Inner Ear Hair Cell Regeneration — Maybe We Can Know More

Discussion in 'Research News' started by Hopeful, Sep 6, 2013.

    1. wwtsai
      Assassinator

      wwtsai Member Podcast Patron Benefactor

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      Professor Fuchs did a webinar back in January on the ear, hearing, and upcoming treatments for hearing loss. He talks a bit about genetic deafness and how gene therapy can address it. He also seems pretty positive about hair cell regeneration as being a thing. I just skimmed through it, but looks really informative.

      How the Ear Hears, and What We Can Do About It
       
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    2. serendipity1996
      No Mood

      serendipity1996 Member Podcast Patron Hall of Fame

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      Fuchs briefly mentioned that his colleagues are looking at hair cell regeneration via support cell transdifferentiation I think, going by what was said on the slide.

      Wasn't this Audion's method and they didn't have much success with it?
       
    3. paul mclean

      paul mclean Member

      Tinnitus Since:
      2018
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      falling asleep with headphones in on loud
      .
       
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    4. tomytl
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    5. Bobb77
      Cynical

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      I just contacted the company per eMail and asked about the study. I live only 140 miles away from their location.
       
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    6. tomytl
      Grumpy

      tomytl Member Benefactor

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      Cool, I live about 200 km south of Tübingen, in Switzerland. Please let me know what they answer.

      Thanks.
       
    7. RichieTheKid
      Question it

      RichieTheKid Member

      Tinnitus Since:
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      Please let me know as well.
       
    8. Bobb77
      Cynical

      Bobb77 Member Benefactor

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      They did not answer.
       
    9. serendipity1996
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      serendipity1996 Member Podcast Patron Hall of Fame

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    10. Tezcatlipoca
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      Tezcatlipoca Member

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    11. frpp

      frpp Member

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    12. Tezcatlipoca
      Question it

      Tezcatlipoca Member

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      Is that what that is? I don't know anything about Rinri's approach...
       
    13. FGG
      No Mood

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      Rinri is auditory nerve repair.
       
    14. Tezcatlipoca
      Question it

      Tezcatlipoca Member

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      Could you explain how it works? Or how it could help us?
       
    15. FGG
      No Mood

      FGG Member Podcast Patron Benefactor Ambassador Hall of Fame Advocate

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      It's not likely to help you specifically unless you have auditory neuropathy (usually genetic or immune, things like GBS). At least that's what they had been working on for years but...

      I read the press release just now and it says "cytoarchitecture". I'm not sure what structures that refers to. Mostly the support cells provide that... I think?
       
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    16. Tezcatlipoca
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      Tezcatlipoca Member

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      Well that's a bummer.
       
    17. FGG
      No Mood

      FGG Member Podcast Patron Benefactor Ambassador Hall of Fame Advocate

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      It could help a lot of people though...
       
    18. frpp

      frpp Member

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      I thought they were also working on implanting transdifferentiated hair cells as well?
       
    19. FGG
      No Mood

      FGG Member Podcast Patron Benefactor Ambassador Hall of Fame Advocate

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      If they are, that is new/news to me.
       
    20. serendipity1996
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    21. OptimusPrimed
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      Yes. It was an autopsy study. It talks about the importance of knowing what’s going on because a lot of regenerative therapies are entering clinical trials. Damage to striatum doesn’t occur until around age 75 in noise-induced hearing loss and presbycusis.Before age 75 striatum is usually still good.
       
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    22. Óscar PP

      Óscar PP Member

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      Will these treatments help SSHL caused by a virus?
       
    23. star-affinity
      Gloomy

      star-affinity Member Benefactor

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      Very interesting and informative. At the end of the video at 40:47 there's someone (Elen) asking about tinnitus: ”Why do hard of hearing have ringing in their ears”?

      and the answer is:

      ”Wow, that's a toughie. So, tinnitus is ringing in the ears. It's a common consequence of hearing-loss for many, many people. For some it is really morbid, it can produce quite sever depression, social avoidance, a variety of other sorts of problems. So tinnitus has been a really quite intractable problem for a long time. And, there have been sound therapy strategies to try to decondition the ear and things of that sort. I think these are of limited utility. I'm hoping that in the long-term strategies like we've been exploring with enhancing the strength of efferent feedback might, may actually have application to pathologies like tinnitus and hyperacusis, but that's a little ways off for now. We're still trying to make sure that it works on the experimental level.

      Hopeful, but still a bit discouraging that is seems there's quite a way to go.

      Sounds like what I've been thinking many times since I got my new high-pitched tinnitus about one and a half months ago; why did I manage to get this now? If it would have happened 10-20 years from now there might (or even should?) be a medical cure available.

      Here's to hoping it goes way faster. :)

      But maybe other researchers feel they have come further?
       
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    24. Brian Newman

      Brian Newman Member

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      The above quote was posted 8 years ago and we still have nothing. What garbage tinnitus is.
       
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    25. star-affinity
      Gloomy

      star-affinity Member Benefactor

      Tinnitus Since:
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      I'm afraid 8 years isn't much when it comes to this kind of research, but I agree tinnitus (depending on its severity) is one of the most stinking bags of garbage one can endure as a human.

      My latest one sometimes wants me to remove the left inner ear from my head and smash it with a hammer out of frustration. Shut up! You are torturing a mind here, don't you understand?! :mad:o_O

      I know – that won't help and I can't communicate with my inner ear. :(
       
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    26. Brian Newman

      Brian Newman Member

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      Hopefully we’re only 5-10 years away.
       
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    27. RB2014
      Confused

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    28. tommyd87

      tommyd87 Member

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      There seems to be a big focus on gene research with hearing. Hough Ear Institute, Sound Pharmaceuticals and others all actually are focused on genes through either deleting or triggering them to treat.
       
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    29. RB2014
      Confused

      RB2014 Member Benefactor

      Location:
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      From reading the article it seems like they are still missing pieces to the puzzle. I remember when Novartis and GenVec tried just Atoh1. It didn't work as anticipated. Hopefully if they can find the right combination, this could be a good therapy.
       
    30. tommyd87

      tommyd87 Member

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      It will be interesting. If information about the Sound Pharmaceuticals' (and others') approach is right, then the theory behind gene deletion could work to deliver outcomes.
       
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