Sound Pharmaceuticals (SPI-5557 & SPI-1005)

Discussion in 'Research News' started by joe, Jan 26, 2012.

    1. FGG
      No Mood

      FGG Member Podcast Patron Benefactor Hall of Fame Advocate

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Multi-factorial
      https://clinicaltrials.gov/ct2/show/NCT02779192?term=Sound+pharmaceuticals&draw=2&rank=2

      Looks like they haven't posted the Meniere's continuation study but here is separate one they are doing for NIHL. It's a bit sketchy though as they actually induce a noise challenge in people who have prior NIHL.
       
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    2. BBakkers
      Tired

      BBakkers Member Podcast Patron Benefactor

      Location:
      Netherlands
      Tinnitus Since:
      2011, Spike 2019, Spike 2020
      Cause of Tinnitus:
      1e Loud Music, 2e earwax irrigation, 3e padel tennis
    3. BBakkers
      Tired

      BBakkers Member Podcast Patron Benefactor

      Location:
      Netherlands
      Tinnitus Since:
      2011, Spike 2019, Spike 2020
      Cause of Tinnitus:
      1e Loud Music, 2e earwax irrigation, 3e padel tennis
      For whom it may be interesting. I took some steps to find out their stance on Expanded Access/Compassionate Use possibilities. I can update if anyone is interested. See the email down below:


      Dear to whom it may concern,

      myTomorrows is a company that helps patients with an unmet medical need and their physicians find and get access to treatment options. We facilitate the search and enrolment into trials and Expanded Access Programs, some of which we manage ourselves.

      Recently I have been in contact with Mike ..... (in CC) who has been suffering from Tinnitus. He is extremely pro-active in his search to treatment options and came across the Phase 1/2b CT with SPI-1005. Although the indication is Meniere’s disease, tinnitus is a sub-feature that was significantly reduced according to the recent news release with clinical findings.

      I am inquiring on his behalf about Expanded Access/Compassionate Use possibilities and are curious about Sound Pharmaceuticals’ policy regarding this.

      Any information would be greatly appreciated.

      Kind regards,

      ..................

      Patient Navigator
       
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    4. Emgee

      Emgee Member Podcast Patron Benefactor

      Tinnitus Since:
      03/2020
      Cause of Tinnitus:
      Modern Society = Too Loud
      I’ve also reached out to the company regarding their stance on expanded access. This may be a helpful drug due to its safety profile and effectiveness on inflammation. 30% reduction in tinnitus loudness for the 400 mg group? This seems to be worth a shot. This is exciting.
       
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    5. serendipity1996

      serendipity1996 Member Podcast Patron

      Tinnitus Since:
      2011
      Cause of Tinnitus:
      Unknown but suspect noise-induced
      I'd be very interested whether this could also potentially reduce hyperacusis-related inflammation.
       
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    6. BBakkers
      Tired

      BBakkers Member Podcast Patron Benefactor

      Location:
      Netherlands
      Tinnitus Since:
      2011, Spike 2019, Spike 2020
      Cause of Tinnitus:
      1e Loud Music, 2e earwax irrigation, 3e padel tennis
      I have emailed two times and called them once leaving a message. No reaction so far. No answer yet, ofcourse.

      But don't you worry I'm going to stalk them until I get an answer. I don't really give a S...
       
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    7. Emgee

      Emgee Member Podcast Patron Benefactor

      Tinnitus Since:
      03/2020
      Cause of Tinnitus:
      Modern Society = Too Loud
      I was thinking about this. Should there be a difference in tinnitus effectiveness if a person doesn’t have Ménière’s Disease?

      Tinnitus is tinnitus, right? Ménière’s Disease does damage to the inner ear causing hearing loss which influences tinnitus prevalence. I would think the effect on tinnitus would have a shot at working for all tinnitus sufferers (providing the drug does indeed help). Which, it looks like it does.
       
    8. HootOwl

      HootOwl Member Podcast Patron Benefactor Advocate

      Location:
      California
      Tinnitus Since:
      2009
      Cause of Tinnitus:
      Explanation in About You
      Meniere's is a tad bit different, because it has more to do with excessive endolymph produced by the stria, than structural damage.

