Hough Ear Institute's Hair Cell Regeneration Project

Discussion in 'Research News' started by all to gain, Oct 2, 2019.

    1. tommyd87

      tommyd87 Member

      Tinnitus Since:
      1999
      Cause of Tinnitus:
      tmj music
      Not going to disagree with this. But the thing is, Hough Ear Institute needs to get this done soon or at least explain what is going on at present.
       
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    2. Mica Rambin

      Mica Rambin Member

      Tinnitus Since:
      09/2020
      Cause of Tinnitus:
      NIHL
      I signed up for Hough Ear Institute's quarterly newsletter to get updates. Does anyone know when their next newsletter is released?
       
    3. frpp

      frpp Member

      Tinnitus Since:
      2010
      Cause of Tinnitus:
      Tmj, Nihl, ototoxic drugs, nerve/ vascular issues
      They have been super shady lately, not even a single word on progress or a word on what they are doing, other than straight panhandling.

      When established multimillion dollar companies need to beg to get funding for their product it just raises all kinds of red flags.
       
      • Agree Agree x 3
    4. Jrblovsky

      Jrblovsky Member

      Location:
      USA
      Tinnitus Since:
      Christmas 2019
      Cause of Tinnitus:
      Gunfire (Maybe) & Menieres
      It would be an absolute shame to see a drug that works never be released due to corporate greed. Sounds like the people running development (funding) need to be fired.
       
      • Agree Agree x 2
    5. tommyd87

      tommyd87 Member

      Tinnitus Since:
      1999
      Cause of Tinnitus:
      tmj music
      They have three things that they haven't yet addressed:

      - The current status of their proof of concept study, started in September. Since this started, they have said nothing about what has been happening other than at the commencement, when we were informed it would take 6-12 months. Most probably there would have been less concern if they had said at least that they tend to not be able to comment on it until it gets finished.

      - The panhandling and donation drive dissemination has actually been fairly generic and vague. I very much agree that zero details have been given on what they are doing or what the money will benefit. The question still remains, why has Hough Ear Institute said nothing on what the funding will be used for and why they need funding for fulfilling the proof of concept study requirements when they are going to eventually profit from a successful medicine treatment.

      - Multiple claims that have been made by Hough Ear Institute about their findings have also been found out or been examined by other organisations overall. These include measuring tinnitus, the treatment of synapses, the essential effect of tinnitus and the synapses among others. Obviously it is incredibly beneficial that multiple groups have discovered the same things, however it also actually again questions the now seemingly mooted claims made by Hough Ear Institute about how they seemingly have been unique in what they have done.

      This is coupled with the previously vague information that they had provided when pressed on other matters such as their timeline to complete things, questions around why they need to obtain donations and why they need to do things like completing the proof of concept study prior to engaging the clinical trials.

      Thus there is very little credibility about what Hough Ear Institute is doing while they fail to address such questions and matters persistently.
       
      • Agree Agree x 3
      • Informative Informative x 3
    6. tommyd87

      tommyd87 Member

      Tinnitus Since:
      1999
      Cause of Tinnitus:
      tmj music
      More donation requests emailed by Hough Ear Institute.

      I am actually amazed because the proof of concept study has supposedly started, so where has the talk about Hough Ear Institute needing the $135,000 (or whatever) gone.

      Going by this, I am assuming at present that the funding for the study has been met or that Hough Ear Institute has covered this through some other mechanism. Now they are simply sending subsequent emails stating that you can help research by donating to them.

      From what Hough Ear Institute has disseminated, the only thing that has been specifically mentioned is the fact that they need money to buy a new drill for Hanoi which we could say is completely independent to the other work that they are doing.

      This just adds much more vagueness and makes me much more intrigued as to what the funding is going towards. I think that the time has arrived for either Justin De Moss or Hough Ear Institute to actually comment on what the funding is going to be used for...
       
      • Agree Agree x 2
    7. Mica Rambin

      Mica Rambin Member

      Tinnitus Since:
      09/2020
      Cause of Tinnitus:
      NIHL
      Hough Ear Institute needs to do a better job of keeping the public up to date on their research. If their pill works, I think it may be one of the best NIHL drugs on the horizon.

      I signed up for their quarterly newsletter in September but I never receive any emails or other communication from them aside from an email exchange I had with Justin a few months ago.

