Gabapentin (Neurontin)

Discussion in 'Treatments' started by Jeff M., Jan 17, 2014.

    1. Sayeed

      Sayeed Member Benefactor

      Location:
      miami fl
      Tinnitus Since:
      4/1/21
      Cause of Tinnitus:
      unsure
      Gabapentin has helped me over the past year but I feel as though I've developed a tolerance to it. I take 400 mg twice a day. I don't want to increase any further as I'm scared of the withdrawal once I come off of it.
       
      • Informative Informative x 2
    2. David S

      David S Member Benefactor Ambassador

      Tinnitus Since:
      10/2013
      I am already on a low dose of benzo. I am planning to try Gabapentin as well. My tinnitus is very related to my nerves in the cochlea. What dosage would you recommend of the combination?
       
      • Informative Informative x 1
    3. linearb
      Psychedelic

      linearb Member Benefactor Hall of Fame

      Location:
      beliefs are makyo and reality ignores them
      Tinnitus Since:
      1999
      Cause of Tinnitus:
      karma
      Sorry, I am not a doctor and I am not vaguely qualified to answer this, I only know that I take 600 mg of Gabapentin a day which seems to do something in conjunction with the Klonopin, but I would not say I am on a "low" dose of benzo.
       
      • Informative Informative x 1
    4. Stacken77
      Wishful

      Stacken77 Member Benefactor Hall of Fame

      Location:
      Sweden
      Tinnitus Since:
      October 2020
      Cause of Tinnitus:
      Noise (likely headphones & cars), Acoustic trauma did me in
      Just curious; how do you know that?
      I've also been looking into Gabapentin. Thanks for sharing these studies!

      Wish you well,
      Stacken
       
      • Friendly Friendly x 1
      • Useful Useful x 1
    5. David S

      David S Member Benefactor Ambassador

      Tinnitus Since:
      10/2013
      Hi Stacken,

      I just perceive it very much in my ears. Also it has got worse with bad sound exposure. It might have a somatic connection as well but I have not really figured it out yet.

      Hope you get something good out of your ENT visit today.

      David
       
      • Hug Hug x 1
      • Informative Informative x 1
    6. Hottopic29

      Hottopic29 Member Benefactor

      Location:
      Niagara falls
      Tinnitus Since:
      11/2013
      Cause of Tinnitus:
      Zithromycin acoustic trauma 2022
      I'm thinking about Gabapentin since my doctor says no to benzos. Can Gabapentin spike or worsen or affect hyperacusis?
       
    7. Greg Sacramento

      Greg Sacramento Member Benefactor Ambassador Hall of Fame Advocate

      Tinnitus Since:
      04/2011
      Cause of Tinnitus:
      Syringing + Somatic tinnitus from dental work
      The Cochrane Database System - including that of PubMed has recently shown more bias towards Gabapentin use with tinnitus.

      Cochrane mentions that one study showed a significant negative effect of Gabapentin compared to placebo with an increase in Tinnitus Questionnaire (TQ) score of 18.4 points (standardized mean difference (SMD) 0.82, 95% confidence interval (CI) 0.07 to 1.58).
       
      • Agree Agree x 1
      • Informative Informative x 1
    8. Hottopic29

      Hottopic29 Member Benefactor

      Location:
      Niagara falls
      Tinnitus Since:
      11/2013
      Cause of Tinnitus:
      Zithromycin acoustic trauma 2022
      What does that mean? Gabapentin made their tinnitus worse?
       
    9. GuitarMan

      GuitarMan Member

      Tinnitus Since:
      2010
      Cause of Tinnitus:
      Mild hearing loss due to high volume sounds
      Can anyone clarify this? It's very confusing. The study shows more bias toward GABA use with tinnitus. Does this mean they are leaning toward using it?

      By significant negative effect, do they mean the same as a test result being negative, in other words, it reduced the symptoms of tinnitus? Or do they mean negative as in bad, as in it made the symptoms worse?
       
    10. Joey72
      Approved

      Joey72 Member

      Tinnitus Since:
      4/2021
      Cause of Tinnitus:
      Unknown
      I’d like to know as well. My doctor prescribed it to me but I’m afraid to try it.
       
    11. LD Sea

      LD Sea Member

      Tinnitus Since:
      04/2022
      Cause of Tinnitus:
      Gabapentin
      Gabapentin caused my tinnitus. I took it for 1 month. Currently I have had tinnitus for 3 months.
       
