Frequency Therapeutics — Hearing Loss Regeneration

Discussion in 'Research News' started by RB2014, Dec 8, 2016.

    1. Daniel Lion
      Ape-like

      Daniel Lion Member Podcast Patron Benefactor Hall of Fame

      Location:
      SE Asia
      Tinnitus Since:
      2017
      Cause of Tinnitus:
      Noise trauma, hearing loss
      @mrbrightside614, @FGG, @Hazel, @Markku... Hi.

      I know this is unscientific, but perhaps at the end of the interview, you could convey to Mr. Lucchino, or the powers that be, that there are a bunch of people on Tinnitus Talk who are quite desperate and have been following this company since its inception. These folks are clued up about hearing regeneration and some are facing Cochlear Implants, hearing aids, and many have high frequency hearing loss and are desperate for help. Tinnitus Talk members are already planning to share accommodation to help each other get treatment. We are huge fans and know hearing regeneration is our only hope. We are grateful for Frequency’s work and mission.

      Shoot... This cochlear damage is hard work. Digging deep everyday.
      Glad you hearing regeneration die hards are here...
       
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    2. AtlasFainted

      AtlasFainted Member Podcast Patron

      Tinnitus Since:
      12/19
      Cause of Tinnitus:
      Noise Exposure + Viral Infection
      I said "for now". For now, in the U.S, we haven't seen so many deaths as to think that the top researchers of Frequency Therapeutics will be wiped out by it.

      If you disagree that's fine. I'm not saying that it's not dangerous, just that it's not the bubonic plague 2.0.
       
    3. serendipity1996

      serendipity1996 Member

      Tinnitus Since:
      2011
      Cause of Tinnitus:
      Unknown but suspect noise-induced
      From what Frequency has said, the drug will also regenerate the corresponding synapses if hair cells are damaged but its primary function is a a hair-cell regeneration drug so it's probably not gonna be a complete slam-dunk from the POV of neural regeneration.
       
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    4. john paul
      English

      john paul Member

      Tinnitus Since:
      11/11/17
      Cause of Tinnitus:
      acoustic trauma
      Nightmare isn't it. :(
       
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    5. AtlasFainted

      AtlasFainted Member Podcast Patron

      Tinnitus Since:
      12/19
      Cause of Tinnitus:
      Noise Exposure + Viral Infection
      Stay safe! South Korea has likely seen the worst of COVID-19 in their country because their private sector was permitted to develop tests months ago.

      In the United States, our FDA has tighter regulations and the private sector is only just now allowed to take action.

      I understand that things can get worse. I'm only saying that as of now, the death toll here is pretty low and there's no reason to prematurely fear the death of top researchers!
       
    6. AtlasFainted

      AtlasFainted Member Podcast Patron

      Tinnitus Since:
      12/19
      Cause of Tinnitus:
      Noise Exposure + Viral Infection
      That does make sense.

      I have no clue, but I'm going to pretend it's likely that synapse damage without corresponding hair cell damage will be minimal.

      I've also been taking Lion's Mane (Hericium erinaceus) mushroom capsules daily for a while, which according to science can help repair nerve damage for the duration that you take it. So fingers crossed that will help any synapse issues.
       
    7. FGG
      No Mood

      FGG Member Podcast Patron Benefactor Hall of Fame Advocate

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Multi-factorial
      They have said in their JP Morgan Q and A that the synapses are repaired *only* in places where hair cells are regenerated. Ie: if you have cochlear synaptopathy without hair cell loss in a location, the drug won't work.
       
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    8. Tweedleman

      Tweedleman Member Benefactor

      Tinnitus Since:
      2001
      Cause of Tinnitus:
      Unknown/Noise
      I always had it mild since I was 10 but made it a lot worse with hearing damage after a loud concert.
       
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    9. AtlasFainted

      AtlasFainted Member Podcast Patron

      Tinnitus Since:
      12/19
      Cause of Tinnitus:
      Noise Exposure + Viral Infection
      Thanks that makes perfect sense!

      I wonder how common cochlear synaptopathy without hair cell loss is? Especially with noise-induced hearing loss?
       
