Hough Ear Institute's Hair Cell Regeneration Project

Discussion in 'Research News' started by all to gain, Oct 2, 2019.

    1. Tezcatlipoca
      Question it

      Tezcatlipoca Member

      Location:
      Mexico
      Tinnitus Since:
      June 2020
      Cause of Tinnitus:
      NIHL
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    2. VeryUnfortunate
      Stressed

      VeryUnfortunate Member Benefactor

      Tinnitus Since:
      January 2021
      Cause of Tinnitus:
      Acoustic Trauma
      I only listened to the interview at the end. At around 52 minutes he talks about 3-5 years where people can use it? And starting clinical trials in a couple of years? Not too sure about the wording on that one.

      He said that the Phase 2 trial for the Pill will be expensive, at around $10-20 million. The Phase 1 trial was "cheap" apparently at $1 million. They aren't sure whether the Phase 2 trial will be for noise-induced hearing loss, tinnitus or ototoxicity.

      The Injection technology is apparently in the preclinical phase while the Pill is at Phase 2.

      The sweet spot is at 52 minutes - 57 minutes.

      Sorry if my post is confusing. I'm sleepy and it's late lol. After watching it again it appears that this is intended for Acute Acoustic Trauma (24 minutes time stamp). I wonder if it will be too late for us by the time this comes to the market.
       
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    3. OptimusPrimed
      Spaced

      OptimusPrimed Member Benefactor

      Tinnitus Since:
      10/2007
      Cause of Tinnitus:
      Acoustic trauma
      Would this work for acoustic trauma from years past?
       
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    4. Tezcatlipoca
      Question it

      Tezcatlipoca Member

      Location:
      Mexico
      Tinnitus Since:
      June 2020
      Cause of Tinnitus:
      NIHL
      Yes, it takes literally decades for the treatment window to close.
       
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    5. VeryUnfortunate
      Stressed

      VeryUnfortunate Member Benefactor

      Tinnitus Since:
      January 2021
      Cause of Tinnitus:
      Acoustic Trauma
      Can I ask for a source on this?
       
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    6. spacehunter

      spacehunter Member Benefactor

      Tinnitus Since:
      10/2019 (mild), 09/2020 (severe)
      Cause of Tinnitus:
      SSHL
      To explain it very quickly: Some papers showed, that NHPN-1010 increases the BDNF concentration (not sure whether studies where animal studies or on vitro). By this, synaptic growth is enhanced and hidden hearing loss hopefully treated (basically in the same way as OTO-413 intends to). As long as the hair cells and the neurons (with the missing synapses) still exist, it is possible to restore the synaptic connection between these two. It is believed that the neurons do not die for many years or even decades in humans even if they do not receive any input anymore (due to destroyed synapses). Therefore the treatment window only closes if the neurons die.

      As a warning though: NHPN-1010 has not been in any clinical trials for efficacy for tinnitus so far and therefore there are only animal or even in vitro studies to rely on. In animal studies where one administered NHPN-1010 more than a month after noise injury it showed normalisation of important biomarkers related to tinnitus.

      We do not know so far, whether it will also work in humans and to what extent it does lead to curing hidden hearing loss or tinnitus. As far as I know not even the exact dosing is known. HPN-07 has already been in clinical trials in the mid 2000s to treat ischemic strokes (just like SPI-1005/Ebselen in the 90s) but failed.

      Here are a few links as sources:
      1. Antioxidants Reduce Cellular and Functional Changes Induced by Intense Noise in the Inner Ear and Cochlear Nucleus
      2. Electrophysiological assessment and pharmacological treatment of blast-induced tinnitus
      3. Disufenton Sodium
      4. Safety and Tolerability of NXY-059 for Acute Intracerebral Hemorrhage
       
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    7. Tezcatlipoca
      Question it

      Tezcatlipoca Member

      Location:
      Mexico
      Tinnitus Since:
      June 2020
      Cause of Tinnitus:
      NIHL
      So I direct messaged Hough Ear Institute's Instagram account and asked:

      Me: Any date to start clinical trials?

      Hough Ear Institute's Instagram account: We're not sure. We hope in 2023, but we have to assess our data from the two-year proof-of-concept study we began in September of last year and will complete September 1, 2022.
       
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    8. Artemis2K
      Kick ass

      Artemis2K Member Benefactor

      Location:
      South Carolina
      Tinnitus Since:
      2012
      Cause of Tinnitus:
      I had tinnitus for as long as I can remember. Got bad later.
      If FDA is banning NAC, how will that affect this research?
       
    9. Diesel

      Diesel Member Benefactor Ambassador Hall of Fame Advocate

      Tinnitus Since:
      1-2019
      Cause of Tinnitus:
      20+ Years of Live Music, Motorcycles, and Power Tools
      FDA banned NAC as a supplement.
       
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    10. DebInAustralia
      No Mood

      DebInAustralia Member Benefactor Advocate

      Location:
      Geelong, Victoria
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      30/12/13
      Why?
       
    11. frpp

      frpp Member

      Tinnitus Since:
      2010
      Cause of Tinnitus:
      Tmj, Nihl, ototoxic drugs, nerve/ vascular issues
      When?
       
    12. tommyd87

      tommyd87 Member

      Tinnitus Since:
      1999
      Cause of Tinnitus:
      tmj music
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    13. AfroSnowman
      Balanced

      AfroSnowman Member Podcast Patron Benefactor

      Tinnitus Since:
      April 16 2019
      Cause of Tinnitus:
      Nonnatural energy source
      Why would it impact this research? It appears that the FDA has issues with it being sold as a supplement, not with it being sold/used as a prescription drug.
       
