Sound Pharmaceuticals (SPI-5557 & SPI-1005)

Discussion in 'Research News' started by joe, Jan 26, 2012.

    1. swc5150

      swc5150 Member

      Tinnitus Since:
      06/2012
      Click the "quote" button on the lower right of the posting box.
       
    2. Nate

      Nate Member Benefactor

      Location:
      MA
      Tinnitus Since:
      1989
      WOW! I can't believe I didn't see that! :) Thanks again!
       
    3. jdjd09

      jdjd09 Member

      So, are there any release dates on this? Have they put any messages out on how many DB's this may bring back?
       
    4. Aaron123

      Aaron123 Member

      Tinnitus Since:
      00/0000
      Cause of Tinnitus:
      Irrelevant
      If you look at the pipeline page on their web site, SP-5557 seems to be the drug candidate for regeneration. They say they are looking at an IND filing in the fourth quarter 2017. (Looking around, it has been in the pre-clinical stage since at least 2009...) If that is accepted, then they will start phase 1 trials sometime after that. Of course that drug is targeted at people with severe to profound hearing loss. They have other drugs that are farther along for other indications.

      Regarding dBs, the Walters et al (2014) paper that they cite on their technology page reports that they were able to essentially restore hearing (as measured by ABR) to deaf mice by "knocking out" a particular protein (p27). Looking around, there seems to be a number of papers focusing on p27. There's a article at hearing review that describes a bit about how this work http://www.hearingreview.com/2015/12/molecule-discovery-may-help-advance-hearing-restoration/
       
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    5. Aaron123

      Aaron123 Member

      Tinnitus Since:
      00/0000
      Cause of Tinnitus:
      Irrelevant
      There's some new information on SPI-1005. Possibly good news for folks with Meniere's Disease. I don't usually post links to press releases, but there is no paper at this time: http://www.prnewswire.com/news-rele...ical-trial-in-menieres-disease-300530256.html

      The claim is positive Phase 1 test results, but we won't really know what that means until the results are published. Nonetheless, they are starting a Phase II trial. No info on that trial in clinicaltrials.gov, but here is the info on the Phase 1 trial: https://www.clinicaltrials.gov/ct2/show/NCT02603081
       
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    6. jer

      jer Member

      Tinnitus Since:
      06/2015
      Cause of Tinnitus:
      Acoustic trauma
      Someone stated that this was an ear and brain disease. What if the difference between the acute and chronic phases are that the tinnitus moves from the ear into the brain and it settles there. And that is the difference between these.

      And may I also point out that we already had some sort of a treatment/cure for tinnitus in the form of trobalt/retigabine. The only problem was the side effects in that it was not sustainable for longer periods.
       
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    7. Fabrikat

      Fabrikat Member

      Tinnitus Since:
      1973
      Cause of Tinnitus:
      Otosclerosis then volume then viral infection
      It is indeed an exciting bit of news @Aaron123, not just for Meniere's Disease but, by the sounds of it, a few other inflammatory inner ear conditions as well, including noise induced hearing threshold shift, if I read it correctly.

      Crucial, is the sentence; 'SPI-1005 treatment also resulted in improvements in word recognition, tinnitus loudness,......', linking cochlear salvage with improvement in T loudness. Though it doesn't say complete elimination.

      This is good news for acute early treatment, but I wonder what they have in the works for us long time chronic sufferers?
       
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    8. Frédéric

      Frédéric Member Benefactor

      Location:
      Marseille, France
      Tinnitus Since:
      11/19/2012
      Cause of Tinnitus:
      acoustic trauma
      I missed (and nothing was published on this forum) this phase 2 trial entitled:
      Otoprotection With SPI-1005 for Prevention of Temporary Auditory Threshold Shift
      https://clinicaltrials.gov/show/NCT01444846

      Although, it is listed in the company website pipeline:
      https://soundpharma.com/pipeline/

      However sadly, tinnitus is only listed as a possible condition, but not as a secondary outcome (improvement or not).