      For many Meniere’s suffers their tinnitus and hearing loss/distortions fluctuate according to whether or not the stria is behaving normally. Over time though you can get damage to the hair cells if the swelling isn’t controlled.

      BUT, what’s interesting is that there can be a strong viral component underlying Meniere's, which studies by Richard Gacek have demonstrated. So if you get the viral inflammation under control, you get the Meniere's under control. Thanks to @FGG for tipping me off to this. He basically took a group of people who had been diagnosed with Meniere's - didn’t even bother with subtyping - and said “hey, let’s throw antivirals at you and see what happens.”

      A group of people 1-2 years out from diagnosis got actual positive audiogram changes on his regiment, which is actually kind of incredible. Some didn’t, but again, Gacek wasn't really concerned with subtyping. Their problem might not have been viral, or the virus had already done too much structural damage.

      Most importantly though, he was trying to show that the inner ear can be highly susceptible to viral infections, resulting in inflammation that can generate some pretty nasty hearing symptoms.

      So if your tinnitus is generated by viral inflammation - or any inflammation outside of maybe autoimmune -then this could be seriously helpful. Tinnitus from other factors, or actual cochlear damage? Probably not so much.

      If it’s autoimmune you would have to treat the underlying cause or possibly be on this stuff for life, which honestly given the safety profile might not be a huge deal.
       
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    9. FGG
      No Mood

      FGG Member Podcast Patron Benefactor Hall of Fame Advocate

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Multi-factorial
      I just wanted to clarify that true Meniere's might not be viral but it is frequently misdiagnosed. And many of these misdiagnoses can be etiologies like viruses.
       
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    10. Pre55ure

      Pre55ure Member

      Location:
      California
      Tinnitus Since:
      May 2019
      Cause of Tinnitus:
      Cochlear migraines
      Thanks for that info, I'm very interested in SPI-1005. I haven't been diagnosed with Meniere's - but I share a lot of the same symptoms (episodic intense tinnitus, fluctuating hearing loss).
      The potential connection to viral inflammation is really interesting. Do you have a link where I could read more on that study?

      The doctor who I am currently being treated by is of the opinion that Meniere's (or more specifically E. hydrops) is a symptom of a problem with the inner ear, but not causative (if that makes sense). He was telling me that in some research he was following (I think he might be involved in) - they had essentially been able to trigger the onset of Meniere's symptoms (and the resulting E hydrops) by stimulating the brains of mice to essentially have intense migraines. Certain migraines seem to be implicated in causing the blood vessels that supply the inner ear to constrict, cutting off the blood flow and causing bad stuff to happen. Intense enough and often enough and it can result in all sorts of different types of damage to the inner ear (Often resulting in E. hydrops and Meniere's symptoms).

      Anyway, probably not relevant to SPI-1005. But just thought it was interesting to hear some different theories behind what can lead to Meniere's type symptoms.
       
    11. HootOwl

      HootOwl Member Podcast Patron Benefactor Advocate

      Location:
      California
      Tinnitus Since:
      2009
      Cause of Tinnitus:
      Explanation in About You
      No problem, here’s a link to the study. It’s behind a paywall unfortunately, but the abstract gives you the basic gist.

      https://pubmed.ncbi.nlm.nih.gov/25940200/
       
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    12. annV
      Fine

      annV Member

      Tinnitus Since:
      2005
      Cause of Tinnitus:
      unknown - possibly hereditary
      F*ck the paywall. I attached the full paper.
       

      Attached Files:

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    13. HootOwl

      HootOwl Member Podcast Patron Benefactor Advocate

      Location:
      California
      Tinnitus Since:
      2009
      Cause of Tinnitus:
      Explanation in About You
      @annV comin’ in hot!! Thank you!!
       
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    14. Pre55ure

      Pre55ure Member

      Location:
      California
      Tinnitus Since:
      May 2019
      Cause of Tinnitus:
      Cochlear migraines
      Thank you both for posting that / informing me of that study.
       

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