New University of Michigan Tinnitus Discovery — Signal Timing

Discussion in 'Research News' started by Hudson, Jun 20, 2013.

    1. Mathew Gould

      Mathew Gould Member Benefactor

      Tinnitus Since:
      6/2017
      Cause of Tinnitus:
      Neck/Jaw misalignment
      Nothing ever "launched" or tried works the first time. Continuous improvement is more likely. She should just launch it, get results and then improve it.
       
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    2. GlennS

      GlennS Member Podcast Patron Hall of Fame

      Tinnitus Since:
      1992
      Cause of Tinnitus:
      Loud music
      On the flipside, using paying customers to beta-test an unfinished product was bad PR, especially when you factor in those who have had negative reactions, some apparently permanent.
       
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    3. GlennS

      GlennS Member Podcast Patron Hall of Fame

      Tinnitus Since:
      1992
      Cause of Tinnitus:
      Loud music
      Two? What about Minnesota?
       
    4. Christiaan
      Vegged out

      Christiaan Member Podcast Patron Benefactor

      Location:
      The Hague, the Netherlands
      Tinnitus Since:
      2016
      Cause of Tinnitus:
      Bloody headphones in 2016,worsened in 2020
      Do you people think that it would be possible to hear silence again when using the Michigan device longterm? I thought I read somewhere that Susan Shore wants to test the idea in the next trial that long term use of her device might incrementally decrease the hyperactivity of the fusiform cells over time, which in turn could decrease tinnitus. I am living on a prayer here.
       
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    5. F-u-T

      F-u-T Member Podcast Patron Benefactor

      Location:
      AZ USA
      Tinnitus Since:
      10/2018
      Cause of Tinnitus:
      Acoustic Trama
      Yes. I do think it is possible. If not silence then hopefully a big reduction that is easier to cope with.
       
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    6. Piney

      Piney Member

      Tinnitus Since:
      March 2018
      Cause of Tinnitus:
      Shingles virus
      Why does this device have a trial completion date years away? Is that an estimation? How much hearing do you have to have to use it?
       
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    7. tommyd87

      tommyd87 Member

      Tinnitus Since:
      1999
      Cause of Tinnitus:
      tmj music
      This thing tends to have heaps of questions around it much like there was with Hough Ear Institute until they put out their video on the trial progress.

      I'm pretty positive people have been questioning this device and also its progress probably for reasons like you have been and that there is no direct information forthcoming from those that are trying to make it.

      I reckon it is a bit shaky and actually a medication will come first before this treatment does because of the vagueness and definite hold ups.
       
    8. gerhei

      gerhei Member

      Tinnitus Since:
      March 2019
      Cause of Tinnitus:
      Unknown/After a cold
      Also tinnitus that is not caused by hearing loss?
       
    9. FGG
      No Mood

      FGG Member Podcast Patron Benefactor Hall of Fame Advocate

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Multi-factorial
      Medical devices have different trial requirements than drugs. I think the hold up on the trial is less the FDA and more investigating the treatment and how, when and for who it should be used.

      This site has a good overview of drugs vs device trials:

      https://premier-research.com/blog/perspectivesmedical-devices-vs-drug-trials/

      Maybe you weren't alluding to the FDA here but using the video as an example of Hough explaining their particular delay.
       
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    10. DebInAustralia
      No Mood

      DebInAustralia Member Benefactor Advocate

      Location:
      Geelong, Victoria
      Tinnitus Since:
      30/12/13
      So, skimming through this thread, does anyone know if Shore has indicated when her device will be released?
       
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    11. Emgee

      Emgee Member Podcast Patron Benefactor

      Location:
      United States
      Tinnitus Since:
      03/2020
      Cause of Tinnitus:
      Modern Society = Too Loud
      At the end of May, she indicated that they were in the midst of their second trial. She estimated it would be completed by early fall. I’m not sure if there are delays caused by COVID-19. Lastly, she could not estimate a timeframe to commercialization.
       
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    12. Thuan

      Thuan Member

      Location:
      California
      Tinnitus Since:
      05/2018
      Cause of Tinnitus:
      Ear infection
      What clinical phase is this supposed to be?

      PS.
      This thread was started in 2013...
       
    13. DebInAustralia
      No Mood

      DebInAustralia Member Benefactor Advocate

      Location:
      Geelong, Victoria
      Tinnitus Since:
      30/12/13
      Thanks Emgee.

      Has she published her findings?

      How many trials does the device need to pass through to get to market?
       
    14. F-u-T

      F-u-T Member Podcast Patron Benefactor

      Location:
      AZ USA
      Tinnitus Since:
      10/2018
      Cause of Tinnitus:
      Acoustic Trama
      My guess is still a couple years away until we see any device available to purchase.
       
    15. GlennS

      GlennS Member Podcast Patron Hall of Fame

      Tinnitus Since:
      1992
      Cause of Tinnitus:
      Loud music
      She could have done a dozen by now if she wanted to.

      giphy.gif
       
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    16. asey20
      Curious

      asey20 Member Benefactor

      Location:
      Toronto
      Tinnitus Since:
      July 13, 2020
      Cause of Tinnitus:
      Not sure.
      Is the Susan Shore device the same as Lenire?
       
    17. WillBeNimble
      Buzzed

      WillBeNimble Member Podcast Patron Benefactor

      Location:
      Ohio
      Tinnitus Since:
      2017
      Cause of Tinnitus:
      Acoustic Damage from earphones
      No, Shore's device is more specific, from my understanding.
       
