Inner Ear Hair Cell Regeneration — Maybe We Can Know More

Discussion in 'Research News' started by Hopeful, Sep 6, 2013.

    1. serendipity1996
      No Mood

      serendipity1996 Member Podcast Patron

      Tinnitus Since:
      2011
      Cause of Tinnitus:
      Unknown but suspect noise-induced
      I just came across this post from Action on Hearing Loss.
      https://www.actiononhearingloss.org...auditory-nerve-underlies-hidden-hearing-loss/
      Researchers at UCL were looking into developing diagnostic tests for hidden hearing loss/cochlear synaptopathy. This project spanned Feb 2016-2019. I know the issue of inadequate diagnostics gets brought up a lot on this forum - I'll investigate and see if there's any news as to what came out of it.

      EDIT: Okay so this project is still listed under currently funded projects and is dated 2017-20.
       
      • Like Like x 3
    2. FGG
      No Mood

      FGG Member Podcast Patron Benefactor Hall of Fame Advocate

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Multi-factorial
      They seem to be using synaptopathy and neuropathy interchangeably there unless that's just how Action on Hearing Loss is reporting it.
       
    3. serendipity1996
      No Mood

      serendipity1996 Member Podcast Patron

      Tinnitus Since:
      2011
      Cause of Tinnitus:
      Unknown but suspect noise-induced
      Yeah that's actually something that I noticed and I'm a bit confused as some sources seem to use these phrases interchangeably but I think there's some distinction between them?
       
      • Agree Agree x 1
    4. serendipity1996
      No Mood

      serendipity1996 Member Podcast Patron

      Tinnitus Since:
      2011
      Cause of Tinnitus:
      Unknown but suspect noise-induced
      New article published in The Hearing Journal entitled 'Defining Different Types of Hidden Hearing Loss':

      https://journals.lww.com/thehearing...fferent_Types_of__Hidden_Hearing_Loss_.8.aspx

      It also mentions that: "In addition to cochlear synaptopathy, research in humans and animals suggests that OHC function may also contribute to speech understanding in the presence of background noise."

      So this sounds Frequency Therapeutics etc will be able to make a good case for their drug in terms of hair cell function playing an important role in clarity.
       
      • Agree Agree x 3
      • Like Like x 2
      • Informative Informative x 1
    5. WickedCarnival

      WickedCarnival Member

      Tinnitus Since:
      Late Autumn 2016
      Cause of Tinnitus:
      Unsure between azithromycin or viral infection
      • Like Like x 1
    6. WickedCarnival

      WickedCarnival Member

      Tinnitus Since:
      Late Autumn 2016
      Cause of Tinnitus:
      Unsure between azithromycin or viral infection
      Sorry I didn't see that you already posted this, I impulsively posted the same link without reading this page of the thread haha
       
      • Friendly Friendly x 1
    7. PeteJ
      Depressed

      PeteJ Member

      Tinnitus Since:
      02/2019
      Cause of Tinnitus:
      acoustic trauma?
      Is this the same tech and science as Frequency Therapeutics'?
       
    8. xyz
      Alienated

      xyz Member

      Location:
      Germany
      Tinnitus Since:
      2006 mild T 2019 T worsening H onset
      Cause of Tinnitus:
      unknown / probably noise induced
      This is just a general thread on hair cell regeneration I think. From what I got the following is currently in the pipeline:
      • FX-322 (Frequency Therapeutics). Currently in phase 2a trial testing efficacy. Results expected 09/2020. Probably the most promising as they already had some positive results in phase 1 trial.
      • Audion Therapeutics. Phase 2 trial finished. Results expected 30/4/2020 (nobody has heard something yet)
      • The Hough Ear Institute seems to have something in the pipeline but they seem to be in the early stages and are lacking funding
      • Then when googling around I found the hearing restoration project https://hearinghealthfoundation.org/hearing-restoration-project. But don't know if they have some drug / treatment in the pipeline or if this is just some meet and greet for scientists working on this problem.
       
      • Informative Informative x 1
    9. serendipity1996
      No Mood

      serendipity1996 Member Podcast Patron

      Tinnitus Since:
      2011
      Cause of Tinnitus:
      Unknown but suspect noise-induced
      https://www.oto.theclinics.com/article/S0030-6665(20)30050-5/fulltext
      'Avenue For Future Tinnitus Treatments'

      "Tinnitus is a common symptom. Standard therapies aim at improving the quality of life and reducing the psychological stress associated with tinnitus. Most interventions have little or no effect on the main symptom. Those affected subjects, however, want such a change and prefer a specific solution, such as pharmacologic therapy to other modalities. Scientific efforts have not yet led to significant improvement in the range of therapies. This article outlines existing efforts and develops ideas on how research for improved tinnitus therapy might look in the future."
       
      • Funny Funny x 1
      • Winner Winner x 1
      • Informative Informative x 1
    10. serendipity1996
      No Mood

      serendipity1996 Member Podcast Patron

      Tinnitus Since:
      2011
      Cause of Tinnitus:
      Unknown but suspect noise-induced
      @Michael Leigh why is the above post funny? Or is this just you being petty and creeping on people's post history because people disagree with you and your contradictory views on thr TRT threads?
       