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    10. FGG
      No Mood

      FGG Member Podcast Patron Benefactor Hall of Fame Advocate

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Multi-factorial
      I don't think anyone knows for sure but I believe synapses are generally more prone to being damaged and can be damaged with more mild insults.
       
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    11. serendipity1996

      serendipity1996 Member

      Tinnitus Since:
      2011
      Cause of Tinnitus:
      Unknown but suspect noise-induced
      I'm pretty sure this has been the focus of much of Charles Liberman's work on hidden hearing loss - that the nerve connections are far more vulnerable to damage and that this type of damage can be widespread even with a normal audiogram. Don't have the specific journal articles on hand but there's an interview with him here where he talks more about it.

      https://www.entandaudiologynews.com...-conversation-with-professor-charles-liberman

      But idk I guess it's difficult to know for sure given it's impossible to go in and image a living person's ear.
       
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    12. Jorge1984
      Wishful

      Jorge1984 Member

      Tinnitus Since:
      02/2020
      Cause of Tinnitus:
      Loud music
      How do you cope with it? And do you think FX-322 will work for us noise induced hearing lost and tinnitus folks?
       
    13. Tweedleman

      Tweedleman Member Benefactor

      Tinnitus Since:
      2001
      Cause of Tinnitus:
      Unknown/Noise
      Still trying to figure out how to cope with it and all the shame and regret for causing it. It's a daily struggle.

      I do think FX-322 will help, but those of us with low frequency damage will have to wait for another formulation that can penetrate below 3500 Hz. We will also need an effective synaptopathy drug to touch up remaining hair cells with damaged synapses.
       
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    14. Paulmanlike

      Paulmanlike Member Hall of Fame

      Tinnitus Since:
      2008
      Cause of Tinnitus:
      Noise
      This is correct, I've read it too.

      Decibel Therapeutics' approach may be better for those with tinnitus and normal audiograms (like myself).
       
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    15. Jorge1984
      Wishful

      Jorge1984 Member

      Tinnitus Since:
      02/2020
      Cause of Tinnitus:
      Loud music
      Thank you for responding. Try using white noise. And how long do you think it will take until they come up with another formulation for us?
       
    16. GregCA
      Jaded

      GregCA Member Benefactor Hall of Fame

      Tinnitus Since:
      03/2016
      Cause of Tinnitus:
      Otosclerosis
      So were they.
       
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    17. AtlasFainted

      AtlasFainted Member Podcast Patron

      Tinnitus Since:
      12/19
      Cause of Tinnitus:
      Noise Exposure + Viral Infection
      From the article: "As soon as we got the new staining techniques working, we saw that noise exposures caused dramatic loss of synapses on surviving inner hair cells, even in ears where thresholds had completely recovered."

      Yeah, this doesn't sound like good news for FX-322. He also goes on to say it's likely that disconnected synapses could be a cause for tinnitus... damn. I guess I have to find another drug to watch alongside FX-322?
       
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    18. Tweedleman

      Tweedleman Member Benefactor

      Tinnitus Since:
      2001
      Cause of Tinnitus:
      Unknown/Noise
      We don't know, but that was one of my questions for the podcast. Frequency needs to reformulate first, which could theoretically begin soon considering @FGG pointed out they had a job posting for some kind of formulation specialist on their website. Then there's the question of whether or not the reformulation would require a whole new batch of clinical trials.
       
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    19. HootOwl

      HootOwl Member Podcast Patron Benefactor Advocate

      Location:
      California
      Tinnitus Since:
      2009
      Cause of Tinnitus:
      Explanation in About You
      Decibel dropped their cochlear neuropathy drug. I believe their focus is now only on preventing Cisplatin toxicity, congenital deafness, and a hair cell regenerative compound that is still in preclinicals.
       
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    20. FGG
      No Mood

      FGG Member Podcast Patron Benefactor Hall of Fame Advocate

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Multi-factorial
      Decibel isn't developing a synaptopathy drug anymore. They have switched gears to develop other parts of their pipeline (including genetic hearing loss and balance orders). They haven't completely abandoned acquired hearing loss, though, as they just bought the rights to the LATS inhibitors being researched at The Rockefeller University.