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    18. DebInAustralia
      No Mood

      DebInAustralia Member Benefactor Advocate

      Location:
      Geelong, Victoria
      Tinnitus Since:
      30/12/13
      No. They're not the same. I can't give you details. I know others here could. But, from what I have read, Shore teams sound therapy with carefully timed electrical stimulation to the trigeminal nerve with the placement of an electrode either on the cheek or neck, as opposed to Lenire, that involves sound therapy (that is not synchronised?) and placement of a mouth piece to deliver electrical impulses to activate the trigeminal nerve.

      I have read about a poster's experience here who got trigeminal neuralgia during the Lenire trial (I hope they are OK now), and others who have experienced permanent spikes using Lenire.

      I think I would be more comfortable using Shore's device if it is ever released to the market.
       
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    19. BBakkers
      Not amused

      BBakkers Member Podcast Patron Benefactor

      Location:
      Netherlands
      Tinnitus Since:
      2011, Spike 2019, Spike 2020
      Cause of Tinnitus:
      1e Loud Music, 2e earwax irrigation, 3e padel tennis
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    20. Christiaan
      Vegged out

      Christiaan Member Podcast Patron Benefactor

      Location:
      The Hague, the Netherlands
      Tinnitus Since:
      2016
      Cause of Tinnitus:
      Bloody headphones in 2016,worsened in 2020

      Attached Files:

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    21. Christiaan
      Vegged out

      Christiaan Member Podcast Patron Benefactor

      Location:
      The Hague, the Netherlands
      Tinnitus Since:
      2016
      Cause of Tinnitus:
      Bloody headphones in 2016,worsened in 2020
      Info about next trial:

      Capture d’écran 2020-09-02 à 20.30.28.png
       
    22. Adaś
      Curious

      Adaś Member Podcast Patron Benefactor

      Location:
      Switzerland
      Tinnitus Since:
      02/2013
      Cause of Tinnitus:
      Headphones, Stress, Rock concerts
      Looking there I read "In the fall, her team will begin the next phase of research, with the goal of replicating earlier results and gaining Food and Drug Administration approval for commercialization of the technique".

      There's a transcript here: https://www.ata.org/sites/default/files/Podcast 7 Susan Shore Transcript.pdf

      So I have listened to this podcast. Long story short, the next NIH funded trial is supposed to be concluded by the end of the next year, and depending on the outcome of this next trial that will look into e.g. long term effects of bi-modal stimulation therapy, they will decide whether to purse commercialization for this technique.

      I guess we need to wait till (at least) end of the next year to know if this will work at all and if it has (any) chances of commercialization.

      It is worth to listen to this podcast though. It is disappointing however that the hosts were so euphoric (nervously laughing) when Dr. Shore says the next trial is to be concluded end of next year. They were like "oh that so quick", even if she meant that as maybe... maybe they will start commercialization efforts if that trial goes well, without talking how long it would take to have it commercialized. It only shows how much we starve for some viable therapies and remedies for this condition.
       
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    23. Watasha
      No Mood

      Watasha Member Benefactor Advocate

      Tinnitus Since:
      03/2018
      Cause of Tinnitus:
      Unknown
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    24. ruud1boy

      ruud1boy Member Podcast Patron Benefactor

      Location:
      Huddersfield, UK
      Tinnitus Since:
      Mild since 2006. Severe since 2016
      Cause of Tinnitus:
      An enthusiastic youth
      She wasn't part of the trial - she bought the device as a commercial patient. I feel pretty peed off that I've spunked the thick end of £3k on Lenire to no effect, but I'm thankful to say the least that I didn't experience any 'disimprovements'.
       
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    25. Bambam0
      Cool

      Bambam0 Member Podcast Patron Benefactor

      Tinnitus Since:
      2/2018
      Cause of Tinnitus:
      Rock N Roll
      This podcast is from July 2018 y'all.

      I emailed her a few months back and she said to expect news "later this year." Which would be in the next 4 months.
       
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    26. BBakkers
      Not amused

      BBakkers Member Podcast Patron Benefactor

      Location:
      Netherlands
      Tinnitus Since:
      2011, Spike 2019, Spike 2020
      Cause of Tinnitus:
      1e Loud Music, 2e earwax irrigation, 3e padel tennis
      My bad then! Apologies. On google it said july 2020.
       
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    27. Bambam0
      Cool

      Bambam0 Member Podcast Patron Benefactor

      Tinnitus Since:
      2/2018
      Cause of Tinnitus:
      Rock N Roll
      I just remember listening to that podcast a few years ago and confirmed by looking at the ATA podcast lineup. I'm just glad we're going to hear something soon!
       
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    28. DebInAustralia
      No Mood

      DebInAustralia Member Benefactor Advocate

      Location:
      Geelong, Victoria
      Tinnitus Since:
      30/12/13
      Hear something soon... as in commercialisation?
       
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    29. DebInAustralia
      No Mood

      DebInAustralia Member Benefactor Advocate

      Location:
      Geelong, Victoria
      Tinnitus Since:
      30/12/13
      Even in the midst of COVID-19?
       
    30. Bambam0
      Cool

      Bambam0 Member Podcast Patron Benefactor

      Tinnitus Since:
      2/2018
      Cause of Tinnitus:
      Rock N Roll
      Yup! I asked her if there were any updates on Phase 2 trial and to quote her she said "should be updates later this year"

      This was 5 weeks ago
       
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