Otonomy OTO-313 — Treatment of Tinnitus

Discussion in 'Research News' started by Michael Larsen, Jan 9, 2018.

    1. Philip83
      Jaded

      Philip83 Member Podcast Patron Benefactor

      Location:
      Sweden
      Tinnitus Since:
      2001
      Cause of Tinnitus:
      Moped (2001) Noise blast (2014) Club (2017) Snowboard (2018)
    2. serendipity1996
      No Mood

      serendipity1996 Member Podcast Patron Hall of Fame

      Tinnitus Since:
      2011
      Cause of Tinnitus:
      Unknown but suspect noise-induced
      I think these results were discussed on this thread a few page back! When they came out in the summer. Check out page 11 of this thread.
       
    3. Philip83
      Jaded

      Philip83 Member Podcast Patron Benefactor

      Location:
      Sweden
      Tinnitus Since:
      2001
      Cause of Tinnitus:
      Moped (2001) Noise blast (2014) Club (2017) Snowboard (2018)
      Ooh, ok! Sorry, completely missed that.
       
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    4. kingsfan
      Mellow

      kingsfan Member

      Location:
      Southern California
      Tinnitus Since:
      mild for years. severe on 09/17/2020
      Cause of Tinnitus:
      turning everything up to 11
      Anyone know if OTO-313 has any similarities to Ketamine? All I understand is that they both act on NMDA receptors.
       
    5. FGG
      No Mood

      FGG Member Podcast Patron Benefactor Hall of Fame Advocate

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Multi-factorial
      OTO-313 is Gacyclidine. Like Ketamine it is an NMDA antagonist (though it's closer to PCP than Ketamine apparently) but given intratympanically in this case.

      https://en.wikipedia.org/wiki/Gacyclidine
       
    6. GBB

      GBB Member

      Location:
      NYC
      Tinnitus Since:
      2016-2019 (Mild, Cured) 8/2020 (Severe)
      Cause of Tinnitus:
      Microsuction / Additional Acoustic Trauma in Close Proximity
      They both antagonize NMDA receptors meaning they reduce the receptor activity. Beyond that I don't know.
       
    7. kingsfan
      Mellow

      kingsfan Member

      Location:
      Southern California
      Tinnitus Since:
      mild for years. severe on 09/17/2020
      Cause of Tinnitus:
      turning everything up to 11
      Tomorrow is my 3 month anniversary with this. I didn't realize until today that OTO-313 may only be effective during the acute phase, so I'm feeling pressure to decide if I'm going to try the Ketamine infusion route as I'm assuming I'm running out of time.
       
    8. GBB

      GBB Member

      Location:
      NYC
      Tinnitus Since:
      2016-2019 (Mild, Cured) 8/2020 (Severe)
      Cause of Tinnitus:
      Microsuction / Additional Acoustic Trauma in Close Proximity
      To the medically inclined people here - would blocking NMDA activity in the ear result in upregulation of Glutamate, and presumably trigger homeostatic adjustment in the long term?
       
    9. FGG
      No Mood

      FGG Member Podcast Patron Benefactor Hall of Fame Advocate

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Multi-factorial
      The only thing I could find on this is with alcohol, which has small NMDA blocking properties, and with very long term use, or withdrawal there is an upregulation of Glutamate receptors.

      I suspect if this is an issue here it would be more of a long term use issue rather than a single dose of OTO-313.
       
    10. GBB

      GBB Member

      Location:
      NYC
      Tinnitus Since:
      2016-2019 (Mild, Cured) 8/2020 (Severe)
      Cause of Tinnitus:
      Microsuction / Additional Acoustic Trauma in Close Proximity
      I see, thanks! Hopefully chronic sufferers won’t have to rely on this medication longer term.
       
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    11. Jack V

      Jack V Member Benefactor

      Tinnitus Since:
      1/2020
      Interestingly, the molecule itself is very similar.
       
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    12. morgothaod

      morgothaod Member

      Tinnitus Since:
      03/2009
      Cause of Tinnitus:
      Ear infection
      Would OTO-313 or OTO-413 help with chronic tinnitus in someone without hearing loss?
       
      • Good Question Good Question x 2
    13. patorjk

      patorjk Member

      Tinnitus Since:
      2008
      Cause of Tinnitus:
      Several reasons
      OTO-313 is for tinnitus and showed positive results in its Phase I/II trial. It would probably be your best bet of the two.

