Gabapentin (Neurontin)

Discussion in 'Treatments' started by Jeff M., Jan 17, 2014.

    1. Chinmoku

      Chinmoku Member Benefactor

      Tinnitus Since:
      10/2018
      Cause of Tinnitus:
      Unknown, possibly medication
      @linearb , I was thinking of you and wondering how you have been doing with the gabapentin reduction?
      On the pregabalin side, I dropped 25mg of pregabalin and the tinnitus went up a notch, plus my eye floaters became more prominent and I got restless leg type symptoms.
       
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    2. linearb
      Psychedelic

      linearb Member Benefactor Hall of Fame

      Location:
      destroy all creatures. they cannot be regenerated.
      Tinnitus Since:
      1999
      Cause of Tinnitus:
      karma
      @Chinmoku I had no problem getting down to about 300mg, but once I went lower, the really nasty "metallic, grating, piercing" aspect of my tinnitus started to rear up again. I am unsure if that is a withdrawal effect, but I'm a little skeptical because that "metallic, gating, piercing" sound was what drove me the most insane about this condition for the number of years I was unmedicated, so it does look to me at this point like there is some synergy for me between GabaP and Klonopin.

      I might try to tamp it down further again at some point, but, now back to ~400mg and feeling a lot more normal and thinking about tinnitus a lot less again... eh.... being on these drugs isn't great, but neither is being miserable all the time.

      I've also been through a sort of insanely stressful couple weeks as far as a serious health scare with our kid and then my own exposure to tetanus along with a bad bite from a probable lyme tick, causing two different antibiotics. So, I am sure all that piled on, and if I reduce again it will be a month or so down the line when I've got a 6-8 week period of things being a lot more relaxed.
       
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    3. Chinmoku

      Chinmoku Member Benefactor

      Tinnitus Since:
      10/2018
      Cause of Tinnitus:
      Unknown, possibly medication
      Whoa, you are a superhero @linearb. I read about your adventures with powered saws, motorbikes, snow, injuries, your kid (I hope she is well now) and I always wonder how on earth can this guy do all this stuff with tinnitus, visual snow etc when I struggle to get out of bed and get on a bus due to tinnitus, eye floaters and restless legs? I used to drive a motorcycle too pre-tinnitus, I hope I'll be able to drive again some day.

      I am trying to reduce pregabalin again but the metallic grating tinnitus is exactly what I get, at an insanely high frequency. I am very concerned about what pregabalin can do to me and my brain in the long run, but if I need to live the next 20-30 years miserably all the time I may have to make a different choice, I understand that, but I would like to make at least an attempt to get off and stay off for a while. Apparently, both gabapentin/pregabalin and clonazepam work on gaba but through different mechanisms, gabapentin/pregabalin do not work on gaba receptors directly. I can see why Schulman thinks there is a sinergy, but who knows what happens to our brains. However your experience is interesting, you can have a good life while on those meds. It makes me think.
       
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    4. Darktale

      Darktale Member

      Tinnitus Since:
      2010
      Cause of Tinnitus:
      Acoutstic Trauma
      Hi there,
      Even if it is my first message on Tinnitus Talk, I have been reading for quite a while now.
      I have tinnitus (+ mild hyperacusis) from an acoustic trauma 10 years ago + worsenings since then.

      After a recent spike making my tinnitus really bothering, an ENT specialized in tinnitus and hyperacusis in France prescribed me Gabapentin, saying he had strong results over the last years with a dosage of 300mg per day.

      I have also read the below study, not too old, which seems to show good performance of Gabapentin as well (even if very small sample)
      https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5380395/[/COLOR]

      The French Doctor said he has never encountered any tinnitus worsening with Gabapentin among hundreds of patients treated.

      But, I am now scared to start the Gabapentin after having read the Neil Bauman's website where he says it is known to have caused or worsen tinnitus with hundreds of people (reported to FDA).
      Gabapentin is also listed as inducing tinnitus in this list of ototoxic drugs that I am using the most.
      https://www.europeanreview.org/wp/wp-content/uploads/956.pdf

      But maybe not with that 300mg/day dosage???