      • Agree Agree x 6
      • Winner Winner x 2
      • Hug Hug x 1
    11. BBakkers
      Not amused

      BBakkers Member Podcast Patron Benefactor

      Location:
      Netherlands
      Tinnitus Since:
      2011, Spike 2019, Spike 2020
      Cause of Tinnitus:
      1e Loud Music, 2e earwax irrigation, 3e padel tennis
      @serendipity1996

      Don't worry too much about this Michael guy. I and most members of T-talk agree with you that we would be better off with more real treatments instead of those TRT/CBT mental guilt games.
       
      • Agree Agree x 5
      • Winner Winner x 1
      • Friendly Friendly x 1
    12. xyz
      Alienated

      xyz Member

      Location:
      Germany
      Tinnitus Since:
      2006 mild T 2019 T worsening H onset
      Cause of Tinnitus:
      unknown / probably noise induced
      As FGG already noted the best we currently have as comparison for the regeneration technology are the CIs and I came about this paper.

      One-Year Results for Patients with Unilateral Hearing Loss and Accompanying Severe Tinnitus and Hyperacusis Treated with a Cochlear Implant

      https://www.karger.com/Article/Pdf/488755

      which stated

      Hyperacusis handicap (THS) decreased significantly from a preoperative score of 26 to 17 at 12 months.

      So there is hope that the hair cell regeneration also improves hyperacusis.
       
      • Informative Informative x 3
      • Like Like x 2
      • Optimistic Optimistic x 1
    13. Lucifer

      Lucifer Member Podcast Patron Benefactor

      Tinnitus Since:
      2017
      Cause of Tinnitus:
      Ear Infection
      Wow, cochlear implant actually reduces hyperacusis. This is great news. Hopefully that’s the case with FX-322.
       
      • Like Like x 1
    14. FGG
      No Mood

      FGG Member Podcast Patron Benefactor Hall of Fame Advocate

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Multi-factorial
      And keep in mind that CIs are very crude in their current form and only hit a few frequencies (and also don't work well in cochlear dead zones with very profound loss, which many CI patients have). But the fact that they improved anyway bodes well for loudness hyperacusis folks imo.
       
      • Agree Agree x 2
    15. xyz
      Alienated

      xyz Member

      Location:
      Germany
      Tinnitus Since:
      2006 mild T 2019 T worsening H onset
      Cause of Tinnitus:
      unknown / probably noise induced
      They don't differentiate between loudness and pain hyperacusis. This is certainly a deficiency. Does anybody know a study which checks the effect of CIs on pain hyperacusis?
       
      • Agree Agree x 2
      • Good Question Good Question x 1
    16. Coleoptere
      Alone

      Coleoptere Member

      Location:
      The Hague
      Tinnitus Since:
      2002
      Cause of Tinnitus:
      Bell's Palsy, hearing loss
      • Like Like x 1
    17. serendipity1996
      No Mood

      serendipity1996 Member Podcast Patron

      Tinnitus Since:
      2011
      Cause of Tinnitus:
      Unknown but suspect noise-induced
      This was posted on the Hyperacusis Research Facebook page:

      https://hearinghealthfoundation.org/blogs/tinnitus-and-noise-trauma-to-the-inner-ear

      Does curing tinnitus mean first curing hearing loss? Almost certainly, according to this piece from our partner, the Hearing Health Foundation[/URL].

      "Scientists believe that tinnitus is always associated with one or more forms of hearing loss, often noise-induced. . . Mounting evidence implicates tinnitus as an indicator of underlying auditory deficits, however mild these deficits might be, and including “hidden hearing loss” that isn’t captured via the standard audiogram. This takes us from the former concept of “some form of hearing loss is associated with tinnitus” to a picture in which “tinnitus is a symptom of a form of hearing loss.”"

      Similar neural activity "may also underlie the hyperacusis, or a lowered threshold to discomfort from sound, often associated with chronic noise-induced tinnitus."

      Tinnitus is also an "early symptom of an underlying auditory injury before measurable audiometric changes."
       
      • Like Like x 2
      • Informative Informative x 2
    18. xyz
      Alienated

      xyz Member

      Location:
      Germany
      Tinnitus Since:
      2006 mild T 2019 T worsening H onset
      Cause of Tinnitus:
      unknown / probably noise induced
      In the same article it says:

      Even normal hearing volunteers who wore silicone earplugs for seven days to simulate a temporary hearing loss developed tinnitus in that short timescale, although the tinnitus resolved after removing the earplug.

      This is new to me. If you wear too much hearing protection you can actually make things worse.
       
    19. Akk

      Akk Member Benefactor

      Location:
      Finland
      Tinnitus Since:
      2006
      Cause of Tinnitus:
      Unkonown
      ^ I used to sleep with ear plugs, lastly I had even custom build ear plugs. But then I got this left ear tinnitus (hiss) and hyperacusis. HA went away but T remained. I belive that ear plugs have something to do with, perhaps ears add amplification (sensitivy) when they are blocked some way. When I wear ear plugs I hear constant ”hisss” sound.
       
