Hough Ear Institute's Hair Cell Regeneration Project

Discussion in 'Research News' started by all to gain, Oct 2, 2019.

    1. tommyd87

      tommyd87 Member

      Tinnitus Since:
      1999
      Cause of Tinnitus:
      tmj music
      They have quoted that the treatment cost would be about the cost of a hearing aid.

      At this stage, I think that would be a reasonable and plausible price point. We do not know exactly where that price point sits since it could be the cost of an expensive one (so $5K) or a cheap one (so $1K). It definitely won't be anywhere near the cost of what @weab00 noted of $267,120 or whatever it was.
       
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    2. Watasha
      No Mood

      Watasha Member Benefactor Advocate

      Tinnitus Since:
      03/2018
      Cause of Tinnitus:
      Unknown
      In the meantime, hop on over to this thread and take 3 minutes to email the American Tinnitus Association and ask them to use their recently received $2.7M bequest on funding research instead of call lines.

      Call to Action: Contact the ATA Right Now — 3 Minutes to Make a Difference

      The more paths for treatment, the more affordable it can be!
       
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    3. Sam99
      No Mood

      Sam99 Member

      Tinnitus Since:
      02/2020
      Cause of Tinnitus:
      Acoustic trauma/Loud noise for 3 hours straight.
      @weab00 was calculating price according to the price of HPN-07 on Sigma-Aldrich. It's not surprising considering they are notoriously known for their absurd pricing, I read somewhere they add up to 60x markup and even more on the chemicals they sell.

      So it will be much cheaper, although it will cost several thousands still.
       
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    4. Sam99
      No Mood

      Sam99 Member

      Tinnitus Since:
      02/2020
      Cause of Tinnitus:
      Acoustic trauma/Loud noise for 3 hours straight.
      I am not sure if this was posted before or not.

      This paper suggests that cochlear synaptopathy is more likely responsible for generation of tinnitus and hyperacusis rather than the death of sensory hearing cells.

      If that's the case then Hough Ear Institute's Pill or OTO-413 are more likely to reduce or eliminate tinnitus & hyperacusis than FX-322, at least in those with normal audiograms.

      @FGG

      Is noise-induced cochlear neuropathy key to the generation of hyperacusis or tinnitus?
       
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    5. FGG
      No Mood

      FGG Member Podcast Patron Benefactor Ambassador Hall of Fame Advocate

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Multi-factorial
      It's not one thing. If it was always cochlear synaptopathy, hydrops wouldn't cause tinnitus. Neither would middle ear disease.

      Anything that interferes with the hearing signal will cause "phantom cochlea" i.e. tinnitus.

      It's not one structure.

      But cochlear synaptopathy is probably the most common cause in noise induced because the synapses are more sensitive to noise but it's not the only cause and a lot of people will have mixed hair cell loss and synaptopathy.
       
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    6. Artemis2K
      Kick ass

      Artemis2K Member Benefactor

      Location:
      South Carolina
      Tinnitus Since:
      2012
      Cause of Tinnitus:
      I had tinnitus for as long as I can remember. Got bad later.
      Mass producing, making something widely available, would normally reduce the price significantly, especially if an item is highly produced by multiple manufacturers (therefore reducing manufacturing price by competition) and sold by multiple companies (therefore reducing sales price by competition.) The less unique something is, the less valuable it is. If everyone competes for the demand & value of the item, then it's eventually everywhere and worth a lot less over time, and brand recognized value becomes more crucial. This is why you'd find brands selling the exact same item from the same Chinese manufacturer on Amazon, but the brands with the largest recognition (therefore largest presumed trustworthiness) selling at a higher price... even if other sellers are selling the same thing for cheap.

      Unfortunately, the drug industry is not as simple, because (as far as I understand it) patents/IP laws AND government regulation can determine the availability and price of a product, so it's hard for me to say.
       
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    7. reggie green
      Balanced

      reggie green Member

      Tinnitus Since:
      03/08/2001
      Hs anyone done a follow up with Hough Ear Institute? They seem quiet.
       
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    8. weab00
      Gloomy

      weab00 Member Benefactor

      Location:
      Joe Dart's basement
      Tinnitus Since:
      05/2019
      Cause of Tinnitus:
      some good mf music
      Probably going the way of Audion lol.
       
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    9. wwtsai
      Assassinator

      wwtsai Member Podcast Patron Benefactor

      Location:
      San Francisco
      Tinnitus Since:
      Mild (2016) Bothersome (8/20)
      Cause of Tinnitus:
      SNHL
      Someone on the Hough Ear Institute Facebook page asked a week ago and got the following response:

      "Rest assured that we're working hard to get treatments to the clinic! FDA approval takes time though, so hold on to hope! Our pill is in the planning stage of phase 2 trials and the injection is in earlier phases. We won't stop until there are viable options for those who are suffering."
      Thing is, on their webpage, they state that they need to conduct a proof of concept study before going into Phase 2 clinicals for tinnitus. Does that mean they've already conducted the proof of concept study? They could also be referring to Phase 2 for hearing loss as that is a different indication.
       
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    10. reggie green
      Balanced

      reggie green Member

      Tinnitus Since:
      03/08/2001
      Huh, what do you mean?
       
    11. rid0871

      rid0871 Member

      Tinnitus Since:
      may of 2015
      Cause of Tinnitus:
      had my neck adjusted
      Hough Ear Institute is nothing but a scam... Why talk about them...
       
    12. Jrblovsky

      Jrblovsky Member

      Location:
      USA
      Tinnitus Since:
      Christmas 2019
      Cause of Tinnitus:
      NOISE/Menieres Who knows
      Hopefully not. :(
       
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    13. Artemis2K
      Kick ass

      Artemis2K Member Benefactor

      Location:
      South Carolina
      Tinnitus Since:
      2012
      Cause of Tinnitus:
      I had tinnitus for as long as I can remember. Got bad later.
      ...Their pill isn't even on the market yet. I think it's quite too early to call it that, especially since they really are trying and want to get government approval and funding.
       