      Now I do not know what to do anymore… I am frustrated not to start the Gabapentin having in mind it could maybe help even a bit… but I am so scared to possibly make my tinnitus worse...

      Is there really a chance that Gabapentin could make my tinnitus worse?
      Usually I have no or very little side effect when taking whatever drug so I am not very sensitive to the side effects... normally… but once would be enough...
       
    5. Kam75

      Kam75 Member

      Location:
      FRANCE
      Tinnitus Since:
      26/02/2019
      Cause of Tinnitus:
      Noise induced trauma
      Salut @Darktale.

      I assume that you saw Dr Timsit or Dr Fain, right?

      As far as I'm concerned, I also took 300 mg of Neurontin for 2 months and it did absolutely nothing to me unfortunately (nothing positive, nothing negative).
       
    6. alanisnotadj
      Batty

      alanisnotadj Member Benefactor

      Location:
      Germany
      Tinnitus Since:
      1992 (got much worse in 2018)
      Cause of Tinnitus:
      Loud noise exposure
      I have been using Gabapentin (200mg) for one month and the results are quite good for me. It was given to me by my neurologist to treat the pain in my hyperacusic ear (permanent pain /noxacusis).

      The pain has decreased a lot and I would say that it also helps with the tinnitus.
      I am also using Lenire so it might be a combination of both but even if it is early days I am very happy with Gabapentin so far. Let's see in a few months if it is still the case.

      The first 2 weeks with Gabapentin were a bit difficult though as it seemed to increase my pain and sound sensitivity but that changed for the best 2 weeks ago.

      Btw I was also supposed to see Dr Fain in March but because of the virus apocalypse my appointment has been postponed to July.
       
    7. Darktale

      Darktale Member

      Tinnitus Since:
      2010
      Cause of Tinnitus:
      Acoutstic Trauma
      Salut Kam75

      Indeed, it was Dr Fain.
      I am old enough in this Tinnitus "Market" (10 years) not to believe and take for granted all what he was saying but my recent spike makes me quite desperate...

      it is now bothering me when watching TV so difficult to enjoy watching TV Shows or movies at night...

      Actually, if Neurontin does nothing, it would still be ok for me... What I am afraid of is that it could worsen my tinnitus permanently.
      Dr Fain says with 200mg/day dosage there is no risk of side effect but Neil Bauman also says on its website that he got reports from people getting T. after one pill of 100mg...and there also some reports in the previous pages here...

      Though I really feel I have to try otherwise I will always have this "doubt" in my head and it will prevent me from habituating to my new T. level, if it worsen my T. then I do not know how I would bear this.

      When digging, you can Indeed find some testimonies regarding Tinnitus after Gabapentin but it is mainly people who were not suffering from Tinnitus prior to taking Gabapentin. In the few cases of worsening I have the impression it was mainly people who had tinnitus from another cause than Noise/acoustic trauma or people very sensitive to drugs side effects and for whom any drug spike their T anyhow which is not my case. I read extensively the litterature and various studies regarding tinnitus/gabapentin and no study or trial or article never mention the case of worsening of existing tinnitus (from acoustic trauma) during the trials/studies.

      Did you go through the whole drugs protocol trying successively the different molecules? (trobalt...)
      You were not afraid of any possible worsening when starting the Neurontin?
       
    8. Darktale

      Darktale Member

      Tinnitus Since:
      2010
      Cause of Tinnitus:
      Acoutstic Trauma
      The fact that it increased your hyperacusis during the first two weeks does not reassure me… :)
       
    9. Kam75

      Kam75 Member

      Location:
      FRANCE
      Tinnitus Since:
      26/02/2019
      Cause of Tinnitus:
      Noise induced trauma
      @Darktale Yes I completed the entire protocol, to no avail... I tried Neurontin, Tegretol, Lamictal, Lyrica, Depakine with no results. Lyrica seemed to work at the beginning. My tinnitus was a bit quieter the first days but the effects didn't last long.