      OTO-413 is speculated to help, since tinnitus is due to cochlear damage. If your tinnitus is due to synapse damage it would possibly help, if it's due to something else (like hair cell damage) it wouldn't help.

      We may know more after Tinnitus Talk interviews Otonomy early next year.
       
    14. Mads-Emil Hansen

      Mads-Emil Hansen Member

      Tinnitus Since:
      10/2020
      Cause of Tinnitus:
      Unknown
      I am a little confused. Is this not really good news for us? I have not been on this forum for long, so I guess people have been let down by a lot of 'treatments' and this might just be another one of those, but it seems like there is some clinical evidence that it can help.
       
    15. tommyd87

      tommyd87 Member

      Tinnitus Since:
      1999
      Cause of Tinnitus:
      tmj music
      I think we will widely know more after all the medicines are hopefully available as at the moment we cannot exactly pinpoint what treats tinnitus and this will vary and/or be made clearer consequently after the treatments become available.
      There is a lot more evidence that this treatment will assist than many of the previously examined treatments.
       
    16. kingsfan
      Mellow

      kingsfan Member

      Location:
      Southern California
      Tinnitus Since:
      mild for years. severe on 09/17/2020
      Cause of Tinnitus:
      turning everything up to 11
      I think many here are discouraged that OTO-313 appears to be only for acute tinnitus.

      Although the next clinical trial in the first quarter of 2021 will be accepting chronic tinnitus sufferers.
       
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    17. tommyd87

      tommyd87 Member

      Tinnitus Since:
      1999
      Cause of Tinnitus:
      tmj music
      I think some are discouraged by OTO-313 being only for acute tinnitus because they are not aware of the subsequent clinical trials for chronic tinnitus, nor is there any information and/or data relating to chronic tinnitus.

      I am not disheartened by this at the moment and believe that this tends to be a matter of waiting and watching this space.
       
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    18. Jack V

      Jack V Member Benefactor

      Tinnitus Since:
      1/2020
      That's a misunderstanding based on misinformation recycling on the internet.

      Otonomy is currently exploring if, and under what circumstances, OTO-313 might be helpful.

      Until we know more, until Otonomy itself knows more, no need to get discouraged.
       
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    19. GBB

      GBB Member

      Location:
      NYC
      Tinnitus Since:
      2016-2019 (Mild, Cured) 8/2020 (Severe)
      Cause of Tinnitus:
      Microsuction / Additional Acoustic Trauma in Close Proximity
      If tinnitus is exacerbated by excess Glutamate in and around the cochlea, causing things to act hyperexcited and fire erratically, why would this therapy be limited to acute cases? I have never read anything that suggests that this ceases to be the case as time goes on, or else by the same logic, wouldn't the tinnitus soften and/or abate? I am not an expert, but conceptually it seems ambiguous as to why this would only be helpful to chronic cases.

      The only thing I can think of is that somehow the brain internalizes the erraticism of the ear over time, but this is quite an abstract concept and I'm not sure there is concrete evidence.
       
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    20. FGG
      No Mood

      FGG Member Podcast Patron Benefactor Hall of Fame Advocate

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Multi-factorial
      It wouldn't be necessarily. The Glutamate surge affects everyone acutely and is a more variable factor chronically.

      Some people would likely benefit chronically (if say neuro excitability is more of a factor for them than the physical damage and "phantom cochlea") but i don't think that would universally be the case. I.e. I think it might help chronic cases at least a little but some people it would help a lot (like Sound Pharmaceuticals' drug). I am interested to see how exactly they recruit for the chronic cases unless they do it as an exploratory. My two cents.

      But this would be another good question for Otonomy...
       
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    21. Markku
      Inspired

      Markku Founder Staff Podcast Patron Benefactor Hall of Fame Advocate

      Tinnitus Since:
      04/2010
      Cause of Tinnitus:
      Syringing
      Indeed.

      We're still taking questions until the end of year, so we're encouraging everyone to submit them below:

       
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    22. Piney

      Piney Member

      Tinnitus Since:
      March 2018
      Cause of Tinnitus:
      Shingles virus
      Does anyone know when the next clinical trial is going to start?
       
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    23. kingsfan
      Mellow

      kingsfan Member

      Location:
      Southern California
      Tinnitus Since:
      mild for years. severe on 09/17/2020
      Cause of Tinnitus:
      turning everything up to 11
      I spoke with Otonomy a couple of weeks ago, and they had no real information other than Q1 of 2021. I was advised to keep checking the "latest news" section on their homepage.
       
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