      I see they have some promotional videos on YouTube that they uploaded this month but that isn't enough.
       
      • Agree Agree x 1
    8. tommyd87

      tommyd87 Member

      Tinnitus Since:
      1999
      Cause of Tinnitus:
      tmj music
      Question to Hough Ear Institute:
      Answer from Hough Ear Institute:
      Based off of this response, I believe that Hough Ear institute inevitably has been vague and rather unclear with what they have been communicating regarding the progression of the proof of concept study. It seems that they are now trying to distinguish hearing research and tinnitus research funding from one another, despite previously indicating that their pill treats both.

      Since they have simply stopped sending marketing indicating that they require funding for the proof of concept study because it has started, this would indicate that they seem to have enough funds to proceed with this, though what we know now is that they supposedly don't have funding to finish this. This is despite Hough Ear Institute telling us that the study would be completed in 6 to 12 months.

      There are two ways which this can be looked at. The first is that Hough Ear Institute has simply been poor in their communications by wording things in a manner which can imply multiple things or imply one thing but mean another. The second is Hough Ear Institute has deliberately been vague in their communication.

      Either way the information provided by Hough Ear Institute has been confusing and vague and doesn't give me a clear understanding as to what they are doing.
       
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    9. ajc

      ajc Member

      Tinnitus Since:
      11/2002; spike 2009; worse 2017-18
      Cause of Tinnitus:
      Loud music - noise damage
      Dear Tommy. You should forget about Hough Ear Institute. They're just trying to milk us for all our worth.

      It's beyond laughable how Oblato requires Hough Ear Institute to do grassroots fundraising for a study that - if successful - will yield billions of dollars in profit.

      Now they're hoping tinnitus sufferers foot the bill, and Oblato reaps the profits.

      We shouldn't support shit like this.
       
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    10. Jrblovsky

      Jrblovsky Member

      Location:
      USA
      Tinnitus Since:
      Christmas 2019
      Cause of Tinnitus:
      Gunfire (Maybe) & Menieres
      Like I stated before, these guys have a steaming pile of shit for marketing and development (fundraising).

      My guess is they have secured the funding.

      I would guess that the MBAs in the Pharmaceutical are trying to figure out how to do a little trick called profit maximization.

      Corporate greed at its finest.

      The fact that they gave such a horseshit answer goes to show they will allocate the funds to whatever they want.
       
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    11. Mica Rambin

      Mica Rambin Member

      Tinnitus Since:
      09/2020
      Cause of Tinnitus:
      NIHL
      I'm not an expert on creating or selling pharmaceuticals - so I don't want to be too quick to judge the merits of what's going on at Hough Ear Institute. Those of us with damaged synapses/nerves from noise induced situations really need something like the drug Hough Ear Institute is proposing to address that damage to fix our tinnitus/hyperacusis/hearing loss. I feel bad for veterans dealing with this issue too, they need something to fix the damage from all those blasts they were dealing with. I just really want Hough Ear Institute to get their business in order and communicate with the ear issue community more frequently - especially if they want to solicit donations to us.
       
      • Agree Agree x 1
    12. serendipity1996
      No Mood

      serendipity1996 Member Podcast Patron Hall of Fame

      Tinnitus Since:
      2011
      Cause of Tinnitus:
      Unknown but suspect noise-induced
      I think Otonomy will help us if Hough Ear Institute doesn't since they're both essentially synaptopathy drugs and Otonomy is ahead anyway.
       
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    13. Pete88

      Pete88 Member

      Tinnitus Since:
      02/2018
      Cause of Tinnitus:
      Likely noise
      If FX-322 and OTO-413 are successful, I think that leaves this Hough Ear Institute pill even further in the dust with possibly a final nail in the coffin.

      As many people have been pointing out, this company is extremely vague and arguably sketchy with their behaviour. Maybe passable if they were the only player in the game and had a monopoly but when they are a distant 3rd in terms of potentially repairing hearing loss, a serious company wouldn't be pulling these stunts if they actually were confident they had a superior product. They can see Frequency Therapeutics' excellent example of "how to fund, market and produce" a hearing loss drug. All they'd have to do is follow their lead. Otonomy clearly thinks their product can compete with FX-322 by their behaviour and interactions. Hough Ear Institute seems like that kid who claims he has the coolest toy on the block but never demonstrates it actually exists.