      • Informative Informative x 3
    12. GuitarMan

      GuitarMan Member

      Tinnitus Since:
      2010
      Cause of Tinnitus:
      Mild hearing loss due to high volume sounds
      • Informative Informative x 2
    13. Tasty
      Feminine

      Tasty Member Benefactor

      Location:
      Sendai, Japan
      Tinnitus Since:
      2009
      Cause of Tinnitus:
      Visual Snow Syndrome, possibly TMJD/Cervical Instability
      Has anyone who has visual snow syndrome induced tinnitus tried Gabapentin here?

      I would consider Gabapentin together with a higher dose of Clonazepam but I'm not quite sure, at least yet.
       
      • Good Question Good Question x 1
    14. Frédéric

      Frédéric Member Podcast Patron Benefactor Advocate

      Location:
      Marseille, France
      Tinnitus Since:
      11/19/2012
      Cause of Tinnitus:
      acoustic trauma
      FYI: I tried Gabapentin (prescribed by my psychiatrist), 2 pills of 100 mg in the evening for 3 months (July, August and September). No effect on tinnitus, no side effects either.
       
      • Informative Informative x 2
    15. Nick47

      Nick47 Member Benefactor

      Location:
      UK
      Tinnitus Since:
      2015
      Cause of Tinnitus:
      Viral/noise
      When you say Gabapentin helped, in what way did it help? How did it affect your tinnitus?
       
    16. Nick47

      Nick47 Member Benefactor

      Location:
      UK
      Tinnitus Since:
      2015
      Cause of Tinnitus:
      Viral/noise
      Hi @just1morething, I have read most of your posts on the Abraham Shulman protocol and seeing as you have experience with it, I wanted to ask a couple of questions if I may:

      1) Was your tinnitus noise induced? Do you have hearing loss?
      2) Did you experience negative side effects from Gabapentin, like mood changes?
      3) How long was this substantially effective before you had to re-evaluate?

      Better to ask the old hands like yourself with real experience.

      Best wishes,
      Nick
       
    17. just1morething
      Benevolent

      just1morething Member Podcast Patron Benefactor Hall of Fame

      Location:
      U.S.
      Tinnitus Since:
      2008
      Cause of Tinnitus:
      Airplane barotrauma to left ear, noise exposure.
      I do have high frequency hearing loss but I think my left ear tinnitus was caused by an airplane barotrauma in 2008 from Chicago to Minneapolis/St. Paul. We were coming back from Puerto Rico. I knew something was wrong when we landed. My doctor said I had 2/3rds fluid level in my left ear.

      I don’t think I had too much mood changes from the Klonopin/Gabapentin combination. I did get some dry mouth from Gabapentin. I think Gabapentin is a mood stabilizer as well as a nerve medication. I did talk to Dr. Shulman a couple times by phone. I was very desperate at the time. I’m still desperate today as I have static in my left ear right now. I found out I had TMJ in my left jaw (bone on bone) in 2020 and I had read that can be linked to tinnitus. I recently had a fat graft from my stomach to my jaw. So far it hasn’t helped my tinnitus but it’s only been 2 weeks.

      I only have Diazepam and Gabapentin on hand at present, plus I have Lyrica. The Klonopin plus Gabapentin used to knock out my tinnitus until I fell asleep and awakened from overnight sleep or a nap. I’m thinking the airplane barotrauma damaged my left middle ear. How I wish I could go back in time and not take that flight. I was fine in Chicago. The short flights I always had more trouble with. I had taken some decongestants but I guess not enough. Or maybe chewed gum, did the valsalva maneuver or had an EarPopper. But it’s all history now and I’m still not better. I have 3 sets of hearing aids including the Widex Moment. Sometimes they help, sometimes not.

      Best wishes to you Nick. I truly hope you find relief from this debilitating condition. I don’t have any good answers. I’m going to evaluate my TMJ later. ENT years ago said my left Eustachian tube was somewhat abnormal so maybe a balloon dilation procedure up my Eustachian tube could help but I have low confidence in that. Truly a brutal condition for me at times although sometimes it goes away until my sleep cycle resets it. Frustrating is an understatement.
       
      • Helpful Helpful x 1
    18. Nick47

      Nick47 Member Benefactor

      Location:
      UK
      Tinnitus Since:
      2015
      Cause of Tinnitus:
      Viral/noise
      @just1morething, thank you!

      I think it's time we ALL stopped looking back. Is it helping us?

      I get some reduction in the reactivity and volume with Clonazepam for sure. I guess trialling Gabapentin on its own for a week would be best before deciding on a combination.

