Frequency Therapeutics — Hearing Loss Regeneration

Discussion in 'Research News' started by RB2014, Dec 8, 2016.

    1. Tweedleman

      Tweedleman Member Benefactor

      Tinnitus Since:
      2001
      Cause of Tinnitus:
      Unknown/Noise
      I'm not sure what the protocol is. I don't imagine them being obligated to make any announcements other than informing the trial participants and those directly involved of postponings.
       
    2. AtlasFainted

      AtlasFainted Member Podcast Patron

      Tinnitus Since:
      12/19
      Cause of Tinnitus:
      Noise Exposure + Viral Infection
      Yeah it just seems like they would at least send something out on Twitter. But who knows.
       
    3. Tweedleman

      Tweedleman Member Benefactor

      Tinnitus Since:
      2001
      Cause of Tinnitus:
      Unknown/Noise
      It would be nice of them, so I could add time to my cryosleep accordingly.
       
      • Funny Funny x 2
    4. FGG
      No Mood

      FGG Member Podcast Patron Benefactor Hall of Fame Advocate

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Multi-factorial
      • Informative Informative x 9
      • Like Like x 1
    5. serendipity1996

      serendipity1996 Member

      Tinnitus Since:
      2011
      Cause of Tinnitus:
      Unknown but suspect noise-induced
      Anyone know if this will have any impact on the Audion Regain results coming out at the end of April?
       
    6. FGG
      No Mood

      FGG Member Podcast Patron Benefactor Hall of Fame Advocate

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Multi-factorial
      I doubt it as their trial is completed and they just need to release their results.
       
      • Like Like x 1
    7. AtlasFainted

      AtlasFainted Member Podcast Patron

      Tinnitus Since:
      12/19
      Cause of Tinnitus:
      Noise Exposure + Viral Infection
      Just finished reading the article, I take this as really good news, or at least the best we can expect.

      They basically said that they think they can still hit their key objectives for phase 2a with less enrollment, but can't give an estimate on when results will get out since it is unknown what the future impact of COVID-19 will be.

      It seems like, as of now, it hasn't stopped them.
       
      • Like Like x 10
    8. erhar

      erhar Member

      Location:
      Netherlands
      Tinnitus Since:
      20-3-2020
      Cause of Tinnitus:
      Loud noise
      Let's say that your tinnitus comes from your brain, caused by hyperactive neurons, how could regenerating your hair cells undo the problem?
       
      • Good Question Good Question x 4
    9. Jorge1984
      Wishful

      Jorge1984 Member

      Tinnitus Since:
      02/2020
      Cause of Tinnitus:
      Loud music
      What are Audion Regain doing? And what phase are they in?
       
    10. AfroSnowman
      Balanced

      AfroSnowman Member Podcast Patron Benefactor

      Tinnitus Since:
      April 16 2019
      Cause of Tinnitus:
      Unknown, viral?
      Perhaps the lack of the input of the hair cells create the hyperactivity (think of the non-t person who experiences t in a silent room). Though I don't don't know the source of the stats that ~40% of the people with hearing aid experience reduced tinnitus. This is often pointed to as a real world example of how increased stimuli can decrease perception of tinnitus.
       
      • Agree Agree x 2
    11. FGG
      No Mood

      FGG Member Podcast Patron Benefactor Hall of Fame Advocate

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Multi-factorial
      It doesn't make sense that neuroplasticity would only work one way and be "stuck". The brain doesn't have preferences. Reversing the cause should reverse maladaptive plasticity just like mirror therapy treats maladaptive plasticity with phantom limb pain.

      Now if tinnitus is from a direct head injury, then yes treating the cochlea won't help.
       
