Xenon Pharmaceuticals' XEN1101 — Kv7 Potassium Channel Modulator

Discussion in 'Research News' started by jer, Mar 3, 2018.

    1. JPGL
      Frustrated

      JPGL Member Benefactor

      Location:
      Spain
      Tinnitus Since:
      10/2015
      Cause of Tinnitus:
      Hearing loss? Noise? Stress? Unknown
      The idea would be to hold out here with XEN-1101 as a palliative treatment until regenerative drugs come on to the market.
       
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    2. Toby1972
      Sleepy

      Toby1972 Member Benefactor

      Tinnitus Since:
      2021
      Cause of Tinnitus:
      Noise drama and stress
      Haha, I would also have to lie to take part in the study because my depression is severely severe, so I would have to lie that I only have moderate depression. I would not falsify the results. Haha, my psychotherapist (actually quite a good one) also says I should downplay the stressful things (can't do with 9/10 tinnitus, 24/7) lol.
       
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    3. Jerad

      Jerad Member

      Location:
      Ohio; United States
      Tinnitus Since:
      2002
      Cause of Tinnitus:
      Medication ototoxicity
      I wouldn’t have to lie. I have symptoms of MDD and PTSD. My biggest concern about the upcoming clinical trial(s) for this is that it looks like MRIs might be a requirement, as they want to image the brain as part of the study. With severe tinnitus and hyperacusis, MRIs would be a no-no.
       
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    4. StoneInFocus
      Fine

      StoneInFocus Member

      Tinnitus Since:
      2012
      Cause of Tinnitus:
      Hearing damage, ear infections
      If I had tinnitus alone I would never even consider lying to participate in a trial.

      I've had tinnitus for a long time, and even though I've been through some excruciatingly dark moments, I've managed to function with it at least somewhat.

      What I cannot do is reconciling chronic hyperacusis with a somewhat normal life. It's just not possible.
       
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    5. Ela Stefan

      Ela Stefan Member

      Tinnitus Since:
      11/2018
      Cause of Tinnitus:
      Ear Infection
      Found this study:

      The Role of Inflammation in Tinnitus: A Systematic Review and Meta-Analysis

      Maybe someone has some insight on it! Potassium channel modulators are not mentioned, but they do say this:

      ''Accumulating evidence suggests that inflammation plays a role in the pathogenesis of subjective tinnitus. Noise exposure and salicylate administration both lead to inflammation throughout the whole auditory pathway. In particular, TNF-α, IL-1β, glia and activated platelets are associated with acute tinnitus. TNF-α and IL-1β influence NMDA and GABAA receptors, leading to an increased excitatory and decreased inhibitory neurotransmission. These changes can lead to neuroplasticity and thus chronic tinnitus. Whether inflammatory mediators still play a role in chronic tinnitus remains to be elucidated. Nevertheless, drugs targeting the involved inflammatory mediators could be a potential effective treatment for (acute) tinnitus.''​

      So how can potassium channel modulators help if there are so many other inflammatory factors that can alter neuroplasticity and therefore sustain chronic tinnitus?
       
    6. dd314

      dd314 Member

      Tinnitus Since:
      2013
      Cause of Tinnitus:
      Acoustic Trauma + stress?
      They have quiet MRIs. Look for Siemens Quiet Suite.
       
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    7. Nobody19

      Nobody19 Member Podcast Patron Benefactor

      Tinnitus Since:
      2012
      Cause of Tinnitus:
      Clubbing
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    8. Padraigh Griffin

      Padraigh Griffin Member Podcast Patron Benefactor

      Tinnitus Since:
      05/2020
      Cause of Tinnitus:
      Unknown/Stress
      • Agree Agree x 3
    9. InNeedOfHelp

      InNeedOfHelp Member

      Tinnitus Since:
      08/2021
      Cause of Tinnitus:
      MRI Scan
      What I like is the fact that Xenon does not BS around with publishing papers, peer reviewing before publishing results etc. Commercial companies with an incentive for business is what will drive the treatments. They won't hesitate with their FDA submissions once the trials are over.

      I'm also excited about Oxytocin. It provided 25% reduction against placebo in a small study, it is widely available and does not require FDA approvals. The study closes 6th of May and I don't expect them to take years to come with the results. Might be our first temporary relief. Not sure why it gets so little attention. This treatment is the furthest in the entire tinnitus pipeline.
       