      Results:
      http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(17)31791-9/fulltext
      @Aaron123 : thanks for the source (prnews article)
       
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    9. VRZ78

      VRZ78 Member Benefactor

      Tinnitus Since:
      08/2016
      Cause of Tinnitus:
      Viral Infection
      I think this is different than the trial Aaron were talking about for Ménière's Disease ?
      This seems to be for protection
       
    10. Frédéric

      Frédéric Member Benefactor

      Location:
      Marseille, France
      Tinnitus Since:
      11/19/2012
      Cause of Tinnitus:
      acoustic trauma
      I know we are not talking about the same clinical trial. I am talking about the clinical trial which is mentioned at the end of the article provided by prnewswire: http://www.prnewswire.com/news-rele...ical-trial-in-menieres-disease-300530256.html

      Quote :" In an earlier Phase 2 clinical trial, SPI-1005 was shown to prevent the temporary threshold shift due to acute noise exposure or noise induced hearing loss in young adults (average age 20 years old). These data were published July 14, 2017 online in The Lancet, a leading medical journal." End quote.
       
    11. HomeoHebbian
      Question it

      HomeoHebbian Member Benefactor

      Location:
      United States
      Tinnitus Since:
      2012
      Cause of Tinnitus:
      Noise exposure
      That's not how tinnitus works. Damage to the ear has virtually immediate effects on the brain. The perception of tinnitus -whether acute or chronic- obligatory involves the brain, though does not always involve the ear.
       
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    12. Contrast

      Contrast Member Benefactor Hall of Fame

      Location:
      Retrovile
      Tinnitus Since:
      late 2017
      Cause of Tinnitus:
      injury from noxious noise
      Tinnitus starts out in auditory regions of the brain and then spreads to other regions of the brain.

      This is where the mystery arises.
       
    13. dpdx
      Disappointed

      dpdx Member Benefactor Hall of Fame

      Location:
      Murica
      Tinnitus Since:
      Onset:09/23/2017 Worsened: 1/17/2018
      Cause of Tinnitus:
      Acoustic Trauma, worsened by caloric test/VEMP test 90db nhL
      I think Tinnitus damages the brain or re-wires it somehow, making us more prone to other brain conditions like eye floaters (which I have), visual snow, insomnia,etc
       
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    14. dpdx
      Disappointed

      dpdx Member Benefactor Hall of Fame

      Location:
      Murica
      Tinnitus Since:
      Onset:09/23/2017 Worsened: 1/17/2018
      Cause of Tinnitus:
      Acoustic Trauma, worsened by caloric test/VEMP test 90db nhL
      If I were to compare myself last year during this time and now, it is like sky and earth in every sense. I feel always tired now, forgetful, tired, etc.
       
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    15. Flamingo1

      Flamingo1 Member Benefactor

      Location:
      Orlando, FL
      Tinnitus Since:
      4-15-2017
      Cause of Tinnitus:
      Acoustic trauma
      This thread had been trending since 2012. I can see why you feel this way!!
       
    16. FGG

      FGG Member

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Meniere's
      For anyone still following Sound Pharmaceuticals, they finished Phase 2b for SPI-1005 to treat vertigo and hearing loss associated with Meniere's a few days ago. May not apply to many people on this forum but I think SPI-1005, a glutathione peroxodase inducer is still being additionally tested for multiple pathologies/applications.

      Not sure when they will announce results, hopefully soon.
       
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    17. FGG

      FGG Member

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Meniere's
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    18. ChrisBoyMonkey

      ChrisBoyMonkey Member Podcast Patron

      Location:
      Los Angeles, CA
      Tinnitus Since:
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      Cause of Tinnitus:
      U.S. Army/Field Artillery Veteran
    19. Chinmoku

      Chinmoku Member

      Tinnitus Since:
      10/2018
      Cause of Tinnitus:
      Unknown, possibly medication
      It would work mostly on low frequency tinnitus cases, apparently.
       
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    20. Fabrikat

      Fabrikat Member

      Tinnitus Since:
      1973
      Cause of Tinnitus:
      Otosclerosis then volume then viral infection
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    21. Ken219
      Frustrated

      Ken219 Member

      Location:
      New York Area
      Tinnitus Since:
      Summer of 1990
      Cause of Tinnitus:
      Noise exposure?
      I'm with you. As much as I'd like my hearing back stop the tinnitus!
       
    22. JohnAdams
      Starving

      JohnAdams Member Benefactor Hall of Fame

      Location:
      here
      Tinnitus Since:
      it started.
      Cause of Tinnitus:
      hearing loss
      Wow, never heard of this company before. Great to know more groups are working on hair cell regeneration.
       
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    23. JohnAdams
      Starving

      JohnAdams Member Benefactor Hall of Fame

      Location:
      here
      Tinnitus Since:
      it started.
      Cause of Tinnitus:
      hearing loss
      nah.
       
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