      Otonomy has a synaptopathy drug in phase 2 and Pipeline has one about to start phase 1, though.
       
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    21. mrbrightside614

      mrbrightside614 Member Podcast Patron Benefactor Advocate

      Location:
      NE Ohio, USA
      Tinnitus Since:
      July 2019
      Cause of Tinnitus:
      Acoustic trauma
      The new hair cell makes the necessary synaptic connections, otherwise they’d be non-functional. If you have synaptic damage with no hair cell loss in the area, it won’t fix that.

      However, I don’t think many people's problems are primarily derived from auditory nerve damage. I’m only guessing, but I think hair cell damage is much more common and a more typical source of tinnitus.
       
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    22. serendipity1996

      serendipity1996 Member

      Tinnitus Since:
      2011
      Cause of Tinnitus:
      Unknown but suspect noise-induced
      Yeah it's a bit confusing but didn't Frequency say in one of their presentations that like 90% of hearing loss is due to hair cell loss?
       
    23. serendipity1996

      serendipity1996 Member

      Tinnitus Since:
      2011
      Cause of Tinnitus:
      Unknown but suspect noise-induced
      How come Decibel dropped their synaptopathy drug?
       
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    24. Tweedleman

      Tweedleman Member Benefactor

      Tinnitus Since:
      2001
      Cause of Tinnitus:
      Unknown/Noise
      OTO-413 and PIPE-515. They've each got their own thread in the Research News section.
       
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    25. Jorge1984
      Wishful

      Jorge1984 Member

      Tinnitus Since:
      02/2020
      Cause of Tinnitus:
      Loud music
      Hopefully they don’t do clinical trials but at the same time I understand the reason for people's safety but seriously it’s hard to wait.
       
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    26. Tweedleman

      Tweedleman Member Benefactor

      Tinnitus Since:
      2001
      Cause of Tinnitus:
      Unknown/Noise
      Ya this is kinda irking me, too. I hope it signals that they have complete confidence in the other players to fulfill the need.
       
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    27. FGG
      No Mood

      FGG Member Podcast Patron Benefactor Hall of Fame Advocate

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Multi-factorial
      But at least they didn't drop anything while in clinical trials. That would have been much worse news imo. It seems like just a reprioritizing.
       
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    28. AtlasFainted

      AtlasFainted Member Podcast Patron

      Tinnitus Since:
      12/19
      Cause of Tinnitus:
      Noise Exposure + Viral Infection
      I hope you're right! I certainly hope that FX-322 will fix my noise-induced issues. I unquestionably have hair cell loss (I've had countless acoustic traumas) and expect Frequency's drug to help there.

      What has me concerned is Charles Liberman's take on it, but I might be misunderstanding things...

      He used the word "dramatic" when describing the level of synapse loss concerning still intact hair cells in ears that suffered acoustic trauma... but maybe you've already considered this?

      I am working from a very limited understanding here!
       
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    29. Lucifer

      Lucifer Member Podcast Patron Benefactor

      Tinnitus Since:
      2017
      Cause of Tinnitus:
      Ear Infection
      Imagine if Frequency Therapeutics were to drop FX-322 and focus on something else. Likelihood of that happening is 0.01% since they got a lot of funding from Astellas which to me suggests FX-322 helps with hearing loss but whether it helps with tinnitus and hyperacusis we are not too sure on.

      Good thing the podcast with Frequency Therapeutics is happening next month. I was not expecting to hear from them anytime soon so I would like to say thank you to the guys that got this interview to happen. When I first saw that the interview was happening I had an OMG reaction lol.
       
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    30. Tweedleman

      Tweedleman Member Benefactor

      Tinnitus Since:
      2001
      Cause of Tinnitus:
      Unknown/Noise
      This is what the synaptopathy drugs will be for. If you've had multiple acoustic traumas (concerts etc.) then chances are you have widespread synaptic damage, too. FX-322 is one piece to the puzzle, it's a big one, but it may not be everything you need.
       
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