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    10. ploughna

      ploughna Member

      Tinnitus Since:
      2017
      Cause of Tinnitus:
      motor racing and power tools
      So if the stars are all aligned with respect to outcomes for this and future trials, is 2024 a reasonable guess as to when it might appear on the market?
       
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    11. Ela Stefan

      Ela Stefan Member

      Tinnitus Since:
      11/2018
      Cause of Tinnitus:
      Ear Infection
      So can we get Oxytocin from the market as of now?
       
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    12. InNeedOfHelp

      InNeedOfHelp Member

      Tinnitus Since:
      08/2021
      Cause of Tinnitus:
      MRI Scan
      They are using high dosage, not sure what the other ingredients are but it is a well documented substance which is used during giving birth etc. I would wait a few months until the study results are published.
       
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    13. Hottopic29

      Hottopic29 Member Benefactor

      Location:
      Niagara falls
      Tinnitus Since:
      11/2013
      Cause of Tinnitus:
      Zithromycin acoustic trauma 2022
      Xenon Pharmaceuticals is Canadian. I wonder if it will be released first in the United States before Canada or at the same time. They did trial the drug here and there.
       
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    14. Padraigh Griffin

      Padraigh Griffin Member Podcast Patron Benefactor

      Tinnitus Since:
      05/2020
      Cause of Tinnitus:
      Unknown/Stress
      This is my guess. I feel there is a 90% chance of it being released as an epilepsy drug in mid 2024. Then I think it will follow quickly for depression as they will have accumulated enough efficacy and safety data from the various trials to market it for depression.

      When already on the market for epilepsy, will a Phase 3 trial for depression even be necessary?

      Maybe someone with better knowledge than I can clarify this.
       
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    15. Ela Stefan

      Ela Stefan Member

      Tinnitus Since:
      11/2018
      Cause of Tinnitus:
      Ear Infection
      Could you get it without a prescription so I could buy it for tinnitus? What do you think about the price? When a company is private I know they are free to go on market with a price that will allow them to recover their costs, so the price can be high?

      That of course will go against my first sentence, so probably the drug will not be covered by insurance!

      Another question that is in my mind, does this drug modulate the potassium channels of all the cranial nerves or is it so selective that it modulates the auditory nerve only?
       
    16. InNeedOfHelp

      InNeedOfHelp Member

      Tinnitus Since:
      08/2021
      Cause of Tinnitus:
      MRI Scan
      I've read an analysis somewhere that it has the potential to be priced around €80,000 EUR per year. Cannot find the exact wording but there is a very interesting analysis on XEN1101 / XEN496 here:

      Xenon Pharmaceuticals, Inc. (XENE) - INITIATION REPORT (PDF)
       
    17. Ela Stefan

      Ela Stefan Member

      Tinnitus Since:
      11/2018
      Cause of Tinnitus:
      Ear Infection
      And for what potassium channels they work on? For which nerves...? Some of us have sensory tinnitus...
       
      • Good Question Good Question x 1
    18. StoneInFocus
      Fine

      StoneInFocus Member

      Tinnitus Since:
      2012
      Cause of Tinnitus:
      Hearing damage, ear infections
      I am totally clueless on the pharmaceutical industry and healthcare in America, but my god that price is depressing. Would people actually have to buy that out of their own pocket? In that case I'd rather go full Walter White mode and cook something up myself. Or shoot some Quercetin up my bum...
       
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    19. Padraigh Griffin

      Padraigh Griffin Member Podcast Patron Benefactor

      Tinnitus Since:
      05/2020
      Cause of Tinnitus:
      Unknown/Stress
      XEN496 might be priced high as it is a niche market, with a severe need for treatment.

      XEN1101 has many competitors for focal epilepsy treatment and if it's going after the depression market it will not be priced relatively high in my opinion.
       
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    20. Padraigh Griffin

      Padraigh Griffin Member Podcast Patron Benefactor

      Tinnitus Since:
      05/2020
      Cause of Tinnitus:
      Unknown/Stress
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    21. InNeedOfHelp

      InNeedOfHelp Member

      Tinnitus Since:
      08/2021
      Cause of Tinnitus:
      MRI Scan
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    22. Padraigh Griffin

      Padraigh Griffin Member Podcast Patron Benefactor

      Tinnitus Since:
      05/2020
      Cause of Tinnitus:
      Unknown/Stress
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