      • Agree Agree x 5
      • Like Like x 2
      • Genius Genius x 1
    12. FGG
      No Mood

      FGG Member Podcast Patron Benefactor Hall of Fame Advocate

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Multi-factorial
      • Agree Agree x 1
      • Helpful Helpful x 1
    13. UKBloke

      UKBloke Member Podcast Patron Benefactor

      Tinnitus Since:
      1991
      Cause of Tinnitus:
      Loud Music / family history
      Was watching some more stuff with Ramachandran and it seems they're also using mirror therapy to try and rehabilitate stroke patients. If that is the case, and if I understand correctly stroke causes some physical damage to the brain, then maybe the brain is capable of rewiring itself around the harm. Been trying for the life of me but can't think up a low-tech mirror box solution for tinnitus.
       
      • Like Like x 1
    14. Momme

      Momme Member

      Tinnitus Since:
      2018
      Cause of Tinnitus:
      Loud noise?
      Is FX-322 going to help against presbycusis?
       
      • Good Question Good Question x 1
    15. Sevv

      Sevv Member Benefactor

      Tinnitus Since:
      12.04.2019
      Cause of Tinnitus:
      Loud concert
      I don't see a reason why it wouldn't. It regenerates hair cells, no matter what the cause. Of course, you still might have to treat hidden hearing loss.
       
      • Like Like x 1
      • Agree Agree x 1
    16. MrCrybaby

      MrCrybaby Member Benefactor

      Tinnitus Since:
      2014, 10/2019
      Cause of Tinnitus:
      School Band, Acoustic Trauma
      Presbycusis is a form of sensorineural hearing loss, which is the primary target of this drug.
       
      • Like Like x 2
    17. Ben S
      Curious

      Ben S Member

      Location:
      Connecticut
      Tinnitus Since:
      11/2015
      I hope that FX-322 can be approved for Expanded Access. This would be fantastic for all of us if it happens. Maybe this could be another question for Frequency Therapeutics during the the Tinnitus Talk Podcast.
       
      • Agree Agree x 3
    18. Tweedleman

      Tweedleman Member Benefactor

      Tinnitus Since:
      2001
      Cause of Tinnitus:
      Unknown/Noise
      Ya I think we see this in effect when normies go to concerts and come out with their ears ringing (tinnitus) due to temporary threshold shift. The ringing goes away once their hair cells "recover" over the next 48 hours or so.
       
      • Agree Agree x 1
    19. FGG
      No Mood

      FGG Member Podcast Patron Benefactor Hall of Fame Advocate

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Multi-factorial
      FYI expanded access is already legal in the US but Frequency says on their website they aren't scaled up production wise to meet the demand so they aren't granting it at this time.

      Whether that could change at any point will be asked, however.
       
      • Like Like x 1
      • Informative Informative x 1
    20. Jorge1984
      Wishful

      Jorge1984 Member

      Tinnitus Since:
      02/2020
      Cause of Tinnitus:
      Loud music
      I swear once I get FX-322 I'm going to take care of my ears like they are my children. I’m not going to make the same mistakes.
       
      • Agree Agree x 9
      • Like Like x 3
      • Optimistic Optimistic x 1
    21. AtlasFainted

      AtlasFainted Member Podcast Patron

      Tinnitus Since:
      12/19
      Cause of Tinnitus:
      Noise Exposure + Viral Infection
      I was thinking about this today.

      I already have some earplugs on my keyring that let sound in up to a certain level; just incase I end up somewhere unexpectedly loud such as really loud bars, or those mariachi bands that will show up at Mexican restaurants and deafen the whole place.

      I don't think I'll ever stop listening to music at a somewhat loud level in my car & around the house, it's the only way I really enjoy it...

      Firearms are also super present in my family, so I'll be doubling up (earplugs & muffs) any time I shoot in the future.

      I know my hearing issues aren't as bad as some others here, but I want this drug to be out so badly. I'm just sick of electric buzzing that never goes away. Everytime I think I'm getting used to it, it comes full circle and bothers me even more.

      This COVID-19 stuff makes me nervous too; but a silver lining is that (allegedly) the FDA will be changing their process soon so that drugs can get approved in months, not years.
       
