Inner Ear Hair Cell Regeneration — Maybe We Can Know More

#4,741
Professor Fuchs did a webinar back in January on the ear, hearing, and upcoming treatments for hearing loss. He talks a bit about genetic deafness and how gene therapy can address it. He also seems pretty positive about hair cell regeneration as being a thing. I just skimmed through it, but looks really informative.

How the Ear Hears, and What We Can Do About It
 
#4,742
Fuchs briefly mentioned that his colleagues are looking at hair cell regeneration via support cell transdifferentiation I think, going by what was said on the slide.

Wasn't this Audion's method and they didn't have much success with it?
 
#4,750
#4,754
Tezcatlipoca said:
Could you explain how it works? Or how it could help us?
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It's not likely to help you specifically unless you have auditory neuropathy (usually genetic or immune, things like GBS). At least that's what they had been working on for years but...

I read the press release just now and it says "cytoarchitecture". I'm not sure what structures that refers to. Mostly the support cells provide that... I think?
 
#4,755
FGG said:
It's not likely to help you specifically unless you have auditory neuropathy (usually genetic or immune, things like GBS). At least that's what they had been working on for years but...

I read the press release just now and it says "cytoarchitecture". I'm not sure what structures that refers to. Mostly the support cells provide that... I think?
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Well that's a bummer.
 
#4,760
serendipity1996 said:
New paper out co-authored by Liberman investigating the histopathology of both AHRL and NIHL. Is anybody here able to access the full paper?

Primary Neural Degeneration in Noise-Exposed Human Cochleas: Correlations with Outer Hair Cell Loss and Word-Discrimination Scores
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Yes. It was an autopsy study. It talks about the importance of knowing what's going on because a lot of regenerative therapies are entering clinical trials. Damage to striatum doesn't occur until around age 75 in noise-induced hearing loss and presbycusis.Before age 75 striatum is usually still good.
 
#4,762
wwtsai said:
Professor Fuchs did a webinar back in January on the ear, hearing, and upcoming treatments for hearing loss. He talks a bit about genetic deafness and how gene therapy can address it. He also seems pretty positive about hair cell regeneration as being a thing. I just skimmed through it, but looks really informative.

How the Ear Hears, and What We Can Do About It
Click to expand...
Very interesting and informative. At the end of the video at 40:47 there's someone (Elen) asking about tinnitus: "Why do hard of hearing have ringing in their ears"?

and the answer is:

"Wow, that's a toughie. So, tinnitus is ringing in the ears. It's a common consequence of hearing-loss for many, many people. For some it is really morbid, it can produce quite sever depression, social avoidance, a variety of other sorts of problems. So tinnitus has been a really quite intractable problem for a long time. And, there have been sound therapy strategies to try to decondition the ear and things of that sort. I think these are of limited utility. I'm hoping that in the long-term strategies like we've been exploring with enhancing the strength of efferent feedback might, may actually have application to pathologies like tinnitus and hyperacusis, but that's a little ways off for now. We're still trying to make sure that it works on the experimental level.

Hopeful, but still a bit discouraging that is seems there's quite a way to go.

Sounds like what I've been thinking many times since I got my new high-pitched tinnitus about one and a half months ago; why did I manage to get this now? If it would have happened 10-20 years from now there might (or even should?) be a medical cure available.

Here's to hoping it goes way faster. :)

But maybe other researchers feel they have come further?
 
#4,763
Ty shattuck said:
Soon amputees won't have to worry about living their days without a limb; blindness would soon be a thing of the past. Soon we won't have doctors spitting those loathsome words "get used to i.t" Stem cell research is the next step in human evolution. Or re-evolution.
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The above quote was posted 8 years ago and we still have nothing. What garbage tinnitus is.
 
#4,764
Brian Newman said:
The above quote was posted 8 years ago and we still have nothing. What garbage tinnitus is.
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I'm afraid 8 years isn't much when it comes to this kind of research, but I agree tinnitus (depending on its severity) is one of the most stinking bags of garbage one can endure as a human.

My latest one sometimes wants me to remove the left inner ear from my head and smash it with a hammer out of frustration. Shut up! You are torturing a mind here, don't you understand?! :mad:o_O

I know – that won't help and I can't communicate with my inner ear. :(
 
#4,767
#4,768
tommyd87 said:
There seems to be a big focus on gene research with hearing. Hough Ear Institute, Sound Pharmaceuticals and others all actually are focused on genes through either deleting or triggering them to treat.
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From reading the article it seems like they are still missing pieces to the puzzle. I remember when Novartis and GenVec tried just Atoh1. It didn't work as anticipated. Hopefully if they can find the right combination, this could be a good therapy.
 
#4,769
RB2014 said:
From reading the article it seems like they are still missing pieces to the puzzle. I remember when Novartis and GenVec tried just Atoh1. It didn't work as anticipated. Hopefully if they can find the right combination, this could be a good therapy.
Click to expand...
It will be interesting. If information about the Sound Pharmaceuticals' (and others') approach is right, then the theory behind gene deletion could work to deliver outcomes.
 
#4,770

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