      Dr. Fain finally prescribed me Rivotril. It is the only medicine that enables me to find fast sleep. But it is a very strong medicine so I try to take as little as possible (around 5 drops at night once a week or biweekly).

      I even tried hearing aids, but I have high frequency tinnitus, so unfortunately it didn't help either.

      I've been having noise induced tinnitus from 1 year and 3 months now.

      I've completely stopped living: no parties, no clubs, no bars, no alcohol, no cinema, but my tinnitus is getting worse every 2 or 3 months for absolutely no reasons, I don't know why. I have new noises and the spikes are higher and higher, driving me crazy.

      I am now at the point that I can't sleep without Laroxyl (amitriptyline), I have everyday headaches, dizziness because of the lack of sleep. I stopped going to sport as I became to weak physically.

      All because of a music festival, my life is ruined from my 28 (I'm 29 years old now).
       
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    10. alanisnotadj
      Batty

      alanisnotadj Member Benefactor

      Location:
      Germany
      Tinnitus Since:
      1992 (got much worse in 2018)
      Cause of Tinnitus:
      Loud noise exposure
      It is now much much better. Better than prior to taking it for sure.
       
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    11. Lola808
      Amazed

      Lola808 Member Benefactor

      Location:
      Honolulu
      Tinnitus Since:
      4/2020
      Cause of Tinnitus:
      High frequency hearing loss wearing headphones to bed
      How are things now? I'm thinking of trying Gabapentin.
       
    12. alanisnotadj
      Batty

      alanisnotadj Member Benefactor

      Location:
      Germany
      Tinnitus Since:
      1992 (got much worse in 2018)
      Cause of Tinnitus:
      Loud noise exposure
      My hyperacusis is better no doubt about it. There are still times where it comes out of nowhere without any kind of reason (no loud noise exposure) but overall I am definitely feeling better. I take 200 mg per day.
       
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    13. grate_biff
      Alone

      grate_biff Member Benefactor

      Location:
      Moss, Norway
      Tinnitus Since:
      09/2014
      Cause of Tinnitus:
      Acoustic trauma and or benzo withdrawal
      Did you have pain hyperacusis or just heightened sensitivity?
       
    14. Born To Slay
      Depressed

      Born To Slay Member

      Tinnitus Since:
      10/2019
      Cause of Tinnitus:
      Loud concert
      Well Gabapentin can take a few weeks to take effect for pain issues, so is possible that his pain got worse by coincidence and then drug started taking effect.
       
    15. alanisnotadj
      Batty

      alanisnotadj Member Benefactor

      Location:
      Germany
      Tinnitus Since:
      1992 (got much worse in 2018)
      Cause of Tinnitus:
      Loud noise exposure
      Both. The pain is not gone but things are improving even though my left can still hurt completely randomly.
       
    16. Lola808
      Amazed

      Lola808 Member Benefactor

      Location:
      Honolulu
      Tinnitus Since:
      4/2020
      Cause of Tinnitus:
      High frequency hearing loss wearing headphones to bed
      @alanisnotadj can you describe your pain? I just want to get to tolerable. I'm at suffering.
       
    17. Lola808
      Amazed

      Lola808 Member Benefactor

      Location:
      Honolulu
      Tinnitus Since:
      4/2020
      Cause of Tinnitus:
      High frequency hearing loss wearing headphones to bed
      Did your pain hyperacusis go down with gabapentin?
       
    18. alanisnotadj
      Batty

      alanisnotadj Member Benefactor

      Location:
      Germany
      Tinnitus Since:
      1992 (got much worse in 2018)
      Cause of Tinnitus:
      Loud noise exposure
      I have a quasi permanent dull pain in and around my left ear. It sometimes radiates down my cheek. It is variable in intensity. It is never unbearable but it is bad enough to prevent me from ignoring it. It feels like there is always something wrong with my left ear.