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    14. tommyd87

      tommyd87 Member

      Tinnitus Since:
      1999
      Cause of Tinnitus:
      tmj music
      It won't.
       
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    15. Mica Rambin

      Mica Rambin Member

      Tinnitus Since:
      09/2020
      Cause of Tinnitus:
      NIHL
      Hopefully Hough Ear Institute pulls through with some success. Last time I spoke with them and read their newsletter they said they think their pill can regrow nerves — providing relief from tinnitus and inflammation of the inner ear from noise exposure.

      I’m not expecting anything but I feel like those of us who got noise-induced tinnitus/inflammation have more of an issue with damaged nerves than with hair cell loss, though I’m not an expert and could be wrong on that point.

      Either way, I hope for the best and that we can get more updates from them.
       
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    16. star-affinity
      Gloomy

      star-affinity Member Benefactor

      Tinnitus Since:
      1993, increase in 2020, then new in 2021
      Cause of Tinnitus:
      Maybe during a soundcheck – sudden sound from speaker
      I've been wondering if there's a way to determine whether one has damaged nerves or hair cell loss or both?
       
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    17. Mentos

      Mentos Member Benefactor

      Location:
      Cracow, Poland
      Tinnitus Since:
      03/2015
      Cause of Tinnitus:
      Noise induced, loud rock concert
      There is no way to diagnose cochlear synaptopathy.
       
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    18. Tezcatlipoca
      Question it

      Tezcatlipoca Member

      Location:
      Mexico
      Tinnitus Since:
      June 2020
      Cause of Tinnitus:
      NIHL
      You're correct but we can know it's been damaged if you have difficulty distinguishing words in noise among other things.
       
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    19. OptimusPrimed
      Spaced

      OptimusPrimed Member Benefactor

      Tinnitus Since:
      10/2007
      Cause of Tinnitus:
      Acoustic trauma
      Distortion, hyperacusis and other auditory processing issues likely stem from cochlear synaptopathy.
       
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    20. star-affinity
      Gloomy

      star-affinity Member Benefactor

      Tinnitus Since:
      1993, increase in 2020, then new in 2021
      Cause of Tinnitus:
      Maybe during a soundcheck – sudden sound from speaker
      Do we know if tinnitus can get triggered from synaptopathy or are there likely hair cell damage too? Maybe if there’s some hearings loss at certain frequencies there's likely also (or just?) hair cell damage?
       
    21. Pete88

      Pete88 Member

      Tinnitus Since:
      02/2018
      Cause of Tinnitus:
      Likely noise
      I think it is safe to assume that most people with tinnitus have a few issues wrong and fixing one issue can provide at least partial relief. So even if you have significant hair cell loss plus synapse damage, fixing one issue could provide a decent amount of relief. In some people, even fixing one of the broken inputs may be enough to satisfy the brain.
       
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    22. cjbhab
      Fine

      cjbhab Member

      Tinnitus Since:
      06/2016
      Cause of Tinnitus:
      Concerts, Sinuses, Ear infection
      It is so discouraging to read "come back in 10 years and we might have something."
       
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    23. GBB

      GBB Member Hall of Fame

      Location:
      NYC
      Tinnitus Since:
      2016-2019 (Mild, Cured) 8/2020 (Severe)
      Cause of Tinnitus:
      Virus / Microsuction / Acoustic Trauma
      Where did you see that?
       
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    24. Mica Rambin

      Mica Rambin Member

      Tinnitus Since:
      09/2020
      Cause of Tinnitus:
      NIHL
      To my knowledge Hough Ear Institute currently says that they will be able to get their pill to the market in under ten years. Even if it takes them ten years to release it for us, I will be satisfied assuming that their medication works.
       
    25. Tezcatlipoca
      Question it

      Tezcatlipoca Member

      Location:
      Mexico
      Tinnitus Since:
      June 2020
      Cause of Tinnitus:
      NIHL
      Their website actually claims 3-5 years...
       
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    26. cjbhab
      Fine

      cjbhab Member

      Tinnitus Since:
      06/2016
      Cause of Tinnitus:
      Concerts, Sinuses, Ear infection
      Above it says they hope to start the clinical trial in 2023.

      So that means best case is they start the clinical trial in December 2023. The trial will take years, then it will take more years to get anything to market.

      = 10 years away.
       
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    27. Gb3

      Gb3 Member

      Tinnitus Since:
      12/19
      Cause of Tinnitus:
      Sshl
      Who cares. It’s for acute cases anyway.
       
    28. tommyd87

      tommyd87 Member

      Tinnitus Since:
      1999
      Cause of Tinnitus:
      tmj music
      I don't think that there has been any suggestion that this could take 10 years even from Hough Ear Institute themselves...
       
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    29. Joeseph Stope
      Innocent

      Joeseph Stope Member

      Tinnitus Since:
      1992
      Cause of Tinnitus:
      noise? infection? negative stress? other?
      Is there anyone here who lives in Oklahoma? They could drop around and take a look. I did a web search and it seems that it's like a regular ENT practice and I read some of the reviews. At times it strikes me like a mom & pop enterprise. The teasing thing is, who knows? They might actually have the magic mixture.
       
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    30. Tezcatlipoca
      Question it

      Tezcatlipoca Member

      Location:
      Mexico
      Tinnitus Since:
      June 2020
      Cause of Tinnitus:
      NIHL
      Sorry, but that's not how that works, you can't just "pop around and take a look". It's not a big institution but it's no mom & pop either, it's a research non-profit, looking to go through trials.
       
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