    20. serendipity1996
      No Mood

      serendipity1996 Member Podcast Patron

      Tinnitus Since:
      2011
      Cause of Tinnitus:
      Unknown but suspect noise-induced
      https://www.nih.gov/news-events/new...developmental-map-inner-ear-sound-sensor-mice

      Study Charts Developmental Map of Inner Ear Sound Sensor in Mice
      Data offers valuable resource for developing stem-cell based therapies for hearing loss

      A team of researchers has generated a developmental map of a key sound-sensing structure in the mouse inner ear. Scientists at the National Institute on Deafness and Other Communication Disorders (NIDCD), part of the National Institutes of Health, and their collaborators analyzed data from 30,000 cells from mouse cochlea, the snail-shaped structure of the inner ear. The results provide insights into the genetic programs that drive the formation of cells important for detecting sounds. The study also sheds light specifically on the underlying cause of hearing loss linked to Ehlers-Danlos syndrome and Loeys-Dietz syndrome.
       
      • Like Like x 1
    21. waly
      Chatty

      waly Member

      Tinnitus Since:
      2019
      Cause of Tinnitus:
      unknow
      This is very interesting. I developed tinnitus playing a video game, and I had to force myself to hear small sounds, and when I took off my helmets it appeared.

      And curiously a doctor told me to try never to be silent, and many times when I am silent a small sound appears that increases.

      It is possible that one way to develop tinnitus is by forcing the ear to listen.
       
    22. xyz
      Alienated

      xyz Member

      Location:
      Germany
      Tinnitus Since:
      2006 mild T 2019 T worsening H onset
      Cause of Tinnitus:
      unknown / probably noise induced
      Yes, the ear is a very fragile thing. If you give it too much input you are doomed and if to less also. I am wondering why evolution hasn't given us the capability to regrow hair cells like the birds to make this whole thing more resilient.
       
    23. Jurger

      Jurger Member

      Tinnitus Since:
      2004
      Cause of Tinnitus:
      Hearing loss
      This is very interesting. I notice my tinnitus is less loud when wearing my hearing aids. I have severe hearing loss in my right ear, so the input from my hearing aid is pretty significant. I hope people with mild hearing loss and tinnitus will also see improvement if their hearing is restored.
       
    24. Akk

      Akk Member Benefactor

      Location:
      Finland
      Tinnitus Since:
      2006
      Cause of Tinnitus:
      Unkonown
      ^ I wear hearing aid in my left ear, too. Without it, tinnitus is definetly louder.
       
    25. Coleoptere
      Alone

      Coleoptere Member

      Location:
      The Hague
      Tinnitus Since:
      2002
      Cause of Tinnitus:
      Bell's Palsy, hearing loss
      A new treatment on the horizon:

      https://techtransfer.universityofca...tn_B_GyWiL8-RA7Um2zUnw3IIv0ia175KTHjiCe5PVkmg

       
      • Like Like x 4
    26. Paulmanlike

      Paulmanlike Member Podcast Patron Benefactor Hall of Fame

      Tinnitus Since:
      2008
      Cause of Tinnitus:
      Noise
      Watch the first interview with Neuromod (Lenire). Ross O'Neill talked about a study where it was shown that deprivation of sound can actually induce tinnitus.



      It wasn't permanent but this explains the new theories of 'central gain'.

      Also, the hearing frequency that is damaged often reflects your tinnitus tone(s).
       
      • Agree Agree x 1
      • Informative Informative x 1
    27. Alex0o_o0
      Confused

      Alex0o_o0 Member Benefactor

      Location:
      Belgium
      Tinnitus Since:
      01/10/2018 - 04/04/2020
      Cause of Tinnitus:
      Whiplash/concussion - Sound trauma
    28. Clmnt
      Depressed

      Clmnt Member

      Tinnitus Since:
      11/2016
      Cause of Tinnitus:
      Sound Trauma
      I don't know if I'm the only one who thinks that using animals for tests is a waste of time?
       
      • Like Like x 1
      • Agree Agree x 1
    29. FGG
      No Mood

      FGG Member Podcast Patron Benefactor Hall of Fame Advocate

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Multi-factorial
      You want them to try them in people first? One of the (many) reasons they try drugs in animals first is they can humanely put them down of something horrible and unanticipated happens so they don't have to suffer.

      Another is cost. If you have 20 candidate compounds you have to see which ones have potential. That would mean 20 different FDA trials to get one candidate beyond phase 1. Huge waste of time and resources.
       
      • Agree Agree x 1
    30. BBakkers
      Not amused

      BBakkers Member Podcast Patron Benefactor

      Location:
      Netherlands
      Tinnitus Since:
      2011, Spike 2019, Spike 2020
      Cause of Tinnitus:
      1e Loud Music, 2e earwax irrigation, 3e padel tennis
      I know it is freaking cruel, but if it's done for a greater good for mankind and the animals don't suffer to much. I'm fine with it.
       
      • Agree Agree x 3

Share This Page

Loading...