      With gabapentin these symptoms have reduced quite significantly but there are still times where the pain is there and I don't know why. Of course my ears hurt when I am exposed to loud noises but normal noises don't hurt me.

      Is this hyperacusis, noxacusis or nerve damage?
       
    19. Marko Nakovski
      Bored

      Marko Nakovski Member Benefactor

      Location:
      North Macedonia
      Tinnitus Since:
      27.04.2017
      Cause of Tinnitus:
      Loud music
      The instant pain hasn't changed at all I believe. The delayed pain has become better but I must note I was taking GABA in combo with Amitriptyline so I'm not sure if the the combo made the delayed effect slightly better or just Gabapentin..
       
    20. alanisnotadj
      Batty

      alanisnotadj Member Benefactor

      Location:
      Germany
      Tinnitus Since:
      1992 (got much worse in 2018)
      Cause of Tinnitus:
      Loud noise exposure
      My hyperacusis has never been better. I have just had several days of no pain whatsoever, only a slight discomfort in my left ear when I wake up but it goes away very quickly.

      I believe it is because I normally sleep on my left ear which is the one with hyperacusis.
       
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    21. linearb
      Psychedelic

      linearb Member Benefactor Hall of Fame

      Location:
      destroy all creatures. they cannot be regenerated.
      Tinnitus Since:
      1999
      Cause of Tinnitus:
      karma
      Hey I just wanted to bump this because I've been taking another swipe at this.

      I am still on 2mg/day Clonazepam. I had been at 600-900mg/day Gabapentin (mostly 600, sometimes 900). I held to 600 for a couple weeks, then cut to 450 for about a week and a half, cut to ~350 for a few days and then as of a couple days ago I eliminated the morning dose entirely, so I've only been taking 300.

      Sleep is a little weird, some weird physical sensations, and I do think the real high frequency stuff is flaring a bit, but at the moment this seems tolerable. I will probably attempt to just hold @ 300 at night for a while, and then go from there. If I hit a point where I basically feel as stable as I did at 600, I may reduce further. I don't know if I intend to fully withdraw from Gabapentin, I do think there is a particular synergy there with Klonopin as relates to tinnitus, but I am very interested in understanding what the minimal dose of these drugs I can take is. If I could weasel my way down to 100mg of Gabapentin, I might then start cutting back on the Klonopin very slowly. Again, not with a plan of complete withdrawal, just "less drugs == better"
       
    22. Zugzug

      Zugzug Member Benefactor

      Tinnitus Since:
      05/2019
      Cause of Tinnitus:
      Likely Autoimmune Inner Ear Disease; Sjogren's Syndrome
      Thought I would add: I recently went on gabapentin for ~5 weeks. It didn't help my tinnitus or hyperacusis -- may have even made them worse. I was on 300 mg at night. It did help me sleep though. I am weaning off now.
       
    23. linearb
      Psychedelic

      linearb Member Benefactor Hall of Fame

      Location:
      destroy all creatures. they cannot be regenerated.
      Tinnitus Since:
      1999
      Cause of Tinnitus:
      karma
      I believe this has been most people's experience (including mine) using gabapentin alone (although, I have seen a couple people say it helped hyperacusis but not tinnitus). Combining it with a benzo, and specifically Clonazepam, seems to have a synergistic effect in some people, but if so it is not understood.
       
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    24. grate_biff
      Alone

      grate_biff Member Benefactor

      Location:
      Moss, Norway
      Tinnitus Since:
      09/2014
      Cause of Tinnitus:
      Acoustic trauma and or benzo withdrawal
      I feel like chiming in here. Out of desperation I took 200 mg * 3 Gabapentin on Saturday and Sunday.
      It did wonders with my anxiety and tremors (benzo withdrawal) but most importantly it helped my noxacusis I'd say by 70-80%. I suddenly found sound not to be as painful and piercing. Same experience with tinnitus. It did not go, but became less piercing and I found my noise generator actually masked it. It felt miraculous.