      I'm not a bio engineer or anything but even their mechanism of delivery doesn't sit as comfortable with me. I'd trust an injection to work better on my ear without causing other issues elsewhere than a pill. Consider that for example previous studies regarding FX-322 showed that consuming the drug can influence cancer for example but when delivered directly to the ear, it's fine.

      I hope I'm wrong and Hough Ear Institute knocks it out of the park but based on their behavior, I wouldn't bet on it. I would however bet on Frequency Therapeutics with no issues as well as Otonomy with slightly less confidence.
       
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    14. Paulmanlike

      Paulmanlike Member Podcast Patron Benefactor Hall of Fame

      Tinnitus Since:
      2008
      Cause of Tinnitus:
      Noise
      This was addressed by a very well informed member @Aaron123 a couple of years ago.

      Endless marketing pitches and unfounded claims.

      I have never bothered and I wouldn't entertain @Justin De Moss.

      Alarm bells were raised about these years ago.

      Better off buying shares in companies to fund the clinical trials and donating to Tinnitus Talk and the BTA/ATA than giving money to Hough Ear Institute.
       
      • Agree Agree x 2
      • Informative Informative x 1
    15. frpp

      frpp Member

      Tinnitus Since:
      2010
      Cause of Tinnitus:
      Tmj, Nihl, ototoxic drugs, nerve/ vascular issues
      Agreed, Hough Ear Institute is done - in terms of synapse medicines OTO-413 will smoke it, and as an otoprotectant SPI-1005 will be out years before it.

      Personally I wouldn't worry about its safety consumption wise as it's just two different antioxidants in a pill and one of them you can buy at just about any vitamin shop.
       
      • Agree Agree x 2
    16. tommyd87

      tommyd87 Member

      Tinnitus Since:
      1999
      Cause of Tinnitus:
      tmj music
      Question to Hough Ear Institute:
      Answer from Hough Ear Institute:
      Quality avoidance.

      1. They avoid commenting on the fact that their treatment for tinnitus is also treating hearing loss and tries to walk around this by informing us that they are two different things even though this pill is being worked for both conditions.

      2. They have said on here that the time taken for the study will be 12 months and has subsequently now backtracked on this through the excuse of COVID-19. Something which they were well aware of prior to the study's commencement.

      3. From all accounts, I have seen no information or communication which stated that Hough Ear Institute needed to start when they did in order to avoid losing funding. Fairly handy reason to delay it if it cannot get completed by the required date.

      I definitely do think that there is some really interesting information coming from Hough Ear Institute if you press them on it.
       
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    17. ajc

      ajc Member

      Tinnitus Since:
      11/2002; spike 2009; worse 2017-18
      Cause of Tinnitus:
      Loud music - noise damage
      Carry on the good work! It's important someone presses them on it. It smells fishy. Also how they seem to not have any real two-sided connection with the pharma company, saying "we have not yet heard..."

      Can you imagine Frequency Therapeutics or Otonomy being this unprofessional or disjointed? Justin De Moss probably writes his responses in his bedroom on his iPad. Hough Ear Institute desperately needs to be clearer in their messaging. The vagueness and discrepancies hurt them.
       
    18. Mica Rambin

      Mica Rambin Member

      Tinnitus Since:
      09/2020
      Cause of Tinnitus:
      NIHL
      Sounds like we may also need to contact the biotech firm to get more answers about the progression of these studies. I understand that both Hough Ear Institute and Oblato need to be careful about what they communicate with us for legal purposes. I just hope they don’t play hot potato between each other as we ask them questions. As I said before more frequent communication from them would improve public confidence. They should try to upload a YouTube video on their channel every week.
       
      • Agree Agree x 1
    19. Drachen
      Irritated

      Drachen Member

      Location:
      United States
      Tinnitus Since:
      December 2020
      Cause of Tinnitus:
      Currently unknown; awaiting evaluation
      There is something very off-putting about the way they worded this response.

      Their defensive attitude and lack of any self-awareness is remarkable.
       
