Frequency Therapeutics — Hearing Loss Regeneration

Discussion in 'Research News' started by RB2014, Dec 8, 2016.

    1. kiki

      kiki Member Benefactor

      Tinnitus Since:
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      What are the benefits of injecting into both ears?

      Will the effect be greater?
       
    2. Tezcatlipoca
      Question it

      Tezcatlipoca Member

      Location:
      Mexico
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      Well many members on this forum have always complained that usually only one ear is treated, so at least those people will be content.

      I think injecting into both ears can be beneficial.
       
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    3. kiki

      kiki Member Benefactor

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      Certainly, in the patent application, I think that there were two 5 dB improvements at 6 kHz in Phase 1/2.
       
    4. MrCrybaby

      MrCrybaby Member Benefactor

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      One hypothesis of tinnitus is asymmetrical hearing damage that the brain tries to balance out unsuccessfully. Treating both ears could address this potential mechanism of action.
       
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    5. Gb3

      Gb3 Member

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      No one knows if the drug works like they initially said.
       
    6. Gb3

      Gb3 Member

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      12/19
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      The results will be all over the place. They won’t do that.
       
    7. Diesel

      Diesel Member Benefactor Ambassador Hall of Fame Advocate

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      Why do you think this?
       
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    8. Gb3

      Gb3 Member

      Tinnitus Since:
      12/19
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      Sshl
      The whole point is just to prove its efficacy to get past the clinical trials. I think doing two ears is just harder to gather all the data, too many variables. If you have noticed, all the trials related to hearing treatment focus on one ear. That’s not saying it won’t work for both. It’s just easier to establish the endpoints for the trial when it is about one ear.
       
    9. Tezcatlipoca
      Question it

      Tezcatlipoca Member

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      But all current existing measurements of hearing rely on both ears...
       
    10. Gb3

      Gb3 Member

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      12/19
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      They measure each ear separately.
       
    11. Zugzug

      Zugzug Member Podcast Patron Benefactor Ambassador Hall of Fame Advocate

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      Autoimmune hyperacusis from Sjogren's Syndrome
      Seems difficult from a control perspective. If a sample size of N ears is required to demonstrate (presumably the standard 80%) statistical power, it only really leads to N/2 independent data "pairs." In other words, all of this stuff that we've been speculating about (studying word tests, guessing better, etc.) would have double the weight since the same person would supply two ears.

      Then there's the nightmare of making sense of why one ear improved, while the other didn't. Moreover, there's the issue of double shot = double neuroplasticity improvement (central). So, while it would still be encouraging to see tinnitus improvements from a double shot, it may give a poor representation of how much hair cell + synapse repair really occurred in each ear. I totally understand your desire from a tinnitus and hyperacusis sufferer's perspective though. I'd love for them to double shot me.

      Recruiting wise, it seems to add extra difficulty to a process that will already be a lot harder. I know we've been talking about things like demanding similar word scores at entrance as >= 6 months ago. To get recruited, a person would have to achieve this in both ears. Probably pretty hard, IMO.
       
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    12. Diesel

      Diesel Member Benefactor Ambassador Hall of Fame Advocate

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      My last WR + WIN included a "both ears" test...
       
    13. Gb3

      Gb3 Member

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      Sshl
      Exactly.
       
    14. Diesel

      Diesel Member Benefactor Ambassador Hall of Fame Advocate

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      Thanks for clarifying!
       
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    15. ThomasRobert

      ThomasRobert Member Benefactor

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      Donlon Coatings just published their work on the new building for Frequency Therapeutics HQ...

      Thoughts?

      DCI Projects - 75 Hayden Ave – Frequency...
       
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    16. Keith Handy
      Worried

      Keith Handy Member

      Tinnitus Since:
      11/2020
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      Stress + sleep deprivation + noise
      Nice flooring, but it's not the goop I'm interested in.
       
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    17. Diesel

      Diesel Member Benefactor Ambassador Hall of Fame Advocate

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      That's a big lab.
       
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    18. ThomasRobert

      ThomasRobert Member Benefactor

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      But why did they take this step without having concrete data? It's like burning money...
       
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    19. Zugzug

      Zugzug Member Podcast Patron Benefactor Ambassador Hall of Fame Advocate

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      You know what they say about big labs, right?

      Big scientific discoveries.
       
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    20. Diesel

      Diesel Member Benefactor Ambassador Hall of Fame Advocate

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      I can't speak for scientific work... but from an engineering standpoint, usually when you can throw more engineers at a problem, or set of problems... you get more solutions more quickly.

      We also have to keep in mind that they aren't just working on PCA in the inner ear and for MS. Langer himself at the January webinar mentioned that they are working on "10 other areas of the body"... so they're probably looking to discover as much as possible on the PCA front.
       
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    21. FGG
      No Mood

      FGG Member Podcast Patron Benefactor Ambassador Hall of Fame Advocate

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      It looks the move was planned since at least last December too:

      Frequency Therapeutics plans HQ move for early next year
       
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    22. Aaron91
      Gloomy

      Aaron91 Member Podcast Patron Benefactor Ambassador Advocate

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      And none of the people working on the building are wearing ear protection.

      Ironic.
       
    23. Zugzug

      Zugzug Member Podcast Patron Benefactor Ambassador Hall of Fame Advocate

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      Maybe the photo op is a power move. Like no worries, our drug will just fix these people right up. Then after the recording is done, they all put on their Peltors.
       
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    24. Tezcatlipoca
      Question it

      Tezcatlipoca Member

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      583t9l.jpg
       
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    25. GlennS

      GlennS Member Podcast Patron Hall of Fame

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      Hubris. Hardly unique with risky startups.
       
    26. newfie
      Spaced

      newfie Member

      Location:
      Canada
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      10/2007
      Cause of Tinnitus:
      Acoustic trauma (gun)
      Only a matter of time before one of these companies or research labs makes a big breakthrough and we have some therapies for treating, if not curing, hearing loss. The potential market is huge; big pharma knows this. Huge unmet demand.

      If I were a betting man I'd say that within 10 years a treatment or cure is a realistic possibility. Stark contrast from 2007 when I got my acoustic trauma and tinnitus and regenerating hair cells and cochlear synapses was just an idea.
       
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    27. rid0871

      rid0871 Member

      Tinnitus Since:
      may of 2015
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      had my neck adjusted
      Because it's the only thing of value they have; real estate property. Just saying.
       
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    28. Tezcatlipoca
      Question it

      Tezcatlipoca Member

      Location:
      Mexico
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      Cause of Tinnitus:
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      But it's a lease...
       
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    29. GBB

      GBB Member Hall of Fame

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      NYC
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      2016-2019 (Mild, Cured) 8/2020 (Severe)
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      Are you under the understanding that in the event that the company shuts down, management gets to keep the proceeds from the disposition of real estate? If so, big oof to your brain :(

      They would only be entitled to these assets to the extent they hold the superceding tranche(s) of debt/equity that are given first repayment in the event of bankruptcy - this is held by institutional investors/creditors.
       
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    30. AfroSnowman
      Balanced

      AfroSnowman Member Podcast Patron Benefactor

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