      I became a member of 4 different Facebook Gapapentin groups to educate myself more (even though Gabapentin is what I have read most about besides benzo) It scared me shitless. People who have been on it practically beg newcomers on their knees to not take the drug as it has ruined their lives in many different ways.
      I have not taken any today and everything is back to HELL.

      As I understand it, Gabapentin can do wonders with benzo withdrawal, but not the other way around.
      They say magnesium will alleviate Gabapentin withdrawal though.

      I have to really evaluate this for a while. I'm also up for middle ear surgery next month. Going to cut both the stapedius and the tensor tympani in both ears by an ENT surgeon.
      At this point I'm not even sure I will dare going through with that because of the state I'm in.

      If only this fucking benzo withdrawal would let up, I will know more clearly where I stand and know what is what.
      7 months off. No relief.

      I'm sorry it did not help you @Zugzug.
       
    25. Zugzug

      Zugzug Member Benefactor

      Tinnitus Since:
      05/2019
      Cause of Tinnitus:
      Likely Autoimmune Inner Ear Disease; Sjogren's Syndrome
      Somehow, I'm less surprised that it could help noxacusis than normal hyperacusis. Maybe it's because it helps peripheral neuropathy? Either way, if it helps you, that's wonderful.

      Another thing I didn't like about it is that it made me super loopy, and may have made my depression worse. My thoughts felt incoherent and disconnected. Trouble focusing. For whatever reason, I am extremely sensitive to these kinds of drugs. When I took Cymbalta, I was on the lowest possible dose and had all of the side effects. I experienced brain zaps and pretty moderate discontinuation syndrome after just 6 weeks.

      For me, these kinds of drugs have to be clearly helping for me to want to be on them. I would love it if there was an anti-depressant that helped my mood, but was neutral or positive for my ear issues.

      The middle ear surgery you describe sounds pretty serious. If gabapentin is helping a lot, maybe you should reconsider. Good luck.
       
    26. ajc

      ajc Member

      Tinnitus Since:
      11/2002; spike 2009; worse 2017-18
      Cause of Tinnitus:
      Loud music - noise damage
      I want to try combining Gabapentin with Clonazepam (Klonopin). I read a success story on it I think by @just1morething...

      Finding a doctor who is in favor of prescribing a benzo is difficult tho.
       
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    27. just1morething
      Benevolent

      just1morething Member Benefactor

      Location:
      U.S.
      Tinnitus Since:
      It started
      Cause of Tinnitus:
      Bad luck
      Same here. It seems like all ADs have bad side effects. I tried my old CPAP and that seemed to help my awakening horrible noise.
       
    28. Thuan

      Thuan Member

      Location:
      California
      Tinnitus Since:
      05/2018
      Cause of Tinnitus:
      Ear infection
      @grate_biff

      What is the reason for your middle ear surgery to cut off the middle ear bones? From your profile, it states that your condition was acoustic trauma, which shouldn't relate to middle ear issues.
       
    29. grate_biff
      Alone

      grate_biff Member Benefactor

      Location:
      Moss, Norway
      Tinnitus Since:
      09/2014
      Cause of Tinnitus:
      Acoustic trauma and or benzo withdrawal
      Oh, but it does. In the highest degree possible. It does not involve middle ear bones, just the muscles.

      If you are interested you can read this article:

      https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156190/

      In short there are 3 things that can tense or make your MEM to convulse with or without sound stimuli:

      Acoustic trauma/shock
      Prolonged stress/anxiety
      Being very annoyed by ones tinnitus
       
    30. Thuan

      Thuan Member

      Location:
      California
      Tinnitus Since:
      05/2018
      Cause of Tinnitus:
      Ear infection
      Thank you. That article is quite interesting. Please keep us updated on your progress if you decide to go through the surgery. Also, if and how much hearing loss do you expect with severing the tensor tympani muscle?
       

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