      • Agree Agree x 3
    22. Jack V

      Jack V Member Benefactor

      Tinnitus Since:
      1/2020
      Cause of Tinnitus:
      Something Wicked This Way Comes
      I doubt any of us fully understood the risk we were taking when we damaged our hearing.

      I didn't. :dunno:

      Ear ringing sounds trivial, and is trivial, when it goes away.

      But the idea that ear ringing could turn on and not turn off, that your ears could scream at you all day and all night, was inconceivable to me before I experienced it.

      Hard to imagine any of us making the same mistake again if given a 2nd chance.
       
      • Agree Agree x 9
    23. AtlasFainted

      AtlasFainted Member Podcast Patron

      Tinnitus Since:
      12/19
      Cause of Tinnitus:
      Noise Exposure + Viral Infection
      I also want to add that I am so excited to be able to use drugs occasionally again.

      As of right now, anytime I get stoned or drunk, it seems to make the ringing worse.

      Then I get paranoid about it, which ruins the whole experience. Being totally sober at 24 is torture.
       
      • Agree Agree x 2
      • Hug Hug x 1
    24. aot
      Artistic

      aot Member

      Location:
      USA
      Tinnitus Since:
      2016. Worsened 11/2019
      Cause of Tinnitus:
      Probably sound induced.
      I just want to be able to see a movie in a theatre. Take a cute girl out, eat some popcorn. A part of me wants to try with ear plugs, but I'm too scared. (And all the theatres are closed now I guess.)
       
      • Like Like x 1
    25. Orions Pain
      Surrender

      Orions Pain Member Benefactor

      Tinnitus Since:
      2019
      Cause of Tinnitus:
      Noise damage
      What do you guys think will be the testing standard for those of us with tinnitus but no hearing loss on a standard audiogram? Will extended audiograms be utilized more?

      Seems like there are many of us on here who were told we have “perfect hearing” but we all know about hidden hearing loss.
       
      • Good Question Good Question x 2
    26. Jorge1984
      Wishful

      Jorge1984 Member

      Tinnitus Since:
      02/2020
      Cause of Tinnitus:
      Loud music
      I hope this is true and does happen because you have no clue how much I want to catch up on my sleep again.
       
      • Like Like x 1
    27. Jorge1984
      Wishful

      Jorge1984 Member

      Tinnitus Since:
      02/2020
      Cause of Tinnitus:
      Loud music
      I do have a feeling that FX-322 will work and will give us a second chance to live our lives in peace without the ringing.
       
      • Agree Agree x 3
      • Optimistic Optimistic x 3
      • Like Like x 1
      • Hug Hug x 1
    28. Philip83
      Jaded

      Philip83 Member Benefactor

      Location:
      Swede living in Austria
      Tinnitus Since:
      2001
      Cause of Tinnitus:
      Noise trauma from loud moped (2001) Noise blast (2014)
      Haha, best reason I heard so far to get rid of it. Really hardcore hangovers are actually when my tinnitus is the lowest, it’s super weird.
       
      • Like Like x 1
      • Funny Funny x 1
    29. AtlasFainted

      AtlasFainted Member Podcast Patron

      Tinnitus Since:
      12/19
      Cause of Tinnitus:
      Noise Exposure + Viral Infection
      I still go to movies (when they aren't closed down) and date girls haha. Personally I am really only concerned with abnormal amounts of noise, such as gunshots or indoor concerts.

      I'm not sure what the nature of your hearing problems are, but I try to live my normal life as much as possible. Not doing the things I used to do just makes me focus on the ringing more & then I get depressed as a result.
       
      • Like Like x 4
    30. AtlasFainted

      AtlasFainted Member Podcast Patron

      Tinnitus Since:
      12/19
      Cause of Tinnitus:
      Noise Exposure + Viral Infection
      I agree. Even if it doesn't fully resolve our tinnitus, I think for most of us it will reduce it drastically.

      Then it is just a matter of waiting for one of the synaptopathy drugs to hit the market for our ears to be fully regenerated (or at least damn close).
       
      • Like Like x 1
      • Agree Agree x 1

Share This Page

Loading...