a different delivery method.
       
    15. Rb86

      Rb86 Member

      Tinnitus Since:
      5/31/19
      Cause of Tinnitus:
      Noise
      No shit!
       
    16. Pawel1
      Sheepish

      Pawel1 Member

      Tinnitus Since:
      January 2016
      Cause of Tinnitus:
      Loud Music
      Could someone explain in a few words, how to read the sock of this company, to see whether its potential is increasing or decreasing?

      https://www.marketwatch.com/investing/stock/FREQ
      Does rising price of the share, mean that people are interested in investing into this company?
      Why can't I find anywhere, that Flamingo bought 500 shares? Obviously this is good for the company, but I can't see any figures about the invested money.
       
    17. Gorbeh3

      Gorbeh3 Member

      Tinnitus Since:
      2012
      Cause of Tinnitus:
      Hearing Loss
      Am I misinformed? Because I believe this is a lie. The first round of IPO is only available to major institutions, Goldman, Morgan Stanley, etc.
       
    18. lymebite
      Vegged out

      lymebite Member Podcast Patron Benefactor

      Location:
      United States
      Tinnitus Since:
      2013
      Cause of Tinnitus:
      Unknown
      Click this link below and you may see the stock of Frequency Therapeutics being traded in real time on the public stock market. Anyone may purchase shares if they wish.

      I followed the example of @Flamingo1 and purchased 100 shares. Maybe I will get rich if FX-322 is a big success.

      http://bigcharts.marketwatch.com/quickchart/quickchart.asp?symb=freq
       
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    19. FGG

      FGG Member Podcast Patron Benefactor

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Multi-factorial
      Rising shares means people are interested.

      With small cap biotechs, it can be manipulated a little more easily though, so be cautious about just reading the current stock price (i.e. the "big guns" in the market can artificially inflate or deflate value to write calls or puts or let them expire worthless).

      A stock price over a longer period of time (months to years) is a better indicator of the value of a company imo as sort term to near long term a lot can be messed with.

      You also have to look at volume and the health of the market as a whole. Swings on bigger volume mean a lot more.
       
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    20. Jomo

      Jomo Member

      Tinnitus Since:
      9/4/16
      Cause of Tinnitus:
      going for a rim shot on the snare drum.
      I bought 50 shares... Best advice is don't be a pig and buy big...

      If the stock goes down you can buy more and your average cost is even less...

      If it goes up that's great but your average cost will still be less than what it is currently trading at.
       
    21. ChrisBoyMonkey

      ChrisBoyMonkey Member Podcast Patron

      Location:
      CA
      Tinnitus Since:
      04/2019
      Cause of Tinnitus:
      U.S. Army/Field Artillery Veteran
      True true. Generally, one shouldn't invest what one can't afford to lose.
       
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    22. AUTHOR
      AUTHOR
      RB2014
      Confused

      RB2014 Member Benefactor

      Location:
      US
      Tinnitus Since:
      12/2014 became noticable
      Cause of Tinnitus:
      Loss of hearing and then stress and anxiety
      No one has made money on the stock yet unless they got it for free and sold. Started at $14 and went down to $11.8 the first day. It's at $13.49 as of today though so it did bounce back. I can't see the stock going up unless they post some really good news.

      I wonder if people bought in the initial offering thinking it would skyrocket on day one trying to make a quick buck and when they saw it going down just sold right away.

      Does anyone know if any of the investors were awarded stock that they might have sold right away?
       
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    23. Flamingo1

      Flamingo1 Member Benefactor

      Location:
      Orlando, FL
      Tinnitus Since:
      4-15-2017
      Cause of Tinnitus:
      Acoustic trauma
      I bought through TD Ameritrade.
       
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    24. Greg Sacramento

      Greg Sacramento Member Benefactor Hall of Fame

      Tinnitus Since:
      April 2011
      Cause of Tinnitus:
      syringing and now somatic T dental work
    25. john paul
      English

      john paul Member

      Tinnitus Since:
      11/11/17
      Cause of Tinnitus:
      acoustic trauma
      How did you go about buying the shares?
       
    26. john paul
      English

      john paul Member

      Tinnitus Since:
      11/11/17
      Cause of Tinnitus:
      acoustic trauma
      Is this for US customers only?
       
    27. Flamingo1

      Flamingo1 Member Benefactor

      Location:
      Orlando, FL
      Tinnitus Since:
      4-15-2017
      Cause of Tinnitus:
      Acoustic trauma
      In the US, FREQ is available on the NASDAQ Global Select Market. The best thing to do would be to contact a brokerage house in your country and ask them how to get access to that market and/or FREQ shares.
       
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    28. just1morething
      Benevolent

      just1morething Member Benefactor

      Location:
      U.S.
      Tinnitus Since:
      2008
      Cause of Tinnitus:
      barotrauma, noise exposure, TMJ, neck?
      I hope FREQ stock does better than EARS and OTIC as they both sold off dramatically. I don’t know if FREQ having a public stock offering is a good thing or bad thing? I just hope their IT injections work for tinnitus.
       
    29. JohnK
      Busy

      JohnK Member

      Location:
      London
      Tinnitus Since:
      10/26/2015 (habituated) 5/13/2019
      Cause of Tinnitus:
      Doxycycline (2015) Otimize ear drops [neomycin] (2019)
      But hey, 8000 Hz and above solves a lot of people's problems.
       
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    30. JohnAdams
      In love

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Nasty Swamp
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      The Audion drug for the Regain project is essentially the exact same technology. It has been reported that a trial participant for that drug did in fact have their tinnitus and hyperacusis reduced. Hearing aids make many people's tinnitus go down or away entirely. If this does in fact improved hearing, the evidence is overwhelming that it will help.
       
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