      Hearing aids just make mine louder but I have a pair of Phonak Nova M on the NHS. I wear them on the rationale they give some sound therapy, although I can't go above 30% on them.

      In terms of years, how long did this combo of medications remain useful for you? I read that eventually you reached homeostasis so to speak.

      I was offered balloon dilation last year when I complained of balance problems. They have never looked at my Eustachian tubes in 7 years.

      All the best,
      Nick
       
      • Like Like x 1
    19. Uklawyer

      Uklawyer Member

      Tinnitus Since:
      03/2020
      Cause of Tinnitus:
      Medication - antidepressants
      @Nick47 , a couple of questions if I may to hijack quickly:
      How good/quick was your treatment on the NHS out of interest, i.e. appointment to testing & diagnosis, then getting hearing aids?
      You were offered this just from telling an ENT about balance problem? Did they not test? And they thought balloon dilation can help vestibular issues?
       
    20. Nick47

      Nick47 Member Benefactor

      Location:
      UK
      Tinnitus Since:
      2015
      Cause of Tinnitus:
      Viral/noise
      Setback end of January and hearing aids May. I was pushed forward as the setback saw me in the hands of the crisis team. I had to see a private ENT as it would have been 4-6 months. Waste of time.
      I had balance problems since 2015. I was diagnosed with labyrinthitis. After numerous episodes lasting months, I saw a GP in April/May last year who said it wasn't labyrinthitis as it wouldn't keep coming back. He suggested balloon treatment. I never had the treatment as 12 hospitals had zero appointment slots in Leicestershire.
       
      • Hug Hug x 1
    21. linearb
      Psychedelic

      linearb Member Benefactor Hall of Fame

      Location:
      beliefs are makyo and reality ignores them
      Tinnitus Since:
      1999
      Cause of Tinnitus:
      karma
      I also posted this in the Clonazepam (Klonopin, Rivotril) thread:

      I've reduced from 900 mg Gabapentin to 300 mg, split now to 100 mg pills, looking at cutting to 200 mg, then 100 mg. I will probably stay on the last 100 mg for a while because I have heard there's often significant insomnia with losing the last bit of it.

      I'm still on 2 mg/day of Klonopin.

      No plans on Klonopin reduction at this time, but if I end up feeling okay some months post Gabapentin, I might very slowly and cautiously see what happens when I start to work down. I've done slow tapers off benzos twice so I sort of know what to expect, and what warning signs would be that actually the benefit of the drug is still much outweighing the downsides.

      I have to admit that the more screechy, oscillatory parts of my tinnitus do seem to maybe be more pronounced again, which may be a result of Gabapentin reduction, but so far I am not actually thinking about it or actively experiencing it much more often than I was 3 months ago, so, if the upshot is that the subjective audiological severity is worse off the drug but my brain has plasticized around living with this well enough that I still don't think about it much -- I'd prefer to not take the damn pills, of course.

      The reason is, I was starting to have anger issues which I had read can occur with extended Gabapentin use, and also I think it's kind of a weird drug and I'd prefer to not be on it indefinitely.

      If I can withdraw from one thing, then attempting the same with Klonopin, or at least attempting a reduction, makes sense.

      At this point I don't trust global supply lines to not leave me completely screwed at some point. My insurance policy is a 750 mg bag of Norflurazepam (legal analog) but that would be super dangerous to screw with, it's my doomsday plan for tapering if I somehow lose access to my pharma supply, because I am not willing to be dependent on benzos in 2022 without having enough on hand to taper, yet, my doctor didn't want to give me an extra 6 months of Klonopin ;)

      (My doctor does know about my doomsday box, he doesn't love it but he thinks I am weirdly informed and make weirdly informed decisions on this stuff...)

      Best wishes to @Carlos1, @just1morething and everyone else.
       
      • Like Like x 2
    22. JD SR71

      JD SR71 Member

      Location:
      California
      Tinnitus Since:
      2000
      Cause of Tinnitus:
      Jet noise, shooting, not sure
      Regarding the incidence of tinnitus as a side effect, the PDR makes no mention of it at all. Drugs.com lists it as Rare (0.01% to 0.1%). I'm not saying that there aren't incidents of tinnitus from Gabapentin but it seems that the risk that it could happen to any particular person seems quite remote.

      EDIT:

      Following up, the Neurontin FDA label lists tinnitus as infrequent <1% side effect and it is listed in descending order, relative to other infrequent side effects, indicating its prevalence is much lower, perhaps approaching .1%. (1 in 1,000).

      I think Neurontin is one of the safer drugs as regards to tinnitus being a side effect.
       
Loading...

Share This Page