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    14. reggie green
      Balanced

      reggie green Member

      Tinnitus Since:
      03/08/2001
      I gave Hough Ear Institute a call. I spoke to a recording. No one called back. I don't know. Mmmmh.
       
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    15. Rb86

      Rb86 Member

      Tinnitus Since:
      5/31/19
      Cause of Tinnitus:
      Noise
      Hough Ear Institute is not a scam. I've emailed tons with them. I think they're a non-profit without the financial backing like Frequency Therapeutics has, and so their moves take much longer. As annoying as it is. At least it's not as retarded as that University of Michigan thing with Dr. Susan Shore. That is blatantly stupid.
       
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    16. Jrblovsky

      Jrblovsky Member

      Location:
      USA
      Tinnitus Since:
      Christmas 2019
      Cause of Tinnitus:
      NOISE/Menieres Who knows
      I spoke to these guys today. They said it will be one or two years before the injectable drug starts clinical trials.
       
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    17. Mica Rambin

      Mica Rambin Member

      Tinnitus Since:
      09/2020
      Cause of Tinnitus:
      NIHL
      Did they give any updates on their pill?
       
    18. Jrblovsky

      Jrblovsky Member

      Location:
      USA
      Tinnitus Since:
      Christmas 2019
      Cause of Tinnitus:
      NOISE/Menieres Who knows
      20210216_155913.jpg
       
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    19. Rb86

      Rb86 Member

      Tinnitus Since:
      5/31/19
      Cause of Tinnitus:
      Noise
      Currently in clinical trials... I'm guessing more animal trials. If human, I'd want to try it.
       
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    20. Mica Rambin

      Mica Rambin Member

      Tinnitus Since:
      09/2020
      Cause of Tinnitus:
      NIHL
      Are these trials a new development separate from their proof of concept study?
       
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    21. Piney

      Piney Member

      Tinnitus Since:
      March 2018
      Cause of Tinnitus:
      Shingles virus
      It was said they were in clinical trials with the pill before, but that was years ago.

      They are in a proof of concept study, they ask for donations and you can't reach Oblato to ask when the trial is with a 100 ft pole.
       
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    22. weab00
      Gloomy

      weab00 Member Benefactor

      Location:
      Joe Dart's basement
      Tinnitus Since:
      05/2019
      Cause of Tinnitus:
      some good mf music
      I wish Hough Ear Institute would be more transparent. All of our suspicions could be due to simple misunderstandings. But their silence makes me worry that their drug isn't working the way they thought it would and that they're trying to cover it up.
       
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    23. GBB

      GBB Member Hall of Fame

      Location:
      NYC
      Tinnitus Since:
      2016-2019 (Mild, Cured) 8/2020 (Severe)
      Cause of Tinnitus:
      Virus / Microsuction / Acoustic Trauma
      We should just forget about these guys - if they do produce a breakthrough we'll know about it. If not then we'll not have wasted any time. They'll be last chronologically anyway.
       
    24. wwtsai
      Assassinator

      wwtsai Member Podcast Patron Benefactor

      Location:
      San Francisco
      Tinnitus Since:
      Mild (2016) Bothersome (8/20)
      Cause of Tinnitus:
      SNHL
      If it wasn't for the Phase 1 extension for OTO-413, I would have. If Hough Ear Institute/Oblato manages to initiate their Phase 2 trial this year, that would actually put them ahead of Otonomy and Pipeline Therapeutics. I do wish they'd just tell us what's going on straight up.
       
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    25. Mica Rambin

      Mica Rambin Member

      Tinnitus Since:
      09/2020
      Cause of Tinnitus:
      NIHL
      I got an email from Justin De Moss at Hough answering a question I had. In the message he said:

      “We have a proof-of-concept study going that is very promising and going quite well. Additionally, we just had out tinnitus research published, and it is making quite the splash. First of its kind and has brought a lot of positive attention as tinnitus is one of our primary research verticals, whereas with others it is a secondary concern.

      I checked with our COO and one of our top scientists, and he told me that yes it would be helpful for the inflammation from noise induced acoustic trauma.”​
       
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    26. Jukka

      Jukka Member Podcast Patron Benefactor

      Location:
      Finland
      Tinnitus Since:
      09/2018
      Cause of Tinnitus:
      Exposure to loud noise
      Is there any link to this research?
       
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    27. convolution

      convolution Member Podcast Patron Benefactor

      Location:
      Sweden - Italy
      Tinnitus Since:
      26/11/2020
      Cause of Tinnitus:
      White Noise from Headphones (likely)
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    28. Tezcatlipoca
      Question it

      Tezcatlipoca Member

      Location:
      Mexico
      Tinnitus Since:
      June 2020
      Cause of Tinnitus:
      NIHL
      Is blast induced tinnitus the same as NIHL?
       
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    29. VeryUnfortunate
      Stressed

      VeryUnfortunate Member Benefactor

      Tinnitus Since:
      January 2021
      Cause of Tinnitus:
      Acoustic Trauma
      Okay I know I am really late to the party on this one, but apparently NHPN-1010 finished its Phase 1 trial back in 2015.

      How have they still not finished the Proof of Concept yet for Phase 2? It seems like they are really struggling or something, because they are really taking their time one this one.
       
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    30. tommyd87

      tommyd87 Member

      Tinnitus Since:
      1999
      Cause of Tinnitus:
      tmj music
      I think it comes down to funding being a big part of it. However, the mechanisms and methods utilised by Hough Ear Institute to gain funding have simply been quite poor.
       
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