      • Agree Agree x 1
    20. tommyd87

      tommyd87 Member

      Tinnitus Since:
      1999
      Cause of Tinnitus:
      tmj music
      The issue is in no way related to what Oblato is doing at this stage but rather completely related to what Hough Ear Institute is doing. It appears that Hough Ear Institute is directing what is happening with the proof of concept study and not Oblato.

      Obviously we know that Hough Ear Institute has told us that Oblato needs this data in order to determine whether to conduct a trial for tinnitus, however Hough Ear Institute won't submit this until they have now gotten the full funding that they supposedly need to finish the work with the study.

      We simply know that Hough Ear Institute has said something one day and then contradicted or changed this another day. The study completion time frame is definitely a good example of something Hough Ear Institute has said which is contradictory.
       
      • Informative Informative x 1
    21. tommyd87

      tommyd87 Member

      Tinnitus Since:
      1999
      Cause of Tinnitus:
      tmj music
      Follow Up Question:
      Reply from Hough Ear Institute:
       
      • Informative Informative x 1
    22. frpp

      frpp Member

      Tinnitus Since:
      2010
      Cause of Tinnitus:
      Tmj, Nihl, ototoxic drugs, nerve/ vascular issues
      Trash company.
       
    23. annV
      Fine

      annV Member

      Tinnitus Since:
      2005
      Cause of Tinnitus:
      unknown - possibly hereditary
      This is about NAC/HPN-07 which is the same thing as the pill treatment being investigated by Hough Ear Institute.

      In light of the prevalence and multi-site manifestations of blast-induced histopathological abnormalities, it is remarkable that NAC/HPN-07-treatment significantly normalized the aberrant biomarker expression patterns in the auditory system, suggesting that this treatment strategy can reduce, or perhaps reverse, both primary neurodegeneration and excitotoxic trauma in cochleae and prevent or attenuate maladaptive neural plasticity in central auditory pathways.

      Link:
      Electrophysiological assessment and pharmacological treatment of blast-induced tinnitus
       
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    24. tommyd87

      tommyd87 Member

      Tinnitus Since:
      1999
      Cause of Tinnitus:
      tmj music
      This is their pill properties being tested in lab, probably as a part of the proof of concept study that they are doing.
       
      • Informative Informative x 1
    25. weab00
      Alone

      weab00 Member Benefactor

      Location:
      depression-ville
      Tinnitus Since:
      04/2019
      Cause of Tinnitus:
      noise, whiplash; 08/20 H
      https://www.sigmaaldrich.com/catalog/product/sigma/sml2163?lang=en&region=US

      $318.00/25 mg, at least 21,000 mg required for a human dosing. So $267,120 to do this on your own.
       
    26. GBB

      GBB Member

      Location:
      NYC
      Tinnitus Since:
      2016-2019 (Mild, Cured) 8/2020 (Severe)
      Cause of Tinnitus:
      Microsuction / Additional Acoustic Trauma in Close Proximity
    27. Watasha
      No Mood

      Watasha Member Benefactor Advocate

      Tinnitus Since:
      03/2018
      Cause of Tinnitus:
      Unknown
      They are nice enough to come to this site. That's more than could be said for other entities.
       
      • Agree Agree x 2
    28. weab00
      Alone

      weab00 Member Benefactor

      Location:
      depression-ville
      Tinnitus Since:
      04/2019
      Cause of Tinnitus:
      noise, whiplash; 08/20 H
      Just hypothetically.
       
    29. Drachen
      Irritated

      Drachen Member

      Location:
      United States
      Tinnitus Since:
      December 2020
      Cause of Tinnitus:
      Currently unknown; awaiting evaluation
      So like, assuming an optimistic future where the Hough Ear Institute Pill goes through clinical trials and such and gets on market, is a course of treatment going to be prohibitively expensive like this?

      I don't understand the economics behind pharma, so I assume there's some method for greatly reducing that price, but how much so? Because that figure right there is just... yikes.
       
      • Agree Agree x 1
    30. weab00
      Alone

      weab00 Member Benefactor

      Location:
      depression-ville
      Tinnitus Since:
      04/2019
      Cause of Tinnitus:
      noise, whiplash; 08/20 H
      Definitely. It'd probably be like $4k. They get bulk deals & negotiations, I suppose it's a lot cheaper to mass produce a drug.
       
      • Agree Agree x 1

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