Xenon Pharmaceuticals' XEN1101 — Kv7 Potassium Channel Modulator

Discussion in 'Research News' started by jer, Mar 3, 2018.

    1. Nobody19

      Nobody19 Member Podcast Patron Benefactor

      Tinnitus Since:
      2012
      Cause of Tinnitus:
      Clubbing
      Xenon Pharmaceuticals Announces Positive Outcome of End-of-Phase 2 Meeting with the FDA | Xenon Pharmaceuticals Inc. (xenon-pharma.com)
       
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    2. PeterPan
      Nerdy

      PeterPan Member Advocate

      Location:
      Sydney
      Tinnitus Since:
      09/2016
      Cause of Tinnitus:
      Heat Exhaustion
      We’re lucky Penicillin was invented when it was as otherwise we might have been up for several hundreds of thousands for treatment by a wonder drug...!
       
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    3. ploughna

      ploughna Member

      Tinnitus Since:
      2017
      Cause of Tinnitus:
      motor racing and power tools
      To best of anyone's knowledge, has Xenon ever been asked about the drug's potential for tinnitus and whether it's something they'd consider investigating or running a trial for at some point (even if in the distant future)?

      If it offers benefit, but needs to be off-label, finding someone to prescribe it and paying for it may make it a very expensive proposition for many of us.
       
    4. Ela Stefan

      Ela Stefan Member

      Tinnitus Since:
      11/2018
      Cause of Tinnitus:
      Ear Infection
      How much would it cost if it were to be bought off-label?
       
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    5. Nobody19

      Nobody19 Member Podcast Patron Benefactor

      Tinnitus Since:
      2012
      Cause of Tinnitus:
      Clubbing
      Afaik we only have a quote of their CEO: https://www.fool.com/earnings/call-...maceuticals-inc-xene-q2-2020-earnings-ca.aspx

      We're exploring indications outside of the focal epilepsy indication, which remains our primary indication for this drug, but there's a tremendous amount of literature that's building in the role of the KB72 and/or 3 channel in neuronal hyperexcitability that underlies a number of interesting neurological disorders where hyperexcitability appears to perhaps drive, for example, apoptosis in motor neuron disease in hyperexcitability through this channel, mediating Pain signaling. Hyperexcitability through this channel thought to have potentially a role in anhedonia and major depressive disorder. And we know these channels are also expressed in the ear and the hair cells, in particular, and the potential for treatment using a Kv7.2 modulator for tinnitus is also of interest.
       
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    6. addot

      addot Member

      Location:
      US
      Tinnitus Since:
      Jan 2013
      Cause of Tinnitus:
      Noise exposure
      Yes. TDLR: they are interested in the drug's potential for treating tinnitus but, so far, there are no concrete plans for clinical trials.
       
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    7. lymebite
      Vegged out

      lymebite Member Podcast Patron Benefactor

      Location:
      United States
      Tinnitus Since:
      2013
      Cause of Tinnitus:
      Unknown
      In my experience, which is in the US, if a medication is prescribed off-label, it makes no difference in the price.
       
    8. ploughna

      ploughna Member

      Tinnitus Since:
      2017
      Cause of Tinnitus:
      motor racing and power tools
      Agreed, but (and the reason I asked), is off-label unlikely to be covered by insurance whereas an approved treatment has a much better chance? Anyway, getting ahead of myself here already - let's hopefully see it get on the market soon where I'll definitely be in line to try it out!
       
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    9. grate_biff
      Depressed

      grate_biff Member Benefactor

      Location:
      Moss, Norway
      Tinnitus Since:
      09/2014
      Cause of Tinnitus:
      Acoustic trauma using headphones
      But it does matter regarding insurance or getting it on "blue script" as it's called in my country, i.e. being cheaper.

      An antiemetic drug Zofran is basically free in Norway if you have cancer. But if you have nausea because of benzo withdrawal for instance, it's $5.5 a pill.
       
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    10. Ela Stefan

      Ela Stefan Member

      Tinnitus Since:
      11/2018
      Cause of Tinnitus:
      Ear Infection
      Since XEN1101 targets depression as well, maybe it will not be that hard to get a doctor to prescribe it.
       
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    11. hopes

      hopes Member

      Tinnitus Since:
      02/2020
      Cause of Tinnitus:
      Unknown
      Anyone with epilepsy + tinnitus tried this yet?
       
    12. addot

      addot Member

      Location:
      US
      Tinnitus Since:
      Jan 2013
      Cause of Tinnitus:
      Noise exposure
      It's in clinical trials, not available yet. Many people tried an earlier version of this drug, with varying results. Keep in mind the new version is supposed to be more potent and have less side effects.
       
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    13. Travis Henry
      Cynical

      Travis Henry Member

      Location:
      Dallas,TX
      Tinnitus Since:
      10/2021
      Cause of Tinnitus:
      1 Moderna Vac, Noise and stress I guess, its killing me
      Please Xenon save my soul.

      So has it helped a lot of people with tinnitus?
       
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