Otonomy OTO-413 — Treatment of Hidden Hearing Loss

Discussion in 'Research News' started by Michael Larsen, Jan 9, 2018.

    1. FGG
      No Mood

      FGG Member Podcast Patron Benefactor Hall of Fame Advocate

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Multi-factorial
      Which treatments do you mean? Only OTO-313 is in trial for acute tinnitus.
       
    2. Joly

      Joly Member

      Tinnitus Since:
      22/08/2019
      Cause of Tinnitus:
      Traumatisme sonore
      The Hough pill is also for acute tinnitus. It is apparently easier to repair acute tinnitus.

      What I don't understand is the difference between acute and chronic tinnitus in the ear and the brain?
       
    3. FGG
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      FGG Member Podcast Patron Benefactor Hall of Fame Advocate

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      Hough has said they very much believe it is for chronic too. They just need to prove it with further testing.
       
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    4. FGG
      No Mood

      FGG Member Podcast Patron Benefactor Hall of Fame Advocate

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    5. Ben S
      Curious

      Ben S Member

      Location:
      Connecticut
      Tinnitus Since:
      11/2015
      When I saw this slide from Otonomy's presentation regarding OTO-413 a few questions came to mind...

      On the first graph, it's impressive how there was a huge amount of synapses that were regenerated, but it doesn't seem to have a huge effect on practical hearing (displayed on the second graph). Are the new synapses not as effective? Perhaps hair cell death could be attributed to the lack of hearing restoration? What do you guys think is happening there on the second graph that explains the lack of full auditory function regeneration?

      9.jpg

      Link to full presentation: https://seekingalpha.com/article/4218731-otonomy-otic-updates-on-otominus-413-program-slideshow
       
      • Good Question Good Question x 2
    6. FGG
      No Mood

      FGG Member Podcast Patron Benefactor Hall of Fame Advocate

      Tinnitus Since:
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      It actually seems very good for 10 to 20 Hz but less so at 4Hz and 40Hz. No idea what this means as far as "practical hearing" since you can't do a speech in noise test on a rodent but yes, it could imply those areas were more prone to other non-synapse damage. The trial results later this year on humans will give us a much better idea. Especially in regards to "practical hearing."
       
      